Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology

Biological Psychiatry

Volumn 74, Issue 5, 2013, Pages 357-366

  Baglietto Vargas, David ^a   Medeiros, Rodrigo ^a   Martinez Coria, Hilda ^a   Laferla, Frank M ^a   Green, Kim N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

3xTg AD; Alzheimer's disease; Amyloid beta; glucocorticoids; mifepristone; tau

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CALPAIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MIFEPRISTONE; PROTEIN P25; TAU PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CENTRAL NERVOUS SYSTEM; COGNITIVE DEFECT; CONTROLLED STUDY; MALE; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

EID: 84882262233     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2012.12.003     Document Type: Article

References (55)

1. J.G. Csernansky, H. Dong, A.M. Fagan, L. Wang, C. Xiong, D.M. Holtzman, and J.C. Morris Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia Am J Psychiatry 163 2006 2164 2169
2. W.J. Hoogendijk, G. Meynen, E. Endert, M.A. Hofman, and D.F. Swaab Increased cerebrospinal fluid cortisol level in Alzheimer's disease is not related to depression Neurobiol Aging 27 2006 780.e1 780.e2
3. H. Umegaki, H. Ikari, H. Nakahata, H. Endo, Y. Suzuki, and O. Ogawa Plasma cortisol levels in elderly female subjects with Alzheimer's disease: A cross-sectional and longitudinal study Brain Res 881 2000 241 243
4. K.N. Green, L.M. Billings, B. Roozendaal, J.L. McGaugh, and F.M. LaFerla Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease J Neurosci 26 2006 9047 9056
5. C. Catania, I. Sotiropoulos, R. Silva, C. Onofri, K.C. Breen, N. Sousa, and O.F. Almeida The amyloidogenic potential and behavioral correlates of stress Mol Psychiatry 14 2009 95 105
6. Y.H. Jeong, C.H. Park, J. Yoo, K.Y. Shin, S.M. Ahn, and H.S. Kim Chronic stress accelerates learning and memory impairments and increases amyloid deposition in APPV717I-CT100 transgenic mice, an Alzheimer's disease model FASEB J 20 2006 729 731
7. J.J. Kulstad, P.J. McMillan, J.B. Leverenz, D.G. Cook, P.S. Green, and E.R. Peskind Effects of chronic glucocorticoid administration on insulin-degrading enzyme and amyloid-beta peptide in the aged macaque J Neuropathol Exp Neurol 64 2005 139 146
8. G.P. Lim, F. Yang, T. Chu, P. Chen, W. Beech, and B. Teter Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease J Neurosci 20 2000 5709 5714
9. I. Sotiropoulos, C. Catania, T. Riedemann, J.P. Fry, K.C. Breen, T.M. Michaelidis, and O.F. Almeida Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau J Neurochem 107 2008 385 397
10. J.M. Reul, and E.R. de Kloet Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation Endocrinology 117 1985 2505 2511
11. J. Graff, D. Rei, J.S. Guan, W.Y. Wang, J. Seo, and K.M. Hennig An epigenetic blockade of cognitive functions in the neurodegenerating brain Nature 483 2012 222 226
12. S. Oddo, A. Caccamo, J.D. Shepherd, M.P. Murphy, T.E. Golde, and R. Kayed Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction Neuron 39 2003 409 421
13. C. Andrade, S.A. Shaikh, L. Narayan, C. Blasey, and J. Belanoff Administration of a selective glucocorticoid antagonist attenuates electroconvulsive shock-induced retrograde amnesia J Neural Transm 119 2012 337 344
14. T. Asagami, J.K. Belanoff, J. Azuma, C.M. Blasey, R.D. Clark, and P.S. Tsao Selective glucocorticoid receptor (GR-II) antagonist reduces body weight gain in mice J Nutr Metab 2011 2011 235389
15. J.K. Belanoff, C.M. Blasey, R.D. Clark, and R.L. Roe Selective glucocorticoid receptor (type II) antagonist prevents and reverses olanzapine-induced weight gain Diabetes Obes Metab 12 2010 545 547
