Microsystems for personalized biomolecular diagnostics

Engineering in Life Sciences

Volumn 11, Issue 2, 2011, Pages 121-132

  Shaw, Kirsty J ^a   Birch, Christopher ^a   Hughes, Elizabeth M ^b   Jakes, Adam D ^b   Greenman, John ^a   Haswell, Stephen J ^a  

^a UNIVERSITY OF HULL   (United Kingdom)

^b UNIVERSITY OF HULL   (United Kingdom)

Author keywords

Diagnostics; Healthcare; Integration; Microfluidics; Personalized medicine

Indexed keywords

BIO-MOLECULAR; BIOMOLECULAR ANALYSIS; DESIGN CONSIDERATIONS; DIAGNOSTICS; DRUG SCREENING; GENETIC ANALYSIS; MEDICAL CARE; MICRO FLUIDIC SYSTEM; MICRO-FLUIDIC INTERFACE; MICROFLUIDIC TECHNOLOGIES; PERSONALIZED MEDICINES; POINT OF CARE; POTENTIAL APPLICATIONS; TISSUE BIOPSIES;

GENES; HEALTH CARE; INTEGRATION; TISSUE;

MICROFLUIDICS;

BIOLOGICAL MARKER; IMATINIB;

BIOCHEMISTRY; BIOMARKER; CYTOLOGY; DISEASE TREATMENT; DRUG; FLUID FLOW; GENETIC ANALYSIS; HEALTH CARE; TECHNOLOGICAL DEVELOPMENT;

DIAGNOSTIC PROCEDURE; DRUG SCREENING; EVIDENCE BASED MEDICINE; GENE EXPRESSION PROFILING; GENETIC ENGINEERING; HEALTH CARE; HUMAN; MEDICAL CARE; METHODOLOGY; MICROFLUIDICS; NONHUMAN; PERSONALIZED MEDICINE; POINT OF CARE TESTING; REVIEW;

EID: 79955415154     PISSN: 16180240     EISSN: 16182863     Source Type: Journal    
DOI: 10.1002/elsc.201000175     Document Type: Review

References (60)

