-
1
-
-
84892795827
-
Breast cancer statistics 2013
-
De Santis C, Ma J, Bryan L, Jemal A. Breast cancer statistics, 2013. CA Cancer J Clin 2014; 64: 52-62
-
(2014)
CA Cancer J Clin
, vol.64
, pp. 52-62
-
-
De Santis, C.1
Ma, J.2
Bryan, L.3
Jemal, A.4
-
2
-
-
44049100934
-
Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy
-
Li X, Lewis MT, Huang J, Gutierrez C, Osborne CK, Wu MF, et al. Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J Natl Cancer Inst 2008; 100: 672-679
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 672-679
-
-
Li, X.1
Lewis, M.T.2
Huang, J.3
Gutierrez, C.4
Osborne, C.K.5
Wu, M.F.6
-
3
-
-
84867096523
-
The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension
-
Smit JJ, Monteferrario D, Noordermeer SM, van Dijk WJ, van der Reijden BA, Sixma TK. The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension. Embo J 2012; 31: 3833-3844
-
(2012)
Embo J
, vol.31
, pp. 3833-3844
-
-
Smit, J.J.1
Monteferrario, D.2
Noordermeer, S.M.3
Van Dijk, W.J.4
Van Der Reijden, B.A.5
Sixma, T.K.6
-
4
-
-
1842850748
-
Identification of the protein Zibra, its genomic organization, regulation, and expression in breast cancer cells
-
Thompson HG, Harris JW, Lin L, Brody JP. Identification of the protein Zibra, its genomic organization, regulation, and expression in breast cancer cells. Exp Cell Res 2004; 295: 448-459
-
(2004)
Exp Cell Res
, vol.295
, pp. 448-459
-
-
Thompson, H.G.1
Harris, J.W.2
Lin, L.3
Brody, J.P.4
-
5
-
-
84906935293
-
The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor alpha and modulates estrogen-stimulated breast cancer cell proliferation
-
Zhu J, Zhao C, Kharman-Biz A, Zhuang T, Jonsson P, Liang N, et al. The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor alpha and modulates estrogen-stimulated breast cancer cell proliferation. Oncogene 2014; 33: 4340-4351
-
(2014)
Oncogene
, vol.33
, pp. 4340-4351
-
-
Zhu, J.1
Zhao, C.2
Kharman-Biz, A.3
Zhuang, T.4
Jonsson, P.5
Liang, N.6
-
6
-
-
0027109075
-
Cancer p53, guardian of the genome
-
Lane DP. Cancer. p53, guardian of the genome. Nature 1992; 358: 15-16
-
(1992)
Nature
, vol.358
, pp. 15-16
-
-
Lane, D.P.1
-
7
-
-
77953641048
-
Reduced transcriptional activity in the p53 pathway of senescent cells revealed by the MDM2 antagonist nutlin-3
-
Huang B, Vassilev LT. Reduced transcriptional activity in the p53 pathway of senescent cells revealed by the MDM2 antagonist nutlin-3. Aging (Albany NY) 2009; 1: 845-854
-
(2009)
Aging (Albany NY
, vol.1
, pp. 845-854
-
-
Huang, B.1
Vassilev, L.T.2
-
8
-
-
0842278331
-
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
-
Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004; 303: 1010-1014
-
(2004)
Science
, vol.303
, pp. 1010-1014
-
-
Chipuk, J.E.1
Kuwana, T.2
Bouchier-Hayes, L.3
Droin, N.M.4
Newmeyer, D.D.5
Schuler, M.6
-
9
-
-
0034122591
-
Gain-of-function mutations in the tumor suppressor gene p53
-
van Oijen MG, Slootweg PJ. Gain-of-function mutations in the tumor suppressor gene p53. Clin Cancer Res 2000; 6: 2138-2145
-
(2000)
Clin Cancer Res
, vol.6
, pp. 2138-2145
-
-
Van Oijen, M.G.1
Slootweg, P.J.2
-
10
-
-
84887612980
-
Significance of TP53 mutations determined by next-generation deep sequencing in prognosis of estrogen receptor-positive breast cancer
-
Uji K, Naoi Y, Kagara N, Shimoda M, Shimomura A, Maruyama N, et al. Significance of TP53 mutations determined by next-generation deep sequencing in prognosis of estrogen receptor-positive breast cancer. Cancer Lett 2014; 342: 19-26
-
(2014)
Cancer Lett
, vol.342
, pp. 19-26
-
-
Uji, K.1
Naoi, Y.2
Kagara, N.3
Shimoda, M.4
Shimomura, A.5
Maruyama, N.6
-
11
-
-
0031912860
-
