Liraglutide protects pancreatic β-cells against free fatty acids in vitro and affects glucolipid metabolism in apolipoprotein E-/- mice by activating autophagy

Molecular Medicine Reports

Volumn 12, Issue 3, 2015, Pages 4210-4218

  Wang, Jia ^a   Wu, Jie ^a   Wu, Hong ^a   Liu, Xingzhen ^b   Chen, Yingjian ^c   Wu, Jianying ^c   Hu, Chengjin ^c   Zou, Dajin ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b Hangzhou Sanatorium of Nanjing Military Region ^*  (China)

^c JINAN MILITARY GENERAL HOSPITAL   (China)

Author keywords

Glucolipid metabolism; Liraglutide; Pancreatic cells; Protective effect

Indexed keywords

APOLIPOPROTEIN E; AUTOPHAGY PROTEIN 7; BECLIN 1; CHLOROQUINE; CHOLESTEROL; FATTY ACID; GLUCOSE; GLUCOSE REGULATED PROTEIN 78; HEMOGLOBIN A1C; INSULIN; LIPID; LIRAGLUTIDE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PEPTIDES AND PROTEINS; STREPTOZOCIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; ATG7 PROTEIN, RAT; AUTOPHAGY RELATED PROTEIN 7; BECN1 PROTEIN, RAT; LC3 PROTEIN, RAT; MICROTUBULE ASSOCIATED PROTEIN; PROTECTIVE AGENT; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BODY WEIGHT; CELL PROTECTION; CHOLESTEROL BLOOD LEVEL; CHRONOTHERAPY; CONTROLLED STUDY; DIET RESTRICTION; DOWN REGULATION; DRUG EFFICACY; ELECTRON MICROSCOPY; FLOW CYTOMETRY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLYCEMIC CONTROL; HUMAN; HUMAN CELL; IN VITRO STUDY; INS 1 CELL LINE; INSULIN BLOOD LEVEL; LIPID DIET; LIPID METABOLISM; MALE; MOUSE; MTT ASSAY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; CELL SURVIVAL; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; ENDOPLASMIC RETICULUM STRESS; FLUORESCENCE MICROSCOPY; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; RAT; TUMOR CELL LINE; UPREGULATION;

MUS;

ANIMALS; APOLIPOPROTEINS E; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN 7; BECLIN-1; CELL LINE, TUMOR; CELL SURVIVAL; DIABETES MELLITUS, TYPE 2; DOWN-REGULATION; ENDOPLASMIC RETICULUM STRESS; FATTY ACIDS, NONESTERIFIED; INSULIN-SECRETING CELLS; LIPID METABOLISM; LIRAGLUTIDE; MALE; MICE; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; MICROTUBULE-ASSOCIATED PROTEINS; PROTECTIVE AGENTS; RATS; UBIQUITIN-ACTIVATING ENZYMES; UP-REGULATION;

EID: 84935492881     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.3944     Document Type: Article

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