Monosodium urate crystals trigger Nrf2- and heme oxygenase-1-dependent inflammation in THP-1 cells

Cellular and Molecular Immunology

Volumn 12, Issue 4, 2015, Pages 424-434

  Jhang, Jhih Jia ^a   Cheng, Yu Ting ^a   Ho, Cheng Ying ^a   Yen, Gow Chin ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

HO 1; monosodium urate; NLRP3 inflammasome; Nrf2; THP 1 cells

Indexed keywords

CATALASE; CYCLOOXYGENASE 2; GLUTATHIONE PEROXIDASE; HEME OXYGENASE 1; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTOPORPHYRIN; SMALL INTERFERING RNA; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; URATE; CARRIER PROTEIN; CRYOPYRIN; HMOX1 PROTEIN, HUMAN; IL1B PROTEIN, HUMAN; INTERLEUKIN 1BETA; NFE2L2 PROTEIN, HUMAN; NLRP3 PROTEIN, HUMAN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTOPORPHYRIN ZINC; REACTIVE OXYGEN METABOLITE; URIC ACID;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOKINE RELEASE; GENE; GENE EXPRESSION; GOUT; HOMEOSTASIS; HUMAN; HUMAN CELL; INFLAMMATION; MONOCYTE; NRF2 GENE; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; UPREGULATION; CHEMICALLY INDUCED; DRUG EFFECTS; IMMUNOLOGY; LYSOSOME; OXIDATION REDUCTION REACTION; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

CARRIER PROTEINS; CELL LINE, TUMOR; GOUT; HEME OXYGENASE-1; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; LYSOSOMES; NF-E2-RELATED FACTOR 2; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; OXIDATION-REDUCTION; PROTOPORPHYRINS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; URIC ACID;

EID: 84936146957     PISSN: 16727681     EISSN: 20420226     Source Type: Journal    
DOI: 10.1038/cmi.2014.65     Document Type: Article

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