Two-layered injectable self-assembling peptide scaffold hydrogels for long-term sustained release of human antibodies

Journal of Controlled Release

Volumn 160, Issue 3, 2012, Pages 451-458

  Koutsopoulos, Sotirios ^a   Zhang, Shuguang ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Controlled release; Drug delivery; Multi layer hydrogel; Permeable hydrogel; Protein diffusion; Self assembly

Indexed keywords

ANTIBODY BINDING; BIOLOGICAL ASSAYS; BIOLOGICAL FLUIDS; CONCENTRIC SPHERES; CONTROLLED RELEASE; DIFFUSION PROFILES; ELECTROLYTE SOLUTIONS; EXPERIMENTAL PROTOCOLS; HUMAN ANTIBODIES; HUMAN IGG; HUMAN IMMUNOGLOBULIN; HYDROGEL STRUCTURE; LOADING EFFICIENCY; NANOFIBER DENSITY; NANOFIBER SCAFFOLD; PEPTIDE HYDROGELS; PERMEABLE STRUCTURES; PHOSPHOCHOLINE; POLYCLONAL; PROTEIN DIFFUSION; RELEASE KINETICS; SECONDARY AND TERTIARY STRUCTURES; SELF-ASSEMBLING PEPTIDES; SINGLE-MOLECULE ANALYSIS; SOL-GEL TRANSITIONS; STIMULI-RESPONSIVE MATERIALS; SUSTAINED RELEASE; THERAPEUTIC ANTIBODIES;

ANTIBODIES; ANTIGENS; BIOACTIVITY; DRUG DELIVERY; LOADING; NANOFIBERS; PEPTIDES; SELF ASSEMBLY; SOL-GELS;

HYDROGELS;

ELECTROLYTE; IMMUNOGLOBULIN G; MOLECULAR SCAFFOLD;

ANTIGEN BINDING; ARTICLE; BIOLOGICAL ACTIVITY; DRUG CONFORMATION; HYDROGEL; NANOENCAPSULATION; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE;

ANTIGENS; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; HUMANS; HYDROGELS; IMMUNOGLOBULIN G; INJECTIONS; NANOFIBERS; OLIGOPEPTIDES; PHOSPHORYLCHOLINE; SERUM ALBUMIN, BOVINE;

EID: 84861978000     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.03.014     Document Type: Article

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