메뉴 건너뛰기




Volumn 41, Issue 4, 2015, Pages 980-988

Multifactoriality in Psychiatric Disorders: A Computational Study of Schizophrenia

Author keywords

attractor network; complexity; computational model; multifactoriality; parametric exploration; schizophrenia

Indexed keywords

4 AMINOBUTYRIC ACID; N METHYL DEXTRO ASPARTIC ACID; RECEPTOR;

EID: 84936777573     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbu146     Document Type: Article
Times cited : (8)

References (55)
  • 1
    • 0031968868 scopus 로고    scopus 로고
    • A new intellectual framework for psychiatry
    • Kandel ER. A new intellectual framework for psychiatry. Am J Psychiatry. 1998;155:457-469.
    • (1998) Am J Psychiatry. , vol.155 , pp. 457-469
    • Kandel, E.R.1
  • 2
    • 77950231051 scopus 로고    scopus 로고
    • The future of psychiatric research: Genomes and neural circuits
    • Akil H, Brenner S, Kandel E, et al. The future of psychiatric research: genomes and neural circuits. Science. 2010;327:1580-1581.
    • (2010) Science. , vol.327 , pp. 1580-1581
    • Akil, H.1    Brenner, S.2    Kandel, E.3
  • 3
    • 68449086236 scopus 로고    scopus 로고
    • Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    • The International Schizophrenia Consortium. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature. 2009;460:748-752.
    • (2009) Nature. , vol.460 , pp. 748-752
    • The International Schizophrenia Consortium1
  • 4
    • 68449096727 scopus 로고    scopus 로고
    • Common variants on chromosome 6p22. 1 are associated with schizophrenia
    • Shi J, Levinson DF, Duan J, et al. Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature. 2009;460:753-757.
    • (2009) Nature. , vol.460 , pp. 753-757
    • Shi, J.1    Levinson, D.F.2    Duan, J.3
  • 5
    • 79952722217 scopus 로고    scopus 로고
    • After GWAS: Searching for genetic risk for schizophrenia and bipolar disorder
    • Gershon ES, Alliey-Rodriguez N, Liu C. After GWAS: searching for genetic risk for schizophrenia and bipolar disorder. Am J Psychiatry. 2011;168:253-256.
    • (2011) Am J Psychiatry. , vol.168 , pp. 253-256
    • Gershon, E.S.1    Alliey-Rodriguez, N.2    Liu, C.3
  • 7
    • 84870064521 scopus 로고    scopus 로고
    • Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it
    • Kapur S, Phillips AG, Insel TR. Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it? Mol Psychiatry. 2012;17:1174-1179.
    • (2012) Mol Psychiatry. , vol.17 , pp. 1174-1179
    • Kapur, S.1    Phillips, A.G.2    Insel, T.R.3
  • 8
    • 65549142100 scopus 로고    scopus 로고
    • Beyond reliability: Biomarkers and validity in psychiatry
    • Pies R. Beyond reliability: biomarkers and validity in psychiatry. Psychiatry (Edgmont). 2008;5:48-52.
    • (2008) Psychiatry (Edgmont). , vol.5 , pp. 48-52
    • Pies, R.1
  • 9
    • 33847719511 scopus 로고    scopus 로고
    • Do biomarkers trump behavior?
    • Amaral OB. Do biomarkers trump behavior? Nat Med. 2007;13:237.
    • (2007) Nat Med. , vol.13 , pp. 237
    • Amaral, O.B.1
  • 10
    • 84877626914 scopus 로고    scopus 로고
    • Toward the future of psychiatric diagnosis: The seven pillars of RDoC
    • Cuthbert B, Insel T. Toward the future of psychiatric diagnosis: The seven pillars of RDoC. BMC Med. 2013;11:126.
    • (2013) BMC Med. , vol.11 , pp. 126
    • Cuthbert, B.1    Insel, T.2
  • 11
    • 44949231556 scopus 로고    scopus 로고
    • Explanatory models for psychiatric Illness
    • Kendler MDK. Explanatory models for psychiatric Illness. Am J Psychiatry. 2008;165:695-702.
    • (2008) Am J Psychiatry. , vol.165 , pp. 695-702
    • Kendler, M.D.K.1
  • 12
    • 0032031592 scopus 로고    scopus 로고
    • Psychiatric genetics: Search for phenotypes
    • Leboyer M, Leboyer M, Bellivier F, et al. Psychiatric genetics: search for phenotypes. Trends Neurosci. 1998;21:102-105.
