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Volumn 8, Issue 1, 2015, Pages

Altering cancer transcriptomes using epigenomic inhibitors

Author keywords

C646; Cholesterol biosynthesis; Colon cancer; Epigenetic inhibitor; Histone acetylation; ICG 001; Pancreatic cancer; TCF7L2; WNT signaling

Indexed keywords

ACETYL COENZYME A; ANTINEOPLASTIC AGENT; BETA CATENIN; C 646; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; E1A ASSOCIATED P300 PROTEIN; EPIGENETIC INHIBITOR; LIGAND; N BENZYL 1,2,3,4,8,9 HEXAHYDRO 6 (4 HYDROXYBENZYL) 8 (1 NAPHTHYLMETHYL) 4,7 DIOXO 2H PYRAZINO[1,2 A]PYRIMIDINE 1(6H) CARBOXAMIDE; RECEPTOR; T CELL FACTOR PROTEIN; TRANSCRIPTOME; UNCLASSIFIED DRUG;

EID: 84937147465     PISSN: None     EISSN: 17568935     Source Type: Journal    
DOI: 10.1186/1756-8935-8-9     Document Type: Article
Times cited : (31)

References (49)
  • 1
    • 19944403876 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling pathway as a novel cancer drug target
    • 1:CAS:528:DC%2BD2MXhtVygtw%3D%3D 15578921 10.2174/1568009043332709
    • Luu HH, Zhang R, Haydon RC, Rayburn E, Kang Q, Si W, et al.: Wnt/beta-catenin signaling pathway as a novel cancer drug target. Curr Cancer Drug Targets. 2004, 4: 653-71. 10.2174/1568009043332709
    • (2004) Curr Cancer Drug Targets , vol.4 , pp. 653-671
    • Luu, H.H.1    Zhang, R.2    Haydon, R.C.3    Rayburn, E.4    Kang, Q.5    Si, W.6
  • 3
    • 77953715690 scopus 로고    scopus 로고
    • Targeting Wnt signaling: Can we safely eradicate cancer stem cells?
    • 1:CAS:528:DC%2BC3cXntlKru7o%3D 20530697 10.1158/1078-0432.CCR-09-2943
    • Takahashi-Yanaga F, Kahn M: Targeting Wnt signaling: can we safely eradicate cancer stem cells? Clin Cancer Res. 2010, 16: 3153-62. 10.1158/1078-0432.CCR-09-2943
    • (2010) Clin Cancer Res , vol.16 , pp. 3153-3162
    • Takahashi-Yanaga, F.1    Kahn, M.2
  • 4
    • 84862916465 scopus 로고    scopus 로고
    • Structure-based discovery of a novel inhibitor targeting the beta-Catenin/Tcf4 interaction
    • 1:CAS:528:DC%2BC3MXhs1OjtLfM 22224445 10.1021/bi201428h
    • Tian W, Han X, Yan M, Xu Y, Duggineni S, Lin N, et al.: Structure-based discovery of a novel inhibitor targeting the beta-Catenin/Tcf4 interaction. Biochemistry. 2012, 51: 724-31. 10.1021/bi201428h
    • (2012) Biochemistry , vol.51 , pp. 724-731
    • Tian, W.1    Han, X.2    Yan, M.3    Xu, Y.4    Duggineni, S.5    Lin, N.6
  • 5
    • 84876836223 scopus 로고    scopus 로고
    • Modification of enhancer chromatin: What, how, and why?
