Continuous Flow Microfluidic Bioparticle Concentrator

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Martel, Joseph M ^a   Smith, Kyle C ^a   Dlamini, Mcolisi ^a   Pletcher, Kendall ^a   Yang, Jennifer ^a   Karabacak, Murat ^a   Haber, Daniel A ^b   Kapur, Ravi ^a   Toner, Mehmet ^a,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^c SHRINERS HOSPITALS FOR CHILDREN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CENTRIFUGATION; DEVICES; FLOW CYTOMETRY; MICROFLUIDIC ANALYSIS; MICROFLUIDICS; PROCEDURES;

CENTRIFUGATION; FLOW CYTOMETRY; MICROFLUIDIC ANALYTICAL TECHNIQUES; MICROFLUIDICS;

EID: 84935834106     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep11300     Document Type: Article

References (51)

1. Martinez, A. W., Phillips, S. T., Whitesides, G. M. & Carrilho, E. Diagnostics for the developing world: microfluidic paper-based analytical devices. Anal. Chem. 82, 3-10 (2009).
2. Thorsen, T., Maerkl, S. J. & Quake, S. R. Microfluidic large-scale integration. Science 298, 580-584 (2002).
3. Dittrich, P. S. & Manz, A. Lab-on-a-chip: microfluidics in drug discovery. Nat. Rev. Drug Discov. 5, 210-218 (2006).
4. Shaw, K. J. et al. Microsystems for personalized biomolecular diagnostics. Eng. Life Sci. 11, 121-132 (2011).
5. Weston, A. & Hood, L. Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicine. J. Proteome Res. 3, 179-196 (2004).
6. Aldridge, B. B. et al. Asymmetry and Aging of Mycobacterial Cells Lead to Variable Growth and Antibiotic Susceptibility. Science 335, 100-104 (2012).
7. Wheeler, A. et al. Microfluidic device for single-cell analysis. Anal. Chem. 75, 3581-3586 (2003).
8. Hou, H. W. et al. Isolation and retrieval of circulating tumor cells using centrifugal forces. Sci. Rep. 3, 1259 (2013).
9. Ozkumur, E. et al. Inertial Focusing for Tumor Antigen-Dependent and -Independent Sorting of Rare Circulating Tumor Cells. Sci. Trans. Med. 5, 179ra147 (2013).
10. Davis, J. et al. Deterministic hydrodynamics: Taking blood apart. Proc. Natl. Acad. Sci. 103, 14779-14784 (2006).
11. Nagrath, S. et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450, 1235-1239 (2007).
12. Mazutis, L. et al. Single-cell analysis and sorting using droplet-based microfluidics. Nat. Protoc. 8, 870-891 (2013).
13. Sethu, P., Anahtar, M., Moldawer, L. L., Tompkins, R. G. & Toner, M. Continuous flow microfluidic device for rapid erythrocyte lysis. Anal. Chem. 76, 6247-6253 (2004).
14. King, K. R. et al. A high-throughput microfluidic real-time gene expression living cell array. Lab Chip 7, 77 (2007).
15. Huang, L. R., Cox, E. C., Austin, R. H. & Sturm, J. C. Continuous particle separation through deterministic lateral displacement. Science 304, 987-990 (2004).
16. Inglis, D. W., Davis, J. A., Austin, R. H. & Sturm, J. C. Critical particle size for fractionation by deterministic lateral displacement. Lab Chip 6, 655 (2006).
17. Di Carlo, D., Edd, J., Irimia, D., Tompkins, R. & Toner, M. Equilibrium separation and filtration of particles using differential inertial focusing. Anal. Chem. 80, 2204 (2008).
18. Peterson, B. W., Sharma, P. K., Van Der Mei, H. C. & Busscher, H. J. Bacterial Cell Surface Damage Due to Centrifugal Compaction. Appl. Environ. Microbiol. 78, 120-125 (2012).
19. Kim, H. G., Kim, J. Y., Gim, M. G., Lee, J. M. & Chung, D. K. Mechanical stress induces tumor necrosis factor- production through Ca2+ release-dependent TLR2 signaling. AJP: Cell Physiology 295, C432-C439 (2008).
20. Soto, T. et al. Transduction of centrifugation-induced gravity forces through mitogen-activated protein kinase pathways in the fission yeast Schizosaccharomyces pombe. Microbiology 153, 1519-1529 (2007).
21. Yang, J., Hooper, W., Phillips, D., Tondella, M. & Talkington, D. Centrifugation of human lung epithelial carcinoma A549 cells up-regulates interleukin-1β gene expression. Clin. Diagn. Lab. Immunol. 9, 1142-1143 (2002).
22. Martel, J. & Toner, M. Inertial Focusing in Microfluidics. Annu. Rev. Biomed. Eng. 16, 371-396 (2014).
23. Amini, H., Lee, W. & Di Carlo, D. Inertial Microfluidic Physics. Lab Chip 14, 2739-2761 (2014).
