The role of the central nervous system in osteoarthritis pain and implications for rehabilitation

Current Rheumatology Reports

Volumn 14, Issue 6, 2012, Pages 576-582

  Murphy, Susan L ^a,b,c   Phillips, Kristine ^a,c   Williams, David A ^d   Clauw, Daniel J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^c 300 North Ingalls 9th Floor ^*  (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Central augmentation; Central nervous system; Central sensitization; OA; Occupational therapy; Osteoarthritis; Pain modulation; Pain processing; Physical therapy; Rehabilitation; Treatment

Indexed keywords

4 AMINOBUTYRIC ACID; CALCITONIN GENE RELATED PEPTIDE; CANNABINOID; GALANIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPEPTIDE Y; NORADRENALIN; SEROTONIN; SOMATOSTATIN; SUBSTANCE P;

ALLODYNIA; ARTHRALGIA; CENTRAL NERVOUS SYSTEM FUNCTION; CHRONIC PAIN; COGNITIVE THERAPY; COPING BEHAVIOR; DISEASE SEVERITY; HUMAN; HYPERALGESIA; INDIVIDUALIZATION; KINESIOTHERAPY; MANIPULATIVE MEDICINE; MEDICAL LITERATURE; MEDICAL RESEARCH; NERVE CELL MEMBRANE STEADY POTENTIAL; NEUROPATHIC PAIN; NEUROTRANSMISSION; NOCICEPTION; OCCUPATIONAL THERAPY; OSTEOARTHRITIS; PAIN RECEPTOR; PATIENT CARE; PHYSIOTHERAPY; REVIEW; SENSITIZATION; SENSORY NERVE; SOMATOSENSORY SYSTEM; TRANSCUTANEOUS NERVE STIMULATION;

CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM SENSITIZATION; CHRONIC PAIN; HUMANS; OSTEOARTHRITIS; PAIN; PAIN MANAGEMENT;

EID: 84869224447     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-012-0285-z     Document Type: Review

References (50)

