Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis

Human Molecular Genetics

Volumn 24, Issue 14, 2015, Pages 4006-4023

  Kozol, Robert A ^a   Cukier, Holly N ^b   Zou, Bing ^a   Mayo, Vera ^b   De Rubeis, Silvia ^c   Cai, Guiqing ^c   Griswold, Anthony J ^b   Whitehead, Patrice L ^b   Haines, Jonathan L ^d   Gilbert, John R ^b   Cuccaro, Michael L ^b   Martin, Eden R ^b   Baker, James D ^a   Buxbaum, Joseph D ^c   Pericak Vance, Margaret A ^b   Dallman, Julia E ^a  

^a University of Miami   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; SCAFFOLD PROTEIN; SHANK3 PROTEIN; SYNGAP1 PROTEIN; UNCLASSIFIED DRUG; NERVE PROTEIN; SHANK3 PROTEIN, ZEBRAFISH; SYNGAP1 PROTEIN, RAT; SYNGAP1 PROTEIN, ZEBRAFISH; ZEBRAFISH PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTISM; BEHAVIOR; BEHAVIOR CHANGE; BRAIN DEVELOPMENT; CELL DEATH; COMPULSION; CONTROLLED STUDY; EMBRYO; EXON SKIPPING; FOREBRAIN; GENE MUTATION; GENE SILENCING; INTELLECTUAL IMPAIRMENT; INTRON RETENTION; LOCOMOTION; MORPHOGENESIS; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; NONVERBAL COMMUNICATION; NUCLEOTIDE SEQUENCE; PHENOTYPE; PHYLOGENETIC TREE; POSTSYNAPTIC DENSITY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RHOMBENCEPHALON; SENSORY NERVE CELL; SOCIAL INTERACTION; SYNAPTOGENESIS; ZEBRA FISH; ANIMAL; BRAIN; EMBRYO DEVELOPMENT; EMBRYOLOGY; GENE DUPLICATION; GENE EXPRESSION REGULATION; GENETIC DATABASE; GENETICS; HAPLOINSUFFICIENCY; METABOLISM; ORGANOGENESIS;

DANIO RERIO;

ANIMALS; AUTISM SPECTRUM DISORDER; BRAIN; DATABASES, GENETIC; EMBRYONIC DEVELOPMENT; GENE DUPLICATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKDOWN TECHNIQUES; GTPASE-ACTIVATING PROTEINS; HAPLOINSUFFICIENCY; NERVE TISSUE PROTEINS; ORGANOGENESIS; PHENOTYPE; RAS GTPASE-ACTIVATING PROTEINS; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84936770611     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv138     Document Type: Article

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