Inhibiting lung elastase activity enables lung growth in mechanically ventilated newborn mice

American Journal of Respiratory and Critical Care Medicine

Volumn 184, Issue 5, 2011, Pages 537-546

  Hilgendorff, Anne ^a,d   Parai, Kakoli ^a   Ertsey, Robert ^a   Jain, Noopur ^a   Navarro, Edwin F ^a   Peterson, Joanna L ^a   Tamosiuniene, Rasa ^b   Nicolls, Mark R ^b   Starcher, Barry C ^c   Rabinovitch, Marlene ^a   Bland, Richard D ^a  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS AT TYLER   (United States)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

Bronchopulmonary dysplasia; Elafin; Elastin degradation; Neonatal chronic lung disease; Ventilator induced lung injury

Indexed keywords

CASPASE 3; DESMOSINE; ELAFIN; ELASTASE; ELASTASE INHIBITOR; ELASTIN; GELATINASE B; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ARTIFICIAL VENTILATION; CHRONIC LUNG DISEASE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; HISTOLOGY; LUNG GROWTH; LUNG INJURY; MOUSE; NEWBORN; NONHUMAN; ORGAN GROWTH; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; DISEASE MODELS, ANIMAL; ELAFIN; LUNG; MICE; ORGANOGENESIS; PANCREATIC ELASTASE; PROTEASE INHIBITORS; RESPIRATION, ARTIFICIAL; RESPIRATORY INSUFFICIENCY;

EID: 80052514768     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201012-2010OC     Document Type: Article

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