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Volumn 74, Issue 2, 2011, Pages 165-175

The Influence of Low Oxygen on Macrophage Response to Leishmania Infection

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; EBSELEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; NITRIC OXIDE; OXYGEN; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

EID: 79960086262     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2011.02566.x     Document Type: Article
Times cited : (39)

References (50)
  • 1
    • 0041382820 scopus 로고    scopus 로고
    • The hypoxic response of tumors is dependent on their microenvironment
    • Blouw B, Song H, Tihan T et al. The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell 2003;4:133-46.
    • (2003) Cancer Cell , vol.4 , pp. 133-146
    • Blouw, B.1    Song, H.2    Tihan, T.3
  • 2
    • 28444483921 scopus 로고    scopus 로고
    • Cellular response to tissue hypoxia and its involvement in disease progression
    • Ikeda E. Cellular response to tissue hypoxia and its involvement in disease progression. Pathol Int 2005;55:603-10.
    • (2005) Pathol Int , vol.55 , pp. 603-610
    • Ikeda, E.1
  • 4
    • 27744603002 scopus 로고    scopus 로고
    • Hypoxia regulates macrophage functions in inflammation
    • Murdoch C, Muthana M, Lewis CE. Hypoxia regulates macrophage functions in inflammation. J Immunol 2005;175:6257-63.
    • (2005) J Immunol , vol.175 , pp. 6257-6263
    • Murdoch, C.1    Muthana, M.2    Lewis, C.E.3
  • 5
    • 70249099576 scopus 로고    scopus 로고
    • Interdependence of hypoxic and innate immune responses
    • Nizet V, Johnson RS. Interdependence of hypoxic and innate immune responses. Nat Rev Immunol 2009;9:609-17.
    • (2009) Nat Rev Immunol , vol.9 , pp. 609-617
    • Nizet, V.1    Johnson, R.S.2
  • 6
    • 36849076158 scopus 로고    scopus 로고
    • Hypoxia inducible factor (HIF) function in innate immunity and infection
    • Zinkernagel AS, Johnson RS, Nizet V. Hypoxia inducible factor (HIF) function in innate immunity and infection. J Mol Med 2007;85:1339-46.
    • (2007) J Mol Med , vol.85 , pp. 1339-1346
    • Zinkernagel, A.S.1    Johnson, R.S.2    Nizet, V.3
  • 7
    • 3142714282 scopus 로고    scopus 로고
    • Effect of hypoxia on macrophage infection by Leishmania amazonensis
    • Colhone MC, Arrais-Silva WW, Picoli C, Giorgio S. Effect of hypoxia on macrophage infection by Leishmania amazonensis. J Parasitol 2004;90:510-5.
    • (2004) J Parasitol , vol.90 , pp. 510-515
    • Colhone, M.C.1    Arrais-Silva, W.W.2    Picoli, C.3    Giorgio, S.4
  • 8
    • 10844232932 scopus 로고    scopus 로고
    • Hypoxia modulates expression of the 70-kD heat shock protein and reduces Leishmania infection in macrophages
    • Degrossoli A, Colhone MC, Arrais-Silva WW, Giorgio S. Hypoxia modulates expression of the 70-kD heat shock protein and reduces Leishmania infection in macrophages. J Biomed Sci 2004;11:847-54.
    • (2004) J Biomed Sci , vol.11 , pp. 847-854
    • Degrossoli, A.1    Colhone, M.C.2    Arrais-Silva, W.W.3    Giorgio, S.4
  • 9
    • 33846130929 scopus 로고    scopus 로고
    • Functional alterations in macrophages after hypoxia selection
    • Degrossoli A, Giorgio S. Functional alterations in macrophages after hypoxia selection. Exp Biol Med (Maywood) 2007;232:88-95.
