Synthesis and characterization of the colistin peptide polymyxin E1 and related antimicrobial peptides

Journal of Peptide Research

Volumn 57, Issue 3, 2001, Pages 175-187

  Kline, T ^a   Holub, D ^a   Therrien, J ^a   Leung, T ^a   Ryckman, D ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Cationic antimicrobial peptide; Colistin; Lariat peptide; Polymyxin; Solid phase peptide synthesis

Indexed keywords

ANTIINFECTIVE AGENT; COLISTIN; COLISTIN A; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; GROWTH INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BIOCHEMISTRY; COLISTIN; DRUG EVALUATION, PRECLINICAL; GRAM-NEGATIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; PEPTIDES, CYCLIC; PROTEIN ISOFORMS; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 0035083897     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1397-002X.2,000.00000.x     Document Type: Article

References (39)

1. Polymyxin and related peptide antibiotics
2. The chemistry of the polymyxin antibiotics
3. Structure and orientation of the mammalian antibacterial peptide cecropin P1 within phospholipid membranes
4. Structure and orientation of the antibiotic peptide magainin in membranes by solidstate nuclear magnetic resonance spectroscopy
5. Crystal structure of Defensin HNP3 an amphipathic dimer: Mechanisms of membrane permeabilization
6. Three-dimensional solution structure of lactoferricin b, an antimicrobial peptide derived from bovine lactoferrin
7. Cationic bactericidal peptides
8. Cathelicidns: A novel protein family with a common proregion and a variable C-terminal antimicrobial domain
9. Bactericidal activity and time-kill kinetics of the polypeptide compound PA1420
10. The in vitro activity of PA 1 42o vs. Pseudomonas aeruginosa and other organisms
11. Polymyxin B sulfate and colistin: Old antibiotic for emerging multiresistant Gram-negative bacteria
12. Sodium sulphomethyl derivatives of polymyxins
13. Isolation and characterization of three new polymyxins in polymyxins B and E by high-performance liquid chromatography
14. Separation of polymyxins by micellar electronkinetic capillary chromatogrphy
15. Total structures of colistin minor components
16. Molecular mapping and detoxification of the lipid A binding site by synthetic peptides
17. Structure-activity relationship of colistins
18. Chemical synthesis and characterization of α-N-octanoyl and other α-N-acyl colistin nonapeptide derivatives
19. Effect of colistin on the metabolism of Pseudomonas aeruginosa
20. Mechanism of interaction of different classes of cationic antimicrobial peptides with planar bilayers and with the cytoplasmic membrane of Escherichia coli
21. Solution structure of polymyxins B and E and effect of binding to lipopolysaccharide: An NMR and molecular modeling study
22. Higher-order structure of polymyxin B: The functional significance of topological flexibility
23. The properties and mode of action of the polymyxins
24. Structure-activity relationship of colistins
25. Synthesen in der polymyxin-reihe 4. Synthese des cyclischyen decapeptide 8
26. Lower alkanoyl esters of polymyxin antibiotics
27. Chemical and biological characteristics of monodansyl colistin
28. A fluorescent derivative of polymyxin: Its preparation and use in studying the site of action of the antibiotic
29. 14C)-derivatives of the membrane-specific polypeptide antibiotic polymyxin B
30. Biologically active cyclopeptides: Lysine analogs of polymyxins antibiotics M, D, E & B
31. Studies on the compounds related to colistin. V. Synthesis and pharmacological activity of colistin analogues
32. 1
33. 1
34. Chemical structure of circulin A
35. Polymyxin acylase: Purification and characterization, with special reference to broad substrate specificity
36. Cyclooctanone
37. Synthesis and characterization of enantiomers of 5- and 6-methyloctanoic acids
38. A short synthesis of (Z)-15-methylhexadec-11-enoic acid