Differential role of "signal 3" inflammatory cytokines in regulating CD8 T cell expansion and differentiation in vivo

Frontiers in Immunology

Volumn 2, Issue FEB, 2011, Pages

  Pham, Nhat Long L ^a   Badovinac, Vladimir P ^b   Harty, John T ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Inflammatory cytokines; Memory CD8 T cells

Indexed keywords

EID: 84855873001     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2011.00004     Document Type: Article

References (33)

1. Agarwal, P., Raghavan, A., Nandiwada, S. L., Curtsinger, J. M., Bohjanen, P. R., Mueller, D. L., and Mescher, M. F. (2009). Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory. J. Immunol. 183, 1695-1704.
2. Aichele, P., Unsoeld, H., Koschella, M., Schweier, O., Kalinke, U., and Vucikuja, S. (2006). CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion. J. Immunol. 176, 4525-4529.
3. Badovinac, V. P., Haring, J. S., and Harty, J. T. (2007). Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection. Immunity 26, 827-841.
4. Badovinac, V. P., and Harty, J. T. (2006). Programming, demarcating, and manipulating CD8+T-cell memory. Immunol. Rev. 211, 67-80.
5. Badovinac, V. P., Messingham, K. A., Hamilton, S. E., and Harty, J. T. (2003). Regulation of CD8+T cells undergoing primary and secondary responses to infection in the same host. J. Immunol. 170, 4933-4942.
6. Badovinac, V. P., Messingham, K. A., Jabbari, A., Haring, J. S., and Harty, J. T. (2005). Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination. Nat. Med. 11, 748-756.
7. Badovinac, V. P., Porter, B. B., and Harty, J. T. (2002). Programmed contraction of CD8(+) T cells after infection. Nat. Immunol. 3, 619-626.
8. Bevan, M. J., and Fink, P. J. (2001). The CD8 response on autopilot. Nat. Immunol. 2, 381-382.
9. Blattman, J. N., Antia, R., Sourdive, D. J., Wang, X., Kaech, S. M., Murali-Krishna, K., Altman, J. D., and Ahmed, R. (2002). Estimating the precursor frequency of naive antigen-specific CD8 T cells. J. Exp. Med. 195, 657-664.
10. Cui, W., Joshi, N. S., Jiang, A., and Kaech, S. M. (2009). Effects of signal 3 during CD8 T cell priming: bystander production of IL-12 enhances effector T cell expansion but promotes terminal differentiation. Vaccine 27, 2177-2187.
11. Curtsinger, J. M., Lins, D. C., and Mescher, M. F. (2003). Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function. J. Exp. Med. 197, 1141-1151.
12. Curtsinger, J. M., Schmidt, C. S., Mondino, A., Lins, D. C., Kedl, R. M., Jenkins, M. K., and Mescher, M. F. (1999). Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells. J. Immunol. 162, 3256-3262.
13. Curtsinger, J. M., Valenzuela, J. O., Agarwal, P., Lins, D., and Mescher, M. F. (2005). Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation. J. Immunol. 174, 4465-4469.
14. Haring, J. S., Badovinac, V. P., and Harty, J. T. (2006). Inflaming the CD8+ T cell response. Immunity 25, 19-29.
15. Harty, J. T., and Badovinac, V. P. (2008). Shaping and reshaping CD8+ T-cell memory. Nat. Rev. Immunol. 8, 107-119.
16. Hogquist, K. A., Jameson, S. C., Heath, W. R., Howard, J. L., Bevan, M. J., and Carbone, F. R. (1994). T cell receptor antagonist peptides induce positive selection. Cell 76, 17-27.
17. Intlekofer, A. M., Takemoto, N., Kao, C., Banerjee, A., Schambach, F., Northrop, J. K., Shen, H., Wherry, E. J., and Reiner, S. L. (2007). Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+T cells. J. Exp. Med. 204, 2015-2021.
18. Jabbari, A., and Harty, J. T. (2006). Secondary memory CD8+T cells are more protective but slower to acquire a central-memory phenotype. J. Exp. Med. 203, 919-932.
19. Joshi, N. S., Cui, W., Chandele, A., Lee, H. K., Urso, D. R., Hagman, J., Gapin, L., and Kaech, S. M. (2007). Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity 27, 281-295.
20. Kaech, S. M., and Ahmed, R. (2001). Memory CD8+T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol. 2, 415-422.
21. Kaech, S. M., Hemby, S., Kersh, E., and Ahmed, R. (2002a). Molecular and functional profiling of memory CD8 T cell differentiation. Cell 111, 837-851.
22. Kaech, S. M., Wherry, E. J., and Ahmed, R. (2002b). Effector and memory T-cell differentiation: implications for vaccine development. Nat. Rev. Immunol. 2, 251-262.
23. Kolumam, G. A., Thomas, S., Thompson, L. J., Sprent, J., and Murali-Krishna, K. (2005). Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J. Exp. Med. 202, 637-650.
24. Krieg, A. M. (2002). CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20, 709-760.
25. Mescher, M. F., Curtsinger, J. M., Agarwal, P., Casey, K. A., Gerner, M., Hammerbeck, C. D., Popescu, F., and Xiao, Z. (2006). Signals required for programming effector and memory development by CD8+ T cells. Immunol. Rev. 211, 81-92.
26. Pearce, E. L., and Shen, H. (2007). Generation of CD8 T cell memory is regulated by IL-12. J. Immunol. 179, 2074-2081.
27. Pham, N. L., Badovinac, V. P., and Harty, J. T. (2009). A default pathway of memory CD8 T cell differentiation after dendritic cell immunization is deflected by encounter with inflammatory cytokines during antigendriven proliferation. J. Immunol. 183, 2337-2348.
28. Schluns, K. S., and Lefrancois, L. (2003). Cytokine control of memory T-cell development and survival. Nat. Rev. Immunol. 3, 269-279.
29. Takemoto, N., Intlekofer, A. M., Northrup, J. T., Wherry, E. J., and Reiner, S. L. (2006). Cutting edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+T cell differentiation. J. Immunol. 177, 7515-7519.
30. Thompson, L. J., Kolumam, G. A., Thomas, S., and Murali-Krishna, K. (2006). Innate inflammatory signals induced by various pathogens differentially dictate the IFN-I dependence of CD8 T cells for clonal expansion and memory formation. J. Immunol. 177, 1746-1754.
31. van Stipdonk, M. J., Lemmens, E. E., and Schoenberger, S. P. (2001). Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat. Immunol. 2, 423-429.
32. Wherry, E. J., Teichgraber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., and Ahmed, R. (2003). Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat. Immunol. 4, 225-234.
33. Xiao, Z., Casey, K. A., Jameson, S. C., Curtsinger, J. M., and Mescher, M. F. (2009). Programming for CD8 T cell memory development requires IL-12 or type I IFN. J. Immunol. 182, 2786-2794.