TGFβ1 inhibits IFNγ-mediated microglia activation and protects mDA neurons from IFNγ-driven neurotoxicity

Journal of Neurochemistry

Volumn 134, Issue 1, 2015, Pages 125-134

  Zhou, Xiaolai ^a,b   Zöller, Tanja ^a   Krieglstein, Kerstin ^a   Spittau, Björn ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b School of Integrative Plant Sciences   (United States)

Author keywords

IFN ; mDA neurons; microglia; TGF 1

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; GAMMA INTERFERON RECEPTOR ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; STAT1 PROTEIN; STAT2 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 2; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL STRUCTURE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOWN REGULATION; EMBRYO; GENE; GENE EXPRESSION REGULATION; IMMUNOREGULATION; IN VITRO STUDY; INTRACELLULAR SIGNALING; MICROARRAY ANALYSIS; MICROGLIA; MIDBRAIN DOPAMINERGIC NEURON; MIXED CELL CULTURE; MOLECULAR DYNAMICS; MOUSE; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SOCS2 GENE; SOCS6 GENE; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; MESENCEPHALON; METABOLISM; NERVE CELL; NEWBORN; PATHOLOGY;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; DOPAMINERGIC NEURONS; INTERFERON-GAMMA; MESENCEPHALON; MICE; MICE, INBRED C57BL; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84935878585     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13111     Document Type: Article

References (35)

