β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia

Journal of Neuroinflammation

Volumn 12, Issue 1, 2015, Pages

  Lee, Eun Jung ^a   Ko, Hyun Myung ^a   Jeong, Yeon Hui ^a   Park, Eun Mi ^a   Kim, Hee Sun ^a  

^a Ewha Womans University School of Medicine   (South Korea)

Author keywords

Cytokine; Microglia; MMP; Neuroinflammation; Signaling pathway; Lapachone

Indexed keywords

BETA LAPACHONE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOKINE; GELATINASE B; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MATRIX METALLOPROTEINASE; MEMBRANE PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NEUTROPHIL COLLAGENASE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN NQO1; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE P47PHOX; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; BETA-LAPACHONE; NAPHTHOQUINONE; NITRITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BRAIN TISSUE; CELL ACTIVATION; CELL STIMULATION; CONTROLLED STUDY; DRUG EFFICACY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OXIDATIVE STRESS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TREATMENT DURATION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CELL LINE; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; ENCEPHALITIS; METABOLISM; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALITIS; HEME OXYGENASE-1; IN VITRO TECHNIQUES; INTERLEUKIN-10; LIPOPOLYSACCHARIDES; MATRIX METALLOPROTEINASES; MICE; MICROGLIA; NAPHTHOQUINONES; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 84937031351     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-015-0355-z     Document Type: Article

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