Bioactive Self-Assembling Lipid-Like Peptides as Permeation Enhancers for Oral Drug Delivery

Journal of Pharmaceutical Sciences

Volumn 104, Issue 7, 2015, Pages 2304-2311

  Karavasili, Christina ^a   Spanakis, Marios ^a,c   Papagiannopoulou, Dionysia ^a   Vizirianakis, Ioannis S ^a   Fatouros, Dimitrios G ^a   Koutsopoulos, Sotirios ^b  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b Massachusetts Institute of Technology   (United States)

^c INSTITUTE OF COMPUTER SCIENCE   (Greece)

Author keywords

absorption enhancer; Caco 2 cells; designed tunable peptides; epithelial delivery; everted sacs; formulation; intestinal absorption; lipid like peptides; macromolecular drug delivery; oral absorption; surfactant

Indexed keywords

ALANINE; ASPARTIC ACID; BOVINE SERUM ALBUMIN; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; LIPID; LYSINE; PENETRATION ENHANCING AGENT; DEXTRAN; FLUORESCEIN ISOTHIOCYANATE; PEPTIDE;

ANIMAL EXPERIMENT; ARTICLE; CACO 2 CELL LINE; CELL VIABILITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG TRANSPORT; EPITHELIUM CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; INTESTINE ABSORPTION; MACROMOLECULE; NONHUMAN; RAT; TIGHT JUNCTION; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICAL PHENOMENA; HUMAN; INTESTINE MUCOSA; METABOLISM; ORAL DRUG ADMINISTRATION; PERMEABILITY; PHYSIOLOGY; PROCEDURES; TRANSPORT AT THE CELLULAR LEVEL; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; DEXTRANS; DRUG DELIVERY SYSTEMS; EPITHELIAL CELLS; FLUORESCEIN-5-ISOTHIOCYANATE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; LIPIDS; PEPTIDES; PERMEABILITY; RATS; RATS, WISTAR; TIGHT JUNCTIONS;

EID: 84935033003     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24484     Document Type: Article

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