Biosynthesis of polymyxins B, E, and P using genetically engineered polymyxin synthetases in the surrogate Host Bacillus subtilis

Journal of Microbiology and Biotechnology

Volumn 25, Issue 7, 2015, Pages 1015-1025

  Kim, Se Yu ^a,b   Park, Soo Young ^a   Choi, Soo Keun ^a,b   Park, Seung Hwan ^a,b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

Author keywords

A domain engineering; Bacillus subtilis; Heterologous expression; Polymyxin B; Polymyxin E; Polymyxin synthetase

Indexed keywords

COLISTIN; DEXTRO PHENYLALANINE; LEUCINE; POLYMYXIN B; POLYMYXIN DERIVATIVE; POLYMYXIN P; POLYMYXIN SYNTHETASE; SYNTHETASE; UNCLASSIFIED DRUG; LIGASE; POLYMYXIN; RECOMBINANT PROTEIN;

ARTICLE; BACILLUS SUBTILIS; BACTERIAL GENE; DRUG SYNTHESIS; ECTB GENE; ESCHERICHIA COLI; FOSMID; GENE CLUSTER; GENE DELETION; GENE EXPRESSION; GENE FUSION; GENE STRUCTURE; GENETIC ENGINEERING; GENETIC RECOMBINATION; NONHUMAN; PAENIBACILLUS POLYMYXA; PMXA GENE; PMXB GENE; PMXC GENE; PMXD GENE; PMXE GENE; PROTEIN DOMAIN; SACB GENE; BIOSYNTHESIS; ENZYMOLOGY; GENETICS; METABOLIC ENGINEERING; METABOLISM; PAENIBACILLUS;

BACILLUS SUBTILIS; ESCHERICHIA COLI; PAENIBACILLUS POLYMYXA;

BACILLUS SUBTILIS; LIGASES; METABOLIC ENGINEERING; PAENIBACILLUS; POLYMYXINS; RECOMBINANT PROTEINS;

EID: 84937393697     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: 10.4014/jmb.1505.05036     Document Type: Article

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