The role of climate and out-of-Africa migration in the frequencies of risk alleles for 21 human diseases

BMC Genetics

Volumn 16, Issue 1, 2015, Pages

  Blair, Lily M ^a   Feldman, Marcus W ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Environmental adaptation; Genome wide association studies; Human disease risk loci; Positive selection; Serial founder effect

Indexed keywords

ADAPTATION; AFRICA; ALOPECIA AREATA; ARTICLE; ASTHMA; BILIARY CIRRHOSIS; BREAST CANCER; CELIAC DISEASE; CLIMATE; COLORECTAL CANCER; CROHN DISEASE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETIC RISK; HETEROZYGOSITY; HUMAN; HUMAN IMPACT (ENVIRONMENT); HUMIDITY; INSULIN DEPENDENT DIABETES MELLITUS; MELANOMA; MEMBRANOUS GLOMERULONEPHRITIS; MIGRATION; NEUROBLASTOMA; NON INSULIN DEPENDENT DIABETES MELLITUS; NULL ALLELE; OVARY POLYCYSTIC DISEASE; PANCREAS CANCER; PARKINSON DISEASE; PRIMARY BILIARY CIRRHOSIS; PROSTATE CANCER; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS; ULCERATIVE COLITIS; ALLELE; DIABETES MELLITUS, TYPE 2; ENVIRONMENT; GENETIC ASSOCIATION STUDY; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; HETEROZYGOTE; MOLECULAR EVOLUTION;

ADAPTATION, BIOLOGICAL; ALLELES; CLIMATE; DIABETES MELLITUS, TYPE 2; ENVIRONMENT; EVOLUTION, MOLECULAR; GENE FREQUENCY; GENE-ENVIRONMENT INTERACTION; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HUMAN MIGRATION; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84937034913     PISSN: None     EISSN: 14712156     Source Type: Journal    
DOI: 10.1186/s12863-015-0239-3     Document Type: Article

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