    • (2007) Exp Biol Med (Maywood) , vol.232 , pp. 88-95
    • Degrossoli, A.1    Giorgio, S.2
  • 10
    • 36549027339 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1alpha in mononuclear phagocytes infected with Leishmania amazonensis
    • Degrossoli A, Bosetto MC, Lima CB, Giorgio S. Expression of hypoxia-inducible factor 1alpha in mononuclear phagocytes infected with Leishmania amazonensis. Immunol Lett 2007;114:119-25.
    • (2007) Immunol Lett , vol.114 , pp. 119-125
    • Degrossoli, A.1    Bosetto, M.C.2    Lima, C.B.3    Giorgio, S.4
  • 11
    • 16644389653 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1alpha in the cutaneous lesions of BALB/c mice infected with Leishmania amazonensis
    • Arrais-Silva WW, Paffaro VA Jr, Yamada AT, Giorgio S. Expression of hypoxia-inducible factor-1alpha in the cutaneous lesions of BALB/c mice infected with Leishmania amazonensis. Exp Mol Pathol 2005;78:49-54.
    • (2005) Exp Mol Pathol , vol.78 , pp. 49-54
    • Arrais-Silva, W.W.1    Paffaro Jr, V.A.2    Yamada, A.T.3    Giorgio, S.4
  • 12
    • 0027317582 scopus 로고
    • Leishmaniases of the New World: current concepts and implications for future research
    • Grimaldi G Jr, Tesh RB. Leishmaniases of the New World: current concepts and implications for future research. Clin Microbiol Rev 1993;6:230-50.
    • (1993) Clin Microbiol Rev , vol.6 , pp. 230-250
    • Grimaldi Jr, G.1    Tesh, R.B.2
  • 13
    • 79960077595 scopus 로고    scopus 로고
    • Immunological perspectives of leishmaniasis
    • Nylén S, Gautam S. Immunological perspectives of leishmaniasis. J Glob Infect Dis 2010;2:135-46.
    • (2010) J Glob Infect Dis , vol.2 , pp. 135-146
    • Nylén, S.1    Gautam, S.2
  • 14
    • 0027255711 scopus 로고
    • Glycosphingolipid antigens of Leishmania (Leishmania) amazonensis amastigotes identified by use of a monoclonal antibody
    • Barbieri CL, Giorgio S, Merjan AJ, Figueiredo EN. Glycosphingolipid antigens of Leishmania (Leishmania) amazonensis amastigotes identified by use of a monoclonal antibody. Infect Immun 1993;61:2131-7.
    • (1993) Infect Immun , vol.61 , pp. 2131-2137
    • Barbieri, C.L.1    Giorgio, S.2    Merjan, A.J.3    Figueiredo, E.N.4
  • 15
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 16
    • 0036829586 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine on macrophage and lymphocyte functions in a mouse model of premature ageing
    • Puerto M, Guayerbas N, Víctor V, De la Fuente M. Effects of N-acetylcysteine on macrophage and lymphocyte functions in a mouse model of premature ageing. Pharmacol Biochem Behav 2002;73:797-804.
    • (2002) Pharmacol Biochem Behav , vol.73 , pp. 797-804
    • Puerto, M.1    Guayerbas, N.2    Víctor, V.3    De la Fuente, M.4
  • 17
    • 0038635950 scopus 로고    scopus 로고
    • Cytoprotection against oxidative stress and the regulation of glutathione synthesis
    • Dickinson DA, Moellering DR, Iles KE et al. Cytoprotection against oxidative stress and the regulation of glutathione synthesis. Biol Chem 2003;384:527-37.
    • (2003) Biol Chem , vol.384 , pp. 527-537
    • Dickinson, D.A.1    Moellering, D.R.2    Iles, K.E.3
  • 18
    • 0032955320 scopus 로고    scopus 로고
    • Protective effect of ebselen against hydrogen peroxide-induced cytotoxicity and DNA damage in HepG2 cells
    • Yang CF, Shen HM, Ong CN. Protective effect of ebselen against hydrogen peroxide-induced cytotoxicity and DNA damage in HepG2 cells. Biochem Pharmacol 1999;57:273-9.
