A broadly tuned mouse odorant receptor that detects nitrotoluenes

Journal of Neurochemistry

Volumn 121, Issue 6, 2012, Pages 881-890

  Li, Jingyi ^a   Haddad, Rafi ^b   Chen, Sisi ^a   Santos, Vanessa ^a   Luetje, Charles W ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

Explosives detection; Ligand specificity; Molecular receptive range; Olfactory receptors

Indexed keywords

2 HEPTANONE; 2,4 DINITROTOLUENE; 3 ETHOXY 4 HYDROXYBENZALDEHYDE; ACETOPHENONE; ALDEHYDE; BENZOIC ACID DERIVATIVE; CYCLOHEXANONE; EUGENOL; HEPTYL ALDEHYDE; KETONE; LIMONENE; METHYL BENZOATE; MOUSE ODORANT RECEPTOR 256 17; MOUSE ODORANT RECEPTOR 256 22; MOUSE ODORANT RECEPTOR 256 8; NITROTOLUENE DERIVATIVE; PENTYL ACETATE; RECEPTOR PROTEIN; TOLUENE DERIVATIVE; TRANSMEMBRANE CONDUCTANCE REGULATOR; TRINITROTOLUENE; UNCLASSIFIED DRUG; VANILLIN;

ANIMAL CELL; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ODOR; OLFACTORY DISCRIMINATION; OLFACTORY RECEPTOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SMELLING; STRUCTURE ANALYSIS;

ANIMALS; ELECTROPHYSIOLOGY; EXPLOSIVE AGENTS; MICE; RECEPTORS, ODORANT; SUBSTRATE SPECIFICITY; TOLUENE; TRINITROTOLUENE;

MAMMALIA;

EID: 84861998443     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07740.x     Document Type: Article

References (46)