1. Mease PJ, Hanna S, Frakes EP, Altman RD. Pain mechanisms in osteoarthritis: understanding the role of central pain and current approaches to its treatment. J Rheumatol. 2011; 38(8): 1546-51.
2. Lee YC, Nassikas NJ, Clauw DJ. The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis osteoarthritis and fibromyalgia. Arthritis Res Ther. 2011; 13(2): 211. doi: 10.1186/ar3306.
3. Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011; 152(3 Suppl): S2-15. This review provides a comprehensive explanation of central sensitization and includes evidence from osteoarthritis studies.
4. Staud R. Evidence for shared pain mechanisms in osteoarthritis, low back pain, and fibromyalgia. Curr Rheumatol Rep. 2011; 13 (6): 513-20.
5. Phillips K, Clauw DJ. Central pain mechanisms in chronic pain states - Maybe it is all in their head. Best Practice & Research Clinical Rheumatology. 2011; 25(2): 141-54.
6. Schaible HG, Schmidt RF. Activation of groups III and IV sensory units in medial articular nerve by local mechanical stimulation of knee joint. J Neurophysiol. 1983; 49(1): 35-44. (Pubitemid 13152924)
7. Sisignano M, Park CK, Angioni C. 5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. J Neurosci. 2012; 32(18): 6364-72.
8. Lemons LL, Wiley RG. Neuropeptide Y receptor-expressing dorsal horn neurons: Role in nocifensive reflex and operant responses to aversive cold after CFA inflammation. Neuroscience. 2012; 216: 158-66.
9. Xu X, Yang X, Zhang P, Chen X, Liu H, Li Z. Effects of exogenous galanin on neuropathic pain state and change of galanin and its receptors in DRG and SDH after sciatic nerve-pinch injury in rat. PLoS One. 2012; 7(5): e37621. doi: 10.1371/journal.pone.0037621.
10. Arendt-Nielsen L, Nie H, Laursen MB, Laursen BS, Madeleine P, Simonsen OH et al. Sensitization in patients with painful knee osteoarthritis. Pain. 2010; 149(3): 573-81. Patients with OA had less DNIC, lower pain thresholds, and enhanced temporal summation compared to controls.
11. Creamer P, Hochberg MC. Why does osteoarthritis of the knee hurt-sometimes? Br J Rheumatol. 1997; 36(7): 726-8. (Pubitemid 27348193)
12. Bajaj P, Bajaj P, Graven-Nielsen T, Arendt-Nielsen L. Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study. Pain. 2001; 93(2): 107-14. (Pubitemid 32568395)
13. Felson DT, Chaisson CE, Hill CL, et al. The association of bone marrow lesions with pain in knee osteoarthritis. Ann Intern Med. 2001; 134(7): 541-9. (Pubitemid 32245315)
14. Woolf CJ. Evidence for a central component of post-injury pain hypersensitivity. Nature. 1983; 306(5944): 686-8. (Pubitemid 14201852)
15. Coderre TJ, Katz J, Vaccarino AL, Melzack R. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain (Amsterdam). 1993; 52(3): 259-85. (Pubitemid 23080546)
16. Brandt KD. Neuromuscular aspects of osteoarthritis. In: Felson DT, Schiable H-G, editors. Pain in Osteoarthritis. Hoboken: Wiley-Blackwell; 2009. p. 157-74.
17. Kidd B. Mechanisms of pain in osteoarthritis. HSS J. 2012; 8 (1): 26-8.
18. Imamura M, Imamura ST, Kaziyama HHS, et al. Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: A controlled analysis. Arthritis Care Res. 2008; 59(10): 1424-31.
19. Yarnitsky D. Conditioned pain modulation (the diffuse noxious inhibitory control-like effect): its relevance for acute and chronic pain states. Curr Opin Anaesthesiol. 2010; 23(5): 611-5.
20. Kosek E, Ordeberg G. Abnormalities of somatosensory perception in patients with painful osteoarthritis normalize following successful treatment. Eur J Pain. 2000; 4(3): 229-38.
21. Gwilym SE, Keltner JR, Warnaby CE, et al. Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients. Arthritis Care Res. 2009; 61(9): 1226-34.
22. Kulkarni B, Bentley DE, Elliott R, et al. Arthritic pain is processed in brain areas concerned with emotions and fear. Arthritis Rheum. 2007; 56(4): 1345-54. (Pubitemid 46608660)
23. Yunus MB. Central sensitivity syndromes: A new paradigm and group nosology for fibromyalgia and overlapping conditions, and the related issue of disease versus illness. Semin Arthritis Rheum. 2008; 37(6): 339-52.
24. Clauw D, Witter J. Pain and rheumatology: thinking outside the joint. Arthritis Rheum. 2009; 60(2): 321-4.
25. Wolfe F, Rasker J. The Symptom Intensity Scale, fibromyalgia, and the meaning of fibromyalgia-like symptoms. J Rheumatol. 2006; 33(11): 2291-9. (Pubitemid 44749791)
26. Wolfe F. Fibromyalgianess. Arthritis Care Res. 2009; 61(6): 715-6.
27. Yunus MB. The prevalence of fibromyalgia in other chronic pain conditions. Pain Res Treat. 2012: 584573. doi: 10.1155/2012/584573.
