The Importance of Odorant Conformation to the Binding and Activation of a Representative Olfactory Receptor

Chemistry and Biology

Volumn 15, Issue 12, 2008, Pages 1317-1327

  Peterlin, Zita ^a   Li, Yadi ^b   Sun, Guangxing ^b   Shah, Rohan ^b   Firestein, Stuart ^a   Ryan, Kevin ^b  

^a Columbia University ^*  (United States)

^b CITY COLLEGE OF NEW YORK   (United States)

Author keywords

CHEMBIO; SIGNALING

Indexed keywords

ALDEHYDE;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; METABOLISM; OLFACTORY RECEPTOR; RAT;

ALDEHYDES; ANIMALS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; RATS; RECEPTORS, ODORANT;

RATTUS;

EID: 57649219010     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2008.10.014     Document Type: Article

References (35)

1. Abaffy T., Malhotra A., and Luetje C.W. The molecular basis for ligand specificity in a mouse olfactory receptor: a network of functionally important residues. J. Biol. Chem. 282 (2007) 1216-1224
2. Amoore J.E. Molecular Basis of Odor (1970), C.C. Thomas, Springfield, IL
3. Araneda R.C., Kini A.D., and Firestein S. The molecular receptive range of an odorant receptor. Nat. Neurosci. 3 (2000) 1248-1255
4. Araneda R.C., Peterlin Z., Zhang X., Chesler A., and Firestein S. A pharmacological profile of the aldehyde receptor repertoire in rat olfactory epithelium. J. Physiol. 555 (2004) 743-756
5. Arctander S. Perfume and Flavor Materials of Natural Origin (1960), Arctander Publishing, Elizabeth, NJ
6. Buck L., and Axel R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65 (1991) 175-187
7. Chess A., Simon I., Cedar H., and Axel R. Allelic inactivation regulates olfactory receptor gene expression. Cell 78 (1994) 823-834
8. Dobson C.M. Chemical space and biology. Nature 432 (2004) 824-828
9. Firestein S. How the olfactory system makes sense of scents. Nature 413 (2001) 211-218
10. Firestein S., Picco C., and Menini A. The relation between stimulus and response in olfactory receptor cells of the tiger salamander. J. Physiol. 468 (1993) 1-10
11. Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., et al. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428 (2004) 493-521
12. Hall S.E., Floriano W.B., Vaidehi N., and Goddard III W.A. Predicted 3-D structures for mouse I7 and rat I7 olfactory receptors and comparison of predicted odor recognition profiles with experiment. Chem. Senses 29 (2004) 595-616
13. Ho S.L., Johnson B.A., Chen A.L., and Leon M. Differential responses to branched and unsaturated aliphatic hydrocarbons in the rat olfactory system. J. Comp. Neurol. 499 (2006) 519-532
14. Kaluza J.F., and Breer H. Responsiveness of olfactory neurons to distinct aliphatic aldehydes. J. Exp. Biol. 203 (2000) 927-933
15. Katada S., Hirokawa T., Oka Y., Suwa M., and Touhara K. Structural basis for a broad but selective ligand spectrum of a mouse olfactory receptor: mapping the odorant-binding site. J. Neurosci. 25 (2005) 1806-1815
16. Kobilka B.K., and Deupi X. Conformational complexity of G-protein-coupled receptors. Trends Pharmacol. Sci. 28 (2007) 397-406
17. Krautwurst D., Yau K.W., and Reed R.R. Identification of ligands for olfactory receptors by functional expression of a receptor library. Cell 95 (1998) 917-926
18. Ma M., and Shepherd G.M. Functional mosaic organization of mouse olfactory receptor neurons. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 12869-12874
19. Malnic B., Hirono J., Sato T., and Buck L.B. Combinatorial receptor codes for odors. Cell 96 (1999) 713-723
20. Mori K., Nagao H., and Yoshihara Y. The olfactory bulb: coding and processing of odor molecule information. Science 286 (1999) 711-715
21. Niimura Y., and Nei M. Extensive gains and losses of olfactory receptor genes in Mammalian evolution. PLoS ONE 2 (2007) e708
22. Oka Y., Omura M., Kataoka H., and Touhara K. Olfactory receptor antagonism between odorants. EMBO J. 23 (2004) 120-126
23. Pilpel Y., and Lancet D. The variable and conserved interfaces of modeled olfactory receptor proteins. Protein Sci. 8 (1999) 969-977
24. Raming K., Krieger J., Strotmann J., Boekhoff I., Kubick S., Baumstark C., and Breer H. Cloning and expression of odorant receptors. Nature 361 (1993) 353-356
25. Reed R.R. After the holy grail: establishing a molecular basis for Mammalian olfaction. Cell 116 (2004) 329-336
26. Sakmar T.P., Menon S.T., Marin E.P., and Awad E.S. Rhodopsin: insights from recent structural studies. Annu. Rev. Biophys. Biomol. Struct. 31 (2002) 443-484
27. Sato T., Hirono J., Tonoike M., and Takebayashi M. Tuning specificities to aliphatic odorants in mouse olfactory receptor neurons and their local distribution. J. Neurophysiol. 72 (1994) 2980-2989
28. Schmiedeberg K., Shirokova E., Weber H.P., Schilling B., Meyerhof W., and Krautwurst D. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. J. Struct. Biol. 159 (2007) 400-412
29. Serizawa S., Miyamichi K., and Sakano H. One neuron-one receptor rule in the mouse olfactory system. Trends Genet. 20 (2004) 648-653
30. Shi L., and Javitch J.A. The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop. Annu. Rev. Pharmacol. Toxicol. 42 (2002) 437-467
31. Sicard G., and Holley A. Receptor cell responses to odorants: similarities and differences among odorants. Brain Res. 292 (1984) 283-296
32. Singer M.S. Analysis of the molecular basis for octanal interactions in the expressed rat 17 olfactory receptor. Chem. Senses 25 (2000) 155-165
33. Touhara K. Odor discrimination by G protein-coupled olfactory receptors. Microsc. Res. Tech. 58 (2002) 135-141
34. Touhara K., Sengoku S., Inaki K., Tsuboi A., Hirono J., Sato T., Sakano H., and Haga T. Functional identification and reconstitution of an odorant receptor in single olfactory neurons. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 4040-4045
35. Zhao H., Ivic L., Otaki J.M., Hashimoto M., Mikoshiba K., and Firestein S. Functional expression of a mammalian odorant receptor. Science 279 (1998) 237-242