    • (1999) Biochem Pharmacol , vol.57 , pp. 273-279
    • Yang, C.F.1    Shen, H.M.2    Ong, C.N.3
  • 19
    • 0034534165 scopus 로고    scopus 로고
    • Antioxidant function of thioredoxin and glutaredoxin systems
    • Holmgren A. Antioxidant function of thioredoxin and glutaredoxin systems. Antioxid Redox Signal 2000;2:811-20.
    • (2000) Antioxid Redox Signal , vol.2 , pp. 811-820
    • Holmgren, A.1
  • 20
    • 0024509987 scopus 로고
    • Surface Acid Proteinase (gp63) of Leishmania mexicana a metalloenzyme capable of protecting liposome-encapsulated proteins from phagolysosomal degradation by macrophages
    • Chaudhuri G, Chauduri M, Pan A, Chang K-P. Surface Acid Proteinase (gp63) of Leishmania mexicana a metalloenzyme capable of protecting liposome-encapsulated proteins from phagolysosomal degradation by macrophages. J Biol Chem 1989;264:7483-9.
    • (1989) J Biol Chem , vol.264 , pp. 7483-7489
    • Chaudhuri, G.1    Chauduri, M.2    Pan, A.3    Chang, K.-P.4
  • 21
    • 55849131057 scopus 로고    scopus 로고
    • In vitro activities of ER-119884 and E5700, two potent squalene synthase inhibitors, against Leishmania amazonensis: antiproliferative, biochemical, and ultrastructural effects
    • Rodrigues JCF, Concepcion JL, Rodrigues C, Caldera A, Urbina JA, Souza W. In vitro activities of ER-119884 and E5700, two potent squalene synthase inhibitors, against Leishmania amazonensis: antiproliferative, biochemical, and ultrastructural effects. Antimicrob Agents Chemother 2008;2:4098-114.
    • (2008) Antimicrob Agents Chemother , vol.2 , pp. 4098-4114
    • Rodrigues, J.C.F.1    Concepcion, J.L.2    Rodrigues, C.3    Caldera, A.4    Urbina, J.A.5    Souza, W.6
  • 22
    • 2442657704 scopus 로고    scopus 로고
    • Biological and ultrastructural effetcs of the anti-microtubule agent taxol against Trypanosoma cruzi
    • Dantas AP, Barbosa HS, de Castro SL. Biological and ultrastructural effetcs of the anti-microtubule agent taxol against Trypanosoma cruzi. J Submicrosc Cytol Pathol 2003;35:287-94.
    • (2003) J Submicrosc Cytol Pathol , vol.35 , pp. 287-294
    • Dantas, A.P.1    Barbosa, H.S.2    de Castro, S.L.3
  • 23
    • 41149117388 scopus 로고    scopus 로고
    • Inhibition of in vivo leishmanicidal mechanisms by tempol: nitric oxide down-regulation and oxidant scavenging
    • Linares E, Giorgio S, Augusto O. Inhibition of in vivo leishmanicidal mechanisms by tempol: nitric oxide down-regulation and oxidant scavenging. Free Radic Biol Med 2008;44:1668-76.
    • (2008) Free Radic Biol Med , vol.44 , pp. 1668-1676
    • Linares, E.1    Giorgio, S.2    Augusto, O.3
  • 24
    • 0036397097 scopus 로고    scopus 로고
    • Macrophage-mediated innate host defense against protozoan parasites
    • Stafford JL, Neumann NF, Belosevic M. Macrophage-mediated innate host defense against protozoan parasites. Crit Rev Microbiol 2002;28:187-248.
