Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic β-cells

Journal of Endocrinology

Volumn 226, Issue 1, 2015, Pages 57-66

  Hamano, Kunihisa ^a,b   Nakagawa, Yuko ^a   Ohtsu, Yoshiaki ^a   Li, Longfei ^a   Medina, Johan ^a   Tanaka, Yuji ^b   Masuda, Katsuyoshi ^c   Komatsu, Mitsuhisa ^d   Kojima, Itaru ^a  

^a GUNMA UNIVERSITY   (Japan)

^b NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^c SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

^d SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Glucose; Insulin secretion; Sweet taste receptor; cell

Indexed keywords

CALCIUM ION; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR T1R3; GLUCOSE; INSULIN; LACTISOLE; POTASSIUM CHANNEL; PROPIONIC ACID DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SUCRALOSE; UNCLASSIFIED DRUG; ACETOSULFAME; BENZENE DERIVATIVE; CALCIUM; GLYCYRRHIZIC ACID; SUCROSE; SWEETENING AGENT; TASTE RECEPTORS, TYPE 1; THIAZINE DERIVATIVE; TRICHLOROSUCROSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM SIGNALING; CONCENTRATION CAMP; DEPOLARIZATION; GENETIC TRANSFECTION; GLUCOSE METABOLISM; IC50; INSULIN RELEASE; MIN6 CELL LINE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SWEETNESS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; HEK293 CELL LINE; HUMAN; METABOLISM; SECRETION (PROCESS);

ANIMALS; BENZENE DERIVATIVES; CALCIUM; CELL LINE; CYCLIC AMP; GLUCOSE; GLYCYRRHIZIC ACID; HEK293 CELLS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MICE; RECEPTORS, G-PROTEIN-COUPLED; SUCROSE; SWEETENING AGENTS; THIAZINES;

EID: 84935063339     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-15-0102     Document Type: Article

References (38)