Assessment of sequence-based p53 gene analysis in human breast cancer: Messenger RNA in comparison with genomic DNA targets
-
Williams C, Norberg T, Ahmadian A, Ponten F, Bergh J, Inganas M, et al. Assessment of sequence-based p53 gene analysis in human breast cancer: messenger RNA in comparison with genomic DNA targets. Clin Chem 1998; 44: 455-462
-
(1998)
Clin Chem
, vol.44
, pp. 455-462
-
-
Williams, C.1
Norberg, T.2
Ahmadian, A.3
Ponten, F.4
Bergh, J.5
Inganas, M.6
-
12
-
-
34447314153
-
P-53 gene mutations as a predictive marker in a population of advanced breast cancer patients randomly treated with doxorubicin or docetaxel in the context of a phase III clinical trial
-
Di Leo A, Tanner M, Desmedt C, Paesmans M, Cardoso F, Durbecq V, et al. p-53 gene mutations as a predictive marker in a population of advanced breast cancer patients randomly treated with doxorubicin or docetaxel in the context of a phase III clinical trial. Ann Oncol 2007; 18: 997-1003
-
(2007)
Ann Oncol
, vol.18
, pp. 997-1003
-
-
Di Leo, A.1
Tanner, M.2
Desmedt, C.3
Paesmans, M.4
Cardoso, F.5
Durbecq, V.6
-
13
-
-
70449727603
-
Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53
-
Van Maerken T, Ferdinande L, Taildeman J, Lambertz I, Yigit N, Vercruysse L, et al. Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53. J Natl Cancer Inst 2009; 101: 1562-1574
-
(2009)
J Natl Cancer Inst
, vol.101
, pp. 1562-1574
-
-
Van Maerken, T.1
Ferdinande, L.2
Taildeman, J.3
Lambertz, I.4
Yigit, N.5
Vercruysse, L.6
-
14
-
-
0030961889
-
Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain
-
Selivanova G, Iotsova V, Okan I, Fritsche M, Strom M, Groner B, et al. Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain. Nat Med 1997; 3: 632-638
-
(1997)
Nat Med
, vol.3
, pp. 632-638
-
-
Selivanova, G.1
Iotsova, V.2
Okan, I.3
Fritsche, M.4
Strom, M.5
Groner, B.6
-
15
-
-
0031583962
-
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
-
Honda R, Tanaka H, Yasuda H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 1997; 420: 25-27
-
(1997)
FEBS Lett
, vol.420
, pp. 25-27
-
-
Honda, R.1
Tanaka, H.2
Yasuda, H.3
-
16
-
-
0037432773
-
Polyubiquitination of p53 by a ubiquitin ligase activity of p300
-
Grossman SR, Deato ME, Brignone C, Chan HM, Kung AL, Tagami H, et al. Polyubiquitination of p53 by a ubiquitin ligase activity of p300. Science 2003; 300: 342-344
-
(2003)
Science
, vol.300
, pp. 342-344
-
-
Grossman, S.R.1
Deato, M.E.2
Brignone, C.3
Chan, H.M.4
Kung, A.L.5
Tagami, H.6
-
17
-
-
2342447397
-
The ubiquitin ligase COP1 is a critical negative regulator of p53
-
Dornan D, Wertz I, Shimizu H, Arnott D, Frantz GD, Dowd P, et al. The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature 2004; 429: 86-92
-
(2004)
Nature
, vol.429
, pp. 86-92
-
-
Dornan, D.1
Wertz, I.2
Shimizu, H.3
Arnott, D.4
Frantz, G.D.5
Dowd, P.6
-
18
-
-
22844447871
-
The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation
-
Esser C, Scheffner M, Hohfeld J. The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation. J Biol Chem 2005; 280: 27443-27448
-
(2005)
J Biol Chem
, vol.280
, pp. 27443-27448
-
-
Esser, C.1
Scheffner, M.2
Hohfeld, J.3
-
19
-
-
84896649333
-
Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability
-
Wen W, Peng C, Kim MO, Ho Jeong C, Zhu F, Yao K, et al. Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability. Oncogene 2014; 33: 421-428
-
(2014)
Oncogene
, vol.33
, pp. 421-428
-
-
Wen, W.1
Peng, C.2
Kim, M.O.3
Ho Jeong, C.4
Zhu, F.5
Yao, K.6
-
20
-
-
77954894530
-
Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2
-
Nie J, Xie P, Liu L, Xing G, Chang Z, Yin Y, et al. Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2. J Biol Chem 2010; 285: 22818-22830