    • 1:CAS:528:DC%2BC3sXktVOqu7g%3D 23473601 10.1016/j.molcel.2013.01.038
    • Calo E, Wysocka J: Modification of enhancer chromatin: what, how, and why? Mol Cell. 2013, 49: 825-37. 10.1016/j.molcel.2013.01.038
    • (2013) Mol Cell , vol.49 , pp. 825-837
    • Calo, E.1    Wysocka, J.2
  • 6
    • 77957970301 scopus 로고    scopus 로고
    • Epigenetic modifications and human disease
    • 1:CAS:528:DC%2BC3cXht1yjsLzF 20944598 10.1038/nbt.1685
    • Portela A, Esteller M: Epigenetic modifications and human disease. Nat Biotechnol. 2010, 28: 1057-68. 10.1038/nbt.1685
    • (2010) Nat Biotechnol , vol.28 , pp. 1057-1068
    • Portela, A.1    Esteller, M.2
  • 7
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • 1:CAS:528:DC%2BD28Xht1WhtbbN 17081971 10.1016/j.cell.2006.10.018
    • Clevers H: Wnt/beta-catenin signaling in development and disease. Cell. 2006, 127: 469-80. 10.1016/j.cell.2006.10.018
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 8
    • 41349091246 scopus 로고    scopus 로고
    • Wnt signaling inside the nucleus
    • 1:CAS:528:DC%2BD1cXlsFygu7w%3D 18177486 10.1111/j.1349-7006.2007.00716.x
    • Shitashige M, Hirohashi S, Yamada T: Wnt signaling inside the nucleus. Cancer Sci. 2008, 99: 631-7. 10.1111/j.1349-7006.2007.00716.x
    • (2008) Cancer Sci , vol.99 , pp. 631-637
    • Shitashige, M.1    Hirohashi, S.2    Yamada, T.3
  • 9
    • 33846036984 scopus 로고    scopus 로고
    • ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription
    • 1:CAS:528:DC%2BD2MXovFSjtLk%3D 16787331 10.2174/1573406054864098
    • Eguchi M, Nguyen C, Lee SC, Kahn M: ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription. Med Chem. 2005, 1: 467-72. 10.2174/1573406054864098
    • (2005) Med Chem , vol.1 , pp. 467-472
    • Eguchi, M.1    Nguyen, C.2    Lee, S.C.3    Kahn, M.4
  • 10
    • 4344587136 scopus 로고    scopus 로고
    • A small molecule inhibitor of beta-catenin/CREB-binding protein transcription
    • corrected 1:CAS:528:DC%2BD2cXnsVent70%3D 515116 15314234 10.1073/pnas.0404875101
    • Emami KH, Nguyen C, Ma H, Kim DH, Jeong KW, Eguchi M, et al.: A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Proc Natl Acad Sci U S A. 2004, 101: 12682-7. 10.1073/pnas.0404875101
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 12682-12687
    • Emami, K.H.1    Nguyen, C.2    Ma, H.3    Kim, D.H.4    Jeong, K.W.5    Eguchi, M.6
  • 11
    • 77954204335 scopus 로고    scopus 로고
    • Virtual ligand screening of the p300/CBP histone acetyltransferase: Identification of a selective small molecule inhibitor
    • 1:CAS:528:DC%2BC3cXmslCjsbg%3D 2884008 20534345 10.1016/j.chembiol.2010.03.006
    • Bowers EM, Yan G, Mukherjee C, Orry A, Wang L, Holbert MA, et al.: Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol. 2010, 17: 471-82. 10.1016/j.chembiol.2010.03.006
    • (2010) Chem Biol , vol.17 , pp. 471-482
    • Bowers, E.M.1    Yan, G.2    Mukherjee, C.3    Orry, A.4    Wang, L.5    Holbert, M.A.6
