Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 27, 2015, Pages E3582-E3589

  Shahmoradi, Ali ^a   Radyushkin, Konstantin ^a,c   Rossner, Moritz J ^a,b  

^a MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Aging; Cortex; Insulin like signaling; MAPK signaling; Memory consolidation

Indexed keywords

INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; REGULATOR PROTEIN; S6 KINASE; SOMATOMEDIN B; SOMATOMEDIN C RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SHARP1; TRANSCRIPTION FACTOR SHARP2; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BHLHB3 PROTEIN, MOUSE; BHLHE40 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; SOMATOMEDIN BINDING PROTEIN 5;

AGED; AGING; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR CINGULATE; ARTICLE; BIOCHEMICAL ANALYSIS; BRAIN FUNCTION; CIRCADIAN RHYTHM; COGNITION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FEAR; FOREBRAIN; GENE OVEREXPRESSION; HIPPOCAMPUS; LEARNING; LONG TERM MEMORY; MEMORY CONSOLIDATION; MOLECULAR BIOLOGY; MOUSE; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ANIMAL; BRAIN CORTEX; C57BL MOUSE; GENE EXPRESSION; GENETICS; KNOCKOUT MOUSE; METABOLISM; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TIME FACTOR; WESTERN BLOTTING;

ADENO-ASSOCIATED VIRUS - 2; MUS; PHOS;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOTTING, WESTERN; CEREBRAL CORTEX; GENE EXPRESSION; HOMEODOMAIN PROTEINS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5; INSULIN-LIKE GROWTH FACTOR II; MEMORY, LONG-TERM; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTORS;

EID: 84936805629     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1423989112     Document Type: Article

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