Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60% O2-exposed neonatal rats

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 309, Issue 1, 2015, Pages L53-L62

  Masood, Azhar ^a,d   Yi, Man ^b   Belcastro, Rosetta ^a   Li, Jun ^a   Lopez, Lianet ^a   Kantores, Crystal ^a   Jankov, Robert P ^a,c,d   Tanswell, A Keith ^a,c,d  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

BPD; Elastin fragments; Macrophages; Neonatal lung injury; Oxygen toxicity

Indexed keywords

3 NITROTYROSINE; CHEMOKINE RECEPTOR CXCR2 ANTAGONIST; ELAFIN; ELASTIN; LEUKOCYTE ELASTASE; LEUKOCYTE ELASTASE INHIBITOR; OXYGEN; SIVELESTAT; 1-(2-BROMOPHENYL)-3-(7-CYANO-3H-BENZOTRIAZOL-4-YL)UREA; CARBANILAMIDE DERIVATIVE; CHEMOKINE RECEPTOR CXCR2; GLYCINE; PEROXYNITROUS ACID; SULFONAMIDE; TRIAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LUNG ALVEOLUS MACROPHAGE; LUNG HOMOGENATE; LUNG INJURY; LUNG PARENCHYMA; MACROPHAGE MIGRATION; NEUTROPHIL; NEUTROPHIL COUNT; NEWBORN; NONHUMAN; OXYGEN TOXICITY; PREMATURITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL MOTION; ENVIRONMENTAL EXPOSURE; FEMALE; IMMUNOLOGY; LUNG; MACROPHAGE; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; VASCULAR REMODELING;

ANIMALS; ANIMALS, NEWBORN; CELL MOVEMENT; ELAFIN; ELASTIN; FEMALE; GLYCINE; LEUKOCYTE ELASTASE; LUNG; LUNG INJURY; MACROPHAGES; MATERNAL EXPOSURE; NEUTROPHILS; OXYGEN; PEROXYNITROUS ACID; PHENYLUREA COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, INTERLEUKIN-8B; SULFONAMIDES; TRIAZOLES; VASCULAR REMODELING;

EID: 84936155823     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00298.2014     Document Type: Article

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