Renal control of calcium, phosphate, and magnesium homeostasis

Clinical Journal of the American Society of Nephrology

Volumn 10, Issue 7, 2015, Pages 1257-1272

  Blaine, Judith ^a   Chonchol, Michel ^a   Levi, Moshe ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CALBINDIN; CALCITONIN; CALCITRIOL; CALCIUM; CALCIUM SENSING RECEPTOR; CLAUDIN; COLECALCIFEROL; DOPAMINE; ESTROGEN; FIBROBLAST GROWTH FACTOR 23; GLUCOCORTICOID; MAGNESIUM; MESSENGER RNA; PARATHYROID HORMONE; PHOSPHATE; PHOSPHORUS; SODIUM CHLORIDE; SODIUM PHOSPHATE COTRANSPORTER 2; SODIUM PHOSPHATE COTRANSPORTER 2A; SODIUM PHOSPHATE COTRANSPORTER 2C; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 2; THIAZIDE DIURETIC AGENT; THYROID HORMONE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M6; TRANSIENT RECEPTOR POTENTIAL CHANNEL M7;

ARTICLE; CALCIUM BALANCE; CALCIUM EXCRETION; CALCIUM TRANSPORT; CONCENTRATION (PARAMETERS); DIET; EXTRACELLULAR FLUID; GASTROINTESTINAL ABSORPTION; GENE MUTATION; GLOMERULUS FILTRATION; GLOMERULUS FILTRATION RATE; HOMEOSTASIS; HUMAN; HYPERCALCEMIA; HYPERMAGNESEMIA; HYPERPHOSPHATEMIA; HYPERTENSION; HYPOCALCEMIA; HYPOMAGNESEMIA; HYPOPHOSPHATEMIA; KIDNEY DISTAL TUBULE; KIDNEY FUNCTION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; METABOLIC ACIDOSIS; METABOLIC REGULATION; NEPHRON; NONHUMAN; OSTEOLYSIS; PHOSPHATE BALANCE; PROTEIN EXPRESSION; SECONDARY HYPERPARATHYROIDISM; SIGNAL TRANSDUCTION; URINARY EXCRETION; ANIMAL; BLOOD; KIDNEY; METABOLIC DISORDER; METABOLISM; PATHOPHYSIOLOGY; URINE;

ANIMALS; CALCIUM; GASTROINTESTINAL ABSORPTION; GLOMERULAR FILTRATION RATE; HOMEOSTASIS; HUMANS; KIDNEY; MAGNESIUM; METABOLIC DISEASES; PHOSPHATES; RENAL ELIMINATION; RENAL REABSORPTION;

EID: 84936886086     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.09750913     Document Type: Article

References (111)

1. Kumar R: Calcium metabolism. In: The Principles and Practice of Nephrology, edited by Jacobson HR, Striker GE, Klahr S, 2nd Ed., St. Louis, MO, Mosby-Year Book, 1995, pp 964-971
2. Hebert SC, Brown EM: The scent of an ion: Calcium-sensing and its roles in health and disease. Curr Opin Nephrol Hypertens 5: 45-53, 1996
3. Johnson JA, Kumar R: Renal and intestinal calcium transport: Roles of vitamin D and vitamin D-dependent calcium binding proteins. Semin Nephrol 14: 119-128, 1994
4. Kumar R: Calcium transport in epithelial cells of the intestine and kidney. J Cell Biochem 57: 392-398, 1995
5. Keller J, Schinke T: The role of the gastrointestinal tract in calcium homeostasis and bone remodeling. Osteoporos Int 24: 2737-2748, 2013
6. Friedman PA, Gesek FA: Cellular calcium transport in renal epithelia: Measurement, mechanisms, and regulation. Physiol Rev 75: 429-471, 1995
7. Felsenfeld A, Rodriguez M, Levine B: New insights in regulation of calcium homeostasis. Curr Opin Nephrol Hypertens 22: 371-376, 2013
8. Riccardi D, Brown EM: Physiology and pathophysiology of the calcium-sensing receptor in the kidney. Am J Physiol Renal Physiol 298: F485-F499, 2010
9. Ferré S, Hoenderop JG, Bindels RJ: Sensingmechanisms involved in Ca21 and Mg21 homeostasis. Kidney Int 82: 1157-1166, 2012
10. Houillier P: Calcium-sensing in the kidney. Curr Opin Nephrol Hypertens 22: 566-571, 2013
11. Loupy A, Ramakrishnan SK, Wootla B, Chambrey R, de la Faille R, Bourgeois S, Bruneval P, Mandet C, Christensen EI, Faure H, Cheval L, Laghmani K, Collet C, Eladari D, Dodd RH, Ruat M, Houillier P: PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor. J Clin Invest 122: 3355-3367, 2012
