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Volumn 11, Issue 2, 2015, Pages 109-115

Cytokine and immune system abnormalities in fibromyalgia and other central sensitivity syndromes

Author keywords

Central sensitivity; Central sensitivity syndromes; Clinical pain; Cytokines; Inflammation

Indexed keywords

ALPHA INTERFERON; BETA 2 MICROGLOBULIN; CALCITONIN GENE RELATED PEPTIDE; CYTOKINE; CYTOKINE RECEPTOR; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NERVE GROWTH FACTOR; NEUROTRANSMITTER; NEUROTRANSMITTER RECEPTOR; SUBSTANCE P; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS;

EID: 84937133309     PISSN: 15733971     EISSN: 18756360     Source Type: Journal    
DOI: 10.2174/1573397111666150619094819     Document Type: Article
Times cited : (40)

References (112)
  • 1
    • 36248974200 scopus 로고    scopus 로고
    • Historical insights into cytokines
    • Dinarello CA. Historical insights into cytokines. Eur J Immunol 2007; 37: S34-S45.
    • (2007) Eur J Immunol , vol.37 , pp. 34-45
    • Dinarello, C.A.1
  • 2
    • 72649094040 scopus 로고    scopus 로고
    • Impact of blood collection devices on clinical chemistry assays
    • Bowen RA, Hortin GL, Csako G, et al. Impact of blood collection devices on clinical chemistry assays. Clin Biochem 2010; 43: 4-25.
    • (2010) Clin Biochem , vol.43 , pp. 4-25
    • Bowen, R.A.1    Hortin, G.L.2    Csako, G.3
  • 3
    • 84893588252 scopus 로고    scopus 로고
    • Interferences from blood collection tube components on clinical chemistry assays
    • Bowen RA, Remaley AT. Interferences from blood collection tube components on clinical chemistry assays. Biochem Med (Zagreb) 2014; 24: 31-44.
    • (2014) Biochem Med (Zagreb) , vol.24 , pp. 31-44
    • Bowen, R.A.1    Remaley, A.T.2
  • 4
    • 84878819757 scopus 로고    scopus 로고
    • Cytokine assays: An assessment of the preparation and treatment of blood and tissue samples
    • Keustermans GC, Hoeks SB, Meerding JM, et al. Cytokine assays: an assessment of the preparation and treatment of blood and tissue samples. Methods 2013; 61: 10-7.
    • (2013) Methods , vol.61 , pp. 10-17
    • Keustermans, G.C.1    Hoeks, S.B.2    Meerding, J.M.3
  • 5
    • 70449366867 scopus 로고    scopus 로고
    • Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays
    • de Jager W, Bourcier K, Rijkers GT, et al. Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays. BMC Immunol 2009; 10: 52-10.
    • (2009) BMC Immunol , vol.10 , pp. 52-110
    • de Jager, W.1    Bourcier, K.2    Rijkers, G.T.3
  • 6
    • 84885609205 scopus 로고    scopus 로고
    • Multiplex cytokine concentration measurement: How much do the medium and handling matter?
    • Parkitny L, McAuley JH, Kelly PJ, et al. Multiplex cytokine concentration measurement: how much do the medium and handling matter? Mediators Inflamm 2013; 2013: 890706.
    • (2013) Mediators Inflamm , vol.2013
    • Parkitny, L.1    McAuley, J.H.2    Kelly, P.J.3
  • 7
    • 43849092496 scopus 로고    scopus 로고
    • Effects of blood sample handling procedures on measurable inflammatory markers in plasma, serum and dried blood spot samples
    • Skogstrand K, Ekelund CK, Thorsen P, et al. Effects of blood sample handling procedures on measurable inflammatory markers in plasma, serum and dried blood spot samples. J Immunol Methods 2008; 336: 78-84.
    • (2008) J Immunol Methods , vol.336 , pp. 78-84
    • Skogstrand, K.1    Ekelund, C.K.2    Thorsen, P.3
  • 8
    • 4544304960 scopus 로고    scopus 로고
    • Multiplex bead array assays for detection of soluble cytokines: Comparisons of sensitivity and quantitative values among kits from multiple manufacturers
    • Khan SS, Smith MS, Reda D, et al. Multiplex bead array assays for detection of soluble cytokines: comparisons of sensitivity and quantitative values among kits from multiple manufacturers. Cytometry B Clin Cytom 2004; 61: 35-9.
    • (2004) Cytometry B Clin Cytom , vol.61 , pp. 35-39
    • Khan, S.S.1    Smith, M.S.2    Reda, D.3
  • 9
    • 2342646193 scopus 로고    scopus 로고
    • Recent findings on how proinflammatory cytokines cause pain: Peripheral mechanisms in inflammatory and neuropathic hyperalgesia
    • Sommer C, Kress M. Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia. Neurosci Lett 2004; 361: 184-7.
    • (2004) Neurosci Lett , vol.361 , pp. 184-187
    • Sommer, C.1    Kress, M.2
  • 10
    • 67349164309 scopus 로고    scopus 로고
    • Mode of action of cytokines on nociceptive neurons
    • Uceyler N, Schafers M, Sommer C. Mode of action of cytokines on nociceptive neurons. Exp Brain Res 2009; 196: 67-78.
    • (2009) Exp Brain Res , vol.196 , pp. 67-78
    • Uceyler, N.1    Schafers, M.2    Sommer, C.3
  • 11
    • 0035451059 scopus 로고    scopus 로고
    • Cytokines and sickness behavior: Implications from knockout animal models
    • Inui A. Cytokines and sickness behavior: implications from knockout animal models. Trends Immunol 2001; 22: 469-73.
    • (2001) Trends Immunol , vol.22 , pp. 469-473
    • Inui, A.1
  • 12
    • 0035057629 scopus 로고    scopus 로고
    • Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome
    • Staud R, Vierck CJ, Cannon RL, et al. Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome. Pain 2001; 91: 165-75.