1. Abaffy T., Matsunami H. and Luetje C. W. (2006) Functional analysis of a mammalian odorant receptor subfamily. J. Neurochem. 97, 1506-1518. (Pubitemid 43725588)
2. Araneda R. C., Kini A. D. and Firestein S. (2000) The molecular receptive range of an odorant receptor. Nat. Neurosci. 3, 1248-1255.
3. Bakalyar H. A. and Reed R. R. (1990) Identification of a specialized adenylyl cyclase that may mediate odorant detection. Science 250, 1403-1406.
4. Baud O., Etter S., Spreafico M., Bordoli L., Schwede T., Vogel H. and Pick H. (2011) The mouse eugenol odorant receptor: structural and functional plasticity of a broadly tuned odorant binding pocket. Biochemistry 50, 843-853.
5. Bozza T., Feinstein P., Zheng C. and Mombaerts P. (2002) Odorant receptor expression defines functional units in the mouse olfactory system. J. Neurosci. 22, 3033-3043. (Pubitemid 35379192)
6. Buck L. and Axel R. (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65, 175-187.
7. Corcelli A., Lobasso S., Lopalco P., Dibattista M., Araneda R., Peterlin Z. and Firestein S. (2010) Detection of explosives by olfactory sensory neurons. J. Hazard. Mater. 175, 1096-1100.
8. Dahoun T., Grasso L., Vogel H. and Pick H. (2011) Recombinant expression and functional characterization of mouse olfactory receptor mOR256-17 in mammalian cells. Biochemistry 50, 7228-7235.
9. Esteve-Nunez A., Caballero A. and Ramos J. L. (2001) Biological degradation of 2,4,6-trinitrotoluene. Microbiol. Mol. Biol. Rev. 65, 335-352. (Pubitemid 32881709)
10. Feinstein P., Bozza T., Rodriguez I., Vassalli A. and Mombaerts P. (2004) Axon guidance of mouse olfactory sensory neurons by odorant receptors and the beta2 adrenergic receptor. Cell 117, 833-846. (Pubitemid 38748897)
11. Firestein S., Picco C. and Menini A. (1993) The relation between stimulus and response in olfactory receptor cells of the tiger salamander. J. Physiol. 468, 1-10. (Pubitemid 23254430)
12. Godfrey P. A., Malnic B. and Buck L. B. (2004) The mouse olfactory receptor gene family. Proc. Natl Acad. Sci. USA 101, 2156-2161. (Pubitemid 38229031)
13. Goldsmith B. R., Mitala J. J., Josue J. et al. (2011) Biomimetic chemical sensors using nanoelectronic readout of olfactory receptor proteins. ACS Nano 5, 5408-5416.
14. Grosmaitre X., Fuss S. H., Lee A. C., Adipietro K. A., Matsunami H., Mombaerts P. and Ma M. (2009) SR1, a mouse odorant receptor with an unusually broad response profile. J. Neurosci. 29, 14545-14552.
15. Haddad R., Khan R., Takahashi Y. K., Mori K., Harel D. and Sobel N. (2008) A metric for odorant comparison. Nat. Methods 5, 425-429. (Pubitemid 351619101)
16. Haddad R., Weiss T., Khan R., Nadler B., Mandairon N., Bensafi M., Schneidman E. and Sobel N. (2010) Global features of neural activity in the olfactory system form a parallel code that predicts olfactory behavior and perception. J. Neurosci. 30, 9017-9026.
17. Jenkins T. F., Leggett D. C., Miyares P. H., Walsh M. E., Ranney T. A., Cragin J. H. and George V. (2001) Chemical signatures of TNT-filled land mines. Talanta 54, 501-513. (Pubitemid 32405612)
18. Jones D. T. and Reed R. R. (1989) Golf: an olfactory neuron specific-G protein involved in odorant signal transduction. Science 244, 790-795. (Pubitemid 19163862)
19. Kajiya K., Inaki K., Tanaka M., Haga T., Kataoka H. and Touhara K. (2001) Molecular bases of odor discrimination: reconstitution of olfactory receptors that recognize overlapping sets of odorants. J. Neurosci. 21, 6018-6025. (Pubitemid 32737735)
20. Katada S., Hirokawa T., Oka Y., Suwa M. and Touhara K. (2005) Structural basis for a broad but selective ligand spectrum of a mouse olfactory receptor: mapping the odorant-binding site. J. Neurosci. 25, 1806-1815. (Pubitemid 40279286)
21. Leggett D. C., Jenkins T. F. and Murrmann R. P. (1977) Composition of vapors evolved from military TNT as influenced by temperature, solid composition, age and source. US Army CRREL Special Report 77-16.
22. Leggett D. C., Cragin J. H., Jenkins T. F. and Ranney T. (2001) Release of explosive related vapors from land mines. US Army ERDC/CRREL Technical Report TR-01-6.
23. Lowe G. and Gold G. H. (1993) Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells. Nature 366, 283-286. (Pubitemid 23359714)
