Minireview: Hormonal and metabolic mechanisms of diabetes remission after gastrointestinal surgery

Endocrinology

Volumn 150, Issue 6, 2009, Pages 2518-2525

  Thaler, Joshua P ^a   Cummings, David E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HEMOGLOBIN A1C; INSULIN; INSULIN RECEPTOR; MITOFUSIN 2;

BARIATRIC SURGERY; BILIOPANCREATIC BYPASS; BODY MASS; BODY WEIGHT; CALORIC RESTRICTION; COMORBIDITY; DIABETES CONTROL; DIABETES MELLITUS; DIABETIC PATIENT; DISEASE COURSE; GASTRIC BANDING; GASTROINTESTINAL SURGERY; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTESTINE BYPASS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRIENT; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REMISSION; ROUX Y ANASTOMOSIS; SHORT SURVEY; STOMACH BYPASS; SURGICAL PATIENT; TREATMENT OUTCOME; WEIGHT REDUCTION;

BARIATRIC SURGERY; DIABETES MELLITUS, TYPE 2; GLUCOSE; HOMEOSTASIS; HUMANS; OBESITY; REMISSION INDUCTION;

EID: 66749161611     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-0367     Document Type: Short Survey

References (75)

1. Mun EC, Blackburn GL, Matthews JB 2001 Current status of medical and surgical therapy for obesity. Gastroenterology 120:669-681 (Pubitemid 32171639)
2. Sjöström L, Lindroos AK, Peltonen M, Torgerson J, Bouchard C, Carlsson B, Dahlgren S, Larsson B, Narbro K, Sjöström CD, Sullivan M, Wedel H 2004 Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 351:2683-2693 (Pubitemid 39665322)
3. Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K, Schoelles K 2004 Bariatric surgery: a systematic review and meta-analysis. JAMA 292:1724-1737 (Pubitemid 39346675)
4. Cummings DE, Flum DR 2008 Gastrointestinal surgery as a treatment for diabetes. JAMA 299:341-343
5. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, Purnell JQ 2002 Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 346:1623-1630 (Pubitemid 34755670)
6. Cummings DE, Overduin J, Foster-Schubert KE 2004 Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution. J Clin Endocrinol Metab 89:2608-2615 (Pubitemid 38766339)
7. Cummings DE, Overduin J, Foster-Schubert KE, Carlson MJ 2007 Role of the bypassed proximal intestine in the anti-diabetic effects of bariatric surgery. Surg Obes Relat Dis 3:109-115 (Pubitemid 46444709)
8. Cummings DE, Overduin J, Shannon MH, Foster-Schubert KE 2005 Hormonal mechanisms of weight loss and diabetes resolution after bariatric surgery. Surg Obes Relat Dis 1:358-368
9. Cummings DE 2005 Gastric bypass and nesidioblastosis: too much of a good thing for islets? N Engl J Med 353:300-302
10. Cummings DE, Shannon MH 2003 Ghrelin and gastric bypass: is there a hormonal contribution to surgical weight loss? J Clin Endocrinol Metab 88:2999-3002
11. Thaler JP, Cummings DE 2008 Metabolism: food alert. Nature 452:941-942
12. Heap AJ, Cummings DE 2008 A novel weight-reducing operation: lateral subtotal gastrectomy with silastic ring plus small bowel reduction with omentectomy. Obes Surg 18:819-828
13. Rubino F, Forgione A, Cummings DE, Vix M, Gnuli D, Mingrone G, Castagneto M, Marescaux J 2006 The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes. Ann Surg 244:741-749 (Pubitemid 44629948)
14. Cummings DE, Foster-Schubert KE, Carlson MJ, Shannon MH, Overduin J 2007 Possible hormonal mechanisms mediating the effects of bariatric surgery. In: Pitombo C, ed. Obesity surgery: principle and practice. New York: McGraw-Hill; 137-147
15. Courcoulas AP, Flum DR 2005 Filling the gaps in bariatric surgical research. JAMA 294:1957-1960 (Pubitemid 41464697)
16. Pories WJ, Swanson MS, MacDonald KG, Long SB, Morris PG, Brown BM, Barakat HA, deRamon RA, Israel G, Dolezal JM, Dohm L 1995 Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus. Ann Surg 222:339-350; discussion 350-1332
17. Schauer PR, Burguera B, Ikramuddin S, Cottam D, Gourash W, Hamad G, Eid GM, Mattar S, Ramanathan R, Barinas-Mitchel E, Rao RH, Kuller L, Kelley D 2003 Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus. Ann Surg 238:467-484; discussion 484-1465