    • (2001) Pain , vol.91 , pp. 165-175
    • Staud, R.1    Vierck, C.J.2    Cannon, R.L.3
  • 13
    • 35548934993 scopus 로고    scopus 로고
    • Temporal summation of second pain and its maintenance are useful for characterizing widespread central sensitization of fibromyalgia patients
    • Staud R, Robinson ME, Price DD. Temporal summation of second pain and its maintenance are useful for characterizing widespread central sensitization of fibromyalgia patients. J Pain 2007; 8: 893- 901.
    • (2007) J Pain , vol.8 , pp. 893-901
    • Staud, R.1    Robinson, M.E.2    Price, D.D.3
  • 14
    • 67651225439 scopus 로고    scopus 로고
    • Abnormal pain modulation in patients with spatially distributed chronic pain: Fibromyalgia
    • Staud R. Abnormal pain modulation in patients with spatially distributed chronic pain: Fibromyalgia. Rheum Dis Clin North Am 2009; 35: 263-74.
    • (2009) Rheum Dis Clin North Am , vol.35 , pp. 263-274
    • Staud, R.1
  • 15
    • 77958100380 scopus 로고    scopus 로고
    • Is it all central sensitization? Role of peripheral tissue nociception in chronic musculskeletal pain
    • Staud R. Is it all central sensitization? Role of peripheral tissue nociception in chronic musculskeletal pain. Curr Rheumatol Rep 2010; 12: 448-54.
    • (2010) Curr Rheumatol Rep , vol.12 , pp. 448-454
    • Staud, R.1
  • 16
    • 84875311878 scopus 로고    scopus 로고
    • Objective biomarkers or symptom scores for the classification of fibromyalgia syndrome?
    • Staud R. Objective biomarkers or symptom scores for the classification of fibromyalgia syndrome? Curr Rheum Rev 2012; 8: 307-17.
    • (2012) Curr Rheum Rev , vol.8 , pp. 307-317
    • Staud, R.1
  • 17
    • 84895860455 scopus 로고    scopus 로고
    • Slow temporal summation of pain for assessment of central pain sensitivity and clinical pain of fibromyalgia patients
    • Staud R, Weyl EE, Riley JL, III, et al. Slow temporal summation of pain for assessment of central pain sensitivity and clinical pain of fibromyalgia patients. PLoS One 2014; 9: e89086.
    • (2014) PLoS One , vol.9
    • Staud, R.1    Weyl, E.E.2    Riley, J.L.3
  • 18
    • 0037323263 scopus 로고    scopus 로고
    • The economic cost of chronic fatigue and chronic fatigue syndrome in UK primary care
    • McCrone P, Darbishire L, Ridsdale L, et al. The economic cost of chronic fatigue and chronic fatigue syndrome in UK primary care. Psychol Med 2003; 33: 253-61.
    • (2003) Psychol Med , vol.33 , pp. 253-261
    • McCrone, P.1    Darbishire, L.2    Ridsdale, L.3
  • 19
    • 84876587997 scopus 로고    scopus 로고
    • Health-resource use and costs associated with fibromyalgia in France, Germany, and the United States
    • Knight T, Schaefer C, Chandran A, et al. Health-resource use and costs associated with fibromyalgia in France, Germany, and the United States. Clinicoecon Outcomes Res 2013; 5: 171-80.
    • (2013) Clinicoecon Outcomes Res , vol.5 , pp. 171-180
    • Knight, T.1    Schaefer, C.2    Chandran, A.3
  • 20
    • 35548937457 scopus 로고    scopus 로고
    • The neuropathic pain triad: Neurons, immune cells and glia
    • Scholz J, Woolf CJ. The neuropathic pain triad: Neurons, immune cells and glia. Nat Neurosci 2007; 10: 1361-8.
    • (2007) Nat Neurosci , vol.10 , pp. 1361-1368
    • Scholz, J.1    Woolf, C.J.2
  • 21
    • 84888637560 scopus 로고    scopus 로고
    • Glia and pain: Is chronic pain a gliopathy?
    • Ji RR, Berta T, Nedergaard M. Glia and pain: Is chronic pain a gliopathy? Pain 2013; 154: S10-S28.
    • (2013) Pain , vol.154 , pp. 10-28
    • Ji, R.R.1    Berta, T.2    Nedergaard, M.3
  • 22
    • 68049143450 scopus 로고    scopus 로고
    • Tripartite synapses: Astrocytes process and control synaptic information
    • Perea G, Navarrete M, Araque A. Tripartite synapses: astrocytes process and control synaptic information. Trends Neurosci 2009; 32: 421-31.
    • (2009) Trends Neurosci , vol.32 , pp. 421-431
    • Perea, G.1    Navarrete, M.2    Araque, A.3
  • 24
    • 34249803311 scopus 로고    scopus 로고
    • Cytokine patterns in fibromyalgia and their correlation with clinical manifestations
    • Bazzichi L, Rossi A, Massimetti G, et al. Cytokine patterns in fibromyalgia and their correlation with clinical manifestations. Clin Exp Rheumatol 2007; 25: 225-30.
    • (2007) Clin Exp Rheumatol , vol.25 , pp. 225-230
    • Bazzichi, L.1    Rossi, A.2    Massimetti, G.3
  • 25
    • 79951834544 scopus 로고    scopus 로고
    • Preliminary Evidence of Increased Pain and Elevated Cytokines in Fibromyalgia Patients with Defective Growth Hormone Response to Exercise
    • Ross RL, Jones KD, Bennett RM, et al. Preliminary Evidence of Increased Pain and Elevated Cytokines in Fibromyalgia Patients with Defective Growth Hormone Response to Exercise. Open Immunol J 2010; 3: 9-18.