28. Hawker GA, Gignac MA, Badley E, et al. A longitudinal study to explain the pain-depression link in older adults with osteoarthritis. Arthritis Care Res. 2011; 63(10): 1382-90.
29. Murphy SL, Lyden AK, Phillips K, Clauw DJ, Williams DA. Subgroups of older adults with osteoarthritis with probable central nervous system contributions to their symptoms. Arthritis Res Ther. 2011; 13(R135). doi: 10.1186/ar3449.
30. LA Murphy SL, Phillips K, Clauw DJ, Williams DA. Association between pain, radiographic severity, and centrally-mediated symptoms in women with knee osteoarthritis. Arthritis Care Res. 2011; 63(11): 1543-9.
31. Nickel FT, Seifert F, Lanz S, Maihö fner C. Mechanisms of neuropathic pain. Eur Neuropsychopharmacol. 2012; 22(2): 81-91.
32. Hochman J, French M, Bermingham S, Hawker G. The nerve of osteoarthritis pain. Arthritis Care Res. 2010; 62(7): 1019-23.
33. Hochman JR, Gagliese L, Davis AM, Hawker GA. Neuropathic pain symptoms in a community knee OA cohort. Osteoarthr Cartil. 2011; 19(6): 647-54.
34. Courtney CA, Clark JD, Duncombe AM, O'Hearn MA. Clinical presentation and manual therapy for lower quadrant musculoskeletal conditions. J Man Manip Ther. 2011; 19(4): 212-22.
35. Nijs J, Van Houdenhove B, Oostendorp RAB. Recognition of central sensitization in patients with musculoskeletal pain: Application of pain neurophysiology in manual therapy practice. Man Ther. 2010; 15(2): 135-41.
36. Nijs J, Meeus M, Van Oosterwijck J, et al. Treatment of central sensitization in patients with 'unexplained' chronic pain: what options do we have? Expert Opinion Pharmacother. 2011; 12(7): 1087-98.
37. Moss P, Sluka K, Wright A. The initial effects of knee joint mobilization on osteoarthritic hyperalgesia. Man Ther. 2007; 12(2): 109-18. (Pubitemid 46602065)
38. Nijs J, Van Houdenhove B. From acute musculoskeletal pain to chronic widespread pain and fibromyalgia: application of pain neurophysiology in manual therapy practice. Man Ther. 2009; 14 (1): 3-12.
39. ZhangW, Nuki G, Moskowitz RW, et al. OARSI recommendations for the management of hip and knee osteoarthritis: Part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthr Cartil. 2010; 18 (4): 476-99.
40. Beckwé e D, De Hertogh W, Lievens P, Bautmans I, Vaes P. Effect of TENS on pain in relation to central sensitization in patients with osteoarthritis of the knee: Study protocol of a randomized controlled trial. Trials. 2012; 13.
41. Rutjes AW. Nü esch E, Sterchi R, et al. Transcutaneous electrostimulation for osteoarthritis of the knee. Cochrane Database of Systematic Reviews. 2009(4): CD002823.
42. Vance CGT, Rakel BA, Blodgett NP, et al. Effects of transcutaneous electrical nerve stimulation on pain, pain sensitivity, and function in people with knee osteoarthritis: A randomized controlled trial. Phys Ther. 2012. doi: 10.2522/ptj.20110183.
43. Keefe FJ, Smith SJ, Buffington AL, et al. Recent advances and future directions in the biopsychosocial assessment and treatment of arthritis. J Consult Clin Psychol. 2002; 70(3): 640-55. (Pubitemid 34640736)
44. Somers T, Keefe F, Godiwala N, Hoyler G. Psychosocial factors and the pain experience of osteoarthritis patients: new findings and new directions. Curr Opin Rheumatol. 2009; 21(5): 501-6.
45. Rossy LA, Buckelew SP, Dorr N, et al. A meta-analysis of fibromyalgia treatment interventions. Ann Behav Med. 1999; 21 (2): 180-91. (Pubitemid 29445397)
46. Hurley MV,Walsh NE, Mitchell HL, et al. Clinical effectiveness of a rehabilitation program integrating exercise, self-management, and active coping strategies for chronic knee pain: a cluster randomized trial. Arthritis Rheum. 2007; 57(7): 1211-9. doi: 10.1002/ art.22995. (Pubitemid 47585467)
47. McKnight P, Kasle S, Going S, et al. A comparison of strength training, self-management, and the combination for early osteoarthritis of the knee. Arthritis Care Res. 2010; 62(1): 45-53.
48. Hurley M, Walsh NE, Mitchell H, Nicholas J, Patel A. Long-term outcomes and costs of an integrated rehabilitation program for chronic knee pain: a pragmatic, cluster randomized, controlled trial. Arthritis Care Res. 2012; 64(2): 238-47.
49. Murphy S, Lyden AK, Smith DM, Dong Q, Koliba JF. The effect of tailored activity pacing intervention on pain and fatigue for older adults with osteoarthritis. Am J Occup Ther. 2010; 64: 869-76.
50. Murphy SL, Lyden AK, Clary M, et al. Activity pacing for osteoarthritis symptom management: study design and methodology of a randomized trial testing a tailored clinical approach using accelerometers for veterans and non-veterans. BMC Musculoskelet Disord. 2011; 12(177).