1. Ross, J. S., Ginsburg, G. S., The integration of molecular diagnostics with therapeutics - implications for drug development and pathology practice. Am. J. Clin. Pathol. 2003, 119, 26-36.
2. Bates, S., Progress towards personalized medicine. Drug Discov. Today 2010, 15, 115-120.
3. Versmissen, J., Oosterveer, D. M., Yazdanpanah, M., Mulderm, M. et al., A frequent variant in the ABCA1 gene is associated with increased coronary heart disease risk and a better response to statin treatment in familial hypercholesterolemia patients. Eur. Heart J. 2011, 32, 469-475.
4. Carrara, S., Nano-bio-technology and sensing chips: New systems for detection in personalized therapies and cell biology. Sensors 2010, 10, 526-543.
5. Kim, M. S., Kim, T., Kong, S. Y., Kwon, S. et al., Breast cancer diagnosis using a microfluidic multiplexed immunohistochemistry Platform. PLoS One 2010, 5, e10441.
6. Marko-Varga, G., Ogiwara, A., Nishimura, T., Kawamura, T. et al., Personalized medicine and proteomics: Lessons from non-small cell lung cancer. J. Proteome Res 2007, 6, 2925-2935.
7. Jokerst, J. V., Raamanathan, A., Christodoulides, N., Floriano, P. N. et al., Nano-bio-chips for high performance multiplexed protein detection: Determinations of cancer biomarkers in serum and saliva using quantum dot bioconjugate labels. Biosens. Bioelectron. 2009, 24, 3622-3629.
8. Ong, S. E., Zhang, S., Du, H. J., Fu, Y. Q., Fundamental principles and applications of microfluidic systems. Front. Biosci. 2008, 13, 2757-2773.
9. Chin, C. D., Linder, V., Sia, S. K., Lab-on-a-chip devices for global health: Past studies and future opportunities. Lab Chip 2007, 7, 41-57.
10. Xu, L., Yu, H., Akhras, M. S., Han, S. J. et al., Giant magnetoresistive biochip for DNA detection and HPV genotyping. Biosens. Bioelectron. 2008, 24, 99-103.
11. Do, J., Lee, S., Han, J. Y., Kai, J. H. et al., Development of functional lab-on-a-chip on polymer for point-of-care testing of metabolic parameters. Lab Chip 2008, 8, 2113-2120.
12. Srinivasan, V., Pamula, V. K., Fair, R. B., An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human physiological fluids. Lab Chip 2004, 4, 310-315.
13. Gulliksen, A., Solli, L. A., Drese, K. S., Sorensen, O. et al., Parallel nanoliter detection of cancer markers using polymer microchips. Lab Chip 2005, 5, 416-420.
14. Kaigala, G. V., Huskins, R. J., Preiksaitis, J., Pang, X. L. et al., Automated screening using microfluidic chip-based PCR and product detection to assess risk of BK virus-associated nephropathy in renal transplant recipients. Electrophoresis 2006, 27, 3753-3763.
15. Abruzzo, L. V., Barron, L. L., Anderson, K., Newman, R. J. et al., Identification and validation of biomarkers of IgV(H) mutation status in chronic lymphocytic leukemia using microfluiclics quantitative real-time polymerase chain reaction technology. J. Mol. Diagn. 2007, 9, 546-555.
16. Yokokawa, R., Tamaoki, S., Sakamoto, T., Murakami, A., Sugiyama, S., Transcriptome analysis device based on liquid phase detection by fluorescently labeled nucleic acid probes. Biomed. Microdevices 2007, 9, 869-875.
17. Fang, Z. C., Soleymani, L., Pampalakis, G., Yoshimoto, M. et al., Direct profiling of cancer biomarkers in tumor tissue using a multiplexed nanostructured microelectrode integrated circuit. ACS Nano 2009, 3, 3207-3213.
18. Chowdhury, J., Kagiala, G. V., Pushpakom, S., Lauzon, J. et al., Microfluidic platform for single nucleotide polymorphism genotyping of the thiopurine S-methyltransferase gene to evaluate risk for adverse drug events. J. Mol. Diagn. 2007, 9, 521-529.
19. Nasedkina, T. V., Fedorova, O. E., Glotov, A. S., Chupova, N. V. et al., Rapid genotyping of common deficient thiopurine S-methyltransferase alleles using the DNA-microchip technique. Eur. J. Hum. Genet. 2006, 14, 991-998.