    • (2010) Open Immunol J , vol.3 , pp. 9-18
    • Ross, R.L.1    Jones, K.D.2    Bennett, R.M.3
  • 26
    • 47349104717 scopus 로고    scopus 로고
    • Circulating cytokine levels compared to pain in patients with fibromyalgia - A prospective longitudinal study over 6 months
    • Wang HL, Moser M, Schiltenwolf M, et al. Circulating cytokine levels compared to pain in patients with fibromyalgia - A prospective longitudinal study over 6 months. J Rheumatol 2008; 35: 1366-70.
    • (2008) J Rheumatol , vol.35 , pp. 1366-1370
    • Wang, H.L.1    Moser, M.2    Schiltenwolf, M.3
  • 28
    • 0035029026 scopus 로고    scopus 로고
    • Cytokines and chronic fatigue syndrome
    • Patarca R. Cytokines and chronic fatigue syndrome. Ann N Y Acad Sci 2001; 933: 185-200.
    • (2001) Ann N Y Acad Sci , vol.933 , pp. 185-200
    • Patarca, R.1
  • 29
    • 0028089163 scopus 로고
    • Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: Interrelations with cellular sources and patterns of soluble immune mediator expression
    • Patarca R, Klimas NG, Lugtendorf S, et al. Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of soluble immune mediator expression. Clin Infect Dis 1994; 18 Suppl 1: S147-S153.
    • (1994) Clin Infect Dis , vol.18 , pp. 147-153
    • Patarca, R.1    Klimas, N.G.2    Lugtendorf, S.3
  • 30
    • 77957844957 scopus 로고    scopus 로고
    • Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal comorbidity
    • Scully P, McKernan DP, Keohane J, et al. Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal comorbidity. Am J Gastroenterol 2010; 105: 2235-43.
    • (2010) Am J Gastroenterol , vol.105 , pp. 2235-2243
    • Scully, P.1    McKernan, D.P.2    Keohane, J.3
  • 31
    • 84888175082 scopus 로고    scopus 로고
    • Neuropathic pain and cytokines: Current perspectives
    • Clark AK, Old EA, Malcangio M. Neuropathic pain and cytokines: current perspectives. J Pain Res 2013; 6: 803-14.
    • (2013) J Pain Res , vol.6 , pp. 803-814
    • Clark, A.K.1    Old, E.A.2    Malcangio, M.3
  • 32
    • 61849126809 scopus 로고    scopus 로고
    • Upregulation of IL-6, IL-8 and CCL2 gene expression after acute inflammation: Correlation to clinical pain
    • Wang XM, Hamza M, Wu TX, et al. Upregulation of IL-6, IL-8 and CCL2 gene expression after acute inflammation: Correlation to clinical pain. Pain 2009; 142: 275-83.
    • (2009) Pain , vol.142 , pp. 275-283
    • Wang, X.M.1    Hamza, M.2    Wu, T.X.3
  • 33
    • 33747006154 scopus 로고    scopus 로고
    • Reduced levels of antiinflammatory cytokines in patients with chronic widespread pain
    • Uceyler N, Valenza R, Stock M, et al. Reduced levels of antiinflammatory cytokines in patients with chronic widespread pain. Arthritis and Rheumatism 2006; 54: 2656-64.
    • (2006) Arthritis and Rheumatism , vol.54 , pp. 2656-2664
    • Uceyler, N.1    Valenza, R.2    Stock, M.3
  • 34
    • 26444595334 scopus 로고    scopus 로고
    • An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle
    • Shah JP, Phillips TM, Danoff JV, et al. An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle. J Appl Physiol 2005; 99: 1977-84.
    • (2005) J Appl Physiol , vol.99 , pp. 1977-1984
    • Shah, J.P.1    Phillips, T.M.2    Danoff, J.V.3
  • 35
    • 57349115315 scopus 로고    scopus 로고
    • Uncovering the biochemical milieu of myofascial trigger points using in vivo microdialysis
    • Shah JP. Uncovering the biochemical milieu of myofascial trigger points using in vivo microdialysis. J Musculoskelet Pain 2008; 16: 17-20.
    • (2008) J Musculoskelet Pain , vol.16 , pp. 17-20
    • Shah, J.P.1
  • 36
    • 35848941500 scopus 로고    scopus 로고
    • Biochemical alterations in the trapezius muscle of patients with chronic whiplash associated disorders (WAD) - A microdialysis study
    • Gerdle B, Lemming D, Kristiansen J, et al. Biochemical alterations in the trapezius muscle of patients with chronic whiplash associated disorders (WAD) - A microdialysis study. Eur J Pain 2008; 12: 82- 93.
    • (2008) Eur J Pain , vol.12 , pp. 82-93
    • Gerdle, B.1    Lemming, D.2    Kristiansen, J.3
  • 37
    • 12344271409 scopus 로고    scopus 로고
    • Increase in interstitial interleukin-6 of human skeletal muscle with repetitive low-force exercise
    • Rosendal L, Sogaard K, Kjaer M, et al. Increase in interstitial interleukin-6 of human skeletal muscle with repetitive low-force exercise. J Appl Physiol 2005; 98: 477-81.
    • (2005) J Appl Physiol , vol.98 , pp. 477-481
    • Rosendal, L.1    Sogaard, K.2    Kjaer, M.3
  • 38
    • 64849091212 scopus 로고    scopus 로고
    • Microdialysis of cytokines: Methodological considerations, scanning electron microscopy, and determination of relative recovery
    • Helmy A, Carpenter KL, Skepper JN, et al. Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery. J Neurotrauma 2009; 26: 549-61.
    • (2009) J Neurotrauma , vol.26 , pp. 549-561
    • Helmy, A.1    Carpenter, K.L.2    Skepper, J.N.3
  • 39
    • 41949132283 scopus 로고    scopus 로고
    • Central Sensitivity Syndromes: A New Paradigm and Group Nosology for Fibromyalgia and Overlapping Conditions, and the Related Issue of Disease versus Illness
    • Yunus MB. Central Sensitivity Syndromes: A New Paradigm and Group Nosology for Fibromyalgia and Overlapping Conditions, and the Related Issue of Disease versus Illness. Semin Arthritis Rheum 2008; 37: 339-52.