    • (1998) Trends Neurosci. , vol.21 , pp. 102-105
    • Leboyer, M.1    Leboyer, M.2    Bellivier, F.3
  • 13
    • 33845870419 scopus 로고    scopus 로고
    • Deconstructing schizophrenia: An overview of the use of endophenotypes in order to understand a complex disorder
    • Braff DL, Freedman R, Schork NJ, Gottesman II. Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder. Schizophr Bull. 2007;33:21-32.
    • (2007) Schizophr Bull. , vol.33 , pp. 21-32
    • Braff, D.L.1    Freedman, R.2    Schork, N.J.3    Gottesman, I.I.4
  • 14
    • 40949097635 scopus 로고    scopus 로고
    • The MATRICS consensus cognitive battery, part 1: Test selection, reliability, and validity
    • Nuechterlein PDK, Green PDM, Kern PDR, et al. The MATRICS consensus cognitive battery, part 1: test selection, reliability, and validity. Am J Psychiatry. 2008;165:203-213.
    • (2008) Am J Psychiatry. , vol.165 , pp. 203-213
    • Nuechterlein, P.D.K.1    Green, P.D.M.2    Kern, P.D.R.3
  • 15
    • 77954230363 scopus 로고    scopus 로고
    • Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders
    • Insel T, Cuthbert B, Garvey M, et al. Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry. 2010;167:748-751.
    • (2010) Am J Psychiatry. , vol.167 , pp. 748-751
    • Insel, T.1    Cuthbert, B.2    Garvey, M.3
  • 16
    • 70449353513 scopus 로고    scopus 로고
    • A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB
    • Need AC, Attix DK, McEvoy JM, et al. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. Hum Mol Genet. 2009;18:4650-4661.
    • (2009) Hum Mol Genet. , vol.18 , pp. 4650-4661
    • Need, A.C.1    Attix, D.K.2    McEvoy, J.M.3
  • 17
    • 77953807605 scopus 로고    scopus 로고
    • Common genetic variation and performance on standardized cognitive tests
    • Cirulli ET, Kasperaviciute D, Attix DK, et al. Common genetic variation and performance on standardized cognitive tests. Eur J Hum Genet. 2010;18:815-820.
    • (2010) Eur J Hum Genet. , vol.18 , pp. 815-820
    • Cirulli, E.T.1    Kasperaviciute, D.2    Attix, D.K.3
  • 18
    • 33846525474 scopus 로고    scopus 로고
    • The endophenotype concept in psychiatric genetics
    • Flint J, Munafò MR. The endophenotype concept in psychiatric genetics. Psychol Med. 2007;37:163-180.
    • (2007) Psychol Med. , vol.37 , pp. 163-180
    • Flint, J.1    Munafò, M.R.2
  • 20
    • 13744259954 scopus 로고    scopus 로고
    • Similar network activity from disparate circuit parameters
    • Prinz AA, Bucher D, Marder E. Similar network activity from disparate circuit parameters. Nat Neurosci. 2004;7:1345-1352.
    • (2004) Nat Neurosci. , vol.7 , pp. 1345-1352
    • Prinz, A.A.1    Bucher, D.2    Marder, E.3
  • 21
    • 79251541199 scopus 로고    scopus 로고
    • Multiple models to capture the variability in biological neurons and networks
    • Marder E, Taylor AL. Multiple models to capture the variability in biological neurons and networks. Nat Neurosci. 2011;14:133-138.
    • (2011) Nat Neurosci. , vol.14 , pp. 133-138
    • Marder, E.1    Taylor, A.L.2
  • 22
    • 49949101019 scopus 로고    scopus 로고
    • Computational models of schizophrenia and dopamine modulation in the prefrontal cortex
    • Rolls ET, Loh M, Deco G, Winterer G. Computational models of schizophrenia and dopamine modulation in the prefrontal cortex. Nat Rev Neurosci. 2008;9:696-709.
    • (2008) Nat Rev Neurosci. , vol.9 , pp. 696-709
    • Rolls, E.T.1    Loh, M.2    Deco, G.3    Winterer, G.4
  • 23
    • 79957608463 scopus 로고    scopus 로고
    • Are computational models of any use to psychiatry?
