Receptive range analysis of a mouse odorant receptor subfamily

Journal of Neurochemistry

Volumn 134, Issue 1, 2015, Pages 47-55

  Li, Jingyi ^a,c   Haddad, Rafi ^b   Santos, Vanessa ^a   Bavan, Selvan ^a,d   Luetje, Charles W ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b BAR ILAN UNIVERSITY   (Israel)

^c GENOMATICA INC   (United States)

^d PAREXEL INTERNATIONAL   (United States)

Author keywords

electrophysiology; heterologous expression; ligand specificity; molecular receptive range; olfactory receptors; Xenopus oocytes

Indexed keywords

ALDEHYDE; OLFACTORY RECEPTOR;

AMINO ACID ANALYSIS; ANIMAL EXPERIMENT; ARTICLE; BIOINFORMATICS; CONTROLLED STUDY; FEMALE; MOLECULAR RECEPTIVE RANGE; MOUSE; NONHUMAN; OLFACTORY RECEPTOR; PHYLOGENY; PRIORITY JOURNAL; RECEPTIVE FIELD; SENSITIVITY AND SPECIFICITY; ANIMAL; HUMAN; ODOR; PHYSIOLOGY; XENOPUS LAEVIS;

MAMMALIA;

ANIMALS; FEMALE; HUMANS; MICE; ODORS; RECEPTORS, ODORANT; SMELL; XENOPUS LAEVIS;

EID: 84935862501     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13095     Document Type: Article

References (42)

