Estrogen downregulates the proximal tubule type IIa sodium phosphate cotransporter causing phosphate wasting and hypophosphatemia

Kidney International

Volumn 73, Issue 10, 2008, Pages 1141-1150

  Faroqui, S ^a   Levi, M ^b   Soleimani, M ^a   Amlal, H ^a,c  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Calcium; Phosphorus; PTH; Sex steroids

Indexed keywords

AQUAPORIN 1; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; MESSENGER RNA; PARATHYROID HORMONE; PHOSPHATE; RECEPTOR SUBTYPE; SODIUM PHOSPHATE COTRANSPORTER; SODIUM PHOSPHATE COTRANSPORTER IIA; SODIUM PHOSPHATE COTRANSPORTER IIC; SODIUM PHOSPHATE COTRANSPORTER III; SODIUM PROTON EXCHANGE PROTEIN 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FOOD INTAKE; GENE EXPRESSION; HYPOPHOSPHATEMIA; KIDNEY PROXIMAL TUBULE; NONHUMAN; OVARIECTOMY; PARATHYROIDECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION;

EID: 42949109653     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2008.33     Document Type: Article

References (64)

1. T.J. Berndt F.G. Knox Renal regulation of phosphate excretion D.W. Seldin G. Giebisch The Kidney, Physiology and Pathophysiology 1992 Raven New York, NY 2511 2532
2. G. Danisi H. Murer Inorganic phosphate absorption in small intestine M. Field R.A. Frizzel Handbook of Physiology. The Gastrointestinal System. Intestinal Absorption and Secretion vol. IV 1991 Am Physiol Soc Bethesda, MD 323 336 section 6, chapter 12.
3. VW. Danisi Phosphate homeostasis E.E. Windhager Handbook of Physiology. Renal Physiology vol. II 1992 Am Physiol Soc Bethesda, MD 1785 1815 section 8, chapter 37.
4. H. Murer I. Forster J. Biber The sodium phosphate cotransporter family SLC34 Pflugers Arch 447 2004 763 767
5. H. Hilfiker O. Hattenhauer M. Traebert Characterization of a murine type II sodium-phosphate cotransporter expressed in mammalian small intestine Proc Natl Acad Sci USA 95 1998 14564 14569
6. H. Murer N. Hernando I. Forster Proximal tubular phosphate reabsorption: molecular mechanisms Physiol Rev 80 2000 1373 1409
7. H. Segawa I. Kaneko A. Takahashi Growth-related renal type II Na/Pi cotransporter J Biol Chem 277 2002 19665 19672
8. I.C. Forster N. Hernando J. Biber Proximal tubular handling of phosphate: a molecular perspective Kidney Int 70 2006 1548 1559
9. L. Beck A.C. Karaplis N. Amizuka Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities Proc Natl Acad Sci USA 95 1998 5372 5377
10. H.M. Hoag J. Martel C. Gauthier Effects of Npt2 gene ablation and low-phosphate diet on renal Na(+)/phosphate cotransport and cotransporter gene expression J Clin Invest 104 1999 679 686
11. Y.S. Guner P.R. Kiela H. Xu Differential regulation of renal sodium-phosphate transporter by glucocorticoids during rat ontogeny Am J Physiol Cell Physiol 277 1999 C884 C890
12. M. Arar M. Baum J. Biber Epidermal growth factor inhibits Na-Pi cotransport and mRNA in OK cells Am J Physiol Renal Fluid Electrolyte Physiol 268 1995 F309 F314
13. i cotransport in weaned and suckling rats Am J Physiol Renal Physiol 276 1999 F72 F78
14. i cotransporter in OK-cells Pflugers Arch 438 1999 689 693
15. i Am J Physiol Renal Physiol 277 1999 F676 F684
16. M.F. Pfister J. Forgo U. Ziegler cAMP-dependent and -independent downregulation of type II Na-Pi cotransporters by PTH Am J Physiol Renal Physiol 276 1999 F720 F725