    • (2008) Semin Arthritis Rheum , vol.37 , pp. 339-352
    • Yunus, M.B.1
  • 40
    • 71049139825 scopus 로고    scopus 로고
    • Central Sensitivity Syndromes: An Overview
    • Yunus MB. Central Sensitivity Syndromes: An Overview. J Musculoskelet Pain 2009; 17: 400-8.
    • (2009) J Musculoskelet Pain , vol.17 , pp. 400-408
    • Yunus, M.B.1
  • 41
    • 79951579664 scopus 로고    scopus 로고
    • Central sensitization: Implications for the diagnosis and treatment of pain
    • Woolf CJ. Central sensitization: Implications for the diagnosis and treatment of pain. Pain 2011; 152: S2-S15.
    • (2011) Pain , vol.152 , pp. 2-15
    • Woolf, C.J.1
  • 42
    • 0029833325 scopus 로고    scopus 로고
    • Windup and central sensitization are not equivalent
    • Woolf CJ. Windup and central sensitization are not equivalent. Pain 1996; 66: 105-8.
    • (1996) Pain , vol.66 , pp. 105-108
    • Woolf, C.J.1
  • 43
    • 68949189686 scopus 로고    scopus 로고
    • Central sensitization: A generator of pain hypersensitivity by central neural plasticity
    • Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain 2009; 10: 895-926.
    • (2009) J Pain , vol.10 , pp. 895-926
    • Latremoliere, A.1    Woolf, C.J.2
  • 44
    • 0025787459 scopus 로고
    • NMDA receptors and central hyperalgesic states
    • Dickenson AH, Sullivan AF. NMDA receptors and central hyperalgesic states. Pain 1991; 46: 344-6.
    • (1991) Pain , vol.46 , pp. 344-346
    • Dickenson, A.H.1    Sullivan, A.F.2
  • 45
    • 0034900001 scopus 로고    scopus 로고
    • Cytokines play an aetiopathogenetic role in fibromyalgia: A hypothesis and pilot study
    • Wallace DJ, Linker-Israeli M, Hallegua D, et al. Cytokines play an aetiopathogenetic role in fibromyalgia: a hypothesis and pilot study. Rheumatology 2001; 40: 743-9.
    • (2001) Rheumatology , vol.40 , pp. 743-749
    • Wallace, D.J.1    Linker-Israeli, M.2    Hallegua, D.3
  • 47
    • 4644233272 scopus 로고    scopus 로고
    • Cytokine-induced sickness behaviour: A neuroimmune response to activation of innate immunity
    • Dantzer R. Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity. Eur J Pharmacol 2004; 500: 399-411.
    • (2004) Eur J Pharmacol , vol.500 , pp. 399-411
    • Dantzer, R.1
  • 49
    • 0024571348 scopus 로고
    • Is there an immunologic component to the fibrositis syndrome?
    • Caro XJ. Is there an immunologic component to the fibrositis syndrome? Rheum Dis Clin North Am 1989; 15: 169-86.
    • (1989) Rheum Dis Clin North Am , vol.15 , pp. 169-186
    • Caro, X.J.1
  • 51
    • 0023423181 scopus 로고
    • Increased neurogenic inflammation in fibrositis syndrome
    • Littlejohn GO, Weinstein C, Helme RD. Increased neurogenic inflammation in fibrositis syndrome. J Rheumatol 1987; 14: 1022- 5.
    • (1987) J Rheumatol , vol.14 , pp. 1022-1025
    • Littlejohn, G.O.1    Weinstein, C.2    Helme, R.D.3
  • 52
    • 0032934378 scopus 로고    scopus 로고
    • The immuneinflammatory pathophysiology of fibromyalgia: Increased serum soluble gp130, the common signal transducer protein of various neurotrophic cytokines
    • Maes M, Libbrecht I, Van Hunsel F, et al. The immuneinflammatory pathophysiology of fibromyalgia: increased serum soluble gp130, the common signal transducer protein of various neurotrophic cytokines. Psychoneuroendocrinology 1999; 24: 371- 83.
    • (1999) Psychoneuroendocrinology , vol.24 , pp. 371-383
    • Maes, M.1    Libbrecht, I.2    Van Hunsel, F.3
  • 53
    • 0028104819 scopus 로고
    • Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome
    • Russell IJ, Orr MD, Littman B, et al. Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome. Arthritis Rheumatol 1994; 37: 1593-601.
    • (1994) Arthritis Rheumatol , vol.37 , pp. 1593-1601
    • Russell, I.J.1    Orr, M.D.2    Littman, B.3
  • 54
    • 0029978024 scopus 로고    scopus 로고
    • Neurochemical pathogenesis of fibromyalgia syndrome
    • Russell IJ. Neurochemical pathogenesis of fibromyalgia syndrome. J Musculoskel Pain 1996; 4: 61-92.
    • (1996) J Musculoskel Pain , vol.4 , pp. 61-92
    • Russell, I.J.1
  • 55
    • 84856769108 scopus 로고    scopus 로고
    • Evidence of central inflammation in fibromyalgia - Increased cerebrospinal fluid interleukin-8 levels
    • Kadetoff D, Lampa J, Westman M, et al. Evidence of central inflammation in fibromyalgia - Increased cerebrospinal fluid interleukin-8 levels. J Neuroimmunol 2012; 242: 33-8.
    • (2012) J Neuroimmunol , vol.242 , pp. 33-38
    • Kadetoff, D.1    Lampa, J.2    Westman, M.3
  • 56
    • 38149134422 scopus 로고    scopus 로고
    • HPA axis reactivity and lymphocyte glucocorticoid sensitivity in fibromyalgia syndrome and chronic pelvic pain
    • Wingenfeld K, Heim C, Schmidt I, et al. HPA axis reactivity and lymphocyte glucocorticoid sensitivity in fibromyalgia syndrome and chronic pelvic pain. Psychosomatic Medicine 2008; 70: 65-72.
