Mechanisms of the hepatoprotective effects of tamoxifen against drug-induced and chemical-induced acute liver injuries

Toxicology and Applied Pharmacology

Volumn 264, Issue 1, 2012, Pages 42-50

  Yoshikawa, Yukitaka ^a   Miyashita, Taishi ^a   Higuchi, Satonori ^a   Tsuneyama, Koichi ^b   Endo, Shinya ^a   Tsukui, Tohru ^c   Toyoda, Yasuyuki ^a   Fukami, Tatsuki ^a   Nakajima, Miki ^a   Yokoi, Tsuyoshi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Chemical induced liver injury; Drug induced liver injury; Estrogen receptor ; Monocyte to macrophage differentiation associated 2 (Mmd2); Species differences

Indexed keywords

BROMOBENZENE; CELL PROTEIN; DICLOFENAC; ETHINYLESTRADIOL; MACROPHAGE DIFFERENTIATION ASSOCIATED 2 PROTEIN; PARACETAMOL; RALOXIFENE; SMALL INTERFERING RNA; TAMOXIFEN; THIOACETAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; DNA MICROARRAY; FEMALE; GENE SILENCING; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SPECIES DIFFERENCE; TOXIC HEPATITIS; UPREGULATION;

ANIMALS; CELL DIFFERENTIATION; DRUG-INDUCED LIVER INJURY; ESTROGEN RECEPTOR ALPHA; ETHINYL ESTRADIOL; FEMALE; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; MICE, KNOCKOUT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RALOXIFENE; RNA, MESSENGER; RNA, SMALL INTERFERING; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TAMOXIFEN; UP-REGULATION;

MUS;

EID: 84866001517     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.06.023     Document Type: Article

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