  • 12
    • 82355186665 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in embryonic stem cell self-renewal and somatic cell reprogramming
    • 1:CAS:528:DC%2BC3MXhsFKlurrN 21603945 10.1007/s12015-011-9275-1
    • Miki T, Yasuda SY, Kahn M: Wnt/beta-catenin signaling in embryonic stem cell self-renewal and somatic cell reprogramming. Stem Cell Rev. 2011, 7: 836-46. 10.1007/s12015-011-9275-1
    • (2011) Stem Cell Rev , vol.7 , pp. 836-846
    • Miki, T.1    Yasuda, S.Y.2    Kahn, M.3
  • 13
    • 0037069424 scopus 로고    scopus 로고
    • Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal
    • 1:CAS:528:DC%2BD38Xpt1yrtrw%3D 137497 12397173 10.1073/pnas.232568499
    • Rebel VI, Kung AL, Tanner EA, Yang H, Bronson RT, Livingston DM: Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal. Proc Natl Acad Sci U S A. 2002, 99: 14789-94. 10.1073/pnas.232568499
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 14789-14794
    • Rebel, V.I.1    Kung, A.L.2    Tanner, E.A.3    Yang, H.4    Bronson, R.T.5    Livingston, D.M.6
  • 14
    • 0032808235 scopus 로고    scopus 로고
    • The coactivators p300 and CBP have different functions during the differentiation of F9 cells
    • 1:CAS:528:DyaK1MXmtVSlsL4%3D 10.1007/s001099900021
    • Ugai H, Uchida K, Kawasaki H, Yokoyama KK: The coactivators p300 and CBP have different functions during the differentiation of F9 cells. J Mol Med (Berl). 1999, 77: 481-94. 10.1007/s001099900021
    • (1999) J Mol Med (Berl) , vol.77 , pp. 481-494
    • Ugai, H.1    Uchida, K.2    Kawasaki, H.3    Yokoyama, K.K.4
  • 15
    • 78649318098 scopus 로고    scopus 로고
    • The Wnt signaling pathway in cellular proliferation and differentiation: A tale of two coactivators
    • 1:CAS:528:DC%2BC3cXhsVGitb%2FP 20920541 10.1016/j.addr.2010.09.012
    • Teo JL, Kahn M: The Wnt signaling pathway in cellular proliferation and differentiation: a tale of two coactivators. Adv Drug Deliv Rev. 2010, 62: 1149-55. 10.1016/j.addr.2010.09.012
    • (2010) Adv Drug Deliv Rev , vol.62 , pp. 1149-1155
    • Teo, J.L.1    Kahn, M.2
  • 16
    • 4143098311 scopus 로고    scopus 로고
    • CBP and p300: HATs for different occasions
    • 1:CAS:528:DC%2BD2cXmslOns7w%3D 15313412 10.1016/j.bcp.2004.03.045
    • Kalkhoven E: CBP and p300: HATs for different occasions. Biochem Pharmacol. 2004, 68: 1145-55. 10.1016/j.bcp.2004.03.045
    • (2004) Biochem Pharmacol , vol.68 , pp. 1145-1155
    • Kalkhoven, E.1
  • 17
    • 77956497337 scopus 로고    scopus 로고
    • Genome-wide assessment of differential roles for p300 and CBP in transcription regulation
    • 1:CAS:528:DC%2BC3cXhtFGgsLbO 2938195 20435671 10.1093/nar/gkq184
    • Ramos YF, Hestand MS, Verlaan M, Krabbendam E, Ariyurek Y, van Galen M, et al.: Genome-wide assessment of differential roles for p300 and CBP in transcription regulation. Nucleic Acids Res. 2010, 38: 5396-408. 10.1093/nar/gkq184