1. Abaffy T., Matsunami H., and, Luetje C. W., (2006) Functional analysis of a mammalian odorant receptor subfamily. J. Neurochem. 97, 1506-1518.
2. Araneda R. C., Kini A. D., and, Firestein S., (2000) The molecular receptive range of an odorant receptor. Nat. Neurosci. 3, 1248-1255.
3. Bakalyar H. A., and, Reed R. R., (1990) Identification of a specialized adenylyl cyclase that may mediate odorant detection. Science 250, 1403-1406.
4. Bozza T., Feinstein P., Zheng C., and, Mombaerts P., (2002) Odorant receptor expression defines functional units in the mouse olfactory system. J. Neurosci. 22, 3033-3043.
5. Buck L., and, Axel R., (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65, 175-187.
6. Feinstein P., and, Mombaerts P., (2004) A contextual model for axonal sorting into glomeruli in the mouse olfactory system. Cell 117, 817-831.
7. Godfrey P. A., Malnic B., and, Buck L. B., (2004) The mouse olfactory receptor gene family. Proc. Natl Acad. Sci. USA 101, 2156-2161.
8. Grosmaitre X., Fuss S. H., Lee A. C., Adipietro K. A., Matsunami H., Mombaerts P., and, Ma M., (2009) SR1, a mouse odorant receptor with an unusually broad response profile. J. Neurosci. 29, 14545-14552.
9. Haddad R., Khan R., Takahashi Y. K., Mori K., Harel D., and, Sobel N., (2008) A metric for odorant comparison. Nat. Methods 5, 425-429.
10. Haddad R., Weiss T., Khan R., Nadler B., Mandairon N., Bensafi M., Schneidman E., and, Sobel N., (2010) Global features of neural activity in the olfactory system form a parallel code that predicts olfactory behavior and perception. J. Neurosci. 30, 9017-9026.
11. Jones D. T., and, Reed R. R., (1989) Golf: an olfactory neuron specific-G protein involved in odorant signal transduction. Science 244, 790-795.
12. Kajiya K., Inaki K., Tanaka M., Haga T., Kataoka H., and, Touhara K., (2001) Molecular bases of odor discrimination: reconstitution of olfactory receptors that recognize overlapping sets of odorants. J. Neurosci. 21, 6018-6025.
13. Krautwurst D., Yau K. W., and, Reed R. R., (1998) Identification of ligands for olfactory receptors by functional expression of a receptor library. Cell 95, 917-926.
14. Li J., Haddad R., Chen S., Santos V., and, Luetje C. W., (2012) A broadly tuned mouse odorant receptor that detects nitrotoluenes. J. Neurochem. 121, 881-890.
15. Lowe G., and, Gold G. H., (1993) Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells. Nature 366, 283-286.
16. Ma T., Vetrivel L., Yang H., Pedemonte N., Zegarra-Moran O., Galietta L. J., and, Verkman A. S., (2002) High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening. J. Biol. Chem. 277, 37235-37241.
17. Malnic B., Hirono J., Sato T., and, Buck L. B., (1999) Combinatorial receptor codes for odors. Cell 96, 713-723.
18. Man O., Gilad Y., and, Lancet D., (2004) Prediction of the odorant binding site of olfactory receptor proteins by human-mouse comparisons. Protein Sci. 13, 240-254.
19. Man O., Willhite D. C., Crasto C. J., Shepherd G. M., and, Gilad Y., (2007) A framework for exploring functional variability in olfactory receptor genes. PLoS ONE 2, e682.
20. Mombaerts P., (2004) Genes and ligands for odorant, vomeronasal and taste receptors. Nat. Rev. Neurosci. 5, 263-278.
21. Mori K., Nagao H., and, Yoshihara Y., (1999) The olfactory bulb: coding and processing of odor molecule information. Science 286, 711-715.
22. Nakamura T., and, Gold G. H., (1987) A cyclic nucleotide-gated conductance in olfactory receptor cilia. Nature 325, 442-444.
23. Nara K., Saraiva L. R., Ye X., and, Buck L. B., (2011) A large-scale analysis of odor coding in the olfactory epithelium. J. Neurosci. 31, 9179-9191.
24. Oka Y., Omura M., Kataoka H., and, Touhara K., (2004) Olfactory receptor antagonism between odorants. EMBO J. 23, 120-126.
25. Oka Y., Katada S., Omura M., Suwa M., Yoshihara Y., and, Touhara K., (2006) Odorant receptor map in the mouse olfactory bulb: in vivo sensitivity and specificity of receptor-defined glomeruli. Neuron 52, 857-869.
26. Peterlin Z., Li Y., Sun G., Shah R., Firestein S., and, Ryan K., (2008) The importance of odorant conformation to the binding and activation of a representative olfactory receptor. Chem. Biol. 15, 1317-1327.
27. Reed R. R., (2004) After the holy grail: establishing a molecular basis for Mammalian olfaction. Cell 116, 329-336.
28. Repicky S. E., and, Luetje C. W., (2009) Molecular receptive range variation among mouse odorant receptors for aliphatic carboxylic acids. J. Neurochem. 109, 193-202.
29. Saito H., Kubota M., Roberts R. W., Chi Q., and, Matsunami H., (2004) RTP family members induce functional expression of mammalian odorant receptors. Cell 119, 679-691.
30. Saito H., Chi Q., Zhuang H., Matsunami H., and, Mainland J. D., (2009) Odor coding by a Mammalian receptor repertoire. Sci. Signal., 2, ra9.
31. Schmiedeberg K., Shirokova E., Weber H. P., Schilling B., Meyerhof W., and, Krautwurst D., (2007) Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. J. Struct. Biol. 159, 400-412.
32. Schultz B. D., Singh A. K., Devor D. C., and, Bridges R. J., (1999) Pharmacology of CFTR chloride channel activity. Physiol. Rev. 79, S109-S144.
33. Serizawa S., Miyamichi K., Nakatani H., Suzuki M., Saito M., Yoshihara Y., and, Sakano H., (2003) Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse. Science 302, 2088-2094.
34. Shepherd G. M., (2004) The Synaptic Organization of the Brain, pp. 165-216. Oxford University Press, New York.
35. Touhara K., Sengoku S., Inaki K., Tsuboi A., Hirono J., Sato T., Sakano H., and, Haga T., (1999) Functional identification and reconstitution of an odorant receptor in single olfactory neurons. Proc. Natl Acad. Sci. USA 96, 4040-4045.
36. Uezono Y., Bradley J., Min C., et al,. (1993) Receptors that couple to 2 classes of G proteins increase cAMP and activate CFTR expressed in Xenopus oocytes. Receptors Channels 1, 233-241.
37. Von Dannecker L. E., Mercadante A. F., and, Malnic B., (2006) Ric-8B promotes functional expression of odorant receptors. Proc. Natl Acad. Sci. USA 103, 9310-9314.
38. Wetzel C. H., Oles M., Wellerdieck C., Kuczkowiak M., Gisselmann G., and, Hatt H., (1999) Specificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus Laevis oocytes. J. Neurosci. 19, 7426-7433.
39. Young J. M., Friedman C., Williams E. M., Ross J. A., Tonnes-Priddy L., and, Trask B. J., (2002) Different evolutionary processes shaped the mouse and human olfactory receptor gene families. Hum. Mol. Genet. 11, 535-546.
40. Zhang X., and, Firestein S., (2002) The olfactory receptor gene superfamily of the mouse. Nat. Neurosci. 5, 124-133.
41. Zhang X., Rogers M., Tian H., Zou D. J., Liu J., Ma M., Shepherd G. M., and, Firestein S. J., (2004) High-throughput microarray detection of olfactory receptor gene expression in the mouse. Proc. Natl Acad. Sci. USA 101, 14168-14173.
42. Zhuang H., and, Matsunami H., (2007) Synergism of accessory factors in functional expression of mammalian odorant receptors. J. Biol. Chem. 282, 15284-15293.