    • (2002) Crit Rev Microbiol , vol.28 , pp. 187-248
    • Stafford, J.L.1    Neumann, N.F.2    Belosevic, M.3
  • 25
    • 33745125427 scopus 로고    scopus 로고
    • The prevention of the growth of Leishmania major progeny in BALB/c iron-loaded mice: a process coupled to increased oxidative burst, the amplitude and duration of which depend on initial parasite developmental stage and dose
    • Bisti S, Konidou G, Boelaert J, Lebastard M, Soteriadou K. The prevention of the growth of Leishmania major progeny in BALB/c iron-loaded mice: a process coupled to increased oxidative burst, the amplitude and duration of which depend on initial parasite developmental stage and dose. Microbes Infect 2006;8:1464-72.
    • (2006) Microbes Infect , vol.8 , pp. 1464-1472
    • Bisti, S.1    Konidou, G.2    Boelaert, J.3    Lebastard, M.4    Soteriadou, K.5
  • 26
    • 0019471126 scopus 로고
    • Susceptibility of Leishmania to oxygen intermediates and killing by normal macrophages
    • Murray HW. Susceptibility of Leishmania to oxygen intermediates and killing by normal macrophages. J Exp Med 1981;153:1302-15.
    • (1981) J Exp Med , vol.153 , pp. 1302-1315
    • Murray, H.W.1
  • 27
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-γ: an overview of signals, mechanisms and functions
    • Schroder K, Hertzog PJ, Ravasi Y, Hume DA. Interferon-γ: an overview of signals, mechanisms and functions. J Leukoc Biol 2004;75:163-89.
    • (2004) J Leukoc Biol , vol.75 , pp. 163-189
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, Y.3    Hume, D.A.4
  • 28
    • 0026823339 scopus 로고
    • Phagocytosis and ATP levels in alveolar macrophages during acute hypoxia
    • Leeper-Woodford SK, Mills JW. Phagocytosis and ATP levels in alveolar macrophages during acute hypoxia. Am J Respir Cell Mol Biol 1992;6:326-34.
    • (1992) Am J Respir Cell Mol Biol , vol.6 , pp. 326-334
    • Leeper-Woodford, S.K.1    Mills, J.W.2
  • 29
    • 0036081335 scopus 로고    scopus 로고
    • Nitric oxide-mediated proteasome-dependent oligonucleosomal DNA fragmentation in Leishmania amazonensis amastigotes
    • Holzmuller P, Sereno D, Cavaleyra M et al. Nitric oxide-mediated proteasome-dependent oligonucleosomal DNA fragmentation in Leishmania amazonensis amastigotes. Infect Immun 2002;70:3727-35.
    • (2002) Infect Immun , vol.70 , pp. 3727-3735
    • Holzmuller, P.1    Sereno, D.2    Cavaleyra, M.3
  • 30
    • 52749091889 scopus 로고    scopus 로고
    • Monocytes and dendritic cells in a hypoxic environment: spotlights on chemotaxis and migration
    • Bosco MC, Puppo M, Blengio F et al. Monocytes and dendritic cells in a hypoxic environment: spotlights on chemotaxis and migration. Immunobiology 2008;213:733-49.
    • (2008) Immunobiology , vol.213 , pp. 733-749
    • Bosco, M.C.1    Puppo, M.2    Blengio, F.3
  • 31
    • 0035879106 scopus 로고    scopus 로고
    • Oxidative responses of human and murine macrophages during phagocytosis of Leishmania chagasi
    • Gantt KR, Goldman TL, McCormick ML et al. Oxidative responses of human and murine macrophages during phagocytosis of Leishmania chagasi. J Immunol 2001;167:893-901.
    • (2001) J Immunol , vol.167 , pp. 893-901
    • Gantt, K.R.1    Goldman, T.L.2    McCormick, M.L.3
  • 32
    • 78349265397 scopus 로고    scopus 로고
    • Reactive oxygen species mediate human hepatocyte injury during hypoxia/reoxygenation
    • Bhogal RH, Curbishley SM, Weston CJ, Adams DH, Afford SC. Reactive oxygen species mediate human hepatocyte injury during hypoxia/reoxygenation. Liver Transpl 2010;16:1303-13.
