Chemical Protein Synthesis Using a Second-Generation N-Acylurea Linker for the Preparation of Peptide-Thioester Precursors

Journal of the American Chemical Society

Volumn 137, Issue 22, 2015, Pages 7197-7209

  Blanco Canosa, Juan B ^a   Nardone, Brunello ^b   Albericio, Fernando ^a,c   Dawson, Philip E ^d  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^b UNIVERSITY OF SALERNO   (Italy)

^c UNIVERSITY OF BARCELONA   (Spain)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CYCLIZATION; MICROWAVE HEATING; PEPTIDES; POLYPEPTIDES; PROTEINS; SURGICAL EQUIPMENT;

C-TERMINAL PEPTIDES; CHEMICAL EQUATIONS; CHEMICAL PROTEIN SYNTHESIS; COUPLING CONDITION; COUPLING TEMPERATURE; EFFICIENT SYNTHESIS; NATIVE CHEMICAL LIGATION; NATURAL AMINO ACIDS;

BIOSYNTHESIS;

AMINE; ANILINE DERIVATIVE; CYCLOTIDE; ESTER DERIVATIVE; GLYCINE DERIVATIVE; N ACYLUREA; PROTEIN PRECURSOR; THIOL DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE; ESTER; PEPTIDE; PROTEIN; UREA;

ACYLATION; ALKALINITY; ALKYLATION; AMINO ACID SEQUENCE; ARTICLE; BIOLOGICAL ACTIVITY; CARBAMOYLATION; CATALYST; CHEMICAL PROTEIN SYNTHESIS; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); COVALENT BOND; CYCLIZATION; EPIMERIZATION; HYDROGENATION; HYDROLYSIS; KINETICS; MICROWAVE COOKING; MICROWAVE IRRADIATION; NATIVE CHEMICAL LIGATION; PEPTIDE SYNTHESIS; RACEMIZATION; SOLID; SOLID PHASE SYNTHESIS; SURFACE PROPERTY; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR GENETICS; SYNTHESIS;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESTERS; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEINS; UREA;

EID: 84935911053     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b03504     Document Type: Article

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