12. Toka HR, Al-Romaih K, Koshy JM, DiBartolo S III, Kos CH, Quinn SJ, Curhan GC, Mount DB, Brown EM, Pollak MR: Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. J Am Soc Nephrol 23: 1879-1890, 2012
13. Lambers TT, Bindels RJ, Hoenderop JG: Coordinated control of renal Ca21 handling. Kidney Int 69: 650-654, 2006
14. Hoenderop JG, Nilius B, Bindels RJ: Molecular mechanism of active Ca21 reabsorption in the distal nephron. Annu Rev Physiol 64: 529-549, 2002
15. Mensenkamp AR, Hoenderop JG, Bindels RJ: Recent advances in renal tubular calcium reabsorption. Curr Opin Nephrol Hypertens 15: 524-529, 2006
16. Goodman WG, Quarles LD: Development and progression of secondary hyperparathyroidism in chronic kidney disease: Lessons frommolecular genetics. Kidney Int 74: 276-288, 2008
17. Dusso AS, Brown AJ, Slatopolsky E: Vitamin D. Am J Physiol Renal Physiol 289: F8-F28, 2005
18. Holick MF: Vitamin D deficiency. N Engl J Med 357: 266-281, 2007
19. Drüeke TB, Lacour B: Disorders of calcium, phosphate, and magnesium metabolism. In: Comprehensive Clinical Nephrology, edited by Feehally J, Floege J, Johnson RJ, 3rd Ed., Philadelphia, Mosby/Elsevier, 2007, pp 123-140
20. Biber J, Hernando N, Forster I: Phosphate transporters and their function. Annu Rev Physiol 75: 535-550, 2013
21. Marks J, Debnam ES, Unwin RJ: Phosphate homeostasis and the renal-gastrointestinal axis. Am J Physiol Renal Physiol 299: F285-F296, 2010
22. Blaine J, Weinman EJ, Cunningham R: The regulation of renal phosphate transport. Adv Chronic Kidney Dis 18: 77-84, 2011
23. Forster IC, Hernando N, Biber J, Murer H: Proximal tubular handling of phosphate: A molecular perspective. Kidney Int 70: 1548-1559, 2006
24. Azzarolo AM, Ritchie G, Quamme GA: Some characteristics of sodium-independent phosphate transport across renal basolateral membranes. Biochim Biophys Acta 1064: 229-234, 1991
25. Murer H, Forster I, Biber J: The sodium phosphate cotransporter family SLC 34. Pflugers Arch 447: 763-767, 2004
26. Magagnin S, Werner A, Markovich D, Sorribas V, Stange G, Biber J, Murer H: Expression cloning of human and rat renal cortex Na/Pi cotransport. Proc Natl Acad Sci U S A 90: 5979-5983, 1993
27. Segawa H, Kaneko I, Takahashi A, Kuwahata M, Ito M, Ohkido I, Tatsumi S, Miyamoto K: Growth-related renal type II Na/Pi cotransporter. J Biol Chem 277: 19665-19672, 2002
28. Villa-Bellosta R, Ravera S, Sorribas V, Stange G, Levi M, Murer H, Biber J, Forster IC: The Na1-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi.AmJ Physiol Renal Physiol 296: F691-F699, 2009
29. Segawa H, Onitsuka A, Furutani J, Kaneko I, Aranami F, Matsumoto N, Tomoe Y, Kuwahata M, Ito M, Matsumoto M, Li M, Amizuka N, Miyamoto K: Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolismand skeletal development. AmJ Physiol Renal Physiol 297: F671-F678, 2009
30. Beck L, Karaplis AC, Amizuka N, Hewson AS, Ozawa H, Tenenhouse HS: Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc Natl Acad Sci U S A 95: 5372-5377, 1998
31. Tenenhouse HS, Martel J, Gauthier C, Segawa H, Miyamoto K: Differential effects of Npt2a gene ablation and X-linked Hyp mutation on renal expression of Npt2c. Am J Physiol Renal Physiol 285: F1271-F1278, 2003
32. Bacconi A, Virkki LV, Biber J, Murer H, Forster IC: Renouncing electroneutrality is not free of charge: Switching on electrogenicity in a Na1-coupled phosphate cotransporter. Proc Natl Acad Sci U S A 102: 12606-12611, 2005
