Elevation of bioactive transforming growth factor-β in serum from patients with chronic fatigue syndrome

Journal of Clinical Immunology

Volumn 17, Issue 2, 1997, Pages 160-166

  Bennett, Adrienne L ^a   Chao, Chun C ^b   Hu, Shuxian ^b   Buchwald, Dedra ^c   Fagioli, Laura R ^a   Schur, Peter H ^d   Peterson, Phillip K ^b   Komaroff, Anthony L ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

chronic fatigue syndrome; major depression; multiple sclerosis; systemic lupus erythematosis; transforming growth factor

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BIOASSAY; BLOOD LEVEL; CHRONIC FATIGUE SYNDROME; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

DEPRESSION; FACTOR ANALYSIS, STATISTICAL; FATIGUE SYNDROME, CHRONIC; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MULTIPLE SCLEROSIS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0030982979     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1027330616073     Document Type: Article

References (43)

1. Holmes GP, Kaplan JE, Gantz NM, Komaroff AL, Schonberger LB, Straus SE, Jones JF, DuBois RE, Cunningham-Rundles C, Pahwa S, Tosato G, Zegans LS, Purtilo DT, Brown N, Schooley RT, Brus I: Chronic fatigue syndrome: A working case definition. Ann Intern Med 108:387-389, 1988
2. Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A: The chronic fatigue syndrome: A comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med 121:953-959, 1994
3. Lloyd AR, Wakefield D, Hickie I: Immunity and the pathophysiology of chronic fatigue syndrome. In Chronic Fatigue Syndrome (Ciba Foundation Symposium 173), GR Bock, J Whelan (eds). New York, John Wiley & Sons, 1993, pp 176-192
4. Barker E, Fujimura SF, Fadem MB, Landay AL, Levy JA: Immunologic abnormalities associated with chronic fatigue syndrome. Clin Infect Dis 18 (Suppl 1):S136-S141, 1994
5. McDonald EM, Mann AH, Thomas HC: Interferons as mediators of psychiatric morbidity: An investigation in a trial of recombinant α-interferon in hepatitis-B carriers. Lancet 2:1175-1178, 1987
6. Krueger JM, Majde JA: Sleep as a host defense: Its regulation by microbial products and cytokines. Clin Immunol Immunopathol 57:188-199, 1990
7. Linde A, Andersson B, Svenson SB, Ahrne H, Carlsson M, Forsberg P, Hugo H, Karstorp A, Lenkei R, Lindwall A, Loftenius A, Sall C, Andersson J: Serum levels of lymphokines and soluble cellular receptors in primary Epstein-Barr virus infection and in patients with chronic fatigue syndrome. J Infect Dis 165:994-1000, 1992
8. Cheney PR, Dorman SE: Interleukin-2 and the chronic fatigue syndrome. Ann Intern Med 110:321, 1989
9. Chao CC, Gallagher M, Phair J, Peterson PK: Serum neopterin and interleukin-6 levels in chronic fatigue syndrome. J Infect Dis 162:1412-1413, 1990
10. Ho-Yen DO, Carrington D, Armstrong AA: Myalgic encephalomyelitis and alpha-interferon. Lancet 1:125, 1988
11. Patarca R, Klimas NG, Lugtendorf S, Antoni M, Fletcher MA: Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: Interrelations with cellular sources and patterns of soluble immune mediator expression. Clin Infect Dis 18 (Suppl 1):S147-S153, 1994
12. Straus SE, Dale JK, Peter JB, Dinarello CA: Circulating lymphokine levels in chronic fatigue syndrome. J Infect Dis 160:1085-1086, 1989
13. Lloyd A, Gandevia S, Brockman A, Hales J, Wakefield D: Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise. Clin Infect Dis 18 (Suppl 1):S142-S146, 1994
14. Chao CC, Janoff EN, Hu S, Thomas K, Gallagher M, Tsang M, et al.: Altered cytokine release in peripheral blood mononuclear cell cultures from patients with chronic fatigue syndrome. Cytokine 3:292-398, 1991
15. Peterson PK, Sirr SA, Grammith FC, Schenk C, Pheley AM, Hu S, Chao CC: Effects of mild exercise on cytokines and cerebral blood flow in chronic fatigue syndrome patients. Clin Diag Lab Immunol 1:222-226, 1994
16. Sporn MB, Roberts AB, Wakefield LM, Assoian RK: Transforming growth factor-β: Biological function and chemical structure. Science 233:532-534, 1986
17. Sporn MB, Roberts AB: Introduction: What is TGF-β? In Clinical Applications of TGF-β (Ciba Foundation Symposium 157), GR Bock, J Marsh (eds). New York, John Wiley & Sons, 1991, pp 1-5
18. Massague J: The transforming growth factor-β family. Annu Rev Cell Biol 6:597-641, 1990
19. Roberts AB, Sporn MB: The transforming growth factor-βs. In Handbook of Experimental Pharmacology, Peptide Growth Factors and Their Receptors, Vol 95, Part 1, MB Sporn, AB Roberts (eds). Heidelberg, Springer-Verlag, 1990, pp 419-472
20. Miyazono K, Yuki K, Takaku F, Wernstedt C, Kanzaki T, Olofsson A, Hellman U, Heldin CH: Latent forms of TGF-β: Structure and biology. Ann NY Acad Sci 593:51-58, 1990
