The autophagic inhibitor 3-methyladenine potently stimulates PKA-dependent lipolysis in adipocytes

British Journal of Pharmacology

Volumn 168, Issue 1, 2013, Pages 163-171

  Heckmann, Bradlee L ^a,b   Yang, Xingyuan ^a,b   Zhang, Xiaodong ^a,b   Liu, Jun ^a,b  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

Author keywords

3 methyladenine; 3T3 L1; adipocyte; adipose tissue; autophagy; cAMP; lipolysis; PI3 kinase; PKA; triglyceride hydrolysis

Indexed keywords

3 METHYLADENINE; ADIPOSE TRIGLYCERIDE LIPASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; WORTMANNIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; AUTOPHAGY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE SILENCING; HYDROLYSIS; LIPOLYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

3T3-L1 CELLS; ADENINE; ADIPOCYTES; ANDROSTADIENES; ANIMALS; AUTOPHAGY; HYDROLYSIS; LIPASE; LIPOLYSIS; MICE; PHOSPHATIDYLINOSITOL 3-KINASES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STEROL ESTERASE; TRIGLYCERIDES;

EID: 84872845688     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.02110.x     Document Type: Article

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