Diallyl trisufide protects against oxygen glucose deprivation -induced apoptosis by scavenging free radicals via the PI3K/Akt -mediated Nrf2/HO-1 signaling pathway in B35 neural cells

Brain Research

Volumn 1614, Issue , 2015, Pages 38-50

  Xu, Xian Hua ^a   Li, Gai Li ^a   Wang, Bing Ang ^a   Qin, Yang ^a   Bai, Shu Rong ^a   Rong, Jian ^a   Deng, Tao ^a   Li, Qiang ^a  

^a CHENGDU MILITARY GENERAL HOSPITAL   (China)

Author keywords

Apoptosis; Diallyl trisulfide; Nrf2 HO 1; Oxygen glucosedeprivation; PI3K Akt; Reactive oxygenspecies

Indexed keywords

CASPASE 3; DIALLYL TRISULFIDE; FREE RADICAL; HEME OXYGENASE 1; MALONALDEHYDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; ALLYL COMPOUND; GLUCOSE; NEUROPROTECTIVE AGENT; SMALL INTERFERING RNA; SULFIDE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL VIABILITY; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; LIPID PEROXIDATION; NERVE CELL; NEUROBLASTOMA CELL; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; OXYGEN GLUCOSE DEPRIVATION INJURY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANOXIA; CELL SURVIVAL; DEFICIENCY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEUROBLASTOMA; PATHOLOGY; PATHOPHYSIOLOGY; TIME; TUMOR CELL LINE;

ALLIUM SATIVUM;

ALLYL COMPOUNDS; ANIMALS; ANOXIA; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; FREE RADICALS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCOSE; HEME OXYGENASE-1; NEUROBLASTOMA; NEUROPROTECTIVE AGENTS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SULFIDES; TIME FACTORS;

EID: 84937191314     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2015.04.014     Document Type: Article

References (33)

