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Volumn 73, Issue 1, 2015, Pages 137-150

Comparative assessment of nanomaterial definitions and safety evaluation considerations

Author keywords

Definitions; Nanomaterial; Risk evaluation

Indexed keywords

NANOMATERIAL;

EID: 84936996244     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2015.06.001     Document Type: Article
Times cited : (292)

References (81)
  • 2
    • 84936990487 scopus 로고    scopus 로고
    • American Chemistry Council, Available at:, Accessed 14.01.14.
    • ACC Responsible Care 2014, American Chemistry Council, Available at:, Accessed 14.01.14. http://responsiblecare.americanchemistry.com.
    • (2014) Responsible Care
  • 4
    • 84937019364 scopus 로고    scopus 로고
    • Ministry of Ecology, Sustainable Development, Transportation, and Housing. Decree no. 2012-232 of 17 February 2012 on the annual declaration on substances at nanoscale in application of article R. 523-4 of the Environment code
    • Text 4/44. Available at:, Accessed 14.11.13.
    • ANSES Ministry of Ecology, Sustainable Development, Transportation, and Housing. Decree no. 2012-232 of 17 February 2012 on the annual declaration on substances at nanoscale in application of article R. 523-4 of the Environment code. Off. J. Fr. Repub. 19 February 2012, Text 4/44. Available at:, Accessed 14.11.13. https://www.r-nano.fr/?locale=en.
    • (2012) Off. J. Fr. Repub.
  • 5
    • 70350662344 scopus 로고    scopus 로고
    • Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective
    • Auffan M., Rose J., Bottero J.Y., Lowry G.V., Jolivet J.P., Wiesner M.R. Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective. Nat. Nanotechnol. 2009, 4:634-641.
    • (2009) Nat. Nanotechnol. , vol.4 , pp. 634-641
    • Auffan, M.1    Rose, J.2    Bottero, J.Y.3    Lowry, G.V.4    Jolivet, J.P.5    Wiesner, M.R.6
  • 7
    • 1342267646 scopus 로고    scopus 로고
    • Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles
    • Bermudez E., Mangum J.B., Wong B.A., Asgharian B., Hext P.M., Warheit D.B., Everitt J.I. Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol. Sci. 2004, 77:347-357.
    • (2004) Toxicol. Sci. , vol.77 , pp. 347-357
    • Bermudez, E.1    Mangum, J.B.2    Wong, B.A.3    Asgharian, B.4    Hext, P.M.5    Warheit, D.B.6    Everitt, J.I.7
  • 9
    • 33144477406 scopus 로고    scopus 로고
    • Research strategies for safety evaluation of nanomaterials, part V: role of dissolution in biological fate and effects of nanoscale particles
    • Borm P., Klaessig F.C., Landry T.D., Moudgil B., Pauluhn J., Thomas K., Trottier R., Wood S. Research strategies for safety evaluation of nanomaterials, part V: role of dissolution in biological fate and effects of nanoscale particles. Toxicol. Sci. 2006, 90:23-32.
    • (2006) Toxicol. Sci. , vol.90 , pp. 23-32
    • Borm, P.1    Klaessig, F.C.2    Landry, T.D.3    Moudgil, B.4    Pauluhn, J.5    Thomas, K.6    Trottier, R.7    Wood, S.8
  • 13
    • 85123316636 scopus 로고    scopus 로고
    • Nanomaterials and nanoparticles: sources and toxicity
    • Buzea C., Pacheco I.I., Robbie K. Nanomaterials and nanoparticles: sources and toxicity. Biointerphases 2007, 2:MR17-172.
    • (2007) Biointerphases , vol.2 , pp. MR17-172
    • Buzea, C.1    Pacheco, I.I.2    Robbie, K.3
  • 15
    • 0028104527 scopus 로고
    • The role of clearance and dissolution in determining the durability or biopersistence of mineral fibers
    • Davis J.M. The role of clearance and dissolution in determining the durability or biopersistence of mineral fibers. Environ. Health Perspect. 1994, 102(Suppl.5):113-117.