    • (2010) Nucleic Acids Res , vol.38 , pp. 5396-5408
    • Ramos, Y.F.1    Hestand, M.S.2    Verlaan, M.3    Krabbendam, E.4    Ariyurek, Y.5    Van Galen, M.6
  • 18
    • 66849111902 scopus 로고    scopus 로고
    • Further case of Rubinstein-Taybi syndrome due to a deletion in EP300
    • 1:CAS:528:DC%2BD1MXlvFClsLw%3D 19353645 10.1002/ajmg.a.32771
    • Foley P, Bunyan D, Stratton J, Dillon M, Lynch SA: Further case of Rubinstein-Taybi syndrome due to a deletion in EP300. Am J Med Genet A. 2009, 149A: 997-1000. 10.1002/ajmg.a.32771
    • (2009) Am J Med Genet A , vol.149 A , pp. 997-1000
    • Foley, P.1    Bunyan, D.2    Stratton, J.3    Dillon, M.4    Lynch, S.A.5
  • 19
    • 19944422429 scopus 로고    scopus 로고
    • Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expression
    • 1:CAS:528:DC%2BD2MXktlWisb4%3D 15782138 10.1038/sj.onc.1208433
    • Ma H, Nguyen C, Lee KS, Kahn M: Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expression. Oncogene. 2005, 24: 3619-31. 10.1038/sj.onc.1208433
    • (2005) Oncogene , vol.24 , pp. 3619-3631
    • Ma, H.1    Nguyen, C.2    Lee, K.S.3    Kahn, M.4
  • 20
    • 77957150824 scopus 로고    scopus 로고
    • KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
    • 1:CAS:528:DC%2BC3cXhtFSmsb7P 4085546 20814421 10.1038/nrc2899
    • Morris JP, Wang SC, Hebrok M: KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer. 2010, 10: 683-95. 10.1038/nrc2899
    • (2010) Nat Rev Cancer , vol.10 , pp. 683-695
    • Morris, J.P.1    Wang, S.C.2    Hebrok, M.3
  • 22
    • 84881473798 scopus 로고    scopus 로고
    • Canonical wnt signaling is required for pancreatic carcinogenesis
    • 1:CAS:528:DC%2BC3sXht1SksrjM 3763696 23761328 10.1158/0008-5472.CAN-12-4384
    • Zhang Y, Morris JP, Yan W, Schofield HK, Gurney A, Simeone DM, et al.: Canonical wnt signaling is required for pancreatic carcinogenesis. Cancer Res. 2013, 73: 4909-22. 10.1158/0008-5472.CAN-12-4384
    • (2013) Cancer Res , vol.73 , pp. 4909-4922
    • Zhang, Y.1    Morris, J.P.2    Yan, W.3    Schofield, H.K.4    Gurney, A.5    Simeone, D.M.6
  • 23
    • 84919326707 scopus 로고    scopus 로고
    • Prognostic significance of WNT signaling in pancreatic ductal adenocarcinoma
    • 1:CAS:528:DC%2BC2cXhsVSisbbE 25146168 10.1007/s00428-014-1642-2
    • Nakamoto M, Matsuyama A, Shiba E, Shibuya R, Kasai T, Yamaguchi K, et al.: Prognostic significance of WNT signaling in pancreatic ductal adenocarcinoma. Virchows Arch. 2014, 465: 401-8. 10.1007/s00428-014-1642-2
    • (2014) Virchows Arch , vol.465 , pp. 401-408
    • Nakamoto, M.1    Matsuyama, A.2    Shiba, E.3    Shibuya, R.4    Kasai, T.5    Yamaguchi, K.6
  • 24
    • 84917710464 scopus 로고    scopus 로고
    • Effect of Wnt inhibitors in pancreatic cancer
    • 1:CAS:528:DC%2BC2cXhvFGjsb3N 25275031
    • Wall I, Schmidt-Wolf IG: Effect of Wnt inhibitors in pancreatic cancer. Anticancer Res. 2014, 34: 5375-80.