-
(2010)
J Biol Chem
, vol.285
, pp. 22818-22830
-
-
Nie, J.1
Xie, P.2
Liu, L.3
Xing, G.4
Chang, Z.5
Yin, Y.6
-
21
-
-
84869090231
-
Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis
-
Nikulenkov F, Spinnler C, Li H, Tonelli C, Shi Y, Turunen M, et al. Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis. Cell Death Differ 2012; 19: 1992-2002
-
(2012)
Cell Death Differ
, vol.19
, pp. 1992-2002
-
-
Nikulenkov, F.1
Spinnler, C.2
Li, H.3
Tonelli, C.4
Shi, Y.5
Turunen, M.6
-
22
-
-
0040298568
-
Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
-
Janicke RU, Sprengart ML, Wati MR, Porter AG. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 1998; 273: 9357-9360
-
(1998)
J Biol Chem
, vol.273
, pp. 9357-9360
-
-
Janicke, R.U.1
Sprengart, M.L.2
Wati, M.R.3
Porter, A.G.4
-
23
-
-
76249094935
-
RBCK1 drives breast cancer cell proliferation by promoting transcription of estrogen receptor alpha and cyclin B1
-
Gustafsson N, Zhao C, Gustafsson JA, Dahlman-Wright K. RBCK1 drives breast cancer cell proliferation by promoting transcription of estrogen receptor alpha and cyclin B1. Cancer Res 2010; 70: 1265-1274
-
(2010)
Cancer Res
, vol.70
, pp. 1265-1274
-
-
Gustafsson, N.1
Zhao, C.2
Gustafsson, J.A.3
Dahlman-Wright, K.4
-
24
-
-
84857443702
-
The p53 network: Cellular and systemic DNA damage responses in aging and cancer
-
Reinhardt HC, Schumacher B. The p53 network: cellular and systemic DNA damage responses in aging and cancer. Trends Genet 2012; 28: 128-136
-
(2012)
Trends Genet
, vol.28
, pp. 128-136
-
-
Reinhardt, H.C.1
Schumacher, B.2
-
26
-
-
0032473879
-
BRCA1 physically associates with p53 and stimulates its transcriptional activity
-
Zhang H, Somasundaram K, Peng Y, Tian H, Bi D, Weber BL, et al. BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene 1998; 16: 1713-1721
-
(1998)
Oncogene
, vol.16
, pp. 1713-1721
-
-
Zhang, H.1
Somasundaram, K.2
Peng, Y.3
Tian, H.4
Bi, D.5
Weber, B.L.6
-
27
-
-
45549091754
-
Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase Cbeta
-
Tatematsu K, Yoshimoto N, Okajima T, Tanizawa K, Kuroda S. Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase Cbeta. J Biol Chem 2008; 283: 11575-11585
-
(2008)
J Biol Chem
, vol.283
, pp. 11575-11585
-
-
Tatematsu, K.1
Yoshimoto, N.2
Okajima, T.3
Tanizawa, K.4
Kuroda, S.5
-
28
-
-
64649091704
-
E3 ubiquitin ligase RNF31 cooperates with DAX-1 in transcriptional repression of steroidogenesis
-
Ehrlund A, Anthonisen EH, Gustafsson N, Venteclef N, Robertson Remen K, Damdimopoulos AE, et al. E3 ubiquitin ligase RNF31 cooperates with DAX-1 in transcriptional repression of steroidogenesis. Mol Cell Biol 2009; 29: 2230-2242
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2230-2242
-
-
Ehrlund, A.1
Anthonisen, E.H.2
Gustafsson, N.3
Venteclef, N.4
Robertson Remen, K.5
Damdimopoulos, A.E.6
-
29
-
-
84899558084
-
E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin
-
Mackay C, Carroll E, Ibrahim AF, Garg A, Inman GJ, Hay RT, et al. E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin. Cancer Res 2014; 74: 2246-2257
-
(2014)
Cancer Res
, vol.74
, pp. 2246-2257
-
-
Mackay, C.1
Carroll, E.2
Ibrahim, A.F.3
Garg, A.4
Inman, G.J.5
Hay, R.T.6
-
30
-
-
84897953559
-
Germline polymorphisms in RNF31 regulate linear ubiquitination and oncogenic signaling
-
Grumati P, Dikic I. Germline polymorphisms in RNF31 regulate linear ubiquitination and oncogenic signaling. Cancer Discov 2014; 4: 394-396
-
(2014)
Cancer Discov
, vol.4
, pp. 394-396
-
-
Grumati, P.1
Dikic, I.2
-
31
-
-
84897942317
-
Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms
-
Yang Y, Schmitz R, Mitala J, Whiting A, Xiao W, Ceribelli M, et al. Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms. Cancer Discov 2014; 4: 480-493