1. Annes J. P., Munger J. S., and, Rifkin D. B., (2003) Making sense of latent TGFbeta activation. J. Cell Sci. 116, 217-224.
2. Barcia C., Ros C. M., Annese V., Gómez A., Ros-Bernal F., Aguado-Yera D., Martínez-Pagán M. E., de Pablos V., Fernandez-Villalba E., and, Herrero M. T., (2011) IFN-? signaling, with the synergistic contribution of TNF-a, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease. Cell Death Dis. 2, e142.
3. Block M. L., and, Hong J.-S., (2005) Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog. Neurobiol. 76, 77-98.
4. Block M. L., Zecca L., and, Hong J.-S., (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 8, 57-69.
5. Butovsky O., Jedrychowski M. P., Moore C. S., et al,. (2014) Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nat. Neurosci. 17, 131-143.
6. Chakrabarty P., Ceballos-Diaz C., Lin W.-L., Beccard A., Jansen-West K., McFarland N. R., Janus C., Dickson D., Das P., and, Golde T. E., (2011) Interferon- ? induces progressive nigrostriatal degeneration and basal ganglia calcification. Nat. Neurosci. 14, 694-696.
7. Chen X. P., Losman J. A., and, Rothman P., (2000) SOCS proteins, regulators of intracellular signaling. Immunity 13, 287-290.
8. Cohen M., Matcovitch O., David E., Barnett-Itzhaki Z., Keren-Shaul H., Blecher-Gonen R., Jaitin D. A., Sica A., Amit I., and, Schwartz M., (2014) Chronic exposure to TGFβ1 regulates myeloid cell inflammatory response in an IRF7-dependent manner. EMBO J. 33, 2906-2921.
9. Federici M., Giustizieri M. L., Scarponi C., Girolomoni G., and, Albanesi C., (2002) Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1. J. Immunol. 169, 434-442.
10. Gao H.-M., Liu B., and, Hong J.-S., (2003) Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons. J. Neurosci. 23, 6181-6187.
11. Green L. C., Wagner D. A., Glogowski J., Skipper P. L., Wishnok J. S., and, Tannenbaum S. R., (1982) Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal. Biochem. 126, 131-138.
12. Herrera-Molina R., Flores B., Orellana J. A., and, von Bernhardi R., (2012) Modulation of interferon-?-induced glial cell activation by transforming growth factor ß1: a role for STAT1 and MAPK pathways. J. Neurochem. 123, 113-123.
13. Hirsch E. C., and, Hunot S., (2009) Neuroinflammation in Parkinson's disease: a target for neuroprotection? Lancet Neurol. 8, 382-397.
14. Jellinger K. A., (2001) The pathology of Parkinson's disease. Adv. Neurol. 86, 55-72.
15. Kim W.-K., Hwang S.-Y., Oh E.-S., Piao H. Z., Kim K.-W., and, Han I.-O., (2004) TGF-beta1 represses activation and resultant death of microglia via inhibition of phosphatidylinositol 3-kinase activity. J. Immunol. 172, 7015-7023.
16. Lawson L. J., Perry V. H., Dri P., and, Gordon S., (1990) Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 39, 151-170.
17. Le Y., Iribarren P., Gong W., Cui Y., Zhang X., and, Wang J. M., (2004) TGF-beta1 disrupts endotoxin signaling in microglial cells through Smad3 and MAPK pathways. J. Immunol. 173, 962-968.
18. Mangano E. N., and, Hayley S., (2009) Inflammatory priming of the substantia nigra influences the impact of later paraquat exposure: neuroimmune sensitization of neurodegeneration. Neurobiol. Aging 30, 1361-1378.
19. Miller R. L., James-Kracke M., Sun G. Y., and, Sun A. Y., (2009) Oxidative and inflammatory pathways in Parkinson's disease. Neurochem. Res. 34, 55-65.
20. Mount M. P., Lira A., Grimes D., Smith P. D., Faucher S., Slack R., Anisman H., Hayley S., and, Park D. S., (2007) Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons. J. Neurosci. 27, 3328-3337.
21. Parkhurst C. N., Yang G., Ninan I., Savas J. N., Yates J. R. 3rd, Lafaille J. J., Hempstead B. L., Littman D. R., and, Gan W. B., (2013) Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell 155, 1596-1609.
22. Platanias L. C., (2005) Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat. Rev. Immunol. 5, 375-386.
23. Popko B., Corbin J. G., Baerwald K. D., Dupree J., and, Garcia A. M., (1997) The effects of interferon-gamma on the central nervous system. Mol. Neurobiol. 14, 19-35.
24. Prinz M., and, Priller J., (2014) Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease. Nat. Rev. Neurosci. 15, 300-312.
25. Reale M., Iarlori C., Thomas A., Gambi D., Perfetti B., Nicola M., and, Di Onofrj M., (2009) Peripheral cytokines profile in Parkinson's disease. Brain Behav. Immun. 23, 55-63.
26. Reardon C., and, McKay D. M., (2007) TGF-beta suppresses IFN-gamma-STAT1-dependent gene transcription by enhancing STAT1-PIAS1 interactions in epithelia but not monocytes/macrophages. J. Immunol. 178, 4284-4295.
27. Sharaf A., Krieglstein K., and, Spittau B., (2013) Distribution of microglia in the postnatal murine nigrostriatal system. Cell Tissue Res. 351, 373-382.
28. Shen X., Hong F., Nguyen V. A., and, Gao B., (2000) IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3. FEBS Lett. 480, 132-136.
29. Spittau B., Wullkopf L., Zhou X., Rilka J., Pfeifer D., and, Krieglstein K., (2013) Endogenous transforming growth factor-beta promotes quiescence of primary microglia in vitro. Glia 61, 287-300.
30. Takaki H., Minoda Y., Koga K., Takaesu G., Yoshimura A., and, Kobayashi T., (2006) TGF-beta1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation. Genes Cells 11, 871-882.
31. Tanaka T., Arai M., Jiang X., Sugaya S., Kanda T., Fujii K., Kita K., et al,. (2014) Downregulation of microRNA-431 by human interferon-β inhibits viability of medulloblastoma and glioblastoma cells via upregulation of SOCS6. Int. J. Oncol. 44, 1685-1690.
32. Thomas T., Timmer M., Cesnulevicius K., Hitti E., Kotlyarov A., and, Gaestel M., (2008) MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation-relevance in a mouse model of Parkinson's disease. J. Neurochem. 105, 2039-2052.
33. Tremblay M.-È., Stevens B., Sierra A., Wake H., Bessis A., and, Nimmerjahn A., (2011) The role of microglia in the healthy brain. J. Neurosci. 31, 16064-16069.
34. Wilms H., Zecca L., Rosenstiel P., Sievers J., Deuschl G., and, Lucius R., (2007) Inflammation in Parkinson's diseases and other neurodegenerative diseases: cause and therapeutic implications. Curr. Pharm. Des. 13, 1925-1928.
35. Zhou X., Spittau B., and, Krieglstein K., (2012) TGFβ signalling plays an important role in IL4-induced alternative activation of microglia. J. Neuroinflammation 9, 210.