    • (2008) Psychosomatic Medicine , vol.70 , pp. 65-72
    • Wingenfeld, K.1    Heim, C.2    Schmidt, I.3
  • 57
    • 48749097342 scopus 로고    scopus 로고
    • Status of immune mediators in Fibromyalgia
    • Gur A, Oktayoglu P. Status of immune mediators in Fibromyalgia. Curr Pain Headache Rep 2008; 12: 175-81.
    • (2008) Curr Pain Headache Rep , vol.12 , pp. 175-181
    • Gur, A.1    Oktayoglu, P.2
  • 58
    • 0033675213 scopus 로고    scopus 로고
    • Cytokine activation of the HPA axis
    • Dunn AJ. Cytokine activation of the HPA axis. Ann N Y Acad Sci 2000; 917: 608-17.
    • (2000) Ann N Y Acad Sci , vol.917 , pp. 608-617
    • Dunn, A.J.1
  • 59
    • 0029670561 scopus 로고    scopus 로고
    • Effect of interleukin-1 beta on the release of substance P from rat isolated spinal cord
    • Malcangio M, Bowery NG, Flower RJ, et al. Effect of interleukin-1 beta on the release of substance P from rat isolated spinal cord. Eur J Pharmacol 1996; 299: 113-8.
    • (1996) Eur J Pharmacol , vol.299 , pp. 113-118
    • Malcangio, M.1    Bowery, N.G.2    Flower, R.J.3
  • 60
    • 0032904837 scopus 로고    scopus 로고
    • Somnogenic relationships between tumor necrosis factor and interleukin-1
    • Takahashi S, Kapas L, Fang J, et al. Somnogenic relationships between tumor necrosis factor and interleukin-1. Am J Physiol 1999; 276: R1132-R1140.
    • (1999) Am J Physiol , vol.276 , pp. 1132-1140
    • Takahashi, S.1    Kapas, L.2    Fang, J.3
  • 61
    • 33644859724 scopus 로고    scopus 로고
    • Is there a role for cytokine based therapies in fibromyalgia
    • Wallace DJ. Is there a role for cytokine based therapies in fibromyalgia. Curr Pharm Design 2006; 12: 17-22.
    • (2006) Curr Pharm Design , vol.12 , pp. 17-22
    • Wallace, D.J.1
  • 62
    • 0031963046 scopus 로고    scopus 로고
    • The pathophysiologic roles of interleukin-6 in human disease
    • Papanicolaou DA, Wilder RL, Manolagas SC, et al. The pathophysiologic roles of interleukin-6 in human disease. Ann Intern Med 1998; 128: 127-37.
    • (1998) Ann Intern Med , vol.128 , pp. 127-137
    • Papanicolaou, D.A.1    Wilder, R.L.2    Manolagas, S.C.3
  • 63
    • 80055005734 scopus 로고    scopus 로고
    • Systematic review with metaanalysis: Cytokines in fibromyalgia syndrome
    • Uceyler N, Hauser W, Sommer C. Systematic review with metaanalysis: cytokines in fibromyalgia syndrome. BMC Musculoskeletal Disorders 2011; 12.
    • (2011) BMC Musculoskeletal Disorders , pp. 12
    • Uceyler, N.1    Hauser, W.2    Sommer, C.3
  • 64
    • 33747006154 scopus 로고    scopus 로고
    • Reduced levels of antiinflammatory cytokines in patients with chronic widespread pain
    • Uceyler N, Valenza R, Stock M, et al. Reduced levels of antiinflammatory cytokines in patients with chronic widespread pain. Arthritis Rheumatol 2006; 54: 2656-64.
    • (2006) Arthritis Rheumatol , vol.54 , pp. 2656-2664
    • Uceyler, N.1    Valenza, R.2    Stock, M.3
  • 65
    • 0037541351 scopus 로고    scopus 로고
    • Normal production of inflammatory cytokines in chronic fatigue and fibromyalgia syndromes determined by intracellular cytokine staining in shortterm cultured blood mononuclear cells
    • Kashipaz MRA, Swinden D, Todd I, et al. Normal production of inflammatory cytokines in chronic fatigue and fibromyalgia syndromes determined by intracellular cytokine staining in shortterm cultured blood mononuclear cells. Clin Exp Immunol 2003; 132: 360-5.
    • (2003) Clin Exp Immunol , vol.132 , pp. 360-365
    • Kashipaz, M.R.A.1    Swinden, D.2    Todd, I.3
  • 66
    • 81355138728 scopus 로고    scopus 로고
    • Chronic fatigue syndrome, the immune system and viral infection
    • Bansal AS, Bradley AS, Bishop KN, et al. Chronic fatigue syndrome, the immune system and viral infection. Brain Behav Immun 2012; 26: 24-31.
    • (2012) Brain Behav Immun , vol.26 , pp. 24-31
    • Bansal, A.S.1    Bradley, A.S.2    Bishop, K.N.3
  • 68
    • 0037313180 scopus 로고    scopus 로고
    • Chronic fatigue syndrome: A review
    • Afari N, Buchwald D. Chronic fatigue syndrome: a review. Am J Psychiatry 2003; 160: 221-36.
    • (2003) Am J Psychiatry , vol.160 , pp. 221-236
    • Afari, N.1    Buchwald, D.2
  • 69
    • 79960891277 scopus 로고    scopus 로고
    • Role of Infection and Neurologic Dysfunction in Chronic Fatigue Syndrome
    • Komaroff AL, Cho TA. Role of Infection and Neurologic Dysfunction in Chronic Fatigue Syndrome. Seminars in Neurology 2011; 31: 325-37.
    • (2011) Seminars in Neurology , vol.31 , pp. 325-337
    • Komaroff, A.L.1    Cho, T.A.2
  • 70
    • 0025770311 scopus 로고
    • Symptoms and signs of chronic fatigue syndrome
    • Komaroff AL, Buchwald D. Symptoms and signs of chronic fatigue syndrome. Rev Infect Dis 1991; 13 Suppl 1: S8-11.