21. Ruscetti F, Varesio L, Ochoa A, Ortaldo J: Pleiotropic effects of transforming growth factor-β on cells of the immune system. Ann NY Acad Sci 685:488-500, 1993
22. Fontana A, Constam DB, Frei K, Malipiero U, Pfister HW. Modulation of the immune response by transforming growth factor beta. Int Arch Allergy Immunol 99:1-7, 1992
23. Lucas C, Wallick S, Fendly BM, Figarit I, Palladino MA: TGF-β: A possible autocrine immune regulator. In Clinical Applications of TGF-β (Ciba Foundation Symposium 157), GR Bock, J Marsh (eds). New York, John Wiley & Sons, 1991, pp 98-114
24. Wahl SM, Costa GL, Mizel DE, Allen JB, Skaleric U, Mangan DF: Role of transforming growth factor beta in the pathophysiology of chronic inflammation. J Periodontol 64:450-455, 1993
25. Smith EA, LeRoy EC: A possible role for transforming growth factor-β in systemic sclerosis. J Invest Dermatol 95:125S-127S, 1990
26. Kulozik M, Hogg A, Lankat-Buttgereit B, Krieg T: Co-localization of transforming growth factor β2 with α1(1) procollagen mRNA in tissue sections of patients with systemic sclerosis. J Clin Invest 86:917-922, 1990
27. Kanai H, Mitsuhashi H, Ono K, Yano S, Naruse T: Increased excretion of urinary transforming growth factor beta in patients with focal glomerular sclerosis. Nephron 66:391-395, 1994
28. Deguchi Y, Kishimoto S: Spontaneous activation of Transforming growth factor-β gene transcription in broncho-alveolar mononuclear cells of individuals with systemic autoimmune diseases with lung involvement. Lupus 1:27-30, 1991
29. Dang H, Geiser AG, Letterio JJ, Nakabayashi T, Kong L, Fernandes G, Talal N: SLE-like autoantibodies and sjogren's syndrome-like lymphoproliferation in TGF-β knockout mice. J Immunol 155:3205-3212, 1995
30. Horwitz DA, Wang H, Gray JD: Cytokine gene profile in circulating blood mononuclear cells from patients with systemic lupus erythematosis: Increased interleukin-2 but not interleukin-4 mRNA. Lupus 3:423-428, 1994
31. Rieckmann P, Albrecht BA, Kitze B, Weber T, Tumani H, Broocks A, Luer W, Helwig A, Poser S: Tumor necrosis factor-α messenger RNA expression in patients with relapsing-remitting multiple sclerosis is associated with disease activity. Ann Neurol 37:82-88, 1995
32. Link J, Soderstrom M, Olsson T, Hojeberg B, Ljungdahl A, Link H: Increased transforming growth factor-β, interleukin-4, and interferon-γ in multiple sclerosis. Ann Neurol 36:379-386, 1994
33. Link J, He B, Navikas V, Palasik W, Fredrikson S, Soderstrom M, Link H: Transforming growth factor-β1 suppresses autoantigen-induced expression of proinflammatory cytokines but not of interleukin-10 in multiple sclerosis and myasthenia gravis. J Neuroimmunol 58:21-35, 1995
34. Beck J, Rondot P, Jullien P, Wietzerbin J, Lawrence DA: TGF-β-like activity produced during regression of exacerbations in multiple sclerosis. Acta Neurol Scand 84:452-455, 1991
35. Hafler DA, Chofflon M, Kurt-Jones E, Weiner HL: Interleukin-1 corrects the defective autologous mixed lymphocyte response in multiple sclerosis. Clin Immunol Immunopathol 58:115-125, 1991
36. Kekow J, Wachsman W, McCutchan JA, Cronin M, Carson DA, Lotz M: Transforming growth factor β and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection. Proc Natl Acad Sci USA 87:8321-8325, 1990
37. Landay AL, Jessop C, Lennette ET, Levy JA: Chronic fatigue syndrome: Clinical condition associated with immune activation. Lancet 338:707-712, 1991
38. Straus SE, Fritz S, Dale JK, Gould B, Strober W: Lymphocyte phenotype and function in the chronic fatigue syndrome. J Clin Immunol 13:30-40, 1993
39. Constam DB, Phillip J, Malipiero UV, ten Dijke P, Schachner M, Fontana A: Differential expression of transforming growth factor-β1, β2, and β3 by glioblastoma cells, astrocytes, and microglia. J Immunol 148:1404-1410, 1992
40. da Cunha A, Jefferson JA, Jackson RW, Vitkovic L: Glial cell-specific mechanisms of TGF-β1 induction by IL-1 in cerebral cortex. J Neuroimmunol 42:71-86, 1993
41. Wahl SM, Allen JB, McCartney-Francis N, Morganti-Kossmann MC, Kossmann T, Ellingsworth L, Mai UEH, Mergenhagen SE, Orenstein JM: Macrophage- and astrocyte-derived transforming growth factor β as a mediator of central nervous system dysfunction in acquired immune deficiency syndrome. J Exp Med 173: 981-991, 1991
42. Chao CC, Hu S, Frey WH, II, Ala T, Tourtellotte WW, Peterson PK: Transforming growth factor-β in Alzheimer's disease. Clin Diagn Lab Immunol 1:109-110, 1994
43. Chao CC, Hu S, Kravitz FH, Anderson WR, Tsang M, Peterson PK: Transforming growth factor-β protects human neurons against β-amyloid-induced injury. Mol Chem Neuropathol 23:159-178, 1994