16. A. Ennaceur, and J. Delacour A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data Behav Brain Res 31 1988 47 59
17. L.M. Billings, S. Oddo, K.N. Green, J.L. McGaugh, and F.M. LaFerla Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice Neuron 45 2005 675 688
18. R. Medeiros, M. Kitazawa, A. Caccamo, D. Baglietto-Vargas, T. Estrada-Hernandez, and D.H. Cribbs Loss of muscarinic m(1) receptor exacerbates Alzheimer's disease-like pathology and cognitive decline Am J Pathol 179 2011 980 991
19. L.K. Clinton, L.M. Billings, K.N. Green, A. Caccamo, J. Ngo, and S. Oddo Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice Neurobiol Dis 28 2007 76 82
20. H. Martinez-Coria, K.N. Green, L.M. Billings, M. Kitazawa, M. Albrecht, and G. Rammes Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice Am J Pathol 176 2010 870 880
21. D. Baglietto-Vargas, I. Moreno-Gonzalez, R. Sanchez-Varo, S. Jimenez, L. Trujillo-Estrada, and E. Sanchez-Mejias Calretinin interneurons are early targets of extracellular amyloid-beta pathology in PS1/AbetaPP Alzheimer mice hippocampus J Alzheimers Dis 21 2010 119 132
22. B. Kruszewska, D.L. Felten, S.Y. Stevens, and J.A. Moynihan Sympathectomy-induced immune changes are not abrogated by the glucocorticoid receptor blocker RU-486 Brain Behav Immun 12 1998 181 200
23. A. Pastva, K. Estell, T.R. Schoeb, and L.M. Schwiebert RU486 blocks the anti-inflammatory effects of exercise in a murine model of allergen-induced pulmonary inflammation Brain Behav Immun 19 2005 413 422
24. S. Oddo, A. Caccamo, M. Kitazawa, B.P. Tseng, and F.M. LaFerla Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease Neurobiol Aging 24 2003 1063 1070
25. J.L. McGaugh, C.K. McIntyre, and A.E. Power Amygdala modulation of memory consolidation: Interaction with other brain systems Neurobiol Learn Mem 78 2002 539 552
26. A. Caccamo, M.A. Maldonado, A.F. Bokov, S. Majumder, and S. Oddo CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease Proc Natl Acad Sci U S A 107 2010 22687 22692
27. I. Pinnix, U. Musunuru, H. Tun, A. Sridharan, T. Golde, and C. Eckman A novel gamma-secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor J Biol Chem 276 2001 481 487
28. T.M. Allinson, E.T. Parkin, A.J. Turner, and N.M. Hooper ADAMs family members as amyloid precursor protein alpha-secretases J Neurosci Res 74 2003 342 352
29. S. Lammich, E. Kojro, R. Postina, S. Gilbert, R. Pfeiffer, and M. Jasionowski Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease Proc Natl Acad Sci U S A 96 1999 3922 3927
30. R. Postina, A. Schroeder, I. Dewachter, J. Bohl, U. Schmitt, and E. Kojro A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model J Clin Invest 113 2004 1456 1464
31. R. Vassar, B.D. Bennett, S. Babu-Khan, S. Kahn, E.A. Mendiaz, and P. Denis Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE Science 286 1999 735 741
32. D.J. Selkoe Clearing the brain's amyloid cobwebs Neuron 32 2001 177 180
33. R.A. Rissman, K.F. Lee, W. Vale, and P.E. Sawchenko Corticotropin- releasing factor receptors differentially regulate stress-induced tau phosphorylation J Neurosci 27 2007 6552 6562
34. C.X. Gong, F. Liu, I. Grundke-Iqbal, and K. Iqbal Post-translational modifications of tau protein in Alzheimer's disease J Neural Transm 112 2005 813 838
35. D.P. Hanger, K. Hughes, J.R. Woodgett, J.P. Brion, and B.H. Anderton Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase Neurosci Lett 147 1992 58 62