18. Wittgrove AC, Clark GW 2000 Laparoscopic gastric bypass, Roux-en-Y- 500 patients: technique and results, with 3-60 month follow-up. Obes Surg 10:233-239
19. Torquati A, Lutfi R, Abumrad N, Richards WO 2005 Is Roux-en-Y gastric bypass surgery the most effective treatment for type 2 diabetes mellitus in morbidly obese patients? J Gastrointest Surg 9:1112-1116; discussion 1117-1118
20. Sjöström L, Narbro K, Sjöström CD, Karason K, Larsson B, Wedel H, Lystig T, Sullivan M, Bouchard C, Carlsson B, Bengtsson C, Dahlgren S, Gummesson A, Jacobson P, Karlsson J, Lindroos AK, Lönroth H, Näslund I, Olbers T, Stenlöf K, Torgerson J, Agren G, Carlsson LM 2007 Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 357:741-752 (Pubitemid 47295641)
21. Adams TD, Gress RE, Smith SC, Halverson RC, Simper SC, Rosamond WD, Lamonte MJ, Stroup AM, Hunt SC 2007 Long-term mortality after gastric bypass surgery. N Engl J Med 357:753-761 (Pubitemid 47295642)
22. 2: a tailored approach. Surg Obes Relat Dis 2:401-404; discussion 404
23. 2. J Gastrointest Surg 12:945-952
24. Rubino F, Zizzari P, Tomasetto C, Bluet-Pajot MT, Forgione A, Vix M, Grouselle D, Marescaux J 2005 The role of the small bowel in the regulation of circulating ghrelin levels and food intake in the obese Zucker rat. Endocrinology 146:1745-1751 (Pubitemid 40396883)
25. Rubino F, Marescaux J 2004 Effect of duodenal-jejunal exclusion in a nonobese animal model of type 2 diabetes: a new perspective for an old disease. Ann Surg 239:1-11 (Pubitemid 38176365)
26. Pacheco D, de Luis DA, Romero A, González Sagrado M, Conde R, Izaola O, Aller R, Delgado A 2007 The effects of duodenal-jejunal exclusion on hormonal regulation of glucose metabolism in Goto-Kakizaki rats. Am J Surg 194:221-224 (Pubitemid 47008973)
27. Wang TT, Hu SY, Gao HD, Zhang GY, Liu CZ, Feng JB, Frezza EE 2008 Ileal transposition controls diabetes as well as modified duodenal jejunal bypass with better lipid lowering in a nonobese rat model of type II diabetes by increasing GLP-1. Ann Surg 247:968-975
28. Steinbrook R 2004 Surgery for severe obesity. N Engl J Med 350:1075-1079 (Pubitemid 38298986)
29. Wickremesekera K, Miller G, Naotunne TD, Knowles G, Stubbs RS 2005 Loss of insulin resistance after Roux-en-Y gastric bypass surgery: a time course study. Obes Surg 15:474-481 (Pubitemid 40605068)
30. Dixon JB, O'Brien PE, Playfair J, Chapman L, Schachter LM, Skinner S, Proietto J, Bailey M, Anderson M 2008 Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial. JAMA 299:316-323
31. Muscelli E, Mingrone G, Camastra S, Manco M, Pereira JA, Pareja JC, Ferrannini E 2005 Differential effect of weight loss on insulin resistance in surgically treated obese patients. Am J Med 118:51-57 (Pubitemid 40082459)
32. Laferrère B, Teixeira J, McGinty J, Tran H, Egger JR, Colarusso A, Kovack B, Bawa B, Koshy N, Lee H, Yapp K, Olivan B 2008 Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with type 2 diabetes. J Clin Endocrinol Metab 93:2479-2485
33. Meirelles K, Ahmed T, Culnan DM, Lynch CJ, Lang CH, Cooney RN 2009 Mechanisms of glucose homeostasis after Roux-en-Y gastric bypass surgery in the obese, insulin-resistant Zucker rat. Ann Surg 249:277-285
34. Pattou F, Beraud G, Arnalsteen L, Seguy D, Pigny P, Fermont C, Romon M, P F 2007 Restoration of β-cell function after bariatric surgery in type 2 diabetic patients: a prospective controlled study comparing gastric banding and gastric bypass. Obes Surg 17:1041-1043
35. Pattou F, Beraud G, Arnalsteen L, Seguy D, Pigny P, Fermont C, Romon M, Fontaine P 2008 Catering of insulinosecretion after a gastric bypass in type 2 diabetics is independent from weight loss and correlated to the increase of GLP1. Diabetes Metab 34:A23
36. le Roux CW, Aylwin SJ, Batterham RL, Borg CM, Coyle F, Prasad V, Shurey S, Ghatei MA, Patel AG, Bloom SR 2006 Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg 243:108-114 (Pubitemid 43054062)
