Collagenase mRNA overexpression and decreased extracellular matrix components are early events in the pathogenesis of emphysema

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Robertoni, Fabíola S Z ^a   Olivo, Clarice R ^a   Lourenço, Juliana D ^a   Gonçalves, Natália G ^a   Velosa, Ana Paula P ^a   Lin, Chin J ^a   Fló, Cláudia M ^a   Saraiva Romanholo, Beatriz M ^a,b   Sasaki, Sérgio D ^c   Martins, Milton A ^a   Teodoro, Walcy R ^a   Lopes, Fernanda Degobbi T Q S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b MASTERS AND DOCTORAL PROGRAMS IN PHYSICAL THERAPY   (Brazil)

^c UNIVERSIDADE FEDERAL DO ABC   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGENASE; COLLAGENASE 3; ELASTIN; FIBRILLIN; INTERSTITIAL COLLAGENASE; MACROPHAGE ELASTASE; NEUTROPHIL COLLAGENASE; PANCREATIC ELASTASE; MATRIX METALLOPROTEINASE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLLAGEN FIBER; CONTROLLED STUDY; ELASTIC FIBER; EXTRACELLULAR MATRIX; GENE EXPRESSION; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; LUNG EMPHYSEMA; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; POLYMORPHONUCLEAR CELL; ANIMAL; C57BL MOUSE; ENZYMOLOGY; GENETICS; METABOLISM; NEUTROPHIL; PIG;

MUS; SUS;

ANIMALS; COLLAGEN TYPE I; COLLAGEN TYPE III; COLLAGENASES; ELASTIN; EXTRACELLULAR MATRIX; IMMUNOHISTOCHEMISTRY; MATRIX METALLOPROTEINASES; MICE, INBRED C57BL; NEUTROPHILS; PULMONARY EMPHYSEMA; RNA, MESSENGER; SUS SCROFA;

EID: 84936158286     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0129590     Document Type: Article

References (49)

