Whey proteins have beneficial effects on intestinal enteroendocrine cells stimulating cell growth and increasing the production and secretion of incretin hormones

Food Chemistry

Volumn 189, Issue , 2015, Pages 120-128

  Gillespie, Anna L ^a   Calderwood, Danielle ^a   Hobson, Laura ^a   Green, Brian D ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Diabetes; GIP; GLP 1; Incretin hormones; pGIP Neo STC 1; Protein; Whey

Indexed keywords

BODY FLUIDS; CELL PROLIFERATION; CELLS; CYTOLOGY; ENDOCRINOLOGY; HORMONES; MEDICAL PROBLEMS; NUTRITION; PHYSIOLOGY;

BOVINE SERUM ALBUMINS; ENTEROENDOCRINE CELLS; GIP; GLP-1; INTRACELLULAR LEVELS; PGIP/NEO STC-1; TYPE 2 DIABETES MELLITUS; WHEY;

PROTEINS;

ALPHA LACTALBUMIN; BETA LACTOGLOBULIN; BOVINE SERUM ALBUMIN; CHYMOTRYPSIN; GLUCAGON LIKE PEPTIDE 1; INCRETIN; MILK PROTEIN; TRYPSIN; YOGHURT; ANTIDIABETIC AGENT; LACTALBUMIN; LACTOGLOBULIN; PROTEIN HYDROLYSATE; WHEY PROTEIN;

ARTICLE; CELL COUNT; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENTEROENDOCRINE CELL; HORMONE RELEASE; HORMONE SYNTHESIS; HYDROLYSIS; MITOCHONDRIAL MEMBRANE POTENTIAL; WHEY; ANIMAL; CELL LINE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; INTESTINE; METABOLISM; MOUSE; SECRETION (PROCESS);

BOVINAE;

ANIMALS; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; ENTEROENDOCRINE CELLS; GLUCAGON-LIKE PEPTIDE 1; HYPOGLYCEMIC AGENTS; INCRETINS; INTESTINES; LACTALBUMIN; LACTOGLOBULINS; MICE; PROTEIN HYDROLYSATES; WHEY PROTEINS;

EID: 84937251971     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2015.02.022     Document Type: Article

References (36)