    • (2014) Anticancer Res , vol.34 , pp. 5375-5380
    • Wall, I.1    Schmidt-Wolf, I.G.2
  • 25
    • 84919432686 scopus 로고    scopus 로고
    • Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the Wnt/beta-catenin signaling pathway
    • 1:CAS:528:DC%2BC2cXhslKjsbrE 25305448 10.1016/j.canlet.2014.10.008
    • Xu W, Wang Z, Zhang W, Qian K, Li H, Kong D, et al.: Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the Wnt/beta-catenin signaling pathway. Cancer Lett. 2015, 356: 613-27. 10.1016/j.canlet.2014.10.008
    • (2015) Cancer Lett , vol.356 , pp. 613-627
    • Xu, W.1    Wang, Z.2    Zhang, W.3    Qian, K.4    Li, H.5    Kong, D.6
  • 26
    • 84884314654 scopus 로고    scopus 로고
    • An integrated transcriptome and epigenome analysis identifies a novel candidate gene for pancreatic cancer
    • 3849454 24053169 10.1186/1755-8794-6-33
    • Jia J, Parikh H, Xiao W, Hoskins JW, Pflicke H, Liu X, et al.: An integrated transcriptome and epigenome analysis identifies a novel candidate gene for pancreatic cancer. BMC Med Genomics. 2013, 6: 33. 10.1186/1755-8794-6-33
    • (2013) BMC Med Genomics , vol.6 , pp. 33
    • Jia, J.1    Parikh, H.2    Xiao, W.3    Hoskins, J.W.4    Pflicke, H.5    Liu, X.6
  • 27
    • 70349311616 scopus 로고    scopus 로고
    • Histone acetyl transferases as emerging drug targets
    • 1:CAS:528:DC%2BD1MXhtFygs7fL 19577000 10.1016/j.drudis.2009.06.008
    • Dekker FJ, Haisma HJ: Histone acetyl transferases as emerging drug targets. Drug Discov Today. 2009, 14: 942-8. 10.1016/j.drudis.2009.06.008
    • (2009) Drug Discov Today , vol.14 , pp. 942-948
    • Dekker, F.J.1    Haisma, H.J.2
  • 28
    • 84865402404 scopus 로고    scopus 로고
    • Targeting the epigenome for treatment of cancer
    • 1:CAS:528:DC%2BC3MXhsFKksrbN 22139071 10.1038/onc.2011.552
    • Geutjes EJ, Bajpe PK, Bernards R: Targeting the epigenome for treatment of cancer. Oncogene. 2012, 31: 3827-44. 10.1038/onc.2011.552
    • (2012) Oncogene , vol.31 , pp. 3827-3844
    • Geutjes, E.J.1    Bajpe, P.K.2    Bernards, R.3
  • 29
    • 84886808679 scopus 로고    scopus 로고
    • Chromatin proteins and modifications as drug targets
    • 1:CAS:528:DC%2BC3sXhs1Krt77E 24153301 10.1038/nature12751
    • Helin K, Dhanak D: Chromatin proteins and modifications as drug targets. Nature. 2013, 502: 480-8. 10.1038/nature12751
    • (2013) Nature , vol.502 , pp. 480-488
    • Helin, K.1    Dhanak, D.2
  • 30
    • 57049120143 scopus 로고    scopus 로고
    • Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: Implications for histone acetyltransferase evolution and function
    • 1:CAS:528:DC%2BD1cXhsVOisr%2FI 2643075 18845255 10.1016/j.sbi.2008.09.004
    • Wang L, Tang Y, Cole PA, Marmorstein R: Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function. Curr Opin Struct Biol. 2008, 18: 741-7. 10.1016/j.sbi.2008.09.004
    • (2008) Curr Opin Struct Biol , vol.18 , pp. 741-747
    • Wang, L.1    Tang, Y.2    Cole, P.A.3    Marmorstein, R.4
  • 31
    • 84870542378 scopus 로고    scopus 로고
    • Regulation of cholesterol biosynthesis and cancer signaling
    • 1:CAS:528:DC%2BC38XhtVymsbfJ 3504641 22824431 10.1016/j.coph.2012.06.011