20. Odenthal, M., Barta, N., Lohfink, D., Drebber, U. et al., Analysis of microsatellite instability in colorectal carcinoma by microfluidic-based chip electrophoresis. J. Clin. Pathol. 2009, 62, 850-852.
21. Zamo, A., Bertolaso, A., Franceschetti, I., Weirich, G. et al., Microfluidic deletion/insertion analysis for rapid screening of KIT and PDGFRA mutations in CD117-positive gastrointestinal stromal tumors - diagnostic applications and report of a new KIT mutation. J. Mol. Diagn.. 2007, 9, 151-157.
22. Tian, H. J., Jaquins-Gerstl, A., Munro, N., Trucco, M. et al., Single-strand conformation polymorphism analysis by capillary and microchip electrophoresis: A fast, simple method for detection of common mutations in BRCA1 and BRCA2. Genomics 2000, 63, 25-34.
23. Pereira, S. V., Raba, J., Messina, G. A., IgG anti-gliadin determination with an immunological microfluidic system applied to the automated diagnostic of the celiac disease. Anal. Bioanal. Chem. 2010, 396, 2921-2927.
24. Pereira, S. V., Messina, G. A., Raba, J., Integrated microfluidic magnetic immunosensor for quantification of human serum IgG antibodies to Helicobacter pylori. J. Chromatogr. B 2010, 878, 253-257.
25. Shin, D. M., Ro, J. Y., Hong, W. K., Hittelman, W. N., Dysregulation of epidermal growth-factor receptor expression in premalignant lesions during head and neck tumorignensis. Cancer Res. 1994, 54, 3153-3159.
26. Weigum, S. E., Floriano, P. N., Christodoulides, N., McDevitt, J. T., Cell-based sensor for analysis of EGFR biomarker expression in oral cancer. Lab Chip 2007, 7, 995-1003.
27. Christodoulides, N., Floriano, P. N., Acosta, S. A., Ballard, K. L. M. et al., Toward the development of a lab-on-a-chip dual-function leukocyte and C-reactive protein analysis method for the assessment of inflammation and cardiac risk. Clin. Chem. 2005, 51, 2391-2395.
28. Lenshof, A., Ahmad-Tajudin, A., Jaras, K., Sward-Nilsson, A. M. et al., Acoustic whole blood plasmapheresis chip for prostate specific antigen microarray diagnostics. Anal. Chem. 2009, 81, 6030-6037.
29. Ko, Y. J., Maeng, J. H., Ahn, Y., Hwang, S. Y. et al., Microchip-based multiplex electro-immunosensing system for the detection of cancer biomarkers. Electrophoresis 2008, 29, 3466-3476.
30. Wu, J., Zhang, Z., Fu, Z., Ju, H., A disposable two-throughput electrochemical immunosensor chip for simultaneous multianalyte detennination of tumor markers. Biosens. Bioelectron. 2007, 23, 114-120.
31. Hu, M., Yan, J., He, Y., Lu, H. T. et al., Ultrasensitive, multiplexed detection of cancer biomarkers directly in serum by using a quantum dot-based microfluidic protein chip. ACS Nano 2010, 4, 488-494.
32. Venkatraman, V. L., Reddy, R. K., Zhang, F. Y., Evans, D. et al., Iridium oxide nanomonitors: Clinical diagnostic devices for health monitoring systems. Biosens. Bioelectron. 2009, 24, 3078-3083.
33. Khair, G., Monson, J. R. T., Greenman, J., Epithelial molecular markers in the peripheral blood of patients with colorectal cancer. Dis. Colon Rectum 2007, 50, 1188-1203.
34. Maheswaran, S., Sequist, L. V., Nagrath, S., Ulkus, L. et al., Detection of mutations in EGFR in circulating lung-cancer cells. New England J. Med. 2008, 359, 366-377.
35. Adams, A. A., Okagbare, P. I., Feng, J., Hupert, M. L. et al., Highly efficient circulating tumor cell isolation from whole blood and label-free enumeration using polymer-based microfluidics with an integrated conductivity sensor. J. Am. Chem. Soc. 2008, 130, 8633-8641.
36. Du, Z., Colls, N., Cheng, K. H., Vaughn, M. W., Gollahon, L., Microfluidic-based diagnostics for cervical cancer cells. Biosens. Bioelectron. 2006, 21, 1991-1995.
37. Ng, S. Y., Reboud, J., Wang, K. Y. P., Tang, K. C. et al., Label-free impedance detection of low levels of circulating endothelial progenitor cells for point-of-care diagnosis. Biosens. Bioelectron. 2010, 25, 1095-1101.