    • (1994) Environ. Health Perspect. , vol.102 , Issue.SUPPL.5 , pp. 113-117
    • Davis, J.M.1
  • 17
    • 84880958977 scopus 로고    scopus 로고
    • Nanotoxicity: challenging the myth of nano-specific toxicity
    • Donaldson K., Poland C.A. Nanotoxicity: challenging the myth of nano-specific toxicity. Curr. Opin. Biotechnol. 2013, 24:724-734.
    • (2013) Curr. Opin. Biotechnol. , vol.24 , pp. 724-734
    • Donaldson, K.1    Poland, C.A.2
  • 19
    • 84861607883 scopus 로고    scopus 로고
    • Sol-gel synthesis and washing of amorphous g-FeO (OH) xerogels
    • Durães L., Benedini L., Costa B., Portugal A. Sol-gel synthesis and washing of amorphous g-FeO (OH) xerogels. Mater. Werkst. 2012, 43:427-434.
    • (2012) Mater. Werkst. , vol.43 , pp. 427-434
    • Durães, L.1    Benedini, L.2    Costa, B.3    Portugal, A.4
  • 20
    • 78449295622 scopus 로고    scopus 로고
    • Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products
    • L342
    • EC (2009).European Commission Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products. Off. J. Eur. Union (EN) 12 December 2009, 52:59-209. L342.
    • (2009) Off. J. Eur. Union (EN) , vol.52 , pp. 59-209
  • 21
    • 84857215875 scopus 로고    scopus 로고
    • European Commission. Commission Recommendation of 18 October 2011 on the definition of nanomaterials
    • 20 October 2011. L275
    • EC European Commission. Commission Recommendation of 18 October 2011 on the definition of nanomaterials. Off. J. Eur. Union (EN) 2011, 54:38-40. 20 October 2011. L275.
    • (2011) Off. J. Eur. Union (EN) , vol.54 , pp. 38-40
  • 22
    • 84937019367 scopus 로고    scopus 로고
    • European Commission. Regulation (EU) No 1169/2011 of the European Parliament and of the Council of 25 Ocboer 2011 on the provision of food information to consumers, amending Regulations (EC) No 1924/2006 and (EC) no 1925/2006 of the European Aprliament and of the Council, and repealing Commission Directive 87/250/EEC, Council Directive 90/496/EEC, Commission Directive 1999/10/EC, Directive 2000/13
    • 22 November 2011. L304
    • EC European Commission. Regulation (EU) No 1169/2011 of the European Parliament and of the Council of 25 Ocboer 2011 on the provision of food information to consumers, amending Regulations (EC) No 1924/2006 and (EC) no 1925/2006 of the European Aprliament and of the Council, and repealing Commission Directive 87/250/EEC, Council Directive 90/496/EEC, Commission Directive 1999/10/EC, Directive 2000/13/EC of the European Parliament of the the Council, Commission Directives 2002/67/EC and 2008/5/EC and Commission Regulation (EC) No 608/2004. Official J. Eur. Union (EN) 2011, 18-63. 22 November 2011. L304.
    • (2011) Official J. Eur. Union (EN) , pp. 18-63
  • 23
    • 84871401368 scopus 로고    scopus 로고
    • Regulation (EU) No 528/2012 of the European Parliament and of the Council of 22 May 2012 concerning the making available on the market and use of biocidal products
    • L167
    • EC (2012).European Commission Regulation (EU) No 528/2012 of the European Parliament and of the Council of 22 May 2012 concerning the making available on the market and use of biocidal products. Off. J. Eur. Union (EN) 27 June 2012, 1-123. L167.
    • (2012) Off. J. Eur. Union (EN) , pp. 1-123
  • 24
    • 41149138571 scopus 로고    scopus 로고
    • Available at:, Accessed 19.05.15.
    • Environmantal Defense Fund and Dupont NANO Risk Framework 2007, Available at:, Accessed 19.05.15. http://www.nanoriskframework.com.
