Protein and calorie restriction contribute additively to protection from renal ischemia reperfusion injury partly via leptin reduction in male mice

Journal of Nutrition

Volumn 145, Issue 8, 2015, Pages 1717-1727

  Robertson, Lauren T ^a   Treviño Villarreal, J Humberto ^a   Mejia, Pedro ^a   Grondin, Yohann ^a   Harputlugil, Eylul ^a   Hine, Christopher ^a   Vargas, Dorathy ^a   Zheng, Hanqiao ^a   Ozaki, C Keith ^b   Kristal, Bruce S ^c   Simpson, Stephen J ^d   Mitchell, James R ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Amino acid sensing; AMPK; Calorie restriction; Dietary restriction; GCN2; Geometric framework; Ischemia reperfusion injury; Leptin; mTOR; Protein restriction

Indexed keywords

ADIPONECTIN; ESSENTIAL AMINO ACID; HORMONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEPTIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; RECOMBINANT LEPTIN; RECOMBINANT PROTEIN; EIF2AK4 PROTEIN, MOUSE; PROTEIN INTAKE; PROTEIN SERINE THREONINE KINASE; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALORIC INTAKE; CALORIC RESTRICTION; CONTROLLED STUDY; DIETARY INTAKE; ENERGY BALANCE; GEOMETRY; HISTOLOGY; ISCHEMIC PRECONDITIONING; KIDNEY ISCHEMIA; MALE; MOUSE; NONHUMAN; PROTEIN RESTRICTION; RENAL PROTECTION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; WEIGHT REDUCTION; ACUTE KIDNEY INJURY; ADMINISTRATION AND DOSAGE; ANIMAL; AREA UNDER THE CURVE; BLOOD; C57BL MOUSE; GENETICS; KNOCKOUT MOUSE; METABOLISM; PROTEIN INTAKE;

MUS; RODENTIA;

ACUTE KIDNEY INJURY; ANIMALS; AREA UNDER CURVE; CALORIC RESTRICTION; DIETARY PROTEINS; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN-SERINE-THREONINE KINASES; REPERFUSION INJURY; UREA;

EID: 84935114351     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.114.199380     Document Type: Article

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