33. Virkki LV, Forster IC, Biber J, Murer H: Substrate interactions in the human type IIa sodium-phosphate cotransporter (NaPi-IIa). Am J Physiol Renal Physiol 288: F969-F981, 2005
34. Ravera S, Virkki LV, Murer H, Forster IC: Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements. Am J Physiol Cell Physiol 293: C606-C620, 2007
35. Virkki LV, Biber J, Murer H, Forster IC: Phosphate transporters: A tale of two solute carrier families. Am J Physiol Renal Physiol 293: F643-F654, 2007
36. Breusegem SY, Takahashi H, Giral-Arnal H, Wang X, Jiang T, Verlander JW, Wilson P, Miyazaki-Anzai S, Sutherland E, Caldas Y, Blaine JT, Segawa H, Miyamoto K, Barry NP, Levi M: Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency. Am J Physiol Renal Physiol 297: F350-F361, 2009
37. Dé liot N, Hernando N, Horst-Liu Z, Gisler SM, Capuano P, Wagner CA, Bacic D, O’Brien S, Biber J, Murer H: Parathyroid hormone treatment induces dissociation of type IIa Na1-P(i) cotransporter-Na1/H1 exchanger regulatory factor-1 complexes. Am J Physiol Cell Physiol 289: C159-C167, 2005
38. Millar AL, Jackson NA, Dalton H, Jennings KR, Levi M, Wahren B, Dimmock NJ: Rapid analysis of epitope-paratope interactions between HIV-1 and a 17-amino-acid neutralizing microantibody by electrospray ionizationmass spectrometry. Eur J Biochem 258: 164-169, 1998
39. Lederer ED, Khundmiri SJ, Weinman EJ: Role of NHERF-1 in regulation of the activity of Na-K ATPase and sodium-phosphate co-transport in epithelial cells. J Am Soc Nephrol 14: 1711-1719, 2003
40. Mahon MJ, Cole JA, Lederer ED, Segre GV: Na1/H1exchangerregulatory factor 1 mediates inhibition of phosphate transport by parathyroid hormone and second messengers by acting at multiple sites in opossum kidney cells. Mol Endocrinol 17: 2355-2364, 2003
41. Blaine J, Okamura K, Giral H, Breusegem S, Caldas Y, Millard A, Barry N, Levi M: PTH-induced internalization of apical membrane NaPi2a: Role of actin and myosin VI. Am J Physiol Cell Physiol 297: C1339-C1346, 2009
42. Berndt T, Kumar R: Phosphatonins and the regulation of phosphate homeostasis. Annu Rev Physiol 69: 341-359, 2007
43. Hasegawa H, Nagano N, Urakawa I, Yamazaki Y, Iijima K, Fujita T, Yamashita T, Fukumoto S, Shimada T: Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease. Kidney Int 78: 975-980, 2010
44. Kurnik BR, Hruska KA: Mechanism of stimulation of renal phosphate transport by 1,25-dihydroxycholecalciferol. Biochim Biophys Acta 817: 42-50, 1985
45. Levi M, Shayman JA, Abe A, Gross SK, McCluer RH, Biber J, Murer H, Lötscher M, Cronin RE: Dexamethasone modulates rat renal brush border membrane phosphate transporter mRNA and protein abundance and glycosphingolipid composition. J Clin Invest 96: 207-216, 1995
46. Faroqui S, Levi M, Soleimani M, Amlal H: Estrogen downregulates the proximal tubule type IIa sodium phosphate cotransporter causing phosphate wasting and hypophosphatemia. Kidney Int 73: 1141-1150, 2008
47. Cannata-Andía JB, Carrillo-López N, Naves-Díaz M: Estrogens and bone disease in chronic kidney disease: Role of FGF 23. Curr Opin Nephrol Hypertens 19: 354-358, 2010
48. Alcalde AI, Sarasa M, Raldúa D, Aramayona J, Morales R, Biber J, Murer H, Levi M, Sorribas V: Role of thyroid hormone in regulation of renal phosphate transport in young and aged rats. Endocrinology 140: 1544-1551, 1999
49. Ishiguro M, Yamamoto H, Masuda M, Kozai M, Takei Y, Tanaka S, Sato T, Segawa H, Taketani Y, Arai H, Miyamoto K, Takeda E: Thyroid hormones regulate phosphate homoeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter (Npt2a) gene. Biochem J 427: 161-169, 2010