    • (2007) NANO Risk Framework
  • 25
    • 84858998451 scopus 로고    scopus 로고
    • The toxicological mode of action and the safety of synthetic amorphous silica-a nanostructured material
    • Fruijtier-Polloth C. The toxicological mode of action and the safety of synthetic amorphous silica-a nanostructured material. Toxicology 2012, 294:61-79.
    • (2012) Toxicology , vol.294 , pp. 61-79
    • Fruijtier-Polloth, C.1
  • 26
    • 45449088907 scopus 로고    scopus 로고
    • Effects of particle size, particle/matrix interface adhesion and particle loading on mechanical properties of particulate-polymer composites
    • Fu S.Y., Feng X.Q., Lauke B., Mai Y.W. Effects of particle size, particle/matrix interface adhesion and particle loading on mechanical properties of particulate-polymer composites. Compos. Part B: Eng. 2008, 39:933-961.
    • (2008) Compos. Part B: Eng. , vol.39 , pp. 933-961
    • Fu, S.Y.1    Feng, X.Q.2    Lauke, B.3    Mai, Y.W.4
  • 27
    • 84867012116 scopus 로고    scopus 로고
    • Invivo assessment of CdSe-ZnS quantum dots: coating dependent bioaccumulation and genotoxicity
    • Galeone A., Vecchio G., Malvindi M.A., Brunetti V., Cingolani R., Pompa P.P. Invivo assessment of CdSe-ZnS quantum dots: coating dependent bioaccumulation and genotoxicity. Nanoscale 2012, 4:6401-6407.
    • (2012) Nanoscale , vol.4 , pp. 6401-6407
    • Galeone, A.1    Vecchio, G.2    Malvindi, M.A.3    Brunetti, V.4    Cingolani, R.5    Pompa, P.P.6
  • 29
    • 33845686331 scopus 로고    scopus 로고
    • Studies of robustness of industrial aciniform aggregates and agglomerates: carbon black and amorphous silicas: a review amplified by new data
    • Gray C.A., Muranko H. Studies of robustness of industrial aciniform aggregates and agglomerates: carbon black and amorphous silicas: a review amplified by new data. J.Occup. Environ. Med. 2006, 48:1279-1290.
    • (2006) J.Occup. Environ. Med. , vol.48 , pp. 1279-1290
    • Gray, C.A.1    Muranko, H.2
  • 31
    • 84859950790 scopus 로고    scopus 로고
    • FDA's approach to regulation of products of nanotechnology
    • Hamburg M.A. FDA's approach to regulation of products of nanotechnology. Science 2012, 336:299-300.
    • (2012) Science , vol.336 , pp. 299-300
    • Hamburg, M.A.1
  • 32
    • 32044451341 scopus 로고    scopus 로고
    • Atoxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors
    • Hardman R. Atoxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Environ. Health Perspect. 2006, 114:165-172.
    • (2006) Environ. Health Perspect. , vol.114 , pp. 165-172
    • Hardman, R.1
  • 34
    • 82755162606 scopus 로고    scopus 로고
    • Pulmonary toxicity of inhaled nanoscale and fine zinc oxide particles: mass and surface area as an exposure metric
    • Ho M., Wu K.Y., Chein H.M., Chen L.C., Cheng T.J. Pulmonary toxicity of inhaled nanoscale and fine zinc oxide particles: mass and surface area as an exposure metric. Inhal. Toxicol. 2011, 23:947-956.
    • (2011) Inhal. Toxicol. , vol.23 , pp. 947-956
    • Ho, M.1    Wu, K.Y.2    Chein, H.M.3    Chen, L.C.4    Cheng, T.J.5
  • 38
    • 84878040249 scopus 로고    scopus 로고
    • An assessment of fluorescence- and absorbance-based assays to study metal-oxide nanoparticle ROS production and effects on bacterial membranes
    • Horst A.M., Vukanti R., Priester J.H., Holden P.A. An assessment of fluorescence- and absorbance-based assays to study metal-oxide nanoparticle ROS production and effects on bacterial membranes. Small 2013, 9:1753-1764.
    • (2013) Small , vol.9 , pp. 1753-1764
    • Horst, A.M.1    Vukanti, R.2    Priester, J.H.3    Holden, P.A.4
  • 39
    • 84937019369 scopus 로고    scopus 로고
    • International Council of Chemical Associations, Available at:, Accessed 10.01.14.