-
(2014)
Cancer Discov
, vol.4
, pp. 480-493
-
-
Yang, Y.1
Schmitz, R.2
Mitala, J.3
Whiting, A.4
Xiao, W.5
Ceribelli, M.6
-
32
-
-
34548051074
-
Estrogen receptor alpha inhibits p53-mediated transcriptional repression: Implications for the regulation of apoptosis
-
Sayeed A, Konduri SD, Liu W, Bansal S, Li F, Das GM. Estrogen receptor alpha inhibits p53-mediated transcriptional repression: implications for the regulation of apoptosis. Cancer Res 2007; 67: 7746-7755
-
(2007)
Cancer Res
, vol.67
, pp. 7746-7755
-
-
Sayeed, A.1
Konduri, S.D.2
Liu, W.3
Bansal, S.4
Li, F.5
Das, G.M.6
-
33
-
-
0031869758
-
Predicting response to cancer chemotherapy: The role of p53
-
Weller M. Predicting response to cancer chemotherapy: the role of p53. Cell Tissue Res 1998; 292: 435-445
-
(1998)
Cell Tissue Res
, vol.292
, pp. 435-445
-
-
Weller, M.1
-
34
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004; 303: 844-848
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
-
35
-
-
16444380911
-
Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors
-
Carvajal D, Tovar C, Yang H, Vu BT, Heimbrook DC, Vassilev LT. Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors. Cancer Res 2005; 65: 1918-1924
-
(2005)
Cancer Res
, vol.65
, pp. 1918-1924
-
-
Carvajal, D.1
Tovar, C.2
Yang, H.3
Vu, B.T.4
Heimbrook, D.C.5
Vassilev, L.T.6
-
36
-
-
34047271954
-
Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation
-
Jiang M, Pabla N, Murphy RF, Yang TX, Yin XM, Degenhardt K, et al. Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation. J Biol Chem 2007; 282: 2636-2645
-
(2007)
J Biol Chem
, vol.282
, pp. 2636-2645
-
-
Jiang, M.1
Pabla, N.2
Murphy, R.F.3
Yang, T.X.4
Yin, X.M.5
Degenhardt, K.6
-
37
-
-
67649442533
-
The MDM2 antagonist nutlin-3 sensitizes p53-null neuroblastoma cells to doxorubicin via E2F1 and TAp73
-
Peirce SK, Findley HW. The MDM2 antagonist nutlin-3 sensitizes p53-null neuroblastoma cells to doxorubicin via E2F1 and TAp73. Int J Oncol 2009; 34: 1395-1402
-
(2009)
Int J Oncol
, vol.34
, pp. 1395-1402
-
-
Peirce, S.K.1
Findley, H.W.2
-
38
-
-
71549151624
-
Suppression of Hypoxia-inducible factor 2 alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells
-
Roberts AM, Watson IR, Evans AJ, Foster DA, Irwin MS, Ohh M. Suppression of Hypoxia-inducible factor 2 alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells. Cancer Res 2009; 69: 9056-9064
-
(2009)
Cancer Res
, vol.69
, pp. 9056-9064
-
-
Roberts, A.M.1
Watson, I.R.2
Evans, A.J.3
Foster, D.A.4
Irwin, M.S.5
Ohh, M.6
-
39
-
-
0242721592
-
Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway
-
Zhang Y, Wolf GW, Bhat K, Jin A, Allio T, Burkhart WA, et al. Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol 2003; 23: 8902-8912
-
(2003)
Mol Cell Biol
, vol.23
, pp. 8902-8912
-
-
Zhang, Y.1
Wolf, G.W.2
Bhat, K.3
Jin, A.4
Allio, T.5
Burkhart, W.A.6
-
40
-
-
34248586255
-
Estrogen receptor beta2 negatively regulates the transactivation of estrogen receptor alpha in human breast cancer cells
-
Zhao C, Matthews J, Tujague M, Wan J, Strom A, Toresson G, et al. Estrogen receptor beta2 negatively regulates the transactivation of estrogen receptor alpha in human breast cancer cells. Cancer Res 2007; 67: 3955-3962
-
(2007)
Cancer Res
, vol.67
, pp. 3955-3962
-
-
Zhao, C.1
Matthews, J.2
Tujague, M.3
Wan, J.4
Strom, A.5
Toresson, G.6
-
41
-
-
84877028141
-
Comprehensive molecular portraits of human breast tumours
-
Cancer Genome Atlas Network
-
Cancer Genome Atlas Network, Comprehensive molecular portraits of human breast tumours. Nature 2012; 490: 61-70
-
(2012)
Nature
, vol.490
, pp. 61-70
-
-
|