50. Weinman EJ, Biswas R, Steplock D, Douglass TS, Cunningham R, Shenolikar S: Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney. J Biol Chem 285: 13454-13460, 2010
51. Nowik M, Picard N, Stange G, Capuano P, Tenenhouse HS, Biber J, Murer H, Wagner CA: Renal phosphaturia during metabolic acidosis revisited: Molecular mechanisms for decreased renal phosphate reabsorption. Pflugers Arch 457: 539-549, 2008
52. Biber J, Hernando N, Forster I, Murer H: Regulation of phosphate transport in proximal tubules. Pflugers Arch 458: 39-52, 2009
53. Magyar CE, Zhang Y, Holstein-Rathlou NH, McDonough AA: Proximal tubule Na transporter responses are the same during acute and chronic hypertension. Am J Physiol Renal Physiol 279: F358-F369, 2000
54. Felsenfeld AJ, Levine BS: Approach to treatment of hypophosphatemia. Am J Kidney Dis 60: 655-661, 2012
55. Carpenter TO: The expanding family of hypophosphatemic syndromes. J Bone Miner Metab 30: 1-9, 2012
56. Gravelyn TR, Brophy N, Siegert C, Peters-Golden M: Hypophosphatemia- associated respiratory muscle weakness in a general inpatient population. Am J Med 84: 870-876, 1988
57. Markowitz GS, Perazella MA: Acute phosphate nephropathy. Kidney Int 76: 1027-1034, 2009
58. Kendrick J, Kestenbaum B, Chonchol M: Phosphate and cardiovascular disease. Adv Chronic Kidney Dis 18: 113-119, 2011
59. Ben-Dov IZ, Galitzer H, Lavi-Moshayoff V, Goetz R, Kuro-o M, Mohammadi M, Sirkis R, Naveh-Many T, Silver J: The parathyroid is a target organ for FGF23 in rats. J Clin Invest 117: 4003-4008, 2007
60. Whang R, Hampton EM, Whang DD: Magnesium homeostasis and clinical disorders of magnesium deficiency. Ann Pharmacother 28: 220-226, 1994
61. Konrad M, Schlingmann KP, Gudermann T: Insights into the molecular nature of magnesium homeostasis. Am J Physiol Renal Physiol 286: F599-F605, 2004
62. Topf JM, Murray PT: Hypomagnesemia and hypermagnesemia. Rev Endocr Metab Disord 4: 195-206, 2003
63. Ayuk J, Gittoes NJ: How should hypomagnesaemia be investigated and treated? Clin Endocrinol (Oxf) 75: 743-746, 2011
64. Agus ZS: Hypomagnesemia. J AmSoc Nephrol 10: 1616-1622, 1999
65. Quamme GA: Recent developments in intestinal magnesium absorption. Curr Opin Gastroenterol 24: 230-235, 2008
66. Fine KD, Santa Ana CA, Porter JL, Fordtran JS: Intestinal absorption ofmagnesium fromfood and supplements. J Clin Invest 88: 396-402, 1991
67. Schlingmann KP, Weber S, Peters M, Niemann Nejsum L, Vitzthum H, Klingel K, Kratz M, Haddad E, Ristoff E, Dinour D, Syrrou M, Nielsen S, Sassen M, Waldegger S, Seyberth HW, Konrad M: Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Nat Genet 31: 166-170, 2002
68. Walder RY, Landau D, Meyer P, Shalev H, Tsolia M, Borochowitz Z, Boettger MB, Beck GE, Englehardt RK, Carmi R, Sheffield VC: Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia. Nat Genet 31: 171-174, 2002
69. Ryazanova LV, Rondon LJ, Zierler S, Hu Z, Galli J, Yamaguchi TP, Mazur A, Fleig A, Ryazanov AG: TRPM7 is essential for Mg (21) homeostasis in mammals. Nat Commun 1: 109, 2010
70. Milla PJ, Aggett PJ, Wolff OH, Harries JT: Studies in primary hypomagnesaemia: Evidence for defective carrier-mediated small intestinal transport of magnesium. Gut 20: 1028-1033, 1979
71. Karbach U: Cellular-mediated and diffusive magnesium transport across the descending colon of the rat. Gastroenterology 96: 1282-1289, 1989
72. Jü ttner R, Ebel H: Characterization of Mg21 transport in brush border membrane vesicles of rabbit ileum studied with magfura- 2. Biochim Biophys Acta 1370: 51-63, 1998