    • (1991) Rev Infect Dis , vol.13 , pp. 8-11
    • Komaroff, A.L.1    Buchwald, D.2
  • 72
    • 0034728235 scopus 로고    scopus 로고
    • Chronic fatigue syndrome
    • Reid S, Chalder T, Cleare A, et al. Chronic fatigue syndrome. BMJ 2000; 320: 292-6.
    • (2000) BMJ , vol.320 , pp. 292-296
    • Reid, S.1    Chalder, T.2    Cleare, A.3
  • 73
    • 0035004772 scopus 로고    scopus 로고
    • Cytokine and other immunologic markers in chronic fatigue syndrome and their relation to neuropsychological factors
    • Patarca-Montero R, Antoni M, Fletcher MA, et al. Cytokine and other immunologic markers in chronic fatigue syndrome and their relation to neuropsychological factors. Appl Neuropsychol 2001; 8: 51-64.
    • (2001) Appl Neuropsychol , vol.8 , pp. 51-64
    • Patarca-Montero, R.1    Antoni, M.2    Fletcher, M.A.3
  • 74
    • 1542319261 scopus 로고    scopus 로고
    • Predictive immunophenotypes: Disease-related profile in chronic fatigue syndrome
    • Stewart CC, Cookfair DL, Hovey KM, et al. Predictive immunophenotypes: Disease-related profile in chronic fatigue syndrome. Cytometry 2003; 53B: 26-33.
    • (2003) Cytometry , vol.53 B , pp. 26-33
    • Stewart, C.C.1    Cookfair, D.L.2    Hovey, K.M.3
  • 75
    • 84888264788 scopus 로고    scopus 로고
    • Natural killer cells in patients with severe chronic fatigue syndrome
    • Brenu EW, Hardcastle SL, Atkinson GM, et al. Natural killer cells in patients with severe chronic fatigue syndrome. Autoimmune Highlights 2013; 4: 69-80.
    • (2013) Autoimmune Highlights , vol.4 , pp. 69-80
    • Brenu, E.W.1    Hardcastle, S.L.2    Atkinson, G.M.3
  • 76
    • 84937113602 scopus 로고    scopus 로고
    • Characterization of natural killer cell phenotypes in chronic fatigue syndrome/myalgic encephalitis
    • Huth TK, Brenu EW, Nguyen T, et al. Characterization of natural killer cell phenotypes in chronic fatigue syndrome/myalgic encephalitis. Clin Cell Immunol 2014; 5: 1-8.
    • (2014) Clin Cell Immunol , vol.5 , pp. 1-8
    • Huth, T.K.1    Brenu, E.W.2    Nguyen, T.3
  • 77
    • 84857359512 scopus 로고    scopus 로고
    • Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Increased interleukin-1, tumor necrosis factor-alpha, PMN-elastase, lysozyme and neopterin
    • Maes M, Twisk FNM, Kubera M, et al. Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Increased interleukin-1, tumor necrosis factor-alpha, PMN-elastase, lysozyme and neopterin. J Affect Disord 2012; 136: 933-9.
    • (2012) J Affect Disord , vol.136 , pp. 933-939
    • Maes, M.1    Twisk, F.N.M.2    Kubera, M.3
  • 78
    • 84875891464 scopus 로고    scopus 로고
    • Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: Evidence of inflammatory pathology
    • Stringer EA, Baker KS, Carroll IR, et al. Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology. Journal of Translational Medicine 2013; 11.
    • (2013) Journal of Translational Medicine , pp. 11
    • Stringer, E.A.1    Baker, K.S.2    Carroll, I.R.3
  • 79
    • 84937131524 scopus 로고    scopus 로고
    • Biological phenotypes underpin the physio-somatic symptoms of somatization, depression, and chronic fatigue syndrome
    • Anderson G, Berk M, Maes M. Biological phenotypes underpin the physio-somatic symptoms of somatization, depression, and chronic fatigue syndrome. Acta Psychiatr Scand 2013;10.
    • (2013) Acta Psychiatr Scand , pp. 10
    • Anderson, G.1    Berk, M.2    Maes, M.3
  • 80
    • 77349101120 scopus 로고    scopus 로고
    • Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence
    • Chia J, Chia A, Voeller M, et al. Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence. J Clin Pathol 2010; 63: 165-8.
    • (2010) J Clin Pathol , vol.63 , pp. 165-168
    • Chia, J.1    Chia, A.2    Voeller, M.3
  • 81
    • 38449119227 scopus 로고    scopus 로고
    • Enterovirus infection of the stomach in chronic fatigue syndrome/myalgic encephalomyelitis
    • Kerr JR. Enterovirus infection of the stomach in chronic fatigue syndrome/myalgic encephalomyelitis. J Clin Pathol 2008; 61: 1-2.
    • (2008) J Clin Pathol , vol.61 , pp. 1-2
    • Kerr, J.R.1
  • 82
    • 33845955692 scopus 로고    scopus 로고
    • Twenty years of research on cytokineinduced sickness behavior
    • Dantzer R, Kelley KW. Twenty years of research on cytokineinduced sickness behavior. Brain Behav Immun 2007; 21: 153-60.
    • (2007) Brain Behav Immun , vol.21 , pp. 153-160
    • Dantzer, R.1    Kelley, K.W.2
  • 83
    • 0031054858 scopus 로고    scopus 로고
    • Markers of inflammation and immune activation in chronic fatigue and chronic fatigue syndrome
    • Buchwald D, Wener MH, Pearlman T, et al. Markers of inflammation and immune activation in chronic fatigue and chronic fatigue syndrome. J Rheumatol 1997; 24: 372-6.
