Retrospective analysis of 4-week inhalation studies in rats with focus on fate and pulmonary toxicity of two nanosized aluminum oxyhydroxides (boehmite) and pigment-grade iron oxide (magnetite): The key metric of dose is particle mass and not particle surface area

Toxicology

Volumn 259, Issue 3, 2009, Pages 140-148

  Pauluhn, Jürgen ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Aggregates; Clearance; Disposition; Dose metric; Dosimetry; Nanoparticles; Pulmonary toxicity; Repeated inhalation exposure; Respirability

Indexed keywords

ALUMINUM OXIDE; IRON OXIDE; MAGNETITE; NANOPARTICLE; PIGMENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOASSAY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSIMETRY; DUST; EXPOSURE; INFLAMMATION; INHALATION; ISOMETRICS; LUNG BURDEN; LUNG LAVAGE; LUNG PARENCHYMA; LUNG TOXICITY; MALE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; RETROSPECTIVE STUDY; SOLUBILITY; SPECIES IDENTIFICATION; TOXICITY TESTING; TOXICOKINETICS;

ADMINISTRATION, INHALATION; ALUMINUM HYDROXIDE; ALUMINUM OXIDE; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; FERROSOFERRIC OXIDE; LUNG; LUNG DISEASES; MALE; NANOSTRUCTURES; ORGAN SIZE; PARTICLE SIZE; RATS; RATS, WISTAR; RETROSPECTIVE STUDIES; SPECIFIC PATHOGEN-FREE ORGANISMS;

RATTUS;

EID: 63749117256     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.02.012     Document Type: Article

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