Genomic organization and effects of ivermectin selection on Onchocerca volvulus P-glycoprotein

Molecular and Biochemical Parasitology

Volumn 143, Issue 1, 2005, Pages 58-66

  Ardelli, Bernadette F ^a   Guerriero, Sean B ^a   Prichard, Roger K ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Genetic polymorphism; Ivermectin; Onchocerca volvulus; P glycoprotein

Indexed keywords

GLYCOPROTEIN P; IVERMECTIN;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EXON; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; INTRON; MAJOR CLINICAL STUDY; MALE; NEMATODE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCHOCERCA VOLVULUS; PARASITE TRANSMISSION; PRIORITY JOURNAL;

ANIMALS; ANTHELMINTICS; EXONS; FEMALE; GENES, HELMINTH; INTRONS; IVERMECTIN; MALE; ONCHOCERCA VOLVULUS; P-GLYCOPROTEIN; SELECTION (GENETICS);

NEMATODA; ONCHOCERCA VOLVULUS;

EID: 22844449116     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2005.05.006     Document Type: Article

References (36)

1. E.J. Albiez, G. Walter, and A. Kaiser Histological examination of onchocercomata after therapy with ivermectin Trop Med Parasitol 39 1998 93 99
2. Y Dadzie, M. Neira, and D. Hopkins Final report of the conference on the eradicability of Onchocerciasis Filaria J 2 2003 2
3. J. Gardon, M. Boussinesq, J. Kamgno, N. Gardon-Wendel, Demanga-Ngangue, and B.O. Duke Effects of standard and high doses of ivermectin on adult worms of Onchocerca volvulus: a randomised controlled trial Lancet 360 2002 203 210
4. K. Awadzi, D.A. Boakye, and G. Edwards An investigation of persistent microfilaridermia despite multiple treatments with ivermectin in two onchocerciasis endemic foci in Ghana Ann Trop Med Parasitol 98 2004 231 249
5. C.F. Higgins ABC transporters: from microorganisms to man Annu Rev Cell Biol 8 1992 67 113
6. A. Didier, and F. Loor The abamectin derivative ivermectin is a potent P-glycoprotein inhibitor Anticancer Drugs 7 1996 745 751
7. J.F. Pouliot, F. L'Heureux, Z. Liu, R.K. Prichard, and E. Georges Reversal of P-glycoprotein-associated multidrug resistance by ivermectin Biochem Pharmacol 53 1997 17 25
8. A.H. Schinkel, J.J. Smit, and O. van Tellingen Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs Cell 77 1994 491 502
9. A.H. Schinkel, E. Wagenaar, L. van Deemter, C.A. Mol, and P. Borst Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A J Clin Invest 96 1995 1698 1705
10. C.R. Lincke, A. Broeks, I. The, R.H. Plasterk, and P. Borst The expression of two P-glycoprotein (pgp) genes in transgenic Caenorhabditis elegans is confined to intestinal cells EMBO J 12 1993 1615 1620
11. A. Broeks, H.W. Janssen, J. Calafat, and R.H. Plasterk A P-glycoprotein protects Caenorhabditis elegans against natural toxins EMBO J 14 1995 1858 1866
12. M. Xu, M. Molento, W. Blackhall, P. Ribeiro, R. Beech, and R. Prichard Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog Mol Biochem Parasitol 91 1998 327 335
13. A. Broeks, B. Gerrard, R. Allikmets, M. Dean, and R.H. Plasterk Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans EMBO J 15 1996 6132 6143
14. Y.J. Huang, and R.K. Prichard Identification and stage-specific expression of two putative P-glycoprotein coding genes in Onchocerca volvulus Mol Biochem Parasitol 102 1999 273 281
15. Eng KLJ, Prichard RK. A comparison of genetic polymorphism in populations of Onchocerca volvulus from untreated- and ivermectin-treated patients. Mol Biochem Parasitol, in press.