    • (1997) J Rheumatol , vol.24 , pp. 372-376
    • Buchwald, D.1    Wener, M.H.2    Pearlman, T.3
  • 85
    • 61349116729 scopus 로고    scopus 로고
    • Association of peripheral inflammatory markers with chronic fatigue in a population-based sample
    • Raison CL, Lin JMS, Reeves WC. Association of peripheral inflammatory markers with chronic fatigue in a population-based sample. Brain Behavior and Immunity 2009; 23: 327-37.
    • (2009) Brain Behavior and Immunity , vol.23 , pp. 327-337
    • Raison, C.L.1    Lin, J.M.S.2    Reeves, W.C.3
  • 86
    • 0030938643 scopus 로고    scopus 로고
    • Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome
    • Cannon JG, Angel JB, Abad LW, et al. Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. J Clin Immunol 1997; 17: 253-61.
    • (1997) J Clin Immunol , vol.17 , pp. 253-261
    • Cannon, J.G.1    Angel, J.B.2    Abad, L.W.3
  • 87
    • 77949352315 scopus 로고    scopus 로고
    • Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: The role of elastase, complement C4a and interleukin-1beta
    • Nijs J, Van Oosterwijck J, Meeus M, et al. Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1beta. J Intern Med 2010; 267: 418-35.
    • (2010) J Intern Med , vol.267 , pp. 418-435
    • Nijs, J.1    Van Oosterwijck, J.2    Meeus, M.3
  • 89
    • 42149099885 scopus 로고    scopus 로고
    • Alterations in diurnal salivary cortisol rhythm in a population-based sample of cases with chronic fatigue syndrome
    • Nater UM, Youngblood LS, Jones JF, et al. Alterations in diurnal salivary cortisol rhythm in a population-based sample of cases with chronic fatigue syndrome. Psychosomatic Medicine 2008; 70: 298- 305.
    • (2008) Psychosomatic Medicine , vol.70 , pp. 298-305
    • Nater, U.M.1    Youngblood, L.S.2    Jones, J.F.3
  • 90
    • 0032924389 scopus 로고    scopus 로고
    • Is depression associated with immune activation?
    • Natelson BH, Denny T, Zhou XD, et al. Is depression associated with immune activation? J Affect Disord 1999; 53: 179-84.
    • (1999) J Affect Disord , vol.53 , pp. 179-184
    • Natelson, B.H.1    Denny, T.2    Zhou, X.D.3
  • 91
    • 34748826761 scopus 로고    scopus 로고
    • Longitudinal analysis of pro- and anti-inflammatory cytokine production in severely fatigued adolescents
    • ter Wolbeek M, van Doornen LJP, Kavelaars A, et al. Longitudinal analysis of pro- and anti-inflammatory cytokine production in severely fatigued adolescents. Brain Behavior and Immunity 2007; 21: 1063-74.
    • (2007) Brain Behavior and Immunity , vol.21 , pp. 1063-1074
    • ter Wolbeek, M.1    van Doornen, L.J.P.2    Kavelaars, A.3
  • 92
    • 77950631507 scopus 로고    scopus 로고
    • Cytokines across the Night in Chronic Fatigue Syndrome with and without Fibromyalgia
    • Nakamura T, Schwander SK, Donnelly R, et al. Cytokines across the Night in Chronic Fatigue Syndrome with and without Fibromyalgia. Clinical and Vaccine Immunology 2010; 17: 582-7.
    • (2010) Clinical and Vaccine Immunology , vol.17 , pp. 582-587
    • Nakamura, T.1    Schwander, S.K.2    Donnelly, R.3
  • 93
    • 0035006624 scopus 로고    scopus 로고
    • A twin study of the etiology of prolonged fatigue and immune activation
    • Hickie IB, Bansal AS, Kirk KM, et al. A twin study of the etiology of prolonged fatigue and immune activation. Twin Res 2001; 4: 94- 102.
    • (2001) Twin Res , vol.4 , pp. 94-102
    • Hickie, I.B.1    Bansal, A.S.2    Kirk, K.M.3
  • 94
    • 0029145634 scopus 로고
    • Can the chronic fatigue syndrome be defined by distinct clinical features?
    • Hickie I, Lloyd A, Hadzi-Pavlovic D, et al. Can the chronic fatigue syndrome be defined by distinct clinical features? Psychol Med 1995; 25: 925-35.
    • (1995) Psychol Med , vol.25 , pp. 925-935
    • Hickie, I.1    Lloyd, A.2    Hadzi-Pavlovic, D.3
  • 95
    • 78049413398 scopus 로고    scopus 로고
    • A formal analysis of cytokine networks in chronic fatigue syndrome
    • Broderick G, Fuite J, Kreitz A, et al. A formal analysis of cytokine networks in chronic fatigue syndrome. Brain Behav Immun 2010; 24: 1209-17.
    • (2010) Brain Behav Immun , vol.24 , pp. 1209-1217
    • Broderick, G.1    Fuite, J.2    Kreitz, A.3
  • 96
    • 85039886603 scopus 로고    scopus 로고
    • Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome
    • Hornig M, Gottschalk G, Peterson DL, et al. Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome. Mol Psychiatry 2015;1-9.
    • (2015) Mol Psychiatry , pp. 1-9
    • Hornig, M.1    Gottschalk, G.2    Peterson, D.L.3
  • 97
    • 0041885476 scopus 로고    scopus 로고
    • A systematic review and critical evaluation of the immunology of chronic fatigue syndrome
    • Lyall M, Peakman M, Wessely S. A systematic review and critical evaluation of the immunology of chronic fatigue syndrome. J Psychosom Res 2003; 55: 79-90.
    • (2003) J Psychosom Res , vol.55 , pp. 79-90
    • Lyall, M.1    Peakman, M.2    Wessely, S.3
  • 98
    • 0031015337 scopus 로고    scopus 로고
    • Immune responses associated with chronic fatigue syndrome: A case-control study
    • Mawle AC, Nisenbaum R, Dobbins JG, et al. Immune responses associated with chronic fatigue syndrome: a case-control study. J Infect Dis 1997; 175: 136-41.