1. C.L. Allen, and U. Bayraktutan Oxidative stress and its role in the pathogenesis of ischaemic stroke Int. J. Stroke 4 2009 461 470
2. K. Chen, K. Gunter, and M.D. Maines Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death J. Neurochem. 75 2000 304 313
3. K.P. Doyle, R.P. Simon, and M.P. Stenzel-Poore Mechanisms of ischemic brain damage Neuropharmacology 55 2008 310 318
4. A. Giudice, C. Arra, and M.C. Turco Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents Methods Mol. Biol. 647 2010 37 74
5. Y. Guo, K. Zhang, Q. Wang, Z. Li, Y. Yin, Q. Xu, W. Duan, and C. Li Neuroprotective effects of diallyl trisulfide in SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis Brain Res. 1374 2011 110 115
6. K. Itoh, T. Ishii, N. Wakabayashi, and M. Yamamoto Regulatory mechanisms of cellular response to oxidative stress Free Radic. Res. 31 1999 319 324
7. A. Jazwa, and A. Cuadrado Targeting heme oxygenase-1 for neuroprotection and neuroinflammation in neurodegenerative diseases Curr. Drug Targets 11 2010 1517 1531
8. J. Jordan, I. Ikuta, J. Garcia-Garcia, S. Calleja, and T. Segura Stroke pathophysiology: management challenges and new treatment advances J. Physiol. Biochem. 63 2007 261 277
9. S.M. Keyse, and R.M. Tyrrell Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite Proc. Natl. Acad. Sci. USA 86 1989 99 103
10. W.W. Kuo, W.J. Wang, C.Y. Tsai, C.L. Way, H.H. Hsu, and L.M. Chen Diallyl trisufide (DATS) suppresses high glucose-induced cardiomyocyte apoptosis by inhibiting JNK/NFkappaB signaling via attenuating ROS generation Int. J. Cardiol. 168 2013 270 280
11. L. Li, H. Dong, E. Song, X. Xu, L. Liu, and Y. Song Nrf2/ARE pathway activation, HO-1 and NQO1 induction by polychlorinated biphenyl quinone is associated with reactive oxygen species and PI3K/AKT signaling Chem. Biol. Interact. 209 2014 56 67
12. K.L. Liu, H.W. Chen, R.Y. Wang, Y.P. Lei, L.Y. Sheen, and C.K. Lii DATS reduces LPS-induced iNOS expression, NO production, oxidative stress, and NF-kappaB activation in RAW 264.7 macrophages J. Agric. Food Chem. 54 2006 3472 3478
13. I. Margaill, M. Plotkine, and D. Lerouet Antioxidant strategies in the treatment of stroke Free Radic. Biol. Med. 39 2005 429 443
14. B. Mathew, and R. Biju Neuroprotective effects of garlic a review Libyan J. Med. 3 2008 23 33
15. H.K. Na, E.H. Kim, J.H. Jung, H.H. Lee, J.W. Hyun, and Y.J. Surh Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells Arch. Biochem. Biophys. 476 2008 171 177
16. H.K. Na, and Y.J. Surh Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG Food Chem. Toxicol. 46 2008 1271 1278
17. T. Nguyen, C.S. Yang, and C.B. Pickett The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress Free Radic. Biol. Med. 37 2004 433 441
18. N. Panahian, M. Yoshiura, and M.D. Maines Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice J. Neurochem. 72 1999 1187 1203
19. B.L. Predmore, K. Kondo, S. Bhushan, M.A. Zlatopolsky, A.L. King, J.P. Aragon, D.B. Grinsfelder, M.E. Condit, and D.J. Lefer The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability Am. J. Physiol. Heart Circ. Physiol. 302 2012 H2410 H2418
20. R. Rodrigo, R. Fernandez-Gajardo, R. Gutierrez, J.M. Matamala, R. Carrasco, A. Miranda-Merchak, and W. Feuerhake Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities CNS Neurol. Disord. Drug Targets 12 2013 698 714
21. S. Saleem, H. Zhuang, S. Biswal, Y. Christen, and S. Dore Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury Stroke 39 2008 3389 3396
22. Z.A. Shah, R.C. Li, R.K. Thimmulappa, T.W. Kensler, M. Yamamoto, S. Biswal, and S. Dore Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury Neuroscience 147 2007 53 59
23. Z.A. Shah, S.E. Nada, and S. Dore Heme oxygenase 1, beneficial role in permanent ischemic stroke and in Gingko biloba (EGb 761) neuroprotection Neuroscience 180 2011 248 255
24. D.Y. Shin, G.Y. Kim, H.J. Hwang, W.J. Kim, and Y.H. Choi Diallyl trisulfide-induced apoptosis of bladder cancer cells is caspase-dependent and regulated by PI3K/Akt and JNK pathways Environ. Toxicol. Pharmacol. 37 2014 74 83
25. T.G. Son, S. Camandola, T.V. Arumugam, R.G. Cutler, R.S. Telljohann, M.R. Mughal, T.A. Moore, W. Luo, Q.S. Y.u., D.A. Johnson, J.A. Johnson, N.H. Greig, and M.P. Mattson Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia J. Neurochem. 112 2010 1316 1326
26. M.M. Sun, H. Bu, B. Li, J.X. Yu, Y.S. Guo, and C.Y. Li Neuroprotective potential of phase II enzyme inducer diallyl trisulfide Neurol. Res. 31 2009 23 27
27. C.Y. Tsai, C.C. Wang, T.Y. Lai, H.N. Tsu, C.H. Wang, H.Y. Liang, and W.W. Kuo Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes Int. J. Cardiol. 168 2013 1286 1297
28. D. Xiao, A. Herman-Antosiewicz, J. Antosiewicz, H. Xiao, M. Brisson, J.S. Lazo, and S.V. Singh Diallyl trisulfide-induced G(2)-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc 25 C Oncogene 24 2005 6256 6268
29. T. Zeng, C.L. Zhang, Z.P. Zhu, L.H. Yu, X.L. Zhao, and K.Q. Xie Diallyl trisulfide (DATS) effectively attenuated oxidative stress-mediated liver injury and hepatic mitochondrial dysfunction in acute ethanol-exposed mice Toxicology 252 2008 86 91
30. E. Zeynalov, Z.A. Shah, R.C. Li, and S. Dore Heme oxygenase 1 is associated with ischemic preconditioning-induced protection against brain ischemia Neurobiol. Dis. 35 2009 264 269
31. M. Zhang, An C. Gao, Y. Leak, R.K. Chen, and J. Zhang, F. Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection Prog. Neurobiol. 100 2013 30 47
32. M. Zhang, S. Wang, L. Mao, R.K. Leak, Y. Shi, W. Zhang, X. Hu, B. Sun, G. Cao, Y. Gao, Y. Xu, J. Chen, and F. Zhang Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1 J. Neurosci. 34 2014 1903 1915
33. Y. Zhang, L. Guan, X. Wang, T. Wen, J. Xing, and J. Zhao Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2 Free Radic Res. 42 2008 362 371