1. A. Beucher, E. Gjernes, C. Collin, M. Courtney, A. Meunier, P. Collombat, and et al. The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice PLoS One 7 5 2012 e36449
2. Y. Chen, Z.Y. Li, Y. Yang, and H.J. Zhang Uncoupling protein 2 regulates glucagon-like peptide-1 secretion in L-cells World Journal of Gastroenterology 18 26 2012 3451 3457
3. M. Cordier-Bussat, C. Bernard, F. Levenez, N. Klages, B. Laser-Ritz, J. Philippe, and et al. Peptones stimulate both the secretion of the incretin hormone glucagon-like peptide 1 and the transcription of the proglucagon gene Diabetes 47 7 1998 1038 1045
4. E. Diakogiannaki, F.M. Gribble, and F. Reimann Nutrient detection by incretin hormone secreting cells Physiology & Behavior 106 3 2012 387 393
5. D.J. Drucker Enhancing the action of incretin hormones: A new whey forward? Endocrinology 147 7 2006 3171 3172
6. P.R. Flatt, C.J. Bailey, and B.D. Green Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes Frontiers in bioscience 13 2008 3648 3660
7. M.C.P. Geraedts, F.J. Troost, M.A.J.G. Fischer, L. Edens, and W.H.M. Saris Direct induction of CCK and GLP-1 release from murine endocrine cells by intact dietary proteins Molecular Nutrition & Food Research 55 3 2011 476 484
8. J.C. Gevrey, M. Malapel, J. Philippe, G. Mithieux, J. Chayvialle, J. Abello, and et al. Protein hydrolysates stimulate proglucagon gene transcription in intestinal endocrine cells via two elements related to cyclic AMP response element Diabetologia 47 5 2004 926 936
9. B.D. Green, and P.R. Flatt Incretin hormone mimetics and analogues in diabetes therapeutics Best Practice & Research Clinical Endocrinology & Metabolism 21 2007 497 516
10. A.M. Habib, P. Richards, L.S. Cairns, G.J. Rogers, C.A.M. Bannon, H.E. Parker, and et al. Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry Endocrinology 153 7 2012 3054 3065
11. G. Kontopidis, C. Holt, and L. Sawyer Invited review: Beta-lactoglobulin: Binding properties, structure, and function Journal of Dairy Science 87 4 2004 785 796
12. G. Kroemer, L. Galluzzi, and C. Brenner Mitochondrial membrane permeabilization in cell death Physiological Reviews 87 2007 99 163
13. I.M.E. Lacroix, and E.C.Y. Li-Chan Inhibition of dipeptidyl peptidase (DPP)-IV and α-glucosidase activities by pepsin-treated whey proteins Journal of Agricultural and Food Chemistry 61 31 2013 7500 7506
14. I.M.E. Lacroix, and E.C.Y. Li-Chan Overview of food products and dietary constituents with antidiabetic properties and their putative mechanisms of action: A natural approach to complement pharmacotherapy in the management of diabetes Molecular Nutrition & Food Research 58 1 2014 61 78
15. R. Mahmud, M.A. Matin, and H. Otani Mitogenic effect of bovine b-lactoglobulin and its proteolytic digests on mouse spleen resting cells Pakistan Journal of Biological Sciences 7 12 2004 2045 2050
16. R.A. McGregor, and S.D. Poppitt Milk protein for improved metabolic health: A review of the evidence Nutrition & Metabolism 10 1 2013 46
17. P. Mirmiran, Z. Bahadoran, and F. Azizi Functional foods-based diet as a novel dietary approach for management of type 2 diabetes and its complications: A review World Journal of Diabetes 5 3 2014 267 281
18. F. Moulti-Mati, A. Mati, J. Capiaumont, F. Belleville, G. Linden, and P. Nabet Rôle de la B-Iactoglobuline dans l'activité proliférative du lactosérum Lait 71 1991 543 553
19. A.B. Nongonierma, and R.J. FitzGerald Dipeptidyl peptidase IV inhibitory and antioxidative properties of milk protein-derived dipeptides and hydrolysates Peptides 39 2013 157 163
20. S. Osborne, W. Chen, R. Addepalli, M. Colgrave, T. Singh, C. Tran, and et al. In vitro transport and satiety of a beta-lactoglobulin dipeptide and beta-casomorphin-7 and its metabolites Food & Function 2014 10.1039/c4fo00164h
21. N. Petersen, F. Reimann, S. Bartfeld, H.F. Farin, F.C. Ringnalda, R.G.J. Vries, and et al. Generation of L cells in mouse and human small intestine organoids Diabetes 63 2 2014 410 420
22. E.P. Rafferty, A.R. Wylie, C.T. Elliott, O.P. Chevallier, D.J. Grieve, and B.D. Green In vitro and in vivo effects of natural putative secretagogues of glucagon-like peptide-1 (GLP-1) Scientia Pharmaceutica 79 3 2011 615 621
23. E.B. Ramshur, T.R. Rull, and B.M. Wice Novel insulin/GIP co-producing cell lines provide unexpected insights into Gut K-cell function in vivo Journal of Cellular Physiology 192 3 2002 339 350
24. F. Reimann, P.S. Ward, and F.M. Gribble Signaling mechanisms underlying the release of glucagon-like peptide 1 Diabetes 55 S2 2006 S78 S85
25. R.A. Reimer Meat hydrolysate and essential amino acid-induced glucagon-like peptide-1 secretion, in the human NCI-H716 enteroendocrine cell line, is regulated by extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinases Journal of Endocrinology 191 1 2006 1 19
26. R. Sharma, and U. Schumacher The diet and gut microflora influence the distribution of enteroendocrine cells in the rat intestine Experientia 52 1996 664 670
27. H.G. Shertzer, S.E. Woods, M. Krishan, M.B. Genter, and K.J. Pearson Dietary whey protein lowers the risk for metabolic disease in mice fed a high-fat diet The Journal of Nutrition 141 4 2011 582 587
28. S.T. Silveira, D. Martínez-Maqueda, I. Recio, and B. Hernández-Ledesma Dipeptidyl peptidase-IV inhibitory peptides generated by tryptic hydrolysis of a whey protein concentrate rich in β-lactoglobulin Food Chemistry 141 2 2013 1072 1077
29. M. Speck, Y.M. Cho, A. Asadi, F. Rubino, and T.J. Kieffer Duodenal-jejunal bypass protects GK rats from β-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1 American Journal of Physiology, Endocrinology and Metabolism 300 2011 923 932
30. A.C. Taylor Responses of cells to pH change in the medium Journal of cell biology 15 1962 201 209
31. J.P. Thaler, and D.E. Cummings Minireview: Hormonal and metabolic mechanisms of diabetes remission after gastrointestinal surgery Endocrinology 150 6 2009 2518 2525
32. M. Uchida, Y. Ohshiba, and O. Mogami Novel dipeptidyl peptidase-4-inhibiting peptide derived from β-lactoglobulin Journal of Pharmacological Sciences 117 1 2011 63 66
33. World Health Organisation. Diabetes fact sheet no. 312, June 2014 (online). Available from URL: < http://www.who.int/mediacentre/factsheets/fs312/en >.
34. S.M. Yoder, Q. Yang, T.L. Kindel, and P. Tso Differential responses of the incretin hormones GIP and GLP-1 to increasing doses of dietary carbohydrate but not dietary protein in lean rats American Journal of Gastrointestinal and Liver Physiology 299 2010 G476 G485
35. P. Zhang, X. Zhang, J. Brown, D. Vistisen, R. Sicree, J. Shaw, and et al. Global healthcare expenditure on diabetes for 2010 and 2030 Diabetes Research and Clinical Practice 87 3 2010 293 301
36. J. Zhou, M.J. Keenan, J.N. Losso, A.M. Raggio, L. Shen, K.L. McCutcheon, and et al. Dietary whey protein decreases food intake and body fat in rats Obesity (Silver Spring, Md.) 19 8 2011 1568 1573