Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes

International Journal of Cardiology

Volumn 168, Issue 2, 2013, Pages 1286-1297

  Tsai, Cheng Yen ^a   Wang, Chien Chung ^a   Lai, Tung Yuan ^b,c   Tsu, Han Nien ^a   Wang, Chung Hsing ^d   Liang, Hsin Yueh ^a,d   Kuo, Wei Wen ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Diallyl trisulfide (DATS); Hyperglycemia; Nuclear factor E2 related factor 2 (Nrf2); Reactive oxygen species (ROS)

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; DIALLYL TRISULFIDE; GLUCOSE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL LINE; CELL PROTECTION; CELL STRAIN H9C2; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EXPOSURE; FLOW CYTOMETRY; GENETIC TRANSFECTION; HEART MUSCLE CELL; HO 1 GENE; HYPERGLYCEMIA; MALE; NEWBORN; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; RAT; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; UPREGULATION; WESTERN BLOTTING;

2′,7′-DICHLOROFLUORESCEIN DIACETATE; APO; APOCYNIN; APOPTOSIS; BODY WEIGHT; BW; DADS; DAS; DATS; DCF; DCFH-DA; DHE; DIALLY TRISULFIDE; DIALLYL DISULFIDE; DIALLYL SULFIDE; DIALLYL TRISULFIDE (DATS); DICHLOROFLUORESCEIN; DIHYDROETHIDIUM; DITHIOTHREITOL; DTT; GLYCOGEN SYNTHASE KINASE 3Β; GSK3Β; HEME OXYGENASE 1; HG; HIGH GLUCOSE; HO-1; HYPERGLYCEMIA; KEAP1; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; NG; NORMAL GLUCOSE; NRF2; NUCLEAR FACTOR E2-RELATED FACTOR 2 (NRF2); NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2; ORGANOSULFUR COMPOUNDS; OSCS; REACTIVE OXYGEN SPECIES; REACTIVE OXYGEN SPECIES (ROS); ROS; SAPKS; SOD; STREPTOZOTOCIN; STRESS-ACTIVATED PROTEIN KINASES; STZ; SUPEROXIDE DISMUTASES; TBARS; TERMINAL DEOXYNUCLEOTIDE TRANSFERASE-MEDIATED DUTP NICK END LABELING; THIOBARBITURIC ACID REACTIVE SUBSTANCES; THIOREDOXIN-1; TUNEL; TXN-1; Γ-GLUTAMYLCYSTEINE SYNTHETASE; ΓGCS;

ALLYL COMPOUNDS; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELL LINE; CELLS, CULTURED; GARLIC; GLUCOSE; MALE; MYOCYTES, CARDIAC; NF-E2-RELATED FACTOR 2; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SULFIDES;

EID: 84885300285     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2012.12.004     Document Type: Article

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