36. R. Medeiros, D. Baglietto-Vargas, and F.M. Laferla The role of tau in Alzheimer's disease and related disorders CNS Neurosci Ther 17 2011 514 524
37. W. Noble, V. Olm, K. Takata, E. Casey, O. Mary, and J. Meyerson Cdk5 is a key factor in tau aggregation and tangle formation in vivo Neuron 38 2003 555 565
38. M.S. Lee, Y.T. Kwon, M. Li, J. Peng, R.M. Friedlander, and L.H. Tsai Neurotoxicity induces cleavage of p35 to p25 by calpain Nature 405 2000 360 364
39. J.C. Carroll, M. Iba, D.A. Bangasser, R.J. Valentino, M.J. James, and K.R. Brunden Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy J Neurosci 31 2011 14436 14449
40. E. Elgh, A. Lindqvist Astot, M. Fagerlund, S. Eriksson, T. Olsson, and B. Nasman Cognitive dysfunction, hippocampal atrophy and glucocorticoid feedback in Alzheimer's disease Biol Psychiatry 59 2006 155 161
41. B.S. McEwen Plasticity of the hippocampus: Adaptation to chronic stress and allostatic load Ann N Y Acad Sci 933 2001 265 277
42. N.R. Nichols, M. Zieba, and N. Bye Do glucocorticoids contribute to brain aging? Brain Res Brain Res Rev 37 2001 273 286
43. K. Sooy, S.P. Webster, J. Noble, M. Binnie, B.R. Walker, J.R. Seckl, and J.L. Yau Partial deficiency or short-term inhibition of 11beta-hydroxysteroid dehydrogenase type 1 improves cognitive function in aging mice J Neurosci 30 2010 13867 13872
44. E.G. Mohler, K.E. Browman, V.A. Roderwald, E.A. Cronin, S. Markosyan, and R. Scott Bitner Acute inhibition of 11beta-hydroxysteroid dehydrogenase type-1 improves memory in rodent models of cognition J Neurosci 31 2011 5406 5413
45. N. Pomara, P.M. Doraiswamy, H. Tun, and S. Ferris Mifepristone (RU 486) for Alzheimer's disease Neurology 58 2002 1436
46. K.N. Green, H. Khashwji, T. Estrada, and F.M. Laferla ST101 induces a novel 17 kDa APP cleavage that precludes Abeta generation in vivo Ann Neurol 69 2011 831 844
47. C.L. Gibson, and S.P. Murphy Progesterone enhances functional recovery after middle cerebral artery occlusion in male mice J Cereb Blood Flow Metab 24 2004 805 813
48. J. He, S.W. Hoffman, and D.G. Stein Allopregnanolone, a progesterone metabolite, enhances behavioral recovery and decreases neuronal loss after traumatic brain injury Restor Neurol Neurosci 22 2004 19 31
49. C.A. Frye, and A.A. Walf Effects of progesterone administration and APPswe+PSEN1Deltae9 mutation for cognitive performance of mid-aged mice Neurobiol Learn Mem 89 2008 17 26
50. J.C. Carroll, E.R. Rosario, L. Chang, F.Z. Stanczyk, S. Oddo, F.M. LaFerla, and C.J. Pike Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice J Neurosci 27 2007 13357 13365
51. C. Singh, L. Liu, J.M. Wang, R.W. Irwin, J. Yao, and S. Chen Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice Neurobiol Aging 33 2012 1493 1506
52. J.M. Wang, C. Singh, L. Liu, R.W. Irwin, S. Chen, and E.J. Chung Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease Proc Natl Acad Sci U S A 107 2010 6498 6503
53. S. Chen, J.M. Wang, R.W. Irwin, J. Yao, L. Liu, and R.D. Brinton Allopregnanolone promotes regeneration and reduces beta-amyloid burden in a preclinical model of Alzheimer's disease PloS One 6 2011 e24293
54. H.L. Lin, H. Zhang, and P.F. Hollenberg Metabolic activation of mifepristone [RU486; 17beta-hydroxy-11beta-(4-dimethylaminophenyl)-17alpha-(1- propynyl)-estra-4,9-dien -3-one] by mammalian cytochromes P450 and the mechanism-based inactivation of human CYP2B6 J Pharmacol Exp Ther 329 2009 26 37
55. O. Heikinheimo, K. Kontula, H. Croxatto, I. Spitz, T. Luukkainen, and P. Lahteenmaki Plasma concentrations and receptor binding of RU 486 and its metabolites in humans J Steroid Biochem 26 1987 279 284