24. Gifford, S. C., Spillane, A. M., Vignes, S. M. & Shevkoplyas, S. S. Controlled incremental filtration: a simplified approach to design and fabrication of high-throughput microfluidic devices for selective enrichment of particles. Lab Chip 14, 4496-4505 (2014).
25. Di Carlo, D., Irimia, D., Tompkins, R. & Toner, M. Continuous inertial focusing, ordering, and separation of particles in microchannels. Proc. Natl. Acad. Sci. 104, 18892-18897 (2007).
26. Hur, S. C., Henderson-Maclennan, N. K., Mccabe, E. R. B. & Di Carlo, D. Deformability-based cell classification and enrichment using inertial microfluidics. Lab Chip 11, 912-920 (2011).
27. Gossett, D. R. et al. Hydrodynamic stretching of single cells for large population mechanical phenotyping. Proc. Natl. Acad. Sci. 109, 7630-7635 (2012).
28. Xiang, N. et al. High-throughput inertial particle focusing in a curved microchannel: Insights into the flow-rate regulation mechanism and process model. Biomicrofluidics 7, 044116 (2013).
29. Di Carlo, D. Inertial microfluidics. Lab Chip 9, 3038-3046 (2009).
30. Gossett, D. R. & Carlo, D. D. Particle Focusing Mechanisms in Curving Confined Flows. Anal. Chem. 81, 8459-8465 (2009).
31. Martel, J. M. & Toner, M. Particle Focusing in Curved Microfluidic Channels. Sci. Rep. 3, 3340 (2013).
32. Lee, W., Amini, H., Stone, H. A. & Di Carlo, D. Dynamic self-assembly and control of microfluidic particle crystals. Proc. Natl. Acad. Sci. 107, 22413-22418 (2010).
33. Roscoe, R. The viscosity of suspensions of rigid spheres. Br. J. Appl. Phys. 3, 267-269 (1952).
34. Lim, E. J. et al. Inertio-elastic focusing of bioparticles in microchannels at high throughput. Nat. Comm. 5, 1-9 (2014).
35. Love, C. & Palestro, C. Radionuclide imaging of infection. J. Nucl. Med. Technol. 32, 47-57 (2004).
36. Karabacak, N. M. et al. Microfluidic, marker-free isolation of circulating tumor cells from blood samples. Nat. Protoc. 9, 694-710 (2014).
37. Sochol, R. D., Li, S., Lee, L. P. & Lin, L. Continuous Flow Multi-Stage Microfluidic Reactors via Hydrodynamic Microparticle Railing. Lab Chip 12, 4168-4177 (2012).
38. Chung, K., Rivet, C., Kemp, M. & Lu, H. Imaging single-cell signaling dynamics with a deterministic high-density single-cell trap array. Anal. Chem. 83, 7044-7052 (2011).
39. Tan, W.-H. & Takeuchi, S. A trap-and-release integrated microfluidic system for dynamic microarray applications. Proc. Natl. Acad. Sci. 104, 1146-1151 (2007).
40. Edd, J. et al. Controlled encapsulation of single cells into monodisperse picoliter drops. Lab Chip 8, 1262 (2008).
41. Sun, J. et al. Double Spiral Microchannel for Label-free Tumor Cell Separation and Enrichment. Lab Chip 12, 3952-3960 (2012).
42. Burke, J. M., Zubajlo, R. E., Smela, E. & White, I. M. High-throughput particle separation and concentration using spiral inertial filtration. Biomicrofluidics 8, 024105 (2014).
43. Liu, Z. et al. Rapid isolation of cancer cells using microfluidic deterministic lateral displacement structure. Biomicrofluidics 7, 011801 (2013).
44. Liu, Z. et al. High throughput capture of circulating tumor cells using an integrated microfluidic system. Biosens. Bioelectron. 47, 113-119 (2013).
45. Loutherback, K. et al. Deterministic separation of cancer cells from blood at 10 mL/min. AIP Advances 2, 042107 (2012).
46. Masaeli, M. et al. Continuous Inertial Focusing and Separation of Particles by Shape. Phys. Rev. X 2, 031017 (2012).
47. Mach, A. J. & Di Carlo, D. Continuous scalable blood filtration device using inertial microfluidics. Biotechnol. Bioeng. 107, 302-311 (2010).
48. Lee, S. D. et al. Prognostic significance of peritoneal washing cytology in patients with gastric cancer. Br. J. Surg. 99, 397-403 (2011).
49. Haslam, P. et al. Bronchoalveolar lavage in pulmonary fibrosis: comparison of cells obtained with lung biopsy and clinical features. Thorax 35, 9-18 (1980).
50. Zhou, J., Giridhar, P. V., Kasper, S. & Papautsky, I. Modulation of aspect ratio for complete separation in an inertial microfluidic channel. Lab Chip 13, 1919-1929 (2013).
51. Oh, K., Lee, K., Ahn, B. & Furlani, E. Design of pressure-driven microfluidic networks using electric circuit analogy. Lab Chip 12, 515-545 (2012).