Effects of ketamine on thought disorder, working memory, and semantic memory in healthy volunteers

Biological Psychiatry

Volumn 43, Issue 11, 1998, Pages 811-816

  Adler, Caleb M ^a   Goldberg, Terry E ^b   Malhotra, Anil K ^a   Pickar, David ^a   Breier, Alan ^a  

^a Experimental Therapeutics Branch   (United States)

^b Clinical Brain Disorders Branch   (United States)

Author keywords

Cognition; Ketamine; N methyl D aspartate; Thought disorder; Working memory

Indexed keywords

KETAMINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ADULT; AMNESIA; ARTICLE; CLINICAL TRIAL; COGNITIVE DEFECT; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; THOUGHT DISORDER; WORKING MEMORY;

ADULT; BRAIN; DOUBLE-BLIND METHOD; FEMALE; HUMANS; KETAMINE; MALE; MENTAL RECALL; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; RECEPTORS, N-METHYL-D-ASPARTATE; RETENTION (PSYCHOLOGY); THINKING; VERBAL BEHAVIOR; VERBAL LEARNING;

EID: 0032103160     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(97)00556-8     Document Type: Article

References (23)

1. Andreasen N.C. The Scale for the Assessment of Thought, Language, and Communication (TLC). 1978;The University of Iowa, Iowa City, IA.
2. Axelrod B.N., Goldman R.S., Tompkins L.M., Jiron C.C. Poor differential performance on the Wisconsin card sorting test in schizophrenia, mood disorder, and traumatic brain injury. Neuropsychiatry Neuropsychol Behav Neurol. 7:1994;20-24.
3. Ban T.A., Lohrenz J.J., Lehmann H.E. Observations on the action of Sernyl - A new psychotropic drug. Can J Psychiatry. 6:1961;150-157.
4. Benton A.L., Hamsher K.D.S. Multilingual Aphasia Examination. 1976;University of Iowa Press, Iowa City, IA.
5. Callicott J.H., Ramsey M.F., Tallent K., Bertolino A., Knable B., Coppola R.C., et al. fMRI brain mapping in psychiatry Methodologic issues illustrated in a study of working memory in schizophrenia . Neuropsychopharmacology. 18:1998;186-196.
6. Davies B.M., Beech H.R. The effect of 1-arylcyclohexylamine (Sernyl) on twelve normal volunteers. J Ment Sci. 106:1960;912-924.
7. Ghoneim M.M., Hinrichs J.V., Mewaldt S.P., Peterson R.C. Ketamine Behavioral effects of subanesthetic doses . J Clin Psychopharmacol. 5:1985;70-77.
8. Goldberg T.E., Weinberger D.R. Thought disorder, working memory and attention Interrelationships and the effects of neuroleptic medications . Int Clin Psychopharmacol. 10:(suppl 3):1995;99-104.
9. Goldman-Rakic P.S. Working memory dysfunction in schizophrenia. J Neuropsychiatry Clin Neurosci. 6:1994;348-357.
10. Harvey P.D., Lenzenweger M.F., Keefe R.S., Pogge D.L., Serper M.R., Mohs R.C. Empirical assessment of the factorial structure of clinical symptoms in schizophrenic patients Formal thought disorder . Psychiatry Res. 44:1992;141-151.
11. Hedlund J.L., Vieweg B.W. The brief psychiatric rating scale (BPRS) A comprehensive review . J Oper Psychiatry. 11:1980;48-64.
12. Kerwin R., Patel S., Meldrum B.S., Czudek C., Reynolds G.P. Asymmetrical loss of glutamate receptor subtype in left hippocampus in schizophrenia. Lancet. 12:1988;25-32.
13. Kim J.S., Kornhuber H.H., Holzmuller B., Schmid-Burgk W., Mergner T., Krzepinski G. Reduction of cerebrospinal fluid glutamic acid in Huntington's chorea and in schizophrenic patients. Arch Psychiatr Nervenkr. 228:1980;7-10.
14. 3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients. J Neural Transm. 77:1989;231-236.
15. Krystal J.H., Karper L.P., Seibyl J.P., Freeman G.K., Delaney R., Bremner J.D., et al. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans Psychotomimetic, perceptual, cognitive, and neuroendocrine responses . Arch Gen Psychiatry. 51:1994;199-214.
16. LaPorte D.J., Lahti A.C., Koffel B., Tamminga C.A. Absence of ketamine effects on memory and other cognitive functions in schizophrenic patients. J Psychiatr Res. 30:1996;321-330.
17. Luby E.D., Cohen B.D., Rosenbaum G., Gottlieb J.S., Kelly R. Study of a new schizophrenomimetic drug - Sernyl. Arch Neurol Psychiatry. 81:1959;363-369.
18. Malhotra A.K., Pinals D.A., Weingartner H., Sirocco K., Missar C.D., Pickar D., et al. NMDA receptor function and human cognition The effects of ketamine in healthy volunteers . Neuropsychopharmacology. 14:1996;301-307.
19. Malhotra A.K., Pinals D.A., Adler C.M., Elman I., Clifton A., Pickar D., et al. Ketamine-induced exacerbation or psychotic symptoms and cognitive impairment in neuroseptic-free schizophrenics. Neuropsychopharmacology. 17:1997;141-150.
20. Olney J.W., Farber N.B. Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry. 52:1995;998-1007.
21. Olney J.W., Labruyere J., Price M.T. Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science. 244:1989;1360-1362.
22. Overall J.E., Gorham D.R. The brief psychiatric rating scale. Psychol Rep. 10:1962;799-812.
23. Talland G.A. Deranged Memory. 1965;Academic Press, New York.