1. Snider GL, Lucy EC, Stone PJ. 1986. Animal models of emphysema. Am. Rev. Respir. Dis. 133: 149-169. PMID: 3510579
2. Stockley RA. 2001. Proteases and antiproteases. Novartis Found. Symp. 234: 189-199. PMID: 11199096
3. 1-Antitrypsin determines the pattern of emphysema and function in tobacco smoke-exposed mice: parallels with human disease. Am. J. Respir. Crit. Care Med. 166: 1596-1603. PMID: 12471075
4. Barnes PJ, Shapiro SD, Pauwels RA. 2003. Chronic obstructive pulmonary disease molecular and cellular mechanisms. Eur. Respir. J. 22: 672-688 PMID: 14582923
5. Ito S, Ingenito EP, Brewer KK, Lauren DB, Harikrishnan P, Lutchen KR, et al. 2005. Mechanics, nonlinearity, and failure strenght of lung tissue in a mouse model of emphysema: possible role of collagen remodeling. J. Appl. Physiol. 98: 503-511. PMID: 15465889
6. Shapiro SD. 1994. Elastolytic metalloproteinases produced by human mononuclear phagocytes: potential roles in destructive lung disease. Am. J. Respir. Crit. Care Med. 150: S160-S164. PMID: 7952653
7. Churg A, Zhou S, Wright JL. 2012. Matrix metalloproteinases in COPD. SERIES "MATRIX METALLOPROTEINASES IN LUNG HEALTH AND DISEASE". Eur. Respir. J. 39: 197-209. doi: 10.1183/09031936.00121611 PMID: 21920892
8. Hautamaki RD, Kobayashi DK, Senior RM, Shapiro SD. 1997. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science. 277(5334): 2002-2004. PMID: 9302297
9. Finlay GA, O'Driscoll LR, Russell KJ, D'Arcy EM, Masterson JB, FitzGerald MX, et al. 1997. Matrix metalloproteinase expression and production by alveolar macrophages in emphysema. Am. J. Respir. Crit. Care Med. 156: 240-247. PMID: 9230755
10. Churg A, Wang R, Wang X, Onnervik PO, Thim K, Wright JL. 2007. Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs. Thorax. 62(8): 706-713. PMID: 17311841
11. Segura-Valdez L, Pardo A, Gaxiola M, Uhal B, Becerril C, Selman M. 2000. Upregulation of gelatinase a and b, collagenases 1 and 2, and increased parenchymal cell death in COPD. Chest. 117: 684-694. PMID: 10712992
12. Imai K, Dalal S, Chen E, Downey R, Schulman L, Ginsburg M, et al. 2001. Human collagenase (matrix metalloproteinase-1) expression in the lungs of patients with emphysema. Am. J. Respir. Crit. Care Med. 163: 786-791. PMID: 11254539
13. Abraham T, Hogg J. 2000. Extracellular matrix remodeling of lung alveolar wall in three dimensional space identified using second harmonic generation and multiphoton excitation fluorescence. J. Structural Biol. 171(2): 189-196.
14. Shifren A, Durmowicz AG, Knutsen RH, Hirano E, Mecham RP. 2007. Elastin protein levels are a vital modifier affecting normal lung development and susceptibility to emphysema. Am. J. Physiol. Lung Cell Mol. Physiol. 292: L778-L787. PMID: 17142349
15. Kuhn C, Yu SY, Chraplyvy M, Linder HE, Senior RM. 1976. The induction of emphysema with elastase. Changes in connective tissue. Lab. Invest. 34: 372-380. PMID: 177809
16. Kononov S, Brewer K, Sakai H, Cavalcante FSA, Sabayanagam CR, Ingenito EP, et al. 2001. Roles of mechanical forces and collagen failure in the development of elastase-induced emphysema. Am. J. Respir. Crit. Care Med. 164: 1920-1926. PMID: 11734447
17. Suki B, Bates JHT. 2008. Extracellular matrix mechanics in lung parenchymal diseases. Respir. Physiolo. Neurobiol. 163(1-3): 33-43.
18. Koenders MM, Wismans RG, Starcher B, Hamel BC, Dekhuijzen RP, van Kuppevelt TH. 2009. Fibrillin-1 staining anomalies are associated with increased staining for TGF-beta and elastic fiber degradation; new clues to the pathogenesis of emphysema. J. Pathol. 218(4): 446-57. doi: 10.1002/path.2548 PMID: 19373854
19. From the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2014. Available from: http://www.goldcopd.org/.
20. Snider GL, Lucey EC, Faris B, Jung-Legg Y, Stone PJ, Franzblau C. 1988. Cadmium-chloride-induced air-space enlargement with interstitial pulmonary fibrosis is not associated with destruction of lung elastin. Implications for the pathogenesis of human emphysema. Am Rev Respir Dis. 137(4): 918-23. PMID: 3355000
21. Stone PJ, Gottlieb DJ, O'Connor GT, Ciccolella DE, Breuer R, Bryan-Rhadfi J, et al. 1995. Elastin and collagen degradation products in urine of smokers with and without chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 151(4): 952-9. PMID: 7697272
22. Vlahovic G, Russel ML, Mercer RR, Crapo JD. 1999. Cellular and connective tissue changes in alveolar septal walls in emphysema. Am. J. Respir. Crit. Care Med. 160: 2086-2092. PMID: 10588633
23. Rubio ML, Martin-Mosquero MC, Ortega M, Peces-Barba G, Gonzáles-Mangado N. 2004. Oral N-Acetylcisteine attenuates elastase-induced pulmonary emphysema in rats. Chest. 125: 1500-1506. PMID: 15078764
24. Churg A, Wang RD, Tai H, Wang X, Xie C, Wright JL. 2004. Tumor Necrosis Factor-α Drives 70% of Cigarette Smoke - induced Emphysema in the Mouse. Am. J. Respir. Crit. Care Med. 170: 492-498. PMID: 15184206
25. Anciães AM, Olivo CR, Prado CM, Kagohara KH, Pinto TS, Moriya HT, et al. 2011. Respiratory mechanics do not always mirror pulmonary histological changes in emphysema. Clinics. 66(10): 1797-1803. PMID: 22012054