    • Gorin A, Gabitova L, Astsaturov I: Regulation of cholesterol biosynthesis and cancer signaling. Curr Opin Pharmacol. 2012, 12: 710-6. 10.1016/j.coph.2012.06.011
    • (2012) Curr Opin Pharmacol , vol.12 , pp. 710-716
    • Gorin, A.1    Gabitova, L.2    Astsaturov, I.3
  • 32
    • 84892170909 scopus 로고    scopus 로고
    • Molecular pathways: Sterols and receptor signaling in cancer
    • 1:CAS:528:DC%2BC2cXislKktQ%3D%3D 24158702 10.1158/1078-0432.CCR-13-0122
    • Gabitova L, Gorin A, Astsaturov I: Molecular pathways: sterols and receptor signaling in cancer. Clin Cancer Res. 2014, 20: 28-34. 10.1158/1078-0432.CCR-13-0122
    • (2014) Clin Cancer Res , vol.20 , pp. 28-34
    • Gabitova, L.1    Gorin, A.2    Astsaturov, I.3
  • 33
    • 0030941803 scopus 로고    scopus 로고
    • The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
    • 1:CAS:528:DyaK2sXjtFWisb8%3D 9150132 10.1016/S0092-8674(00)80213-5
    • Brown MS, Goldstein JL: The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 1997, 89: 331-40. 10.1016/S0092-8674(00)80213-5
    • (1997) Cell , vol.89 , pp. 331-340
    • Brown, M.S.1    Goldstein, J.L.2
  • 34
    • 0034804783 scopus 로고    scopus 로고
    • Sterol regulatory element-binding proteins (SREBPs): Transcriptional regulators of lipid synthetic genes
    • 1:CAS:528:DC%2BD3MXovFSju70%3D 11591434 10.1016/S0163-7827(01)00010-8
    • Shimano H: Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes. Prog Lipid Res. 2001, 40: 439-52. 10.1016/S0163-7827(01)00010-8
    • (2001) Prog Lipid Res , vol.40 , pp. 439-452
    • Shimano, H.1
  • 35
    • 84871757651 scopus 로고    scopus 로고
    • SREBP: A novel therapeutic target
    • 1:CAS:528:DC%2BC38XhvFSiur%2FN 10.1093/abbs/gms112
    • Xiao X, Song BL: SREBP: a novel therapeutic target. Acta Biochim Biophys Sin (Shanghai). 2013, 45: 2-10. 10.1093/abbs/gms112
    • (2013) Acta Biochim Biophys Sin (Shanghai) , vol.45 , pp. 2-10
    • Xiao, X.1    Song, B.L.2
  • 36
    • 10544235694 scopus 로고    scopus 로고
    • SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein
    • 1:CAS:528:DyaK28XntFOgtLw%3D 8918891 10.1101/gad.10.22.2903
    • Oliner JD, Andresen JM, Hansen SK, Zhou S, Tjian R: SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein. Genes Dev. 1996, 10: 2903-11. 10.1101/gad.10.22.2903
    • (1996) Genes Dev , vol.10 , pp. 2903-2911
    • Oliner, J.D.1    Andresen, J.M.2    Hansen, S.K.3    Zhou, S.4    Tjian, R.5
  • 37
    • 84921275022 scopus 로고    scopus 로고
    • The CREB-binding protein inhibitor ICG-001 suppresses pancreatic cancer growth
    • 1:CAS:528:DC%2BC2cXhs1yisb%2FO 25082960 10.1158/1535-7163.MCT-13-1005
    • Arensman MD, Telesca D, Lay AR, Kershaw KM, Wu N, Donahue TR, et al.: The CREB-binding protein inhibitor ICG-001 suppresses pancreatic cancer growth. Mol Cancer Ther. 2014, 13: 2303-14. 10.1158/1535-7163.MCT-13-1005
    • (2014) Mol Cancer Ther , vol.13 , pp. 2303-2314
    • Arensman, M.D.1    Telesca, D.2    Lay, A.R.3    Kershaw, K.M.4    Wu, N.5    Donahue, T.R.6
  • 38
    • 84872677684 scopus 로고    scopus 로고
    • Role of gemcitabine-based combination therapy in the management of advanced pancreatic cancer: A meta-analysis of randomised trials
    • 1:CAS:528:DC%2BC38XhtlOnsbjI 22989511 10.1016/j.ejca.2012.08.019