    • Huys QJ, Moutoussis M, Williams J. Are computational models of any use to psychiatry? Neural Netw. 2011;24:544-551.
    • (2011) Neural Netw. , vol.24 , pp. 544-551
    • Huys, Q.J.1    Moutoussis, M.2    Williams, J.3
  • 24
    • 84891334262 scopus 로고    scopus 로고
    • Computational approaches to psychiatry
    • Stephan KE, Mathys C. Computational approaches to psychiatry. Curr Opin Neurobiol. 2014;25:85-92.
    • (2014) Curr Opin Neurobiol. , vol.25 , pp. 85-92
    • Stephan, K.E.1    Mathys, C.2
  • 25
    • 36949035385 scopus 로고    scopus 로고
    • A dynamical systems hypothesis of schizophrenia
    • Loh M, Rolls ET, Deco G. A dynamical systems hypothesis of schizophrenia. PLoS Comput Biol. 2007;3:e228.
    • (2007) PLoS Comput Biol. , vol.3 , pp. e228
    • Loh, M.1    Rolls, E.T.2    Deco, G.3
  • 26
    • 0033936744 scopus 로고    scopus 로고
    • Schizophrenia as a disorder of developmentally reduced synaptic connectivity
    • McGlashan TH, Hoffman RE. Schizophrenia as a disorder of developmentally reduced synaptic connectivity. Arch Gen Psychiatry. 2000;57:637-648.
    • (2000) Arch Gen Psychiatry. , vol.57 , pp. 637-648
    • McGlashan, T.H.1    Hoffman, R.E.2
  • 27
    • 79957586269 scopus 로고    scopus 로고
    • A modeling study suggesting how a reduction in the context-dependent input on CA1 pyramidal neurons could generate schizophrenic behavior
    • Migliore M, De Blasi I, Tegolo D, Migliore R. A modeling study suggesting how a reduction in the context-dependent input on CA1 pyramidal neurons could generate schizophrenic behavior. Neural Netw. 2011;24:552-559.
    • (2011) Neural Netw. , vol.24 , pp. 552-559
    • Migliore, M.1    De Blasi, I.2    Tegolo, D.3    Migliore, R.4
  • 28
    • 77949492770 scopus 로고    scopus 로고
    • A computational model for cerebral cortical dysfunction in autism spectrum disorders
    • Vattikuti S, Chow CC. A computational model for cerebral cortical dysfunction in autism spectrum disorders. Biol Psychiatry. 2010;67:672-678.
    • (2010) Biol Psychiatry. , vol.67 , pp. 672-678
    • Vattikuti, S.1    Chow, C.C.2
  • 29
    • 84865657399 scopus 로고    scopus 로고
    • A computational model for spatial working memory deficits in schizophrenia
    • Cano-Colino M, Compte A. A computational model for spatial working memory deficits in schizophrenia. Pharmacopsychiatry. 2012;45(suppl 1):S49-S56.
    • (2012) Pharmacopsychiatry. , vol.45 , pp. S49-S56
    • Cano-Colino, M.1    Compte, A.2
  • 30
    • 84875085552 scopus 로고    scopus 로고
    • Development of antipsychotic medications with novel mechanisms of action based on computational modeling of hippocampal neuropathology
    • Siekmeier PJ, vanMaanen DP. Development of antipsychotic medications with novel mechanisms of action based on computational modeling of hippocampal neuropathology. PLoS One. 2013;8:e58607.
    • (2013) PLoS One. , vol.8 , pp. e58607
    • Siekmeier, P.J.1    Vanmaanen, D.P.2
  • 31
    • 84896359684 scopus 로고    scopus 로고
    • Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model
    • Murray JD, Anticevic A, Gancsos M, et al. Linking microcircuit dysfunction to cognitive impairment: effects of disinhibition associated with schizophrenia in a cortical working memory model. Cereb Cortex. 2014;24:859-872.
    • (2014) Cereb Cortex. , vol.24 , pp. 859-872
    • Murray, J.D.1    Anticevic, A.2    Gancsos, M.3
  • 32
    • 0034814469 scopus 로고    scopus 로고
    • Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition
    • Brunel N, Wang XJ. Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition. J Comput Neurosci. 2001;11:63-85.