17. 3. Identification of a vitamin D-responsive element in the human NAPi-3 gene J Biol Chem 273 1998 14575 14581
18. A.I. Alcalde M. Sarasa D. Raldua Role of thyroid hormone in regulation of renal phosphate transport in young and aged rats Endocrinology 140 1999 1544 1551
19. V. Sorribas D. Markovich T. Verri Thyroid hormone stimulation of Na/Pi-cotransport in opossum kidney cells Pflugers Arch 431 1995 266 271
20. +/phosphate cotransporter NaPi-IIa in mouse kidney and OK cells Am J Physiol Renal Physiol 288 2005 F740 F747
21. P.M. Ambühl H.K. Zajicek H. Wang Regulation of renal phosphate transport by acute and chronic metabolic acidosis in the rat Kidney Int 53 1998 1288 1298
22. J.F. Collins N. Bulus F.K. Ghishan Sodium-phosphate transporter adaptation to dietary phosphate deprivation in normal and hypophosphatemic mice Am J Physiol Gastrointest Liver Physiol 268 1995 G917 G924
23. S.C. Schiavi R. Kumar The phosphatonin pathway: new insights in phosphate homeostasis Kidney Int 65 2004 1 14
24. i type IIb cotransporter by dietary phosphate intake Am J Physiol Gastrointest Liver Physiol 277 1999 G756 G762
25. 3 Biochem J 343 1999 705 712
26. i-IIb gene promoter by epidermal growth factor Am J Physiol Cell Physiol 280 2001 C628 C636
27. i cotransporter during ontogeny Am J Physiol Gastrointest Liver Physiol 283 2002 G426 G434
28. H. Xu J.K. Uno M. Inouye Regulation of intestinal NaPi-IIb cotransporter gene expression by estrogen Am J Physiol Gastrointest Liver Physiol 285 2003 G1317 G1324
29. S. Eiam-ong N.A. Kurtzman Metabolic acidosis and bone disease Miner Electrolyte Metab 20 1994 72 80
30. J. Lemann N.D. Adams D.R. Wilz Acid and mineral balances and bone in familial proximal renal tubular acidosis Kidney Int 58 2000 1267 1277
31. S. Domrongkitchaiporn C. Pongskul V. Sirikulchayanonta Bone histology and bone mineral density after correction of acidosis in distal renal tubular acidosis Kidney Int 62 2002 2160 2166
32. M.N. Weitzmann R. Pacifici Estrogen deficiency and bone loss: an inflammatory tale J Clin Invest 116 2006 1186 1194
33. R. Pacifici Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis J Bone Miner Res 11 1996 1043 1051
34. S. Adami D. Gatti F. Bertoldo The effects of menopause and estrogen replacement therapy on the renal handling of calcium Osteoporos Int 2 1992 180 185
35. D.L. Citrin P. Elson M.S. Kies Decreased serum phosphate levels after high-dose estrogens in metastatic prostate cancer. Possible implications Am J Med 76 1984 787 793
36. J.L. Stock J.A. Coderre L.E. Mallette Effects of a short course of estrogen on mineral metabolism in postmenopausal women J Clin Endocrinol Metab 61 1985 595 600
37. C. Castelo-Branco M.J. Martínez de Osaba F. Pons The effect of hormone replacement therapy on postmenopausal bone loss Eur J Obstet Gynecol Reprod Biol 44 1992 131 136
38. H. Uemura M. Irahara N. Yoneda Close correlation between estrogen treatment and renal phosphate reabsorption capacity J Clin Endocrinol Metab 85 2000 1215 1219
39. +-P(i) cotransport across renal brush border membranes from ovariectomized rats Biochem Biophys Res Commun 221 1996 442 445
40. Y. Hagenfeldt H.A. Eriksson The estrogen receptor in the rat kidney. Ontogeny, properties and effects of gonadectomy on its concentration J Steroid Biochem 31 1988 49 56
41. M. Davidoff H. Caffier T.H. Schiebler Steroid hormone binding receptors in the rat kidney Histochemistry 69 1980 39 48