73. Anderson JM, Van Itallie CM: Physiology and function of the tight junction. Cold Spring Harb Perspect Biol 1: a002584, 2009
74. Shen L, Weber CR, Raleigh DR, Yu D, Turner JR: Tight junction pore and leak pathways: A dynamic duo. Annu Rev Physiol 73: 283-309, 2011
75. Amasheh S, Fromm M, Günzel D: Claudins of intestine and nephron - A correlation of molecular tight junction structure and barrier function. Acta Physiol (Oxf) 201: 133-140, 2011
76. Günzel D, Yu AS: Claudins and the modulation of tight junction permeability. Physiol Rev 93: 525-569, 2013
77. Lameris AL, Hess MW, van Kruijsbergen I, Hoenderop JG, Bindels RJ:Omeprazole enhances the colonic expression of the Mg(21) transporter TRPM 6. Pflugers Arch 465: 1613-1620, 2013
78. Hess MW, Hoenderop JG, Bindels RJ, Drenth JP: Systematic review: Hypomagnesaemia induced by proton pump inhibition. Aliment Pharmacol Ther 36: 405-413, 2012
79. Bindels RJ: 2009 Homer W. Smith Award: Minerals in motion: From new ion transporters to new concepts. J Am Soc Nephrol 21: 1263-1269, 2010
80. Quamme GA: Molecular identification of ancient and modern mammalian magnesium transporters. Am J Physiol Cell Physiol 298: C407-C429, 2010
81. Ferré S, Hoenderop JG, Bindels RJ: Insight into renal Mg21 transporters. Curr Opin Nephrol Hypertens 20: 169-176, 2011
82. Tyler Miller R: Control of renal calcium, phosphate, electrolyte, and water excretion by the calcium-sensing receptor. Best Pract Res Clin Endocrinol Metab 27: 345-358, 2013
83. Haisch L, Almeida JR, Abreu da Silva PR, Schlingmann KP, Konrad M: The role of tight junctions in paracellular ion transport in the renal tubule: Lessons learned from a rare inherited tubular disorder. Am J Kidney Dis 57: 320-330, 2011
84. Haisch L, Konrad M: Impaired paracellular ion transport in the loop of Henle causes familial hypomagnesemia with hypercalciuria and nephrocalcinosis. Ann N Y Acad Sci 1258: 177-184, 2012
85. Hebert SC: Extracellular calcium-sensing receptor: Implications for calcium and magnesium handling in the kidney. Kidney Int 50: 2129-2139, 1996
86. Wang WH, Lu M, Hebert SC: Cytochrome P-450 metabolites mediate extracellular Ca(21)-induced inhibition of apical K1 channels in the TAL. Am J Physiol 271: C103-C111, 1996
87. Breiderhoff T, Himmerkus N, Stuiver M, Mutig K, Will C, Meij IC, Bachmann S, Bleich M, Willnow TE, Mü ller D: Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis. Proc Natl Acad Sci U S A 109: 14241-14246, 2012
88. Petrelli F, Borgonovo K, CabidduM, Ghilardi M, Barni S: Risk of anti-EGFR monoclonal antibody-related hypomagnesemia: Systematic review and pooled analysis of randomized studies. Expert Opin Drug Saf 11[Suppl 1]: S9-S19, 2012
89. Goytain A, Quamme GA: Functional characterization of human SLC41A1, a Mg21 transporter with similarity to prokaryotic MgtE Mg21 transporters. Physiol Genomics 21: 337-342, 2005
90. Kolisek M, Launay P, Beck A, Sponder G, Serafini N, Brenkus M, Froschauer EM, Martens H, Fleig A, Schweigel M: SLC41A1 is a novel mammalian Mg21 carrier. J Biol Chem 283: 16235-16247, 2008
91. Mandt T, Song Y, Scharenberg AM, Sahni J: SLC41A1 Mg(21) transport is regulated via Mg(21)-dependent endosomal recycling through its N-terminal cytoplasmic domain. Biochem J 439: 129-139, 2011
92. Kolisek M, Nestler A, Vormann J, Schweigel-Röntgen M: Human gene SLC41A1 encodes for theNa1/Mg1exchanger. AmJ Physiol Cell Physiol 302: C318-C326, 2012