26. Lucey EC, Goldstein RH, Stone PJ, Snider GL. 1998. Remodeling of Alveolar Walls after Elastase Treatment of Hamsters. Am. J. Respir. Crit. Care Med. 158: 555-564. PMID: 9700135
27. Kawakami M, Matsuo Y, Yoshiura K, Nagase T, Yamashita N. 2008. Sequential and quantitative analysis of a murine model of elastase-induced emphysema. Biol. Pharm. Bull. 31: 1434-1438. PMID: 18591788
28. Suki B, Stamenovic D, Hubmayr R. 2011. Lung Parenchymal Mechanics. Compr Physiol. 1: 1317-1351. doi: 10.1002/cphy.c100033 PMID: 23733644
29. Kurimoto E, Miyahara N, Kanehiro A, Waseda K, Taniguchi A, Ikeda G, et al. 2013. IL-17A Is Essential To The Development Of Elastase-Induced Pulmonary Inflammation And Emphysema In Mice. Respir. Res. 14: 5. doi: 10.1186/1465-9921-14-5 PMID: 23331548
30. Lourenço JD, Neves LP, Olivo CR, Duran A, Almeida FM, Arantes PMM, et al. 2014. A Treatment with a Protease Inhibitor Recombinant from the Cattle Tick (Rhipicephalus Boophilus microplus) Ameliorates Emphysema in Mice. PLoS ONE 9(6): e98216. doi: 10.1371/journal.pone.0098216 PMID: 24886716
31. Margraf LR, Tomashefski JF, Bruce MC, Dahms BB. 1991. Morphometric analysis of the lung in bronchopulmonary dysplasia. Am Rev. Respir. Dis. 143: 391-400. PMID: 1990959
32. Weibel ER. 1963. Principles and methods for the morphometric study of the lung and other organs. Lab Invest. 12: 131-155. PMID: 13999512
33. Gonçalves CTR, Gonçalves CGR, Almeida FM, Lopes FDTQS, Durão ANCS, Santos FA, et al. 2012. Protective effects of aerobic exercise on acute lung injury induced by LPS in mice. Crit Care. Oct 18; 16(5): R199. doi: 10.1186/cc11807 PMID: 23078757
34. Ramos DS, Olivo CR, Quirino Santos Lopes FD, Toledo AC, Martins MA, Lazo Osório RA, et al. 2010. Low-intensity swimming training partially inhibits lipopolysaccharide-induced acute lung injury. Med Sci Sports Exerc. Jan; 42(1): 113-9. doi: 10.1249/MSS.0b013e3181ad1c72 PMID: 20010123
35. Vieira RP, Toledo AC, Silva LB, Almeida FM, Damaceno-Rodrigues NR, Caldini EG, et al. 2012. Antiinflammatory effects of aerobic exercise in mice exposed to air pollution. Med Sci Sports Exerc. Jul; 44(7): 1227-34. doi: 10.1249/MSS.0b013e31824b2877 PMID: 22297803
36. Spiess K, Teodoro WR, Zorn TMT. 2007. Distribution of collagen types I, III and V in pregnant mouse endometrium. Conective Tissue Res. 48: 99-108. PMID: 17453912
37. ΔΔCt Method. Methods. 25: 402-408. PMID: 11846609
38. Cavarra E, Martorana PA, Gambelli F, de Santi M, van Even P, Lungarella G. 1996. Neutrophil recruitment into the lungs is associated with increased lung elastase burden, decreased lung elastin, and emphysema in alpha 1 proteinase inhibitor-deficient mice. Lab Invest. Aug; 75(2): 273-80. PMID: 8765327
39. Abrams WR, Kucich U, Kimbel P, Glass M, Weinbaum G. 1988. Acute cigarette smoke exposure in dogs: the inflammatory response. Exp Lung Res. 14(4): 459-75. PMID: 3208713
40. Stolk J, Rudolphus A, Davies P, Osinga D, Dijkman JH, Agarwal L, et al. 1992. Induction of emphysema and bronchial mucus cell hyperplasia by intratracheal instillation of lipopolysaccharide in the hamster.J Pathol. Jul; 167(3): 349-56. PMID: 1517904
41. Lang MR, Fiaux GW, Gillooly M, Stewart JA, Hulmes DJ, Lamb D. 1994. Collagen content of alveolar wall tissue in emphysematous and non-emphysematous lungs. Thorax. 49: 319-326. PMID: 8202900
42. Silver FH, Horvath I, Foran DJ. 2002. Mechanical Implications of the Domain Structure of Fiber-Forming Collagens: Comparison of the Molecular and Fibrillar Flexibilities of the α1-Chains Found in Types I-III Collagen. Journal of Theoretical Biology. 216: 243-254 PMID: 12079374
43. Lee EJ, In KH, Kim JH, Lee SY, Shin C, Shim JJ, et al. 2009. Proteomic analysis in lung tissue of smokers and COPD patients. Chest. 135: 344-352. doi: 10.1378/chest.08-1583 PMID: 18753468
44. Betsuyaku T, Nishimura M, Takeyabu K, Tanino M, Venge P, Xu S, et al. 1999. Neutrophil granule proteins in bronchoalveolar lavage fluid from subjects with subclinical emphysema. Am. J. Respir. Crit. Care Med. 159: 1985-1991. PMID: 10351949
45. Shapiro SD, Senior RM. 1999. Matrix metalloproteinases. Matrix degradation and more. Am. J. Respir. Cell Mol. Biol. 20: 1100-1102. PMID: 10340927
46. Ashworth JL, Murphy G, Rock MJ, Sherratt MJ, Shapiro SD, Shuttleworth CA, et al. 1999. Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling. Biochem. J. 340: 171-81. PMID: 10229672
47. Shifren A, Mecham RP. 2006. The Stumbling Block in Lung Repair of Emphysema: Elastic Fiber Assembly. Proc. Am. Thorac. Soc. 3: 428-433. PMID: 16799087
48. D'Armiento J, Dalal SS, Okada Y, Berg RA, Chada K. 1992. Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema. Cell. 71: 955-961. PMID: 1458541
49. Shiomi T, Okada Y, Foronjy R, Schiltz J, Jaenish R, Krane S, et al. 2003. Emphysematous changes are caused by degradation of type III collagen in transgenic mice expressing MMP-1. Exp. Lung. Res. 29: 1-15. PMID: 12775435