    • ICCA Core Elements of a Regulatory Definition of Manufactured Nanomaterials 2010, International Council of Chemical Associations, Available at:, Accessed 10.01.14. http://www.icca-chem.org/ICCADocs/Oct-2010_ICCA-Core-Elements-of-a-Regulatory-Definition-of-Manufactured-Nanomaterials.pdf?epslanguage=en.
    • (2010) Core Elements of a Regulatory Definition of Manufactured Nanomaterials
  • 40
    • 84936990487 scopus 로고    scopus 로고
    • International Council of Chemical Associations, Accessed 14.01.14.
    • ICCA Responsible Care 2014, International Council of Chemical Associations, Accessed 14.01.14. http://www.icca-chem.org/en/Home/Responsible-care/.
    • (2014) Responsible Care
  • 44
  • 47
    • 22044431710 scopus 로고    scopus 로고
    • Technology Analysis, Future Technologies Division of VDI Technologiezentrum GmbH, No. 54, Dusseldorf
    • Luther W. Industrial Application of Nanomaterials - Chances and Risks 2004, Technology Analysis, Future Technologies Division of VDI Technologiezentrum GmbH, No. 54, Dusseldorf.
    • (2004) Industrial Application of Nanomaterials - Chances and Risks
    • Luther, W.1
  • 48
    • 33845696200 scopus 로고    scopus 로고
    • Does lung surfactant promote disaggregation of nanostructured titanium dioxide?
    • Maier M., Hannebauer B., Holldorff H., Albers P. Does lung surfactant promote disaggregation of nanostructured titanium dioxide?. J.Occup. Environ. Med. 2006, 48:1314-1320.
    • (2006) J.Occup. Environ. Med. , vol.48 , pp. 1314-1320
    • Maier, M.1    Hannebauer, B.2    Holldorff, H.3    Albers, P.4
  • 49
    • 79960031926 scopus 로고    scopus 로고
    • Don't define nanomaterials
    • Maynard A.D. Don't define nanomaterials. Nature 2011, 475:31.
    • (2011) Nature , vol.475 , pp. 31
    • Maynard, A.D.1
  • 51
    • 84937019370 scopus 로고    scopus 로고
    • Available at:, Accessed 18.05.15.
    • Norway Environment Agency What Chemicals Must Be Reported? 2014, Available at:, Accessed 18.05.15. http://www.miljodirektoratet.no/no/Tema/Kjemikalier/Produktregisteret/The_Product_Register/What-Chemicals-Must-Be-Reported/.
    • (2014) What Chemicals Must Be Reported?
  • 52
    • 0024947640 scopus 로고
    • Dosimetric principles for extrapolating results of rat inhalation studies to humans, using an inhaled Ni compound as an example
    • Oberdörster G. Dosimetric principles for extrapolating results of rat inhalation studies to humans, using an inhaled Ni compound as an example. Health Phys. 1989, 57(Suppl.1):213-220.
    • (1989) Health Phys. , vol.57 , Issue.SUPPL.1 , pp. 213-220
    • Oberdörster, G.1
  • 53
    • 0028104529 scopus 로고
    • Correlation between particle size, invivo particle persistence, and lung injury
    • Oberdörster G., Ferin J., Lehnert B.E. Correlation between particle size, invivo particle persistence, and lung injury. Environ. Health Perspect. 1994, 102(Suppl.5):173-179.
    • (1994) Environ. Health Perspect. , vol.102 , Issue.SUPPL.5 , pp. 173-179
    • Oberdörster, G.1    Ferin, J.2    Lehnert, B.E.3
  • 56
    • 84886862636 scopus 로고    scopus 로고
    • Organisation for Economic Co-operation and Development, ENV/JM/MONO(2012)8. 28 March 2012
    • OECD Important Issues on Risk Assessment of Manufactured Nanomaterials 2012, Organisation for Economic Co-operation and Development, ENV/JM/MONO(2012)8. 28 March 2012.