42. D.P. Edwards Regulation of signal transduction pathways by estrogen and progesterone Annu Rev Physiol 67 2005 335 376
43. Z. Nawaz D.M. Lonard A.P. Dennis Proteasome-dependent degradation of the human estrogen receptor Proc Natl Acad Sci USA 96 1999 1858 1862
44. B.L. Riggs J. Jowsey P.J. Kelly Effect of sex hormones on bone in primary osteoporosis J Clin Invest 48 1969 1065 1072
45. J.L. Stock J.A. Coderre J.T. Posillico Effects of estrogen on mineral metabolism in postmenopausal women as evaluated by multiple assays measuring parathyrin bioactivity Clin Chem 35 1989 18 22
46. K. Palmer J.M. Gray Central vs peripheral effects of estrogen on food intake and lipoprotein lipase activity in ovariectomized rats Physiol Behav 37 1986 187 189
47. D.M. Nance The developmental and neural determinants of the effects of estrogen on feeding behavior in the rat: a theoretical perspective Neurosci Biobehav Rev 7 1983 189 211
48. G.N. Wade J.M. Gray Gonadal effects on food intake and adiposity: a metabolic hypothesis Physiol Behav 22 1979 583 593
49. S.H. Lee M.M. Mouradian Up-regulation of D1A dopamine receptor gene transcription by estrogen Mol Cell Endocrinol 156 1999 151 157
50. P. Agrati Z.Q. Ma C. Patrone Dopaminergic phenotype induced by oestrogens in a human neuroblastoma cell line Eur J Neurosci 9 1997 1008 1016
51. T. Shimada I. Urakawa Y. Yamazaki Impairment in NaPi-IIa transport activity should correlate with the decrease in its expression to account for increased Pi excretion in EST-injected rats Biochem Biophys Res Commun 314 2004 409 414
52. E.P. Murono R.Y. Kirdani A.A. Sandberg Specific estradiol-17 beta binding component in adult rat kidney J Steroid Biochem 11 1979 1347 1351
53. A.L. Wijayaratne D.P. McDonnell The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators J Biol Chem 276 2001 35684 35692
54. M. Calligé H. Richard-Foy Ligand-induced estrogen receptor alpha degradation by the proteasome: new actors? Nucl Recept Signal 4 2006 e004
55. H. Amlal S. Faroqui A. Balasubramaniam Estrogen up-regulates neuropeptide Y Y1 receptor expression in a human breast cancer cell line Cancer Res 66 2006 3706 3714
56. L. Björnström M. Sjöberg Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes Mol Endocrinol 19 2005 833 842
57. T. Funakoshi A. Yanai K. Shinoda G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane Biochem Biophys Res Commun 346 2006 904 910
58. E.J. Filardo J.A. Quinn A.R. Frackelton Jr Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis Mol Endocrinol 16 2002 70 84
59. P. Chomczynski N. Sacchi Single-step method of RNA isolation by acid guanidinium thiocyanate–phenol–chloroform extraction Anal Biochem 162 1987 156 159
60. G.M. Church W. Gilbert Genomic sequencing Proc Natl Acad Sci USA 81 1984 1991 1995
61. C. Wilke S. Sheriff M. Soleimani Vasopressin-independent regulation of collecting duct aquaporin-2 in food deprivation Kidney Int 67 2005 201 216
62. +-dependent transporters and collecting duct aquaporins to dehydration in 7-month-old rats Kidney Int 64 2003 544 554
63. H.K. Zajicek H. Wang K. Puttaparthi Glycosphingolipids modulate renal phosphate transport in potassium deficiency Kidney Int 60 2001 694 704
64. V. Sorribas N. Halaihel K. Puttaparthi Gentamicin causes endocytosis of Na/Pi cotransporter protein (NaPi-2) Kidney Int 59 2001 1024 1036