1. + channel-independent glucose action in rat pancreatic β-cell. American Journal of Physiology 266 C622-C627.
2. Ashcroft FM & Rorsman P 1989 Electrophysiology of the pancreatic β-cell. Progress in Biophysics and Molecular Biology 54 87-143. (doi:10.1016/ 0079-6107(89)90013-8)
3. Bezencon C, le Coutre J & Damak S 2007 Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chemical Senses 32 41-49. (doi:10.1093/chemse/bjl034)
4. + channels in mouse B cells. Journal of Clinical Investigation 89 1288-1295. (doi:10.1172/JCI115714)
5. Geraedts MC, Takahashi T, Vigues S, Markwardt MC, Nkobena A, Cockerham RE, Hajnal A, Dotson CD, Rizzo MA & Munger SD 2012 Transformation of postingestive glucose responses after deletion of sweet taste receptor subunits or gastric bypass surgery. American Journal of Physiology 303 E464-E474. (doi:10.1152/ajpendo.00163.2012)
6. Gotoh M, Maki T, Koizumi T, Satomi S & Monaco AP 1985 An improved method for isolation of mouse pancreatic islets. Transplantation 40 437-438. (doi:10.1097/00007890-198510000-00018)
7. Henquin JC 2009 Regulation of insulin secretion: a matter of phase control and amplitude modulation. Diabetologia 52 738-751. (doi:10.1007/ s00125-009-1314-y)
8. Jang HJ, Kokrashvili Z, Theodorakis MJ, Carloson OD & Kim BJ 2010 Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. PNAS 104 15069-15074. (doi:10.1073/pnas. 0706890104)
9. Jiang P, Cui M, Zhao B, Liu Z, Snyder LA, Bernard LM, Osman R, Margolskee RF & Max M 2005 Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. Journal of Biological Chemistry 280 15238-15246. (doi:10.1074/jbc.M414287200)
10. Johnson C, Birch GG & MacDougall DB 1994 The effect of the sweetness inhibitor 2(-4-methoxyphenoxy)propanoic acid (sodium salt) (Na-PMP) on the taste of bitter-sweet stimuli. Chemical Senses 19 349-358. (doi:10.1093/chemse/19.4.349)
11. Kojima I, Nakagawa Y, Ohtsu Y, Medina A & Nagasawa M 2014 Sweet tastesensing receptors expressed in pancreatic ß-cells: sweet molecules act as biased agonists. Endocrinology and Metabolism 29 1-8. (doi:10.3803/ EnM.2014.29.1.12)
12. Kojima I, Nakagawa Y, Ohtsu Y, Hamano K, Medina J & Nagasawa M 2015 Return of the glucoreceptor: glucose activates the glucose-sensing receptor T1R3 and facilitates metabolism in pancreatic b-cells. Journal of Diabetes Investigation 6 256-263. (doi:10.1111/jdi.12304)
13. Kyriazis GA, Soundarapandian MM & Tyberg B 2012 Sweet taste receptor signaling in ß cells mediates fructose-induced potentiation of glucosestimulated insulin secretion. PNAS 109 E524-E532. (doi:10.1073/pnas. 1115183109)
14. Kyriazis GA, Smith KR, Tyrberg B, Hussain T & Pratley RE 2014 Sweet taste receptor regulate basal secretion and contribute to compensatory insulin hypersecretion during the development of diabetes in male mice. Endocrinology 155 2112-2121. (doi:10.1210/en. 2013-2015)
15. Malaisse WJ 2014 Insulin release: the receptor hypothesis. Diabetologia 57 1287-1290. (doi:10.1007/s00125-014-3221-0)
16. +-glucose cotransporter 1. PNAS 104 15075-15080. (doi:10.1073/pnas. 0706678104)
17. Masubuchi Y, Nakagawa Y, Ma JH, Sasaki T, Kitamuta T, Yamamoto Y, Kurose H, Kojima I & Shibata H 2013 A novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells. PLoS ONE 8 e54500. (doi:10.1371/journal.pone. 0054500)
18. Masuda K, Koizumi A, Nakajima K, Tanaka T, Abe K, Misaka T & Ishiguro M 2012 Characterization of the modes of binding between human sweet taste receptor and low-molecular-weight sweet compounds. PLoS ONE 7 e35380. (doi:10.1371/journal.pone.0035380)
19. Medina A, Nakagawa Y, Ma J, Li L, Hamano K, Akimoto T, Ninomiya Y & Kojima I 2014 Expression of the glucose-sensing receptor T1R3 in pancreatic islet. Endocrine Journal 61 797-805. (doi:10.1507/endocrj. EJ14-0221)
20. Miyazaki J, Araki K, Yamamoto E, Ikegami H, Asano T, Oka Y & Yamamura Y 1990 Establishment of a pancreatic ß-cell line that retains glucose-inducible insulin secretion. Endocrinology 127 126-132. (doi:10.1210/endo-127-1-126)
21. Nakagawa Y, Nagasawa M, Yamada S, Hara A, Mogami H, Nicolaev VO, Lohse MJ, Shigemura N, Ninomiya Y & Kojima I 2009 Sweet taste receptor expressed in pancreatic ß-cells activates the calcium and cyclic AMP signaling system and stimulates insulin secretion. PLoS ONE 4 e5106. (doi:10.1371/journal.pone.0005106)
22. Nakagawa Y, Nagasawa M, Mogami H, Lohse MJ, Ninomiya Y & Kojima I 2013 Multimodal function of the sweet taste receptor expressed in pancreatic ß-cells: generation of diverse patterns of intracellular signals by sweet agonists. Endocrine Journal 60 1191-1206. (doi:10.1507/ endocrj.EJ13-0282)
23. Nakagawa Y, Ohtsu Y, Nagasawa M, Shibata H & Kojima I 2014 Glucose promotes its own metabolism by acting on the cell-surface glucosesensing receptor T1R3. Endocrine Journal 61 119-131. (doi:10.1507/ endocrj.EJ13-0431)
24. Nakakura T, Mogi C, Tobo M, Tomura H, Sato K, Kobayashi M, Ohnishi H, Tanaka S, Wayama M, Sugiyama T et al. 2012 Deficiency of protonsensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion. Endocrinology 153 4171-4180. (doi:10.1210/en.2012-1164)
25. Nelson G, Hoon MA, Chandrasekar J, Zhang Y, Ryba NJ & Zuker CS 2001 Mammalian sweet taste receptor. Cell 106 381-390. (doi:10.1016/ S0092-8674(01)00451-2)
26. Newsholme P, Cruzat V, Arfuso F & Keane K 2014 Nutrient regulation of insulin secretion. Journal of Endocrinology 221 R105-R120. (doi:10.1530/JOE-13-0616)
27. Nikolaev VO, Bunemann M, Hein L, Hannawacker A & Lohse MJ 2004 Novel signal chain cAMP sensors for receptor-mediated signal propagation. Journal of Biological Chemistry 279 37215-37218. (doi:10.1074/jbc.C400302200)
28. Ohtsu Y, Nakagawa Y, Nagasawa M, Takeda S, Arakawa H & Kojima I 2014 Diverse signaling system activated by the sweet taste-sensing receptor in human GLP-1-secreting cells. Molecular and Cellular Endocrinology 394 70-79. (doi:10.1016/j.mce.2014.07.004)
29. Oya M, Suzuki H, Watanabe Y, Sato M & Tsuboi T 2011 Amino acid taste receptor regulates insulin secretion in pancreatic ß-cell line MIN6 cells. Genes to Cells 16 608-616. (doi:10.1111/j.1365-2443.2011. 01509.x)
30. Rasmussen H, Zawalich KC, Ganesan S, Calle R & Zawalich WS 1990 Physiology and pathophysiology of insulin secretion. Diabetes Care 13 655-666. (doi:10.2337/diacare.13.6.655)
31. Roper SD 2007 Signal transduction and information processing in mammalian taste buds. Pflügers Archiv: European Journal of Physiology 454 759-776. (doi:10.1007/s00424-007-0247-x)
32. Roper SD 2013 Taste buds as peripheral chemosensory processors. Seminars in Cell & Developmental Biology 24 71-79. (doi:10.1016/j.semcdb.2012. 12.002)
33. Rorsman P 1997 The pancreatic ß-cell as a fuel sensor: an electrophysiologist's viewpoint. Diabetologia 40 487-495. (doi:10.1007/ s001250050706)
34. 2+ influx in ray pancreatic B cell. Diabetes 41 438-443. (doi:10.2337/diab.41.4.438)
35. Sclafani A & Perez C 1997 Cypha [propionic acid, 2-(4-methoxyphenol) salt] inhibits sweet taste in humans, but not in rats. Physiology & Behavior 61 25-29. (doi:10.1016/S0031-9384(96)00316-2)
36. Shigemura N, Nakao K, Yasuo T, Murata Y, Yasumatsu K & Ninomiya Y 2008 Gurmarin sensitivity of sweet taste response is associated with co-expression patterns of T1r2, T1r3 and gustducin. Biochemical and Biophysical Research Communications 367 356-363. (doi:10.1016/j.bbrc. 2007.12.146)
37. Temussi P 2007 The sweet taste receptor: a single receptor with multiple sites and modes of interaction. Advances in Food and Nutrition Research 53 199-239. (doi:10.1016/S1043-4526(07)53006-8)
38. Xu H, Staszewski L, Tang H, Adler E, Zoller M & Li X 2004 Different functional roles of T1R subunits in the heteromeric taste receptors. PNAS 101 14258-14263. (doi:10.1073/pnas. 0404384101)