Modulation of the hydrophobic domain of polymyxin B nonapeptide: Effect on outer-membrane permeabilization and lipopolysaccharide neutralization

Molecular Pharmacology

Volumn 62, Issue 5, 2002, Pages 1036-1042

  Tsubery, Haim ^a,c   Ofek, Itzhak ^c   Cohen, Sofia ^c   Eisenstein, Miriam ^b   Fridkin, Mati ^a  

^a Department of Organic Chemistry ^*  (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; BACTERIUM LIPOPOLYSACCHARIDE; LEUCINE; PHENYLALANINE; POLYMYXIN B NONAPEPTIDE; TRYPTOPHAN; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL OUTER MEMBRANE; BACTERIUM ADHERENCE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG BINDING; DRUG STRUCTURE; ESCHERICHIA COLI; HYDROPHOBICITY; IC 50; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; CELL MEMBRANE PERMEABILITY; CIRCULAR DICHROISM; DRUG INTERACTIONS; ESCHERICHIA COLI; HUMANS; HYDROPHOBICITY; LIPOPOLYSACCHARIDES; MODELS, MOLECULAR; POLYMYXIN B; PROTEIN STRUCTURE, TERTIARY; PSEUDOMONAS AERUGINOSA;

EID: 0036840627     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.5.1036     Document Type: Article

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