93. Hurd TW, Otto EA, Mishima E, Gee HY, Inoue H, Inazu M, Yamada H, Halbritter J, Seki G, Konishi M, Zhou W, Yamane T, Murakami S, Caridi G, Ghiggeri G, Abe T, Hildebrandt F: Mutation of the Mg21 transporter SLC41A1 results in a nephronophthisis-like phenotype. J Am Soc Nephrol 24: 967-977, 2013
94. Stuiver M, Lainez S, Will C, Terryn S, Günzel D, Debaix H, Sommer K, Kopplin K, Thumfart J, Kampik NB, Querfeld U, Willnow TE, Nĕmec V, Wagner CA, Hoenderop JG, Devuyst O, Knoers NV, Bindels RJ, Meij IC, Müller D: CNNM2, encoding a basolateral protein required for renal Mg21 handling, is mutated in dominant hypomagnesemia. AmJ Hum Genet 88: 333-343, 2011
95. Ferré S, de Baaij JH, Ferreira P, Germann R, deKlerk JB, Lavrijsen M, van Zeeland F, Venselaar H, Kluijtmans LA, Hoenderop JG, Bindels RJ: Mutations in PCBD1 cause hypomagnesemia and renal magnesium wasting. J Am Soc Nephrol 25: 574-586, 2014
96. Elin RJ: Assessment of magnesium status. Clin Chem 33: 1965-1970, 1987
97. Alfrey AC, Miller NL, Trow R: Effect of age and magnesium depletion on bone magnesium pools in rats. J Clin Invest 54: 1074-1081, 1974
98. Lai CC, Singer L, Armstrong WD: Bone composition and phosphatase activity in magnesium deficiency in rats. J Bone Joint Surg Am 57: 516-522, 1975
99. Burnell JM, Liu C, Miller AG, Teubner E: Effects of dietary alteration of bicarbonate and magnesium on rat bone. Am J Physiol 250: F302-F307, 1986
100. Boskey AL, Rimnac CM, Bansal M, Federman M, Lian J, Boyan BD: Effect of short-term hypomagnesemia on the chemical and mechanical properties of rat bone. J Orthop Res 10: 774-783, 1992
101. Kenney MA, McCoy H, Williams L: Effects of magnesium deficiency on strength, mass, and composition of rat femur. Calcif Tissue Int 54: 44-49, 1994
102. Lameris AL, Monnens LA, Bindels RJ, Hoenderop JG: Druginduced alterations inMg21homoeostasis. Clin Sci (Lond) 123: 1-14, 2012
103. Dimke H, Monnens L, Hoenderop JG, Bindels RJ: Evaluation of hypomagnesemia: Lessons from disorders of tubular transport. Am J Kidney Dis 62: 377-383, 2013
104. Whang R, Ryder KW: Frequency of hypomagnesemia and hypermagnesemia. Requested vs routine. JAMA 263: 3063-3064,1990
105. Thienpont LM, Dewitte K, Sto¨ ckl D: Serum complexed magnesium—A cautionary note on its estimation and its relevance for standardizing serum ionized magnesium. Clin Chem 45: 154-155, 1999
106. Sanders GT, Huijgen HJ, Sanders R: Magnesium in disease: A reviewwith special emphasis on the serum ionized magnesium. Clin Chem Lab Med 37: 1011-1033, 1999
107. Huijgen HJ, Soesan M, Sanders R, Mairuhu WM, Kesecioglu J, Sanders GT: Magnesium levels in critically ill patients. What should we measure? Am J Clin Pathol 114: 688-695, 2000
108. Kü lpmann WR, Gerlach M: Relationship between ionized and total magnesium in serum. Scand J Clin Lab Invest Suppl 224: 251-258, 1996
109. Dewitte K, Dhondt A, Giri M, Sto¨ ckl D, Rottiers R, Lameire N, Thienpont LM: Differences in serum ionized and total magnesium values during chronic renal failure between nondiabetic and diabetic patients: Across-sectional study. Diabetes Care 27: 2503-2505, 2004
110. van Angelen AA, Glaudemans B, van der Kemp AW, Hoenderop JG, Bindels RJ: Cisplatin-induced injury of the renal distal convoluted tubule is associated with hypomagnesaemia in mice. Nephrol Dial Transplant 28: 879-889, 2013
111. Dimke H, van der Wijst J, Alexander TR, Meijer IM, Mulder GM, van Goor H, Tejpar S, Hoenderop JG, Bindels RJ: Effects of the EGFR inhibitor erlotinib on magnesium handling. J Am Soc Nephrol 21: 1309-1316, 2010