Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area with Persistent Microfilaridermia after Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial

Clinical Infectious Diseases

Volumn 61, Issue 4, 2015, Pages 517-526

  Debrah, Alexander Yaw ^a,b   Specht, Sabine ^c   Klarmann Schulz, Ute ^c,d   Batsa, Linda ^b   Mand, Sabine ^c   Marfo Debrekyei, Yeboah ^b   Fimmers, Rolf ^d   Dubben, Bettina ^c   Kwarteng, Alexander ^b   Osei Atweneboana, Mike ^e   Boakye, Daniel ^f   Ricchiuto, Arcangelo ^c,d   Büttner, Marcelle ^g   Adjei, Ohene ^a   MacKenzie, Charles D ^h   Hoerauf, Achim ^c  

^a KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

^b KUMASI CENTRE FOR COLLABORATIVE RESEARCH IN TROPICAL MEDICINE   (Ghana)

^c Institute for Medical Microbiology   (Germany)

^d UNIVERSITY OF BONN   (Germany)

^e Water Research Institute ^*  (Germany)

^f University of Ghana   (Ghana)

^g Ahrensburger Stieg 17   (Germany)

^h LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

doxycycline; ivermectin; Onchocerca volvulus; suboptimal response; Wolbachia

Indexed keywords

DOXYCYCLINE; IVERMECTIN; PLACEBO; ANTIFILARIAL AGENT; ANTIINFECTIVE AGENT;

ADULT; ARTICLE; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; EMBRYO DEVELOPMENT; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROFILARIASIS; MICROFILARIDERMIA; NONHUMAN; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; VOMITING; WOLBACHIA; ADOLESCENT; ANIMAL; DRUG EFFECTS; GHANA; MICROBIOLOGY; MIDDLE AGED; PHYSIOLOGY; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; ANIMALS; ANTI-BACTERIAL AGENTS; DOUBLE-BLIND METHOD; DOXYCYCLINE; FEMALE; FILARICIDES; GHANA; HUMANS; IVERMECTIN; MALE; MIDDLE AGED; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; PLACEBOS; TREATMENT OUTCOME; WOLBACHIA; YOUNG ADULT;

EID: 84935521711     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/civ363     Document Type: Article

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