Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters

American Journal of Respiratory and Critical Care Medicine

Volumn 161, Issue 6, 2000, Pages 2013-2018

  Kawabata, Kazuhito ^a   Hagio, Tetsuya ^a   Matsumoto, Shigeru ^a   Nakao, Shintaro ^a   Orita, Shinichiro ^a   Aze, Yoshiya ^a   Ohno, Hiroyuki ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; ENDOTOXIN; LEUKOCYTE ELASTASE; LEUKOCYTE ELASTASE INHIBITOR; MYELOPEROXIDASE; SIVELESTAT;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; CONTROLLED STUDY; DISEASE COURSE; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; HISTOPATHOLOGY; INFLAMMATORY CELL; LUNG INJURY; LUNG LAVAGE; MALE; NEUTROPHIL; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; SYRIAN HAMSTER;

EID: 0034131354     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.161.6.9904047     Document Type: Article

References (34)

1. 1. Weiner-Kronish, J. P., M. A. Gropper, and M. A. Matthay. 1990. The adult respiratory distress syndrome: definition and prognosis, pathogenesis and treatment. Br. J. Anaesthesia 65:107-129.
2. 2. Artigas, A., G. R. Bernard, J. Carlet, D. Dreyfuss, L. Gattinoni, L. Hudson, M. Lamy, J. J. Marini, M. A. Matthay, M. R. Pinsky, R. Spragg, P. M. Suter, and the Consensus Committee. 1998. Am. J. Respir. Crit. Care Med. 157:1332-1347.
3. 3. Havemann, K., and G. Gramse. 1984. Physiology and pathophysiology of neutral proteinases of human granulocytes. Adv. Exp. Med. Biol. 84:1-20.
4. 4. Suter, P. M., S. Suter, E. Girardin, P. Roux-Lombard, G. E. Grau, and J. M. Dayer. 1992. High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon and elastase in patients with adult respiratory distress syndrome after trauma, shock, or sepsis. Am. Rev. Respir. Dis. 145:1016-1022.
5. 5. Sunnergren, K. P., R. P. Fairman, G. G. de Blois, and F. L. Glauser. 1987. Effects of protamine, heparinase, and hyaluronidase on endothelial cell permeability and surface charge. J. Appl. Physiol. 63:1987-1992.
6. 6. Cepinskas, G., R. Noseworthy, and P. R. Kvietys. 1997. Transendothelial neutrophil migration: role of neutrophil-derived proteases and relationship to transendothelial protein movement. Circ. Res. 81:618-626.
7. 7. Leavell, K. J., M. W. Peterson, and T. J. Gross. 1996. The role of fibrin degradation products in neutrophil recruitment to the lung. Am. J. Respir. Cell Mol. Biol. 14:53-60.
8. 8. Ruef, C., D. M. Jefferson, S. E. Schlegel-Haueter, and S. Suter. 1993. Regulation of cytokine secretion by cystic fibrosis airway epithelial cells. Eur. Respir. J. 6:1429-1436.
9. 9. Ahn, C. M., H. Sandler, M. Glass, and T. Saldeen. 1993. Effect of a synthetic leukocyte elastase inhibitor on thrombin-induced pulmonary edema in the rat. Exp. Lung Res. 19:125-135.
10. 10. Gossage, J. R., Y. Kuratomi, J. M. Davidson, P. L. Lefferts, and J. R. Snapper. 1993. Neutrophil elastase inhibitors, SC-37698 and SC-39026, reduce endotoxin-induced lung dysfunction in awake sheep. Am. Rev. Respir. Dis. 147:1371-1379.
11. 11. Welter, H. F., M. Siebeck, O. Thetter, and M. Jochum. 1987. Influence of the lysosomal elastase inhibitor eglin on the development of interstitial lung edema in E. coli bacteremia in pigs. Prog. Clin. Biol. Res. 236A:121-125.
12. 12. Goldman, G., R. Welbourn, L. Kobzik, C. R. Valeri, D. Shepro, and H. B. Hechtman. 1992. Reactive oxygen species and elastase mediate lung permeability after acid aspiration. J. Appl. Physiol. 73:571-575.
13. 13. Carden, D., F. Xiao, C. Moak, B. H. Willis, S. Robinson-Jackson, and S. Alexander. 1998. Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins. Am. J. Physiol. 275:H385-H392.
14. 14. Kawabata, K., M. Suzuki, M. Sigitani, K. Imaki, M. Toda, and T. Miyamoto. 1991. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem. Biophys. Res. Commun. 177:814-820.