    • (2010) Liver Transpl , vol.16 , pp. 1303-1313
    • Bhogal, R.H.1    Curbishley, S.M.2    Weston, C.J.3    Adams, D.H.4    Afford, S.C.5
  • 33
    • 78549282806 scopus 로고    scopus 로고
    • Hypoxia increases the dependence of glioma cells on glutathione
    • Ogunrinu TA, Sontheimer H. Hypoxia increases the dependence of glioma cells on glutathione. J Biol Chem 2010;285:37716-24.
    • (2010) J Biol Chem , vol.285 , pp. 37716-37724
    • Ogunrinu, T.A.1    Sontheimer, H.2
  • 34
    • 0010471495 scopus 로고
    • Cellular defenses against damage from reactive oxygen species
    • Yu BP. Cellular defenses against damage from reactive oxygen species. Physiol Rev 1994;74:139-62.
    • (1994) Physiol Rev , vol.74 , pp. 139-162
    • Yu, B.P.1
  • 35
    • 24344438196 scopus 로고    scopus 로고
    • Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression
    • Kietzmann T, Gorlach A. Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression. Semin Cell Dev Biol 2005;16:474-86.
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 474-486
    • Kietzmann, T.1    Gorlach, A.2
  • 36
    • 33748121115 scopus 로고    scopus 로고
    • Interleukin-6 and chronic inflammation
    • Gabay C. Interleukin-6 and chronic inflammation. Arthritis Res Ther 2006;8:S3-8.
    • (2006) Arthritis Res Ther , vol.8
    • Gabay, C.1
  • 37
    • 78149413180 scopus 로고    scopus 로고
    • Interleukin 6 mediated recruitment of mesenchymal stem cells to the hypoxic tumor milieu
    • Rattigan Y, Hsu JM, Mishra PJ, Glod J, Banerjee D. Interleukin 6 mediated recruitment of mesenchymal stem cells to the hypoxic tumor milieu. Exp Cell Res 2010;316:3417-24.
    • (2010) Exp Cell Res , vol.316 , pp. 3417-3424
    • Rattigan, Y.1    Hsu, J.M.2    Mishra, P.J.3    Glod, J.4    Banerjee, D.5
  • 38
    • 0027186304 scopus 로고
    • IL-6 down-modulates the cytokine-enhanced antileishmanial activity in human macrophages
    • Hatzigeorgiou DE, He S, Sobel J, Grabstein KH, Hafner A, Ho JL. IL-6 down-modulates the cytokine-enhanced antileishmanial activity in human macrophages. J Immunol 1993;151:3682-92.
    • (1993) J Immunol , vol.151 , pp. 3682-3692
    • Hatzigeorgiou, D.E.1    He, S.2    Sobel, J.3    Grabstein, K.H.4    Hafner, A.5    Ho, J.L.6
  • 39
    • 0033030090 scopus 로고    scopus 로고
    • Acute hypoxia increases alveolar macrophage tumor necrosis factor activity and alters NF-kappaB expression
    • Leeper-Woodford SK, Detmer K. Acute hypoxia increases alveolar macrophage tumor necrosis factor activity and alters NF-kappaB expression. Am J Physiol 1999;276:L909-16.
    • (1999) Am J Physiol , vol.276
    • Leeper-Woodford, S.K.1    Detmer, K.2
  • 40
    • 0034772051 scopus 로고    scopus 로고
    • Receptor-mediated phagocytosis of rat macrophages is regulated differentially for opsonized particles and non-opsonized particles containing beta-glucan
    • Reichner JS, Fitzpatrick PA, Wakshull E, Albina JE. Receptor-mediated phagocytosis of rat macrophages is regulated differentially for opsonized particles and non-opsonized particles containing beta-glucan. Immunology 2001;104:198-206.
    • (2001) Immunology , vol.104 , pp. 198-206
    • Reichner, J.S.1    Fitzpatrick, P.A.2    Wakshull, E.3    Albina, J.E.4
  • 41
    • 0019984423 scopus 로고
    • In vitro parasite-monocyte interactions in human leishmaniasis. Evidence for an active role of the parasite in attachment
    • Wyler DJ. In vitro parasite-monocyte interactions in human leishmaniasis. Evidence for an active role of the parasite in attachment. J Clin Invest 1982;70:82-8.