24. Ma T., Vetrivel L., Yang H., Pedemonte N., Zegarra-Moran O., Galietta L. J. and Verkman A. S. (2002) High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening. J. Biol. Chem. 277, 37235-37241.
25. Malnic B., Hirono J., Sato T. and Buck L. B. (1999) Combinatorial receptor codes for odors. Cell 96, 713-723. (Pubitemid 29122813)
26. Man O., Willhite D. C., Crasto C. J., Shepherd G. M. and Gilad Y. (2007) A framework for exploring functional variability in olfactory receptor genes. PLoS ONE 2, e682.
27. Mombaerts P. (2004) Genes and ligands for odorant, vomeronasal and taste receptors. Nat. Rev. Neurosci. 5, 263-278.
28. Mori K., Nagao H. and Yoshihara Y. (1999) The olfactory bulb: coding and processing of odor molecule information. Science 286, 711-715.
29. Nakamura T. and Gold G. H. (1987) A cyclic nucleotide-gated conductance in olfactory receptor cilia. Nature 325, 442-444. (Pubitemid 17056411)
30. Nara K., Saraiva L. R., Ye X. and Buck L. B. (2011) A large-scale analysis of odor coding in the olfactory epithelium. J. Neurosci. 31, 9179-9191.
31. Pinnaduwage L. A., Thundat T., Hawk J. E., Hedden D. L., Britt P. F., Houser E. J., Stepnowski S., McGill R. A. and Bubb D. (2004) Detection of 2,4-dinitrotoluene using microcantilever sensors. Sens. Actuat. B 99, 223-229.
32. Radhika V., Proikas-Cezanne T., Jayaraman M., Onesime D., Ha J. H. and Dhanasekaran D. N. (2007) Chemical sensing of DNT by engineered olfactory yeast strain. Nat. Chem. Biol. 3, 325-330. (Pubitemid 46789269)
33. Reed R. R. (2004) After the holy grail: establishing a molecular basis for Mammalian olfaction. Cell 116, 329-336.
34. Repicky S. E. and Luetje C. W. (2009) Molecular receptive range variation among mouse odorant receptors for aliphatic carboxylic acids. J. Neurochem. 109, 193-202.
35. Rubin B. D. and Katz L. C. (1999) Optical imaging of odorant representations in the mammalian olfactory bulb. Neuron 23, 499-511. (Pubitemid 29359921)
36. Saito H., Kubota M., Roberts R. W., Chi Q. and Matsunami H. (2004) RTP family members induce functional expression of mammalian odorant receptors. Cell 119, 679-691. (Pubitemid 39535755)
37. Saito H., Chi Q., Zhuang H., Matsunami H. and Mainland J. D. (2009) Odor coding by a mammalian receptor repertoire. Sci. Signal. 2, ra9.
38. Schmiedeberg K., Shirokova E., Weber H. P., Schilling B., Meyerhof W. and Krautwurst D. (2007) Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. J. Struct. Biol. 159, 400-412. (Pubitemid 47348302)
39. Schultz B. D., Singh A. K., Devor D. C. and Bridges R. J. (1999) Pharmacology of CFTR chloride channel activity. Physiol. Rev. 79, S109-S144. (Pubitemid 29058911)
40. Serizawa S., Miyamichi K., Nakatani H., Suzuki M., Saito M., Yoshihara Y. and Sakano H. (2003) Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse. Science 302, 2088-2094. (Pubitemid 38017935)
41. Sicard G. and Holley A. (1984) Receptor cell responses to odorants: similarities and differences among odorants. Brain Res. 292, 283-296. (Pubitemid 14190101)
42. Uezono Y., Bradley J., Min C., McCarty N. A., Quick M., Riordan J. R., Chavkin C., Zinn K., Lester H. A. and Davidson N. (1993) Receptors that couple to 2 classes of G proteins increase cAMP and activate CFTR expressed in Xenopus oocytes. Receptors Channels 1, 233-241. (Pubitemid 2013159)
43. Young J. M., Friedman C., Williams E. M., Ross J. A., Tonnes-Priddy L. and Trask B. J. (2002) Different evolutionary processes shaped the mouse and human olfactory receptor gene families. Hum. Mol. Genet. 11, 535-546. (Pubitemid 34257490)
44. Zhang X. and Firestein S. (2002) The olfactory receptor gene superfamily of the mouse. Nat. Neurosci. 5, 124-133. (Pubitemid 34121579)
45. Zhang X., Rogers M., Tian H., Zou D. J., Liu J., Ma M., Shepherd G. M. and Firestein S. J. (2004) High-throughput microarray detection of olfactory receptor gene expression in the mouse. Proc. Natl Acad. Sci. USA 101, 14168-14173. (Pubitemid 39305048)
46. Zhao H., Ivic L., Otaki J. M., Hashimoto M., Mikoshiba K. and Firestein S. (1998) Functional expression of a mammalian odorant receptor. Science 279, 237-242. (Pubitemid 28103883)