16. D. Kerboeuf, W. Blackhall, R. Kaminsky, and G. von Samson-Himmelstjerna P-glycoprotein in helminths: function and perspectives for anthelmintic treatment and reversal of resistance Int. J Antimicrob Agents 22 2003 332 346
17. B.O. Duke, G. Zea-Flores, J. Castro, E.W. Cupp, and B. Munoz Effects of multiple monthly doses of ivermectin on adult Onchocerca volvulus Am J Trop Med Hyg 43 1990 657 664
18. B.O. Duke, G. Zea-Flores, J. Castro, E.W. Cupp, and B. Munoz Effects of 3 month doses of ivermectin on adult Onchocerca volvulus Am J Trop Med Hyg 46 1992 189 194
19. K. Awadzi, S.K. Attah, E.T. Addy, N.O. Opoku, and B.T. Quartey The effects of high-dose ivermectin regimens on Onchocerca volvulus in onchocerciasis patients Trans R Soc Trop Med Hyg 93 1999 189 194
20. R.L. Juliano, and V. Ling A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants Biochim Biophys Acta 455 1976 152 162
21. H. Schulz-Key, E.J. Albiez, and D.W. Buttner Isolation of living adult Onchocerca volvulus from nodules Tropenmed Parasitol 28 1977 428 430
22. B.F. Ardelli, and R.K. Prichard Identification of variant ABC transporter genes among Onchocerca volvulus collected from ivermectin treated and untreated patients in Ghana, West Africa Ann Trop Med Parasitol 98 2004 371 384
23. U.A. Germann P-glycoprotein - a mediator of multidrug resistance in tumour cells Eur J Cancer 32A 1996 927 944
24. C.A. Hrycyna, L.E. Airan, U.A. Germann, S.V. Ambudkar, I. Pastan, and M.M. Gottesman Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport Biochemistry 37 1998 13660 13673
25. M.B. Shapiro, and P. Senapathy RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression Nucleic Acids Res 15 1987 7155 7174
26. T.R. Unnasch, and S.A. Williams The genomes of Onchocerca volvulus Int J Parasitol 30 2000 543 552
27. M.M. Ali, M.M. Mukhtar, O.Z. Baraka, M.M. Homeida, M.M. Kheir, and C.D. Mackenzie Immunocompetence may be important in the effectiveness of Mectizan (ivermectin) in the treatment of human onchocerciasis Acta Trop 84 2002 49 53
28. Ardelli BF, Prichard RK. Reduced genetic variation of an Onchocerca volvulus ABC transporter gene following treatment with ivermectin. Trans Roy Soc Trop Med Hyg, in press.
29. R.J. Dobson, L. LeJambre, and J.H. Gill Management of anthelmintic resistance: inheritance of resistance and selection with persistent drugs Int J Parasitol 26 1996 993 1000
30. T. Blumenthol, D. Evans, and C.D. Link A global analysis of Caenorhabditis elegans operons Nature 417 2002 851 853
31. H. Schulz-Key Observations on the reproductive biology of Onchocerca volvulus Acta Leidensia 59 1990 27 43
32. BO.L. Duke The population dynamics of Onchocerca volvulus in the human host Trop Med Parasitol 44 1993 62 68
33. K. Szabó, E. Bakos, and E. Welker Phosphorylation site mutations in the human multidrug transporter modulate its drug-stimulated ATPase activity J Biol Chem 272 1997 23165 23171
34. 125I]iodoarylazidoprazosin labeling Mol Pharm 60 2001 254 261
35. Z.E. Sauna, M.M. Smith, M. Müller, K.M. Kerr, and S.V. Ambudkar The mechanism of action of multidrug-resistance-linked P-glycoprotein J Bio Biomembr 33 2001 481 491
36. K. Awadzi, S.K. Attah, and E.T. Addy Thirty-month follow-up of sub-optimal responders to multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana Ann Trop Med Parasitol 98 2004 359 370