    • (2001) J Comput Neurosci. , vol.11 , pp. 63-85
    • Brunel, N.1    Wang, X.J.2
  • 33
    • 0024411787 scopus 로고
    • Unit activity in monkey parietal cortex related to haptic perception and temporary memory
    • Koch KW, Fuster JM. Unit activity in monkey parietal cortex related to haptic perception and temporary memory. Exp Brain Res. 1989;76:292-306.
    • (1989) Exp Brain Res. , vol.76 , pp. 292-306
    • Koch, K.W.1    Fuster, J.M.2
  • 34
    • 0028355435 scopus 로고
    • Functional synergism between putative gamma-aminobutyrate-containing neurons and pyramidal neurons in prefrontal cortex
    • Wilson FA, O'Scalaidhe SP, Goldman-Rakic PS. Functional synergism between putative gamma-aminobutyrate-containing neurons and pyramidal neurons in prefrontal cortex. Proc Natl Acad Sci USA. 1994;91:4009-4013.
    • (1994) Proc Natl Acad Sci USA. , vol.91 , pp. 4009-4013
    • Wilson, F.A.1    O'scalaidhe, S.P.2    Goldman-Rakic, P.S.3
  • 37
    • 0032543598 scopus 로고    scopus 로고
    • High-frequency transitions in cortical spike trains related to short-term memory
    • Bodner M, Zhou YD, Fuster JM. High-frequency transitions in cortical spike trains related to short-term memory. Neuroscience. 1998;86:1083-1087.
    • (1998) Neuroscience. , vol.86 , pp. 1083-1087
    • Bodner, M.1    Zhou, Y.D.2    Fuster, J.M.3
  • 38
    • 0032103160 scopus 로고    scopus 로고
    • Effects of ketamine on thought disorder, working memory, and semantic memory in healthy volunteers
    • Adler CM, Goldberg TE, Malhotra AK, Pickar D, Breier A. Effects of ketamine on thought disorder, working memory, and semantic memory in healthy volunteers. Biol Psychiatry. 1998;43:811-816.
    • (1998) Biol Psychiatry. , vol.43 , pp. 811-816
    • Adler, C.M.1    Goldberg, T.E.2    Malhotra, A.K.3    Pickar, D.4    Breier, A.5
  • 39
    • 0028323167 scopus 로고
    • Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses
    • Krystal JH, Karper LP, Seibyl JP, et al. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry. 1994;51:199-214.
    • (1994) Arch Gen Psychiatry. , vol.51 , pp. 199-214
    • Krystal, J.H.1    Karper, L.P.2    Seibyl, J.P.3
  • 40
    • 79960046671 scopus 로고    scopus 로고
    • A computational neuroscience approach to schizophrenia and its onset
    • Rolls ET, Deco G. A computational neuroscience approach to schizophrenia and its onset. Neurosci Biobehav Rev. 2011;35:1644-1653.
    • (2011) Neurosci Biobehav Rev. , vol.35 , pp. 1644-1653
    • Rolls, E.T.1    Deco, G.2
  • 41
    • 0028938076 scopus 로고
    • Cellular basis of working memory
    • Goldman-Rakic PS. Cellular basis of working memory. Neuron. 1995;14:477-485.
    • (1995) Neuron. , vol.14 , pp. 477-485
    • Goldman-Rakic, P.S.1
  • 42
    • 0031774346 scopus 로고    scopus 로고
    • Expression of NMDAR1, GluR1, GluR7, and KA1 glutamate receptor mRNAs is decreased in frontal cortex of "neuroleptic-free" schizophrenics: Evidence on reversible up-regulation by typical neuroleptics
    • Sokolov BP. Expression of NMDAR1, GluR1, GluR7, and KA1 glutamate receptor mRNAs is decreased in frontal cortex of "neuroleptic-free" schizophrenics: evidence on reversible up-regulation by typical neuroleptics. J Neurochem. 1998;71:2454-2464.
    • (1998) J Neurochem. , vol.71 , pp. 2454-2464
    • Sokolov, B.P.1
  • 43
    • 0034843740 scopus 로고    scopus 로고
    • N-methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia
    • Dracheva S, Marras SA, Elhakem SL, Kramer FR, Davis KL, Haroutunian V. N-methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia. Am J Psychiatry. 2001;158:1400-1410.