38. Jokerst, J. V., Floriano, P. N., Christodoulides, N., Simmons, G. W., McDevitt, J. T., Integration of semiconductor quantum dots into nano-bio-chip systems for enumeration of CD4+T cell counts at the point-of-need. Lab Chip 2008, 8, 2079-2090.
39. Komen, J., Wolbers, F., Franke, H. R., Andersson, H. et al., Viability analysis and apoptosis induction of breast cancer cells in a microfluidic device: effect of cytostatic drugs. Biomed. Microdevices 2008, 10, 727-737.
40. Yu, L. F., Chen, M. C. W., Cheung, K. C., Droplet-based microfluidic system for multicellular tumor spheroid formation and anticancer drug testing. Lab Chip 2010, 10, 2424-2432.
41. Hicks, D. G., Tubbs, R. R., Assessment of the HER2 status in breast cancer by fluorescence in situ hybridization: A technical review with interpretive guidelines. Hum. Pathol. 2005, 36, 250-261.
42. Sun, J., Masterman-Smith, M. D., Graham, N. A., Jiao, J. et al., A microfluidic platform for systems pathology: Multiparameter single-cell signaling measurements of clinical brain tumor specimens. Cancer Res. 2010, 70, 6128-6138.
43. Webster, A., Dyer, C. E., Haswell, S. J., Greenman, J., A microfluidic device for tissue biopsy culture and interrogation. Anal. Methods 2010, 2, 1005-1007.
44. Kim, L., Toh, Y. C., Voldman, J., Yu, H., A practical guide to microfluidic perfusion culture of adherent mammalian cells. Lab Chip 2007, 7, 681-694.
45. Hattersley, S. M., Dyer, C. E., Greenman, J., Haswell, S. J., Development of a microfluidic device for the maintenance and interrogation of viable tissue biopsies. Lab Chip 2008, 8, 1842-1846.
46. van Midwoud, P. M., Groothuis, G. M. M., Merema, M. T., Verpoorte, E., Microfluidic biochip for the perifusion of precision-cut rat liver slices for metabolism and toxicology studies. Biotechnol. Bioeng. 2010, 105, 184-194.
47. Brown, L. F., Berse, B., Jackman, R. W., Tognazzi, K. et al., Senger, Increased expression of vascular-permeability factor (vascular endothelial growth-factor) and its receptors in kidney and bladder carcinomas. Am. J. Pathol. 1993, 143, 1255-1262.
48. Cheah, L., Dou, Y., Seymour, A. L., Dyer, C. E. et al., Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species. Lab Chip 2010, 10, 2720-2726.
49. Liu, L. F., Desai, S. D., Li, T. K., Mao, Y. et al., Mechanism of action of camptothecin. Ann. NY Acad. Sci. 2000, 922, 1-10.
50. Domansky, K., Inman, W., Serdy, J., Dash, A. et al., Perfused multiwell plate for 3D liver tissue engineering. Lab Chip 2010, 10, 51-58.
51. Hsiao, A. Y., Torisawa, Y. S., Tung, Y. C., Sud, S. et al., Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids. Biomaterials 2009, 30, 3020-3027.
52. Sung, J. H., Shuler, M. L., A micro cell culture analog (mu CCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs. Lab Chip 2009, 9, 1385-1394.
53. Wlodkowic, D., Cooper, J. M., Tumors on chips: oncology meets microfluidics. Curr. Opin. Chem. Biol. 2010, 14, 1-12.
54. Hillier, C., Bunton, D., Functional human tissue assays. Drug Discov. Today 2007, 12, 382-388.
55. Erickson, K. A., Wilding, P., Evaluation of a novel point-of-care system, the i-STAT portable clinical analyzer. Clin. Chem. 1993, 39, 283-287.
56. Schulte, T. H., Bardell, R. L., Weigl, B. H., Microfluidic technologies in clinical diagnostics. Clin. Chim. Acta 2002, 321, 1-10.
57. Weigl, B., Domingo, G., LaBarre, P., Gerlach, J., Towards non- and minimally instrumented, microfluidics-based diagnostic devices. Lab Chip 2008, 8, 1999-2014.
58. ® Warfarin Metabolism Nucleic Acid Test, Nanosphere Inc, US. [Accessed 23rd February 2011].
59. Russom, A., Sethu, P., Irimia, D., Mindrinos, M. N. et al., Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients. Clin. Chem. 2008, 54, 891-900.
60. Martinez, A. W., Phillips, S. T., Whitesides, G. M., Carrilho, E., Diagnostics for the developing world: Microfluidic paper-based analytical devices. Anal. Chem. 2010, 82, 3-10.