37. Korner J, Bessler M, Inabnet W, Taveras C, Holst JJ 2007 Exaggerated glucagon-like peptide-1 and blunted glucose-dependent insulinotropic peptide secretion are associated with Roux-en-Y gastric bypass but not adjustable gastric banding. Surg Obes Relat Dis 3:597-601 (Pubitemid 350091417)
38. Gumbs AA, Modlin IM, Ballantyne GH 2005 Changes in insulin resistance following bariatric surgery: role of caloric restriction and weight loss. Obes Surg 15:462-473 (Pubitemid 40605067)
39. Lee WJ, Lee YC, Chen JC, Ser KH, Chen SC, Lin CM 2008 A randomized trial comparing laparoscopic sleeve gastrectomy versus gastric bypass for the treatment of type 2 diabetes mellitus: preliminary report. Surg Obes Relat Dis 4:290
40. Service GJ, Thompson GB, Service FJ, Andrews JC, Collazo-Clavell ML, Lloyd RV 2005 Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery. N Engl J Med 353:249-254 (Pubitemid 41058324)
41. Patti ME, McMahon G, Mun EC, Bitton A, Holst JJ, Goldsmith J, Hanto DW, Callery M, Arky R, Nose V, Bonner-Weir S, Goldfine AB 2005 Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabetologia 48:2236-2240 (Pubitemid 41618912)
42. Clancy TE, Moore Jr FD, Zinner MJ 2006 Post-gastric bypass hyperinsulinism with nesidioblastosis: subtotal or total pancreatectomy may be needed to prevent recurrent hypoglycemia. J Gastrointest Surg 10:1116-1119
43. Bantle JP, Ikramuddin S, Kellogg TA, Buchwald H 2007 Hyperinsulinemic hypoglycemia developing late after gastric bypass. Obes Surg 17:592-594 (Pubitemid 46945415)
44. Goldfine AB, Mun EC, Devine E, Bernier R, Baz-Hecht M, Jones DB, Schneider BE, Holst JJ, Patti ME 2007 Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal. J Clin Endocrinol Metab 92:4678-4685 (Pubitemid 350223444)
45. Z'graggen K, Guweidhi A, Steffen R, Potoczna N, Biral R, Walther F, Komminoth P, Horber F 2008 Severe recurrent hypoglycemia after gastric bypass surgery. Obes Surg 18:981-988
46. Kellogg TA, Bantle JP, Leslie DB, Redmond JB, Slusarek B, Swan T, Buchwald H, Ikramuddin S 2008 Postgastric bypass hyperinsulinemic hypoglycemia syndrome: characterization and response to a modified diet. Surg Obes Relat Dis 4:492-499
47. Meier JJ, Butler AE, Galasso R, Butler PC 2006 Hyperinsulinemic hypoglycemia after gastric bypass surgery is not accompanied by islet hyperplasia or increased β-cell turnover. Diabetes Care 29:1554-1559 (Pubitemid 44127580)
48. Cummings DE, Purnell JQ, Frayo RS, Schimidava K, Wisse BE, Weigle DS 2001 A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50:1714-1719. (Pubitemid 33641587)
49. Cummings DE, Overduin J 2007 Gastrointestinal regulation of food intake. J Clin Invest 117:13-23. (Pubitemid 46048445)
50. Williams DL, Grill HJ, Cummings DE, Kaplan JM 2003 Vagotomy dissociates short- and long-term controls of circulating ghrelin. Endocrinology 144:5184-5187 (Pubitemid 37476045)
51. Cummings DE, Foster-Schubert KE, Overduin J 2005 Ghrelin and energy balance: focus on current controversies. Curr Drug Targets 6:153-169 (Pubitemid 40394311)
52. Drucker DJ 2007 The role of gut hormones in glucose homeostasis. J Clin Invest 117:24-32 (Pubitemid 46048446)
53. Brubaker PL, Anini Y 2003 Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2. Can J Physiol Pharmacol 81:1005-1012 (Pubitemid 38045829)
54. Korner J, Bessler M, Cirilo LJ, Conwell IM, Daud A, Restuccia NL, Wardlaw SL 2005 Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY, and insulin. J Clin Endocrinol Metab 90:359-365 (Pubitemid 40116682)
55. Laferrère B, Heshka S, Wang K, Khan Y, McGinty J, Teixeira J, Hart AB, Olivan B 2007 Incretin levels and effect are markedly enhanced 1 month after Roux-en-Y gastric bypass surgery in obese patients with type 2 diabetes. Diabetes Care 30:1709-1716 (Pubitemid 47036341)
56. Morínigo R, Moizé V, Musri M, Lacy AM, Navarro S, Marín JL, Delgado S, Casamitjana R, Vidal J 2006 Glucagon-like peptide-1, peptide YY, hunger, and satiety after gastric bypass surgery in morbidly obese subjects. J Clin Endocrinol Metab 91:1735-1740 (Pubitemid 46032812)
