Synthesis and biological evaluation of novel steroidal pyrazoles as substrates for bile acid transporters

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 1, 2005, Pages 85-87

  Bhat, Laxminarayan ^a,b   Jandeleit, Bernd ^a   Dias, Tracy M ^a   Moors, Tristen L ^a   Gallop, Mark A ^a  

^a XenoPort Inc   (United States)

^b ARYx Therapeutics   (United States)

Author keywords

Bile acid transporters; Bile acids; Oral bioavailability; Steroidal pyrazoles

Indexed keywords

BILE ACID; PYRAZOLE DERIVATIVE; STEROID;

ANIMAL CELL; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG EFFECT; DRUG SYNTHESIS; FEMALE; NONHUMAN; REACTION ANALYSIS; TRANSPORT KINETICS;

ANIMALS; CARRIER PROTEINS; CHO CELLS; CRICETINAE; DRUG EVALUATION, PRECLINICAL; HUMANS; ILEUM; LIGANDS; MEMBRANE GLYCOPROTEINS; PYRAZOLES; XENOPUS LAEVIS;

CRICETINAE; CRICETULUS GRISEUS; XENOPUS LAEVIS;

EID: 9644262443     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.10.027     Document Type: Article

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