Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency

American Journal of Physiology - Renal Physiology

Volumn 297, Issue 2, 2009, Pages

  Breusegem, Sophia Y ^a,e   Takahashi, Hideaki ^a   Giral Arnal, Hector ^a   Wang, Xiaoxin ^a   Jiang, Tao ^a   Verlander, Jill W ^c   Wilson, Paul ^a   Miyazaki Anzai, Shinobu ^a   Sutherland, Eileen ^a   Caldas, Yupanqui ^a   Blaine, Judith T ^a   Segawa, Hiroko ^d   Miyamoto, Ken Ichi ^d   Barry, Nicholas P ^a,b   Levi, Moshe ^a,b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF TOKUSHIMA   (Japan)

^e WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

Hypokalemia; Phosphaturia; SLC20A2; SLC34A1; SLC34A3

Indexed keywords

PHOSPHATE TRANSPORTER; SODIUM PHOSPHATE COTRANSPORTER 2A; SODIUM PHOSPHATE COTRANSPORTER 2C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRUSH BORDER; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM VESICLE; ELECTRON MICROSCOPY; IMMUNOFLUORESCENCE; KIDNEY PROXIMAL TUBULE; LIPID COMPOSITION; MOUSE; NONHUMAN; PHOSPHATE TRANSPORT; PHOSPHATURIA; POTASSIUM DEFICIENCY; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 68049106297     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.90765.2008     Document Type: Article

References (32)