15. 15. Brigham, K. L., R. E. Bowers, and C. R. Mckeen. 1981. Methylprednisolone prevention of increased lung vascular permeability following endotoxemia in sheep. J. Clin. Invest. 67:1103-1110.
16. 16. Jerome, E. H., M. R. Bonsignore, K. H. Albertine, P. L. Culver, P. D. Dodek, A. Perel, and N. C. Staub. 1990. Timing of corticosteroids treatment: effect on lung lymph dynamics in air embolism lung injury in awake sheep. Am. Rev. Respir. Dis. 142:872-879.
17. 17. Takahara, H., Y. Nakamura, K. Yamamoto, and H. Shinohara. 1983. Comparative studies on the serum levels of α-1-antitrypsin and α-macroglobulin in several mammals. Tohoku J. Exp. Med. 139:265-270.
18. 18. Schulz, H., M. Mohr, and M. Meyer. 1989. Elastase and papain inhibition by serum of mammals. Scand. J. Clin. Lab. Invest. 49:381-388.
19. 19. Nakajima, K.J. C. Powers, B. M. Ashe, and M. Zimmerman. 1979. Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase: studies with peptide substrates related to the alpha 1-protease inhibitor reactive site. J. Biol. Chem. 254:4027-4032.
20. 4-induced lung injury in rabbit. J. Appl. Physiol. 76:91-96.
21. 21. Iwamura, H., A. R. Moore, and D. A. Willoughby. 1993. Interaction between neutrophil-derived elastase and reactive oxygen species in cartilage degradation. Biochim. Biophys. Acta 1156:295-301.
22. 22. Weitz, J. I., A. J. Huang, S. L. Landman, S. C. Nicholson, and S. C. Silverstein. 1987. Elastase-mediated fibrinogenolysis by chemoattractant-stimulated neutrophils occurs in the presence of physiologic concentration of antiproteinases. J. Exp. Med. 166:1836-1850.
23. 23. Campbell, E. J., and M. A. Campbell. 1988. Pericellular proteolysis by neutrophils in the presence of proteinase inhibitors: effects of substrate opsonization. J. Cell Biol. 106:667-676.
24. 24. Travis, J., and G. S. Salvesen. 1983. Human plasma proteinase inhibitors. Ann. Rev. Biochem. 52:655-709.
25. 25. Weiss, S. J. 1989. Tissue destruction by neutrophils. N. Engl. J. Med. 320:365-376.
26. 26. Morrison, H. M., H. G. Welgus, R. A. Stockley, D. Burnett, and E. J. Campbell. 1990. Inhibition of human leukocyte elastase bound to elastin: relative ineffectiveness and two mechanisms of inhibitory activity. Am. J. Respir. Cell Mol. Biol. 2:263-269.
27. 27. Kawabata, K., A. R. Moore, and D. A. Willoughby. 1996. Impaired activity of protease inhibitors towards elastase bound to human articular cartilage. Ann. Rheum. Dis. 55:248-252.
28. 28. Suttorp, N., A. Nolte, A. Wilke, and D. Drenckhahn. 1993. Human neutrophil elastase increases permeability of cultured pulmonary endothelial cell monolayers. Int. J. Microcirc. Clin. Exp. 13:187-203.
29. 29. Peterson, M. W., M. E. Walter, and S. D. Nygaard. 1995. Effect of neutrophil mediators on epithelial permeability. Am. J. Respir. Cell Mol. Biol. 13:719-727.
30. 30. Mehta, J. L., W. W. Nichols, F. A. Nicolini, J. Hendricks, W. H. Donnelly, and T. G. Saldeen. 1994. Neutrophil elastase inhibitor ICI 200,880 protects against attenuation of coronary flow reserve and myocardial dysfunction following temporary coronary artery occlusion in the dog. Cardiovasc. Res. 28:947-956.
31. 31. Zimmerman, B. J., and D. N. Granger. 1990. Reperfusion-induced leukocyte infiltration: role of elastase. Am. J. Physiol. 259:H390-H394.
32. 2) and modulates polymorphonuclear leukocyte adhesion. J. Exp. Med. 184:1213-1223.
33. 33. Sakamaki, F., A. Ishizaka, T. Urano, K. Sayama, H. Nakamura, T. Terashima, Y. Waki, S. Tasaka, N. Hasegawa, K. Sato, N. Nakagawa, T. Obata, and M. Kanazawa. 1996. Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury. Am. J. Respir. Crit. Care Med. 153:391-397.
34. 34. Madri, J. A., D. Graesser, and T. Haas. 1996. The roles of adhesion molecules and proteinases in lymphocyte transendothelial migration. Biochem. Cell Biol. 74:749-757.