    • (1982) J Clin Invest , vol.70 , pp. 82-88
    • Wyler, D.J.1
  • 42
    • 0035958961 scopus 로고    scopus 로고
    • Regulation of energy metabolism in macrophages during hypoxia. Roles of fructose 2,6-bisphosphate and ribose 1,5-bisphosphate
    • Kawaguchi T, Veech RL, Uyeda K. Regulation of energy metabolism in macrophages during hypoxia. Roles of fructose 2, 6-bisphosphate and ribose 1, 5-bisphosphate. J Biol Chem 2001;276:28554-61.
    • (2001) J Biol Chem , vol.276 , pp. 28554-28561
    • Kawaguchi, T.1    Veech, R.L.2    Uyeda, K.3
  • 44
    • 0037338413 scopus 로고    scopus 로고
    • Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia
    • Vijayasarathy C, Damle S, Prabu SK, Otto CM, Avadhani NG. Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia. Eur J Biochem 2003;270:871-9.
    • (2003) Eur J Biochem , vol.270 , pp. 871-879
    • Vijayasarathy, C.1    Damle, S.2    Prabu, S.K.3    Otto, C.M.4    Avadhani, N.G.5
  • 45
    • 3342943546 scopus 로고    scopus 로고
    • Possible mechanism of miltefosine-mediated death of Leishmania donovani
    • Verma NK, Dey CS. Possible mechanism of miltefosine-mediated death of Leishmania donovani. Antimicrob Agents Chemother 2004;48:3010-5.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3010-3015
    • Verma, N.K.1    Dey, C.S.2
  • 46
    • 0042090390 scopus 로고    scopus 로고
    • 2+ through non-selective cation channels in the host and the parasite is responsible for apoptosis of intracellular Leishmania donovani amastigotes
    • 2+ through non-selective cation channels in the host and the parasite is responsible for apoptosis of intracellular Leishmania donovani amastigotes. J Biol Chem 2003;278:25120-32.
    • (2003) J Biol Chem , vol.278 , pp. 25120-25132
    • Sudhandiran, G.1    Shaha, C.2
  • 47
    • 77955384915 scopus 로고    scopus 로고
    • Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens
    • Werth N, Beerlage C, Rosenberger C et al. Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens. PLoS ONE 2010;5:e11576.
    • (2010) PLoS ONE , vol.5
    • Werth, N.1    Beerlage, C.2    Rosenberger, C.3
  • 48
    • 40949088476 scopus 로고    scopus 로고
    • Biology of hypoxia-inducible factor 2α in the development and disease
    • Patel SA, Simon MC. Biology of hypoxia-inducible factor 2α in the development and disease. Cell Death Differ 2008;15:628-34.
    • (2008) Cell Death Differ , vol.15 , pp. 628-634
    • Patel, S.A.1    Simon, M.C.2
  • 49
    • 78349272461 scopus 로고    scopus 로고
    • HIF-1 and HIF-2 transcription factors- similar but not identical
    • Loboda A, Jozkowicz A, Dulak J. HIF-1 and HIF-2 transcription factors- similar but not identical. Mol Cells 2010;29:435-42.
    • (2010) Mol Cells , vol.29 , pp. 435-442
    • Loboda, A.1    Jozkowicz, A.2    Dulak, J.3
  • 50
    • 33644822240 scopus 로고    scopus 로고
    • The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels
    • Spear W, Chan D, Coppens I, Johnson RS, Giaccia A, Blader IJ. The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels. Cell Microbiol 2006;8:339-52.
    • (2006) Cell Microbiol , vol.8 , pp. 339-352
    • Spear, W.1    Chan, D.2    Coppens, I.3    Johnson, R.S.4    Giaccia, A.5    Blader, I.J.6


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