    • (2012) Important Issues on Risk Assessment of Manufactured Nanomaterials
  • 60
    • 63749117256 scopus 로고    scopus 로고
    • Retrospective analysis of 4-week inhalation studies in rats with focus on fate and pulmonary toxicity of two nanosized aluminum oxyhydroxides (boehmite) and pigment-grade iron oxide (magnetite): the key metric of dose is particle mass and not particle surface area
    • Pauluhn J. Retrospective analysis of 4-week inhalation studies in rats with focus on fate and pulmonary toxicity of two nanosized aluminum oxyhydroxides (boehmite) and pigment-grade iron oxide (magnetite): the key metric of dose is particle mass and not particle surface area. Toxicology 2009, 259:140-148.
    • (2009) Toxicology , vol.259 , pp. 140-148
    • Pauluhn, J.1
  • 61
    • 75249100931 scopus 로고    scopus 로고
    • Subchronic 13-week inhalation exposure of rats to multiwalled carbon nanotubes: toxic effects are determined by density of agglomerate structures, not fibrillar structures
    • Pauluhn J. Subchronic 13-week inhalation exposure of rats to multiwalled carbon nanotubes: toxic effects are determined by density of agglomerate structures, not fibrillar structures. Toxicol. Sci. 2010, 113:226-242.
    • (2010) Toxicol. Sci. , vol.113 , pp. 226-242
    • Pauluhn, J.1
  • 64
    • 84894442306 scopus 로고    scopus 로고
    • Scientific Committee on Consumer Safety, Available at:, Accessed 08.04.15.
    • SCCS Guidance on the Safety Assessment of Nanomaterials in Cosmetics 2012, Scientific Committee on Consumer Safety, Available at:, Accessed 08.04.15. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_s_005.pdf.
    • (2012) Guidance on the Safety Assessment of Nanomaterials in Cosmetics
  • 66
    • 84937019373 scopus 로고    scopus 로고
    • Atmospheric nanoparticles and their impacts on public health
    • InTech, Chapter 23, Available from:, A. Rodriguez-Morales (Ed.)
    • Slezakova K., Morais S., Pereira M.C. Atmospheric nanoparticles and their impacts on public health. Current Topics in Public Health 2013, InTech, Chapter 23, Available from:. http://www.intechopen.com/books/current-topics-in-public-health/atmospheric-nanoparticles-and-their-impacts-on-public-health, A. Rodriguez-Morales (Ed.).
    • (2013) Current Topics in Public Health
    • Slezakova, K.1    Morais, S.2    Pereira, M.C.3
  • 67
    • 77954536504 scopus 로고    scopus 로고
    • Rate of formation and dissolution of mercury sulfide nanoparticles: the dual role of natural organic matter
    • Slowey A. Rate of formation and dissolution of mercury sulfide nanoparticles: the dual role of natural organic matter. Geochim. Cosmochim. Acta 2010, 74:4693-4708.
    • (2010) Geochim. Cosmochim. Acta , vol.74 , pp. 4693-4708
    • Slowey, A.1
  • 68
    • 80052051341 scopus 로고    scopus 로고
    • Risk factors: nanomaterials should be defined
    • Stamm H. Risk factors: nanomaterials should be defined. Nature 2011, 476:399.
    • (2011) Nature , vol.476 , pp. 399
    • Stamm, H.1
  • 69
    • 33644746349 scopus 로고    scopus 로고
    • Instillation of six different ultrafine carbon particles indicates a surface area threshold dose for acute lung inflammation in mice
    • Stoeger T., Reinhard C., Takenaka S., Schroeppel A., Karg E., Ritter B., Heyder J., Schulz H. Instillation of six different ultrafine carbon particles indicates a surface area threshold dose for acute lung inflammation in mice. Environ. Health Perspect. 2006, 114:328-333.
