Structure-activity relationship of hybrids of Cinchona alkaloids and bile acids with in vitro antiplasmodial and antitrypanosomal activities

European Journal of Medicinal Chemistry

Volumn 100, Issue 1, 2015, Pages 10-17

  Leverrier, Aurélie ^a   Bero, Joanne ^b   Cabrera, Julián ^a   Frédérich, Michel ^c   Quetin Leclercq, Joëlle ^b   Palermo, Jorge A ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Antiparasitic activity; Barton Zard reaction; Bile acids; Cinchona alkaloids; Hybrids

Indexed keywords

ARTEMISININ; BILE ACID; CAMPTOTHECIN; CHLOROQUINE; CINCHONA ALKALOID; SURAMIN; ANTIMALARIAL AGENT; ANTITRYPANOSOMAL AGENT;

ANTIMALARIAL ACTIVITY; ANTIPLASMODIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ANTITRYPANOSOMAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; FIBROBLAST; HETERONUCLEAR MULTIPLE BOND CORRELATION; HUMAN; HUMAN CELL; HYBRID; IC50; IN VITRO STUDY; LIPOPHILICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; DRUG SENSITIVITY; SYNTHESIS; TRYPANOSOMA BRUCEI BRUCEI;

ANTIMALARIALS; BILE ACIDS AND SALTS; CINCHONA ALKALOIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; MOLECULAR CONFORMATION; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

EID: 84937208428     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.05.044     Document Type: Article

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