    • (1997) J Infect Dis , vol.175 , pp. 136-141
    • Mawle, A.C.1    Nisenbaum, R.2    Dobbins, J.G.3
  • 99
    • 0026199312 scopus 로고
    • Altered cytokine release in peripheral blood mononuclear cell cultures from patients with the chronic fatigue syndrome
    • Chao CC, Janoff EN, Hu SX, et al. Altered cytokine release in peripheral blood mononuclear cell cultures from patients with the chronic fatigue syndrome. Cytokine 1991; 3: 292-8.
    • (1991) Cytokine , vol.3 , pp. 292-298
    • Chao, C.C.1    Janoff, E.N.2    Hu, S.X.3
  • 100
    • 0030982979 scopus 로고    scopus 로고
    • Elevation of bioactive transforming growth factor-beta in serum from patients with chronic fatigue syndrome
    • Bennett AL, Chao CC, Hu S, et al. Elevation of bioactive transforming growth factor-beta in serum from patients with chronic fatigue syndrome. J Clin Immunol 1997; 17: 160-6.
    • (1997) J Clin Immunol , vol.17 , pp. 160-166
    • Bennett, A.L.1    Chao, C.C.2    Hu, S.3
  • 101
    • 84862651150 scopus 로고    scopus 로고
    • Global prevalence of and risk factors for irritable bowel syndrome: A meta-analysis
    • Lovell RM, Ford AC. Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis. Clin Gastroenterol Hepatol 2012; 10: 712-21.
    • (2012) Clin Gastroenterol Hepatol , vol.10 , pp. 712-721
    • Lovell, R.M.1    Ford, A.C.2
  • 102
    • 0035859198 scopus 로고    scopus 로고
    • The irritable bowel syndrome
    • Horwitz BJ, Fisher RS. The irritable bowel syndrome. N Engl J Med 2001; 344: 1846-50.
    • (2001) N Engl J Med , vol.344 , pp. 1846-1850
    • Horwitz, B.J.1    Fisher, R.S.2
  • 104
    • 84855454374 scopus 로고    scopus 로고
    • Cytokines and irritable bowel syndrome: Where do we stand?
    • Bashashati M, Rezaei N, Andrews CN, et al. Cytokines and irritable bowel syndrome: where do we stand? Cytokine 2012; 57: 201-9.
    • (2012) Cytokine , vol.57 , pp. 201-209
    • Bashashati, M.1    Rezaei, N.2    Andrews, C.N.3
  • 105
    • 15744374565 scopus 로고    scopus 로고
    • Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles
    • O'Mahony L, McCarthy J, Kelly P, et al. Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology 2005; 128: 541-51.
    • (2005) Gastroenterology , vol.128 , pp. 541-551
    • O'Mahony, L.1    McCarthy, J.2    Kelly, P.3
  • 106
    • 54749094008 scopus 로고    scopus 로고
    • Enhanced cholinergicmediated increase in the pro-inflammatory cytokine IL-6 in irritable bowel syndrome: Role of muscarinic receptors
    • Dinan TG, Clarke G, Quigley EM, et al. Enhanced cholinergicmediated increase in the pro-inflammatory cytokine IL-6 in irritable bowel syndrome: role of muscarinic receptors. Am J Gastroenterol 2008; 103: 2570-6.
    • (2008) Am J Gastroenterol , vol.103 , pp. 2570-2576
    • Dinan, T.G.1    Clarke, G.2    Quigley, E.M.3
  • 107
    • 84903213255 scopus 로고    scopus 로고
    • Cytokine imbalance in irritable bowel syndrome: A systematic review and metaanalysis
    • Bashashati M, Rezaei N, Shafieyoun A, et al. Cytokine imbalance in irritable bowel syndrome: a systematic review and metaanalysis. Neurogastroenterol Motil 2014; 26: 1036-48.
    • (2014) Neurogastroenterol Motil , vol.26 , pp. 1036-1048
    • Bashashati, M.1    Rezaei, N.2    Shafieyoun, A.3
  • 108
    • 84870298788 scopus 로고    scopus 로고
    • Cytokine gene polymorphisms are associated with irritable bowel syndrome: A systematic review and meta-analysis
    • Bashashati M, Rezaei N, Bashashati H, et al. Cytokine gene polymorphisms are associated with irritable bowel syndrome: a systematic review and meta-analysis. Neurogastroenterol Motil 2012; 24: 1102-e566.
    • (2012) Neurogastroenterol Motil , vol.24 , pp. 566-1102
    • Bashashati, M.1    Rezaei, N.2    Bashashati, H.3
  • 110
    • 84869224447 scopus 로고    scopus 로고
    • The Role of the Central Nervous System in Osteoarthritis Pain and Implications for Rehabilitation
    • Murphy SL, Phillips K, Williams DA, et al. The Role of the Central Nervous System in Osteoarthritis Pain and Implications for Rehabilitation. Current Rheumatology Reports 2012; 14: 576-82.
    • (2012) Current Rheumatology Reports , vol.14 , pp. 576-582
    • Murphy, S.L.1    Phillips, K.2    Williams, D.A.3
  • 111
    • 84908370531 scopus 로고    scopus 로고
    • Evidence for central sensitization in patients with osteoarthritis pain: A systematic literature review
    • Lluch E, Torres R, Nijs J, et al. Evidence for central sensitization in patients with osteoarthritis pain: A systematic literature review. Eur J Pain 2014; 18: 1367-75.
    • (2014) Eur J Pain , vol.18 , pp. 1367-1375
    • Lluch, E.1    Torres, R.2    Nijs, J.3
  • 112
    • 79957440333 scopus 로고    scopus 로고
    • Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
    • Brenu EW, van Driel ML, Staines DR, et al. Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. J Transl Med 2011; 9: 81.
    • (2011) J Transl Med , vol.9 , pp. 81
    • Brenu, E.W.1    van Driel, M.L.2    Staines, D.R.3


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