Synthesis of steroidal quinones and hydroquinones from bile acids by Barton radical decarboxylation and benzoquinone addition. Studies on their cytotoxic and antifungal activities

Steroids

Volumn 77, Issue 1-2, 2012, Pages 45-51

  Siless, Gastón E ^a   Knott, María E ^a   Derita, Marcos G ^b   Zacchino, Susana A ^b   Puricelli, Lydia ^a   Palermo, Jorge A ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

Author keywords

Barton decarboxylation; Benzoquinone; Bile acids; Cytotoxic activity; Quinones

Indexed keywords

23 HYDROQUINOYL 3ALPHA HYDROXY 24 NOR 5BETA CHOLANE; BENZOQUINONE DERIVATIVE; BILE ACID; DOXORUBICIN; HYDROQUINONE DERIVATIVE; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ADDITION REACTION; ANTIFUNGAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DECARBOXYLATION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; PANCREAS CARCINOMA;

ANIMALS; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; BENZOQUINONES; BILE ACIDS AND SALTS; CANDIDA ALBICANS; CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; CELL SURVIVAL; DECARBOXYLATION; DOXORUBICIN; DRUG DESIGN; FREE RADICALS; HUMANS; HYDROQUINONES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PANCREATIC NEOPLASMS; QUINONES; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 83655201253     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2011.09.012     Document Type: Article

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