    • (2001) Am J Psychiatry. , vol.158 , pp. 1400-1410
    • Dracheva, S.1    Marras, S.A.2    Elhakem, S.L.3    Kramer, F.R.4    Davis, K.L.5    Haroutunian, V.6
  • 44
    • 39849085830 scopus 로고    scopus 로고
    • Examining encoding imprecision in spatial working memory in schizophrenia
    • Badcock JC, Badcock DR, Read C, Jablensky A. Examining encoding imprecision in spatial working memory in schizophrenia. Schizophr Res. 2008;100:144-152.
    • (2008) Schizophr Res. , vol.100 , pp. 144-152
    • Badcock, J.C.1    Badcock, D.R.2    Read, C.3    Jablensky, A.4
  • 45
    • 57649128465 scopus 로고    scopus 로고
    • Applying mouse complex-trait resources to behavioural genetics
    • Flint J, Mott R. Applying mouse complex-trait resources to behavioural genetics. Nature. 2008;456:724-727.
    • (2008) Nature. , vol.456 , pp. 724-727
    • Flint, J.1    Mott, R.2
  • 47
    • 84922233014 scopus 로고    scopus 로고
    • A joint history of the nature of genetic variation and the nature of schizophrenia
    • Kendler KS. A joint history of the nature of genetic variation and the nature of schizophrenia. Mol Psychiatry. August 19, 2014. doi:10.1038/mp.2014.94.
    • (2014) Mol Psychiatry. August 19
    • Kendler, K.S.1
  • 48
    • 80052273655 scopus 로고    scopus 로고
    • Exome sequencing supports a de novo mutational paradigm for schizophrenia
    • Xu B, Roos JL, Dexheimer P, et al. Exome sequencing supports a de novo mutational paradigm for schizophrenia. Nat Genet. 2011;43:864-868.
    • (2011) Nat Genet. , vol.43 , pp. 864-868
    • Xu, B.1    Roos, J.L.2    Dexheimer, P.3
  • 49
    • 84884671572 scopus 로고    scopus 로고
    • What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn
    • Kendler KS. What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn. Mol Psychiatry. 2013;18:1058-1066.
    • (2013) Mol Psychiatry. , vol.18 , pp. 1058-1066
    • Kendler, K.S.1
  • 50
    • 84859185055 scopus 로고    scopus 로고
    • From circuits to behavior: A bridge too far?
    • Carandini M. From circuits to behavior: A bridge too far? Nat Neurosci. 2012;15:507-509.
    • (2012) Nat Neurosci. , vol.15 , pp. 507-509
    • Carandini, M.1
  • 51
    • 84866554321 scopus 로고    scopus 로고
    • Re-socializing psychiatry: Critical neuroscience and the limits of reductionism
    • Choudhury S, Slaby J, eds. Chichester, UK: Wiley-Blackwell
    • Kirmayer L, Gold I. Re-socializing psychiatry: critical neuroscience and the limits of reductionism. In: Choudhury S, Slaby J, eds. Critical Neuroscience: A Handbook of the Social and Cultural Contexts of Neuroscience. Chichester, UK: Wiley-Blackwell; 2011:303-330.
    • (2011) Critical Neuroscience: A Handbook of the Social and Cultural Contexts of Neuroscience , pp. 303-330
    • Kirmayer, L.1    Gold, I.2
  • 53
    • 27644535194 scopus 로고    scopus 로고
    • Psychiatry as a clinical neuroscience discipline
    • Insel TR, Quirion R. Psychiatry as a clinical neuroscience discipline. JAMA. 2005;294:2221-2224.
    • (2005) JAMA. , vol.294 , pp. 2221-2224
    • Insel, T.R.1    Quirion, R.2
  • 54
    • 0034702026 scopus 로고    scopus 로고
    • Disruption of two novel genes by a translocation co-segregating with schizophrenia
    • Millar JK, Wilson-Annan JC, Anderson S, et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet. 2000;9:1415-1423.
    • (2000) Hum Mol Genet. , vol.9 , pp. 1415-1423
    • Millar, J.K.1    Wilson-Annan, J.C.2    Anderson, S.3
  • 55
    • 84868337361 scopus 로고    scopus 로고
    • Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
    • Morris AP, Voight BF, Teslovich TM, et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet. 2012;44:981-990.
    • (2012) Nat Genet. , vol.44 , pp. 981-990
    • Morris, A.P.1    Voight, B.F.2    Teslovich, T.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.