    • (2006) Environ. Health Perspect. , vol.114 , pp. 328-333
    • Stoeger, T.1    Reinhard, C.2    Takenaka, S.3    Schroeppel, A.4    Karg, E.5    Ritter, B.6    Heyder, J.7    Schulz, H.8
  • 71
    • 80052636506 scopus 로고    scopus 로고
    • Ultrasonic dispersion of nanoparticles for environmental, health and safety assessment: issues and recommendations
    • Taurozi J., Hackley V., Wiesner M. Ultrasonic dispersion of nanoparticles for environmental, health and safety assessment: issues and recommendations. Nanotoxicology 2011, 5:711-729.
    • (2011) Nanotoxicology , vol.5 , pp. 711-729
    • Taurozi, J.1    Hackley, V.2    Wiesner, M.3
  • 72
    • 84937019375 scopus 로고
    • Comparison of number and respirable mass concentration determinations
    • Lewis Publishers, Chelsea, MI, T. Tomb, R. Haney (Eds.)
    • Comparison of number and respirable mass concentration determinations. Advances in Air Sampling. American Conference of Governmental Industrial Hygienists 1988, Lewis Publishers, Chelsea, MI. T. Tomb, R. Haney (Eds.).
    • (1988) Advances in Air Sampling. American Conference of Governmental Industrial Hygienists
  • 74
    • 38049131598 scopus 로고    scopus 로고
    • U.S. Environmental Protection Agency, EPA 100/B-07/001. Accessed 14.11.13 at
    • US EPA Nanotechnology White Paper 2007, U.S. Environmental Protection Agency, EPA 100/B-07/001. Accessed 14.11.13 at. http://www.epa.gov/osa/pdfs/nanotech/epa-nanotechnology-whitepaper-0207.pdf.
    • (2007) Nanotechnology White Paper
  • 75
    • 84872140039 scopus 로고    scopus 로고
    • Pesticides; policies concerning products containing nanoscale materials; opportunity for public comment
    • (2011a)
    • US EPA Pesticides; policies concerning products containing nanoscale materials; opportunity for public comment. Fed. Regist. 17 June 2011, 76(14):35383-35395. (2011a).
    • (2011) Fed. Regist. , vol.76 , Issue.14 , pp. 35383-35395
  • 76
    • 84855499248 scopus 로고    scopus 로고
    • U.S. Environmental Protection Agency. Proposed significant new use rules on certain chemical substances
    • (2011b)
    • US EPA U.S. Environmental Protection Agency. Proposed significant new use rules on certain chemical substances. Fed. Regist. 28 December 2011, 76(249):81441-81447. (2011b).
    • (2011) Fed. Regist. , vol.76 , Issue.249 , pp. 81441-81447
  • 77
    • 84937019376 scopus 로고    scopus 로고
    • U.S. Environmental Protetion Agency. Chemical substances when manufactured or processed as nanoscale materials; TSCA reporting and recordkeeping requirements
    • (2014)
    • US EPA U.S. Environmental Protetion Agency. Chemical substances when manufactured or processed as nanoscale materials; TSCA reporting and recordkeeping requirements. Fed. Regist. 6 April 2014, 80(65):18330-18342. (2014).
    • (2014) Fed. Regist. , vol.80 , Issue.65 , pp. 18330-18342
  • 79
    • 33847068722 scopus 로고    scopus 로고
    • In search of the most relevant parameter for quantifying lung inflammatory response to nanoparticle exposure: particle number, surface area, or what?
    • Wittmaack K. In search of the most relevant parameter for quantifying lung inflammatory response to nanoparticle exposure: particle number, surface area, or what?. Environ. Health Perspect. 2007, 115:187-194.
    • (2007) Environ. Health Perspect. , vol.115 , pp. 187-194
    • Wittmaack, K.1
  • 80
    • 56049106549 scopus 로고    scopus 로고
    • Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties
    • Xia T., Kovochich M., Liong M., Madler L., Gilbert B., Shi H., Yeh J.I., Zink J.I., Nel A.E. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano 2008, 2:2121-2134.
    • (2008) ACS Nano , vol.2 , pp. 2121-2134
    • Xia, T.1    Kovochich, M.2    Liong, M.3    Madler, L.4    Gilbert, B.5    Shi, H.6    Yeh, J.I.7    Zink, J.I.8    Nel, A.E.9


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