1. Ambuhl PM, Zajicek HK, Wang H, Puttaparthi K, Levi M. Regulation of renal phosphate transport by acute and chronic metabolic acidosis in the rat. Kidney Int 53: 1288-1298, 1998.
2. +-coupled phosphate cotransporter. Proc Natl Acad Sci USA 102: 12606-12611, 2005.
3. Beck L, Karaplis AC, Amizuka N, Hewson AS, Ozawa H, Tenenhouse HS. Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc Natl Acad Sci USA 95: 5372-5377, 1998.
4. Bergwitz C, Roslin NM, Tieder M, Loredo-Osti JC, Bastepe M, Abu-Zahra H, Frappier D, Burkett K, Carpenter TO, Anderson D, Garabedian M, Sermet I, Fujiwara TM, Morgan K, Tenenhouse HS, Juppner H. SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodiumphosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis. Am J Hum Genet 78: 179-192, 2006.
5. i cotransporter, in rabbit kidney proximal tubules. II. Localization by immunohistochemistry. Pflügers Arch 424: 210-215, 1993.
6. Biber J, Hernando N, Forster I, Murer H. Regulation of phosphate transport in proximal tubules. Pflugers Arch 458: 39-52, 2009.
7. Biber J, Stieger B, Stange G, Murer H. Isolation of renal proximal tubular brush-border membranes. Nat Protoc 2: 1356-1359, 2007.
8. Collins JF, Bai L, Ghishan FK. The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. Pflügers Arch 447: 647-652, 2004.
9. Forster IC, Hernando N, Biber J, Murer H. Proximal tubular handling of phosphate: a molecular perspective. Kidney Int 70: 1548-1559, 2006.
10. Ichikawa S, Sorenson AH, Imel EA, Friedman NE, Gertner JM, Econs MJ. Intronic deletions in the SLC34A3 gene cause hereditary hypophosphatemic rickets with hypercalciuria. J Clin Endocrinol Metab 91: 4022-4027, 2006.
11. Inoue M, Digman MA, Cheng M, Breusegem SY, Halaihel N, Sorribas V, Mantulin WW, Gratton E, Barry NP, Levi M. Partitioning of NaPi cotransporter in cholesterol-, sphingomyelin-, and glycosphingolipid-enriched membrane domains modulates NaPi protein diffusion, clustering, and activity. J Biol Chem 279: 49160-49171, 2004.
12. Jaureguiberry G, Carpenter TO, Forman S, Juppner H, Bergwitz C. A novel missense mutation in SLC34A3 that causes hereditary hypophosphatemic rickets with hypercalciuria in humans identifies threonine 137 as an important determinant of sodium-phosphate cotransport in NaPi-IIc. Am J Physiol Renal Physiol 295: F371-F379, 2008.
13. Karim Z, Gerard B, Bakouh N, Alili R, Leroy C, Beck L, Silve C, Planelles G, Urena-Torres P, Grandchamp B, Friedlander G, Prie D. NHERF1 mutations and responsiveness of renal parathyroid hormone. N Engl J Med 359: 1128-1135, 2008.
14. Leung JC, Barac-Nieto M, Hering-Smith K, Silverstein DM. Expression of the rat renal PiT-2 phosphate transporter. Horm Metab Res 37: 265-269, 2005.
15. Levi M. Novel NaPi-2c mutations that cause mistargeting of NaPi-2c protein and uncoupling of Na-Pi cotransport cause HHRH. Am J Physiol Renal Physiol 295: F369-F370, 2008.
16. Levi M, Bruesegem S. Renal phosphate-transporter regulatory proteins and nephrolithiasis. N Engl J Med 359: 1171-1173, 2008.
17. Levi M, McDonald LA, Preisig PA, Alpern RJ. Chronic K depletion stimulates rat renal brush-border membrane Na-citrate cotransporter. Am J Physiol Renal Fluid Electrolyte Physiol 261: F767-F773, 1991.
18. Markovich D, Wang H, Puttaparthi K, Zajicek H, Rogers T, Murer H, Biber J, Levi M. Chronic K depletion inhibits renal brush border membrane Na/sulfate cotransport. Kidney Int 55: 244-251, 1999.
19. Miyamoto K, Segawa H, Ito M, Kuwahata M. Physiological regulation of renal sodium-dependent phosphate cotransporters. Jpn J Physiol 54: 93-102, 2004.
20. Murer H, Forster I, Biber J. The sodium phosphate cotransporter family SLC34. Pflügers Arch 447: 763-767, 2004.
21. Puttaparthi K, Markovich D, Halaihel N, Wilson P, Zajicek HK, Wang H, Biber J, Murer H, Rogers T, Levi M. Metabolic acidosis regulates rat renal Na-Si cotransport activity. Am J Physiol Cell Physiol 276: C1398-C1404, 1999.
22. i cotransporter. J Biol Chem 277: 19665-19672, 2002.
23. i cotransporter in response to a high-phosphate diet. Am J Physiol Renal Physiol 288: F587-F596, 2005.
24. i cotransporter. Am J Physiol Renal Physiol 292: F395-F403, 2007.
25. Takahashi N, Boysen G, Li F, Li Y, Swenberg JA. Tandem mass spectrometry measurements of creatinine in mouse plasma and urine for determining glomerular filtration rate. Kidney Int 71: 266-271, 2007.
26. +-phosphate cotransporter genes in murine kidney. Am J Physiol Renal Physiol 275: F527-F534, 1998.
27. Villa-Bellosta R, Barac-Nieto M, Breusegem SY, Barry NP, Levi M, Sorribas V. Interactions of the growth-related, type IIc renal sodium/phosphate cotransporter with PDZ proteins. Kidney Int 73: 456-464, 2008.
28. i. Am J Physiol Renal Physiol 296: F691-F699, 2009.
29. Virkki LV, Biber J, Murer H, Forster IC. Phosphate transporters: a tale of two solute carrier families. Am J Physiol Renal Physiol 293: F643-F654, 2007.
30. Wagner CA, Biber J, Murer H. Of men and mice: who is in control of renal phosphate reabsorption? J Am Soc Nephrol 19: 1625-1626, 2008.
31. Xu L, Dixit MP, Chen R, Dixit NM, Collins JF, Ghishan FK. Effects of angiotensin II on NaPi-IIa co-transporter expression and activity in rat renal cortex. Biochim Biophys Acta 1667: 114-121, 2004.
32. Zajicek HK, Wang H, Puttaparthi K, Halaihel N, Markovich D, Shayman J, Beliveau R, Wilson P, Rogers T, Levi M. Glycosphingolipids modulate renal phosphate transport in potassium deficiency. Kidney Int 60: 694-704, 2001.