57. Rodieux F, Giusti V, D'Alessio DA, Suter M, Tappy L 2008 Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release. Obesity (Silver Spring) 16:298-305
58. Borg CM, le Roux CW, Ghatei MA, Bloom SR, Patel AG, Aylwin SJ 2006 Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. British Journal of Surgery 93:210-215
59. Vincent RP, le Roux CW 2008 Changes in gut hormones after bariatric surgery. Clin Endocrinol (Oxf) 69:173-179
60. Strader AD, Vahl TP, Jandacek RJ, Woods SC, D'Alessio DA, Seeley RJ 2005 Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats. Am J Physiol Endocrinol Metab 288:E447-E453 (Pubitemid 40110655)
61. Patriti A, Facchiano E, Annetti C, Aisa MC, Galli F, Fanelli C, Donini A 2005 Early improvement of glucose tolerance after ileal transposition in a non-obese type 2 diabetes rat model. Obes Surg 15:1258-1264 (Pubitemid 41565122)
62. Patriti A, Aisa MC, Annetti C, Sidoni A, Galli F, Ferri I, GullàN, Donini A 2007 How the hindgut can cure type 2 diabetes. Ileal transposition improves glucose metabolism and β-cell function in Gotokakizaki rats through an enhanced Proglucagon gene expression and L-cell number. Surgery 142:74-85
63. de Paula AL, Macedo AL, Prudente AS, Queiroz L, Schraibman V, Pinus J 2006 Laparoscopic sleeve gastrectomy with ileal interposition ("neuroendocrine brake"): pilot study of a new operation. Surg Obes Relat Dis 2:464-467 (Pubitemid 44028838)
64. 2. Surg Obes Relat Dis 3:195-197
65. 2. Obes Surg 19:307-312
66. Cohen RV, Schiavon C, Pinheiro JC, Noujaim P, Correa JL, Wachemberg BL, Weight loss-independent remission or improvement of type 2 diabetes mellitus among 30 patients undergoing duodenal-jejunal bypass surgery. Battling Obesity 2009, Miami, FL, 2009
67. Aguirre V, Stylopoulos N, Grinbaum R, Kaplan LM 2008 An endoluminal sleeve induces substantial weight loss and normalizes glucose homeostasis in rats with diet-induced obesity. Obesity (Silver Spring) 16:2585-2592
68. Tarnoff M, Shikora S, Lembo A, Gersin K 2008 Chronic in-vivo experience with an endoscopically delivered and retrieved duodenal-jejunal bypass sleeve in a porcine model. Surg Endosc 22:1023-1028
69. Rodriguez-Grunert L, Galvao Neto MP, Alamo M, Ramos AC, Baez PB, Tarnoff M 2008 First human experience with endoscopically delivered and retrieved duodenal-jejunal bypass sleeve. Surg Obes Relat Dis 4:55-59
70. Tarnoff M, Sorli C, Rodriguez L, Ramos AC, Galvao M, Reyes E, Fagalde P, Soledad Oltra M, Saba J, Alamo M, Aylwin CG, Prieto C 2008 Interim report of a prospective, randomized sham-controlled trial investigating a completely endoscopic duodenal-jejunal bypass sleeve for the treatment of type 2 diabetes Diabetes 57(Suppl):A32
71. Wang PY, Caspi L, Lam CK, Chari M, Li X, Light PE, Gutierrez-Juarez R, Ang M, Schwartz GJ, Lam TK 2008 Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production. Nature 452:1012-1016
72. Patti ME, Houten SM, Bianco A, Bernier R, Larsen PR, Holst JJ, Badman MK, Maratos-Flier E, Mun E, Pihlajamaki J, Auwerx J, Goldfine AB 9 April 2009 Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring) 10.1038/oby.2009.102
73. Mithieux G, Misery P, Magnan C, Pillot B, Gautier-Stein A, Bernard C, Rajas F, Zitoun C 2005 Portal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet protein. Cell Metab 2:321-329
74. Mithieux G, Bady I, Gautier A, Croset M, Rajas F, Zitoun C 2004 Induction of control genes in intestinal gluconeogenesis is sequential during fasting and maximal in diabetes. Am J Physiol Endocrinol Metab 286:E370-E375 (Pubitemid 38292686)
75. Troy S, Soty M, Ribeiro L, Laval L, Migrenne S, Fioramonti X, Pillot B, Fauveau V, Aubert R, Viollet B, Foretz M, Leclerc J, Duchampt A, Zitoun C, Thorens B, Magnan C, Mithieux G, Andreelli F 2008 Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice. Cell Metab 8:201-211