    • Ciliberto D, Botta C, Correale P, Rossi M, Caraglia M, Tassone P, et al.: Role of gemcitabine-based combination therapy in the management of advanced pancreatic cancer: a meta-analysis of randomised trials. Eur J Cancer. 2013, 49: 593-603. 10.1016/j.ejca.2012.08.019
    • (2013) Eur J Cancer , vol.49 , pp. 593-603
    • Ciliberto, D.1    Botta, C.2    Correale, P.3    Rossi, M.4    Caraglia, M.5    Tassone, P.6
  • 39
    • 31544450585 scopus 로고    scopus 로고
    • p8 is a new target of gemcitabine in pancreatic cancer cells
    • 1:CAS:528:DC%2BD28Xht1GksA%3D%3D 16397047 10.1158/1078-0432.CCR-05-1700
    • Giroux V, Malicet C, Barthet M, Gironella M, Archange C, Dagorn JC, et al.: p8 is a new target of gemcitabine in pancreatic cancer cells. Clin Cancer Res. 2006, 12: 235-41. 10.1158/1078-0432.CCR-05-1700
    • (2006) Clin Cancer Res , vol.12 , pp. 235-241
    • Giroux, V.1    Malicet, C.2    Barthet, M.3    Gironella, M.4    Archange, C.5    Dagorn, J.C.6
  • 40
    • 84861821128 scopus 로고    scopus 로고
    • Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis
    • 1:CAS:528:DC%2BC38XosFaru70%3D 3366404 22565310 10.1172/JCI60144
    • Hamidi T, Algul H, Cano CE, Sandi MJ, Molejon MI, Riemann M, et al.: Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis. J Clin Invest. 2012, 122: 2092-103. 10.1172/JCI60144
    • (2012) J Clin Invest , vol.122 , pp. 2092-2103
    • Hamidi, T.1    Algul, H.2    Cano, C.E.3    Sandi, M.J.4    Molejon, M.I.5    Riemann, M.6
  • 41
    • 80053165342 scopus 로고    scopus 로고
    • p8 expression controls pancreatic cancer cell migration, invasion, adhesion, and tumorigenesis
    • 1:CAS:528:DC%2BC3MXht1Sqtb3J 21344397 10.1002/jcp.22702
    • Sandi MJ, Hamidi T, Malicet C, Cano C, Loncle C, Pierres A, et al.: p8 expression controls pancreatic cancer cell migration, invasion, adhesion, and tumorigenesis. J Cell Physiol. 2011, 226: 3442-51. 10.1002/jcp.22702
    • (2011) J Cell Physiol , vol.226 , pp. 3442-3451
    • Sandi, M.J.1    Hamidi, T.2    Malicet, C.3    Cano, C.4    Loncle, C.5    Pierres, A.6
  • 42
    • 48849090170 scopus 로고    scopus 로고
    • NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress
    • 1:CAS:528:DC%2BD1cXpvVOgtbg%3D 18690848 10.2174/156800908785133196
    • Clark DW, Mitra A, Fillmore RA, Jiang WG, Samant RS, Fodstad O, et al.: NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress. Curr Cancer Drug Targets. 2008, 8: 421-30. 10.2174/156800908785133196
    • (2008) Curr Cancer Drug Targets , vol.8 , pp. 421-430
    • Clark, D.W.1    Mitra, A.2    Fillmore, R.A.3    Jiang, W.G.4    Samant, R.S.5    Fodstad, O.6
  • 43
    • 77957832584 scopus 로고    scopus 로고
    • Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer
    • 1:CAS:528:DC%2BC3cXht1GgtLfI 2947220 20811155 10.1172/JCI41939
    • Koster R, di Pietro A, Timmer-Bosscha H, Gibcus JH, van den Berg A, Suurmeijer AJ, et al.: Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer. J Clin Invest. 2010, 120: 3594-605. 10.1172/JCI41939
    • (2010) J Clin Invest , vol.120 , pp. 3594-3605
    • Koster, R.1    Di Pietro, A.2    Timmer-Bosscha, H.3    Gibcus, J.H.4    Van Den Berg, A.5    Suurmeijer, A.J.6
  • 44
    • 84866619153 scopus 로고    scopus 로고
    • Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistance
    • 1:CAS:528:DC%2BC38Xht1aktrzN 22858377 10.1016/j.febslet.2012.07.063
    • Vincent AJ, Ren S, Harris LG, Devine DJ, Samant RS, Fodstad O, et al.: Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistance. FEBS Lett. 2012, 586: 3429-34. 10.1016/j.febslet.2012.07.063
    • (2012) FEBS Lett , vol.586 , pp. 3429-3434
    • Vincent, A.J.1    Ren, S.2    Harris, L.G.3    Devine, D.J.4    Samant, R.S.5    Fodstad, O.6
  • 45
    • 0347628818 scopus 로고    scopus 로고
    • p21Waf1/Cip1 as a therapeutic target in breast and other cancers
    • 1:CAS:528:DC%2BD2cXitFKqug%3D%3D 14706334 10.1016/S1535-6108(03)00308-8
    • Weiss RH: p21Waf1/Cip1 as a therapeutic target in breast and other cancers. Cancer Cell. 2003, 4: 425-9. 10.1016/S1535-6108(03)00308-8
    • (2003) Cancer Cell , vol.4 , pp. 425-429
    • Weiss, R.H.1
  • 46
    • 84863022415 scopus 로고    scopus 로고
    • Inhibition of AKT2 enhances sensitivity to gemcitabine via regulating PUMA and NF-kappaB signaling pathway in human pancreatic ductal adenocarcinoma
    • 1:CAS:528:DC%2BC38XitFemsbs%3D 3269746 22312312 10.3390/ijms13011186
    • Chen D, Niu M, Jiao X, Zhang K, Liang J, Zhang D: Inhibition of AKT2 enhances sensitivity to gemcitabine via regulating PUMA and NF-kappaB signaling pathway in human pancreatic ductal adenocarcinoma. Int J Mol Sci. 2012, 13: 1186-208. 10.3390/ijms13011186
    • (2012) Int J Mol Sci , vol.13 , pp. 1186-1208
    • Chen, D.1    Niu, M.2    Jiao, X.3    Zhang, K.4    Liang, J.5    Zhang, D.6
  • 47
    • 84934292263 scopus 로고    scopus 로고
    • Thymoquinone pretreatment overcomes the insensitivity and potentiates the antitumor effect of gemcitabine through abrogation of notch1, PI3K/Akt/mTOR regulated signaling pathways in pancreatic cancer
    • Mu GG, Zhang LL, Li HY, Liao Y, Yu HG: Thymoquinone pretreatment overcomes the insensitivity and potentiates the antitumor effect of gemcitabine through abrogation of notch1, PI3K/Akt/mTOR regulated signaling pathways in pancreatic cancer. Dig Dis Sci 2014. doi:10.1007/s10620-014-3394-x
    • (2014) Dig Dis Sci
    • Mu, G.G.1    Zhang, L.L.2    Li, H.Y.3    Liao, Y.4    Yu, H.G.5
  • 48
    • 84928987900 scopus 로고    scopus 로고
    • HTSeq-a Python framework to work with high-throughput sequencing data
    • 4287950 25260700 10.1093/bioinformatics/btu638
    • Anders S, Pyl PT, Huber W: HTSeq-a Python framework to work with high-throughput sequencing data. Bioinformatics. 2015, 31: 166-9. 10.1093/bioinformatics/btu638
    • (2015) Bioinformatics , vol.31 , pp. 166-169
    • Anders, S.1    Pyl, P.T.2    Huber, W.3
  • 49
    • 75249087100 scopus 로고    scopus 로고
    • edgeR: A Bioconductor package for differential expression analysis of digital gene expression data
    • 1:CAS:528:DC%2BD1MXhs1WlurvO 2796818 19910308 10.1093/bioinformatics/btp616
    • Robinson MD, McCarthy DJ, Smyth GK: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010, 26: 139-40. 10.1093/bioinformatics/btp616
    • (2010) Bioinformatics , vol.26 , pp. 139-140
    • Robinson, M.